Hepatologie, Gastrointestinale Onkologie (Hepatozelluläres Karzinom)

Targeted Therapy beim Hepatozellulären Karzinom (HCC)

Bedeutung des NF-kappaB Signalweges für die hepatische und intestinale Inflammation und Karzinogenese

Dr. med. Arndt Weinmann

PD Dr. med. Marcus Schuchmann

PD Dr. med. Dr. rer. nat. Andreas Teufel

Prof. Dr. rer. nat. Ari Waisman, Institut für Molekulare Medizin, Mainz

PD Dr. med. Henning Schulze-Bergkamen, Nationales Centrum für Tumorerkrankungen (NCT), Heidelberg

Prof. Dr. med. Thomas Höhler, Prosper Hospital, Recklinghausen

Sunitinib in patients with advanced hepatocellular carcinoma after progression under sorafenib treatment. Wörns MA, Schuchmann M, Düber C, Otto G, Galle PR, Weinmann A. Oncology 2010, in press

Future perspectives in hepatocellular carcinoma. Wörns MA, Galle PR. Dig Liver Dis. 2010 Jul;42 Suppl 3:S302-9.PMID: 20547319 [PubMed - in process]

Novel inhibitors in development for hepatocellular carcinoma. Wörns MA, Galle PR. Expert Opin Investig Drugs. 2010 May;19(5):615-29. PMID: 20374038 [PubMed - indexed for MEDLINE]

Concurrent autoimmune diseases in patients with autoimmune hepatitis. Teufel A, Weinmann A, Kahaly GJ, Centner C, Piendl A, Wörns MA, Lohse AW, Galle PR, Kanzler S. J Clin Gastroenterol. 2010 Mar;44(3):208-13. PMID: 20087196 [PubMed - indexed for MEDLINE]

Systemic therapies in hepatocellular carcinoma. Wörns MA, Weinmann A, Schuchmann M, Galle PR. Dig Dis. 2009;27(2):175-88. Epub 2009 Jun 22. Review. PMID: 19546557 [PubMed - indexed for MEDLINE]

A systems biology perspective on cholangiocellular carcinoma development: focus on MAPK-signaling and the extracellular environment. Wang C, Maass T, Krupp M, Thieringer F, Strand S, Wörns MA, Barreiros AP, Galle PR, Teufel A. J