Visual Universitätsmedizin Mainz

Jun. Prof. Dr. med. Jens U. Marquardt

Jun. Prof. Dr. med. Marquardt
Funktionen: Leiter Lichtenberg Research Group, Stellvertretender Leiter onkologische Ambulanz (Schwerpunkt: Hepatobiliäre Tumore), Leiter Core Facility Bioinformatik (Bium-Mz), Oberarzt Station 605-5B2
Qualifikationen: Facharzt für Innere Medizin und Gastroenterologie, Medikamentöse Tumortherapie, Ernährungsmediziner (DGEM)
jens.marquardt@unimedizin-mainz.de

Klinische Schwerpunkte

Hepatologie, Gastrointestinale Onkologie (Hepatobiliäre Tumore), chronische Lebererkrankungen
  

Wissenschaftliche Schwerpunkte

Molekulare Hepatokarzinogenese, Krebsstammzellen hepatobiliärer Tumore, Pharmakogenomic, Systemhepatologie, Versorgungsforschung bei chronischen Lebererkrankungen
   

Mitarbeiter/innen

  • Monika Herr (MTA)
  • Dr. Monika Hartmann (Post-Doc)
  • Dr. med. Carolin Czauderna (Assistenzärztin)
  • Dr. Sophia Franck (Forschungsaufenthalt am NIH)
  • Diana Becker (Dipl. Bioinformatikerin)
  • Darko Castven (PhD Student)
  • Sharon Pereira (PhD Student)
  • Friederike Mahn (PhD Student)
  • Jovana Hajduk (PhD Student)
  • Rany Daas (cand. med.)
  • Moritz Moldenhauer (cand. med.)
  • Carolin Steinbrenner (cand. med.)
  • Ellen Gebauer (cand. Med.)
  • Julia Jäger (cand. med.)
  • Thomas Austgen (cand. med.)

Reviewer Tätigkeiten

Nature Genetics, Nature Communications, Gastroenterology, Cell Stem Cell, Cell Metabolism, Journal of Clinical Investigation, Hepatology, GUT, Journal of Hepatology, Nature Communications, Cancer Research, Clinical Cancer Research, Oncogene, PNAS, Carcinogenesis, International Journal of Cancer, Current Cancer Drug Targets, American Journal of Physiology - Gastrointestinal and Liver Physiology

Editorial Boards

BMC Genomics
    

Mitgliedschaft in Fachgesellschaften

  • Deutsche Krebsgesellschaft (DKG)
  • Deutsche Gesellschaft Juniorprofessur (DGJ)
  • Deutsche Gesellschaft für Verdauungs- und Stoffwechselerkrankungen (DGVS)
  • European Association for the Study of the Liver (EASL)
  • Deutsche Gesellschaft für Ernährungsmedizin (DGEM)
  • Deutsche Gesellschaft für Innere Medizin e.V. (DGIM)
  • American Association for Cancer Research (AACR)
  • American Association for the Study of the Liver (AASLD)
  • International Liver Cancer Association (ILCA)

    Kooperationen

    • Dr. Snorri S. Thorgeirsson, MD/PhD (Laboratory of Experimental Carcinogenesis (LEC), National Cancer
    • Institute, National Institutes of Health, Bethesda/MD, USA)
    • Prof. Ju-Seog Lee (MD Anderson Cancer Center, Huston/Texas, USA)
    • Prof. Dr. Timo Gaiser (Institut für Pathologie, Universitätsmedizin Mannheim)
    • PD Dr. Kai Breuhahn (Institut für Pathologie, Universitätsklinikum Heidelberg)
    • PD Dr. Johannes Schumacher (Institut für Humangenetik, Universität Bonn)
    • Dr. Frank Edlich (Institut für Biochemie und Molekularbiologie, Freiburg)
    • Prof. Dr. Luis Enrique Gomez-Quiroz, M.Sc., Ph.D., (Laboratory of Cellular Physiology, Universidad Autonoma Metropolitana-Iztapalapa, Mexico)
    • Prof. Dr. Jesper B. Andersen (Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Denmark)
    • Prof. Dr. Ines Gockel (Klinik und Poliklinik für Viszeral-, Transplantations-, Thorax- und Gefäßchirurgie, Universitätsklinikum Leipzig)
    • Prof. Dr. Fernando Moreno (University of Sao Paolo, Sao Paolo, Brazil)

    Publikationen (Auswahl)

    (vollständige Liste)

     

    • Heinrich B., Czauderna C., Marquardt JU. Immunotherapy of Hepatocellular Carcinoma. Oncol Res Treat. 2018;41(5):292-297.
    • Nault JC., Galle PR. Marquardt JU. The role of molecular enrichment on future therapies in hepatocellular carcinoma. J Hepatol. 2018 Mar 2. pii: S0168-8278(18)30134-X
    • Marquardt JU. The role of TGFβ in human hepatocarcinogenesis: mechanistic and therapeutic implications from an integrative multi-omics approach. Gastroenterology 2018 Jan;154(1):17-20.
    • Reichenbach F., Wiedenmann C., Schalk E., Becker D., Funk K., Scholz-Kreisel P., Todt F., Döhner K., Marquardt JU.*, Heidel F.H.*, Edlich F.* Mitochondrial Bax determines the predisposition to apoptosis in human AML. Clin Cancer Res. 2017 Aug 15;23(16):4805-4816. (*shared senior authors)
    • Castven C., Fischer M., Becker D., Heinrich S., Andersen JB., Strand D., Sprinzl MF., Strand S., Czauderna C., Heilmann S., Roessler S., Weinmann A., Wörns MA., Thorgeirsson SS., Galle PR., Matter MS., Lang H., Marquardt JU. Adverse genomic alterations and stemness features are induced by field cancerization in the microenvironment of hepatocellular carcinomas. Oncotarget. 2017 Jul 25;8(30):48688-48700.
    • Marquardt JU. Deconvolution of the cellular origin in hepatocellular carcinoma - hepatocytes take the center stage. Hepatology. 2016 Oct;64(4):1020-3.
    • Gomez-Quiroz LE., Seo D., Lee YH., Kitade M., Gaiser T., Matthew Gillen M., Gutierrez-Ruiz MC:, Palestino-Domínguez M., Lee SB., Conner EA., Factor VM., Thorgeirsson SS., Marquardt JU. Loss of c-Met signaling sensitizes hepatocytes to lipotoxicity and induces cholestatic liver damage by aggravating oxidative stress.  Toxicology 2016 Jul 6. pii: S0300-483X(16)30121-4. [Epub ahead of print]
    • Marquardt JU., Nguyen-Tat M., Galle PR., Wörns MA. HCC Surveillance and Diagnostic Algorithms in Patients with Liver Cirrhosis. Visc Med. 2016 Apr;32(2):110-5.
    • Marquardt JU., Galle PR. Conference Scenes from the 9th Annual Conference of the International Liver Cancer Association (ILCA) 2015 in Paris. Hepat Oncol. (accepted manuscript)
    • Marquardt JU., Andersen JB., Thorgeirsson SS. Functional and Genetic Deconstruction of the Cellular Origin in Liver Cancer. Nat Rev Cancer  2015 Oct 23;15(11):653-67.
    • Marquardt JU., Gomez-Quiroz L., Arreguin Camacho LO., Pinna F., Lee YH., Kitade M., Palestino Domínguez M., Breuhahn K., Conner EA., Galle PR., Andersen JB., Factor VM., Thorgeirsson SS. Curcumin Effectively Depletes Hepatic Cancer Stem-Like Cells by NF-kB Mediated Inhibition of Histone Deacetylases. J. Hepatol. 2015 Apr 30
    • Marquardt JU., Andersen JB. Liver cancer oncogenomics: Opportunities and dilemma for clinical applications. Hepat Oncol. 2015 Jan; 2 (01): 79-93.
    • Nguyen-Tat M., Götz E., Ahrens J., Rey JW., Sivanathan V., Wörns M., Galle PR., Marquardt JU. Response to Terlipressin and albumin is associated with improved outcome in patients with cirrhosis and hepatorenal syndrome (HRS). Dtsch Med Wochenschr. 2015 Jan;140(2):e21-6.
    • Marquardt JU., Thorgeirsson SS. Next-generation Genomic Profiling of Hepatocellular Adenomas: A New Era of Individualized Patient Care. Cancer Cell. 2014 Apr 14;25(4):409-11.
    • Marquardt JU., Thorgeirsson SS. SnapShot: Hepatocellular Carcinoma. Cancer Cell. 2014 Apr 14;25(4):550
    • Marquardt JU., Seo D., Andersen JB., Gillen MC., Kim MS., Conner EA., Factor VM., Park YN, Thorgeirsson SS. Sequential analysis of hepatocarcinogenesis indicates late stage acquisition of malignant traits. J Hepatol. 2014 Feb;60(2):346-53
    • Marquardt JU., Thorgeirsson SS. Linking MLL and the HGF-MET signaling pathway in liver cancer. J Clin Invest. 2013 Jul 1;123(7):2780-3
    • Marquardt JU., Thorgeirsson SS. Sall4 in Stemness-Driven Hepatocarcinogenesis. N Engl J Med 2013 Jun 13;368(24):2316-8
    • Marquardt JU., Fischer K., Baus K., Krupp M., Linke M, Teufel A., Zechner U., Strand D., Thorgeirsson SS., Galle PR., Strand S. SIRT6 dependent genetic and epigenetic alterations are associated with poor clinical outcome in HCC patients. Hepatology 2013 Mar 23. [Epub ahead of print]
    • Marquardt JU., Galle PR. Epigenetic regulation of methionine adenosyltransferase 1A; a role for microRNA-based treatment in liver cancer? Hepatology. 2013 Mar 6. doi: 10.1002/hep.26375. [Epub ahead of print]
    • Marquardt JU., Andersen JB. Next-generation sequencing: Application in liver cancer- past, present and future? Biology 2012, 1(2), 383-394; doi:10.3390/biology1020383
    • Marquardt JU., Galle PR., Teufel A. Hepatocellular carcinoma- Molecular pathogenesis and novel targets for therapy. Dtsch Med Wochenschr. 2012 Apr;137(16):855-60. Epub 2012 Apr 11
    • Marquardt, JU., Seo, D., Gomez-Quirez, L., Uchida, K., Gillen, MC., Kitade, M., Conner, EA., Factor, VM., Thorgeirsson, SS. Loss of c-Met Accelerates Development of Liver Fibrosis in Response to CCl4 Exposure through Deregulation of Multiple Molecular Pathways. Biochim Biophys Acta. 2012 Feb 22. [Epub ahead of print]
    • Marquardt JU., Galle PR., Teufel A. Molecular diagnosis and therapy of hepatocellular carcinoma (HCC); An emerging field for advanced technologies. J. Hepatol. 2011 Jul 23. [Epub ahead of print]
    • Marquardt, JU., Raggi, C., Andersen, JB.,  Seo, D., Avital, I., Geller, D., Lee, YH., Kitade, M., Holczbauer, A., Conner, EA., Factor, VM., Thorgeirsson, SS. Human Hepatic Cancer Stem Cells are Characterized by Common Stemness Traits and Diverse Oncogenic Pathways. Hepatology. 2011 May 26
    • Marquardt, JU., Quasdorff, M., Varnholt, H.,  Curth, HM., Mesghenna, S., Protzer, U., Goeser, T., Nierhoff, D. Neighbor of punc E11, a novel onco-fetal marker for hepatocellular carcinoma. Int J Cancer. 2010 July 23. [Epub ahead of print]
    • Marquardt JU., Factor VM., Thorgeirsson SS. Epigenetic Regulation of Liver Cancer Stem Cells: Current Concepts and Clinical Implications. J Hepatol. 2010 Sep;53(3):568-77. Epub 2010 May 31
    • Marquardt JU., Thorgeirsson SS. Stem Cells in Hepatocarcinogenesis: Evidence from Genomic Data. Semin Liver Dis. 2010; 30(1):26-35a

    Buchkapitel

    • Darko Castven, Carolin Czauderna and Jens U. Marquardt. Contribution of the Cancer Stem Cell Phenotype to Hepatocellular Carcinoma Resistance. Resistance to Molecular Therapies for Hepatocellular Carcinoma. Springer. pp 65-91. 2017. Vol 13. Springer
    • Luis E. Gómez-Quiroz, María Concepción Gutiérrez-Ruiz, Jens U Marquardt, Valentina M Factor, Snorri S. Thorgeirsson. Redox Regulation by cMet/HGF in liver disease. Liver Pathophysiology - Therapies and Antioxidants. 2017, Pages 375–387
    • Jens U. Marquardt and Snorri S. Thorgeirsson. Molecular Biology of Liver Cancer. Cancer. Principles & Practice of Oncology – 2018; 10th and 11th edition. LWW.
    • Jens U. Marquardt and Snorri S. Thorgeirsson. Molecular Biology of Liver Cancer. Cancer: Principles & Practice of Oncology – 2014; 10th edition. LWW.
    • Jens U. Marquardt and Peter R. Galle. MicroRNAs as Novel Targets in Liver Cancer: Facing the Clinical Challenge. MicroRNA Targeted Cancer Therapy - 2014; Chapter 9. Springer.
    • Jens U. Marquardt and Andreas Teufel. Stem Cells. Lehrbuch der Toxikologie – 2013; Wissenschaftliche Verlagsgesellschaft; Auflage: 3.
    • Jens U. Marquardt and Snorri S. Thorgeirsson. Cancer Stem Cells and Liver Cancer. Molecular Genetics of Liver Neoplasia – 2011; Chapter 15. Springer.

    Auszeichnungen und Preise

    • Lichtenberg Stiftungsprofessur “Molekulare Hepatokarzinogenese”. VolkswagenStiftung, Hannover 2015
    • UEG Rising Star Award 2014. United European Gastroenterology (UEG) Week, Vienna, Austria, October 2014
    • European Association for the Study of the Liver (EASL) Young Investigator Bursary 2013. 49th Annual Meeting of the European Association for the Study of the Liver, London, UK, April 2014
    • European Association for the Study of the Liver (EASL) Young Investigator Bursary 2014. EASL HCC Summit (Basic Science): Molecular Pathogenesis and Translational Research in Liver Cancer, Geneva, Switzerland, February 2014
    • GARPS Award 2013. 29th Annual Meeting of the Gastroenterology Association Rhineland-Palatinate and Saarland, Bad Kreuznach, November 2013. 
    • European Association for the Study of the Liver (EASL) Young Investigator Bursary 2013. 48th Annual Meeting of the European Association for the Study of the Liver, Amsterdam, Netherlands, April 2013
    • European Association for the Study of the Liver (EASL) Young Investigator Bursary 2013. Monothematic Conference “Systems Biology of the Liver: Systems Biology and Clinics Face à Face”, Luxembourg, Luxembourg, February 2013
    • European Association for the Study of the Liver (EASL) Young Investigator Bursary 2012. 47th Annual Meeting of the European Association for the Study of the Liver, Barcelona, Spain, April 2012
    • Posterprice 2012  of the German Association for the Study of the Liver (GASL). 28. Jahrestagung der GASL, Hamburg, January 2012
    • German Liver Foundation Award 2011. German Liver Foundation, 8. HepNet Symposium, Hannover June 2011
    • American Association for the Study of Liver Diseases (AASLD) Young Investigator Travel Award 2010. 61th Annual Meeting of the American Association for the Study of Liver Diseases, Boston, Massachusetts, USA, November 2010
    • Posterprice 2010 of the German Association for the Study of the Liver (GASL). 26. Jahrestagung der GASL, Bonn, Januar 2010
    • Cancer Research Training Award (CRTA) 2008-2010 (National Cancer Institute (NIH), Bethesda, MD)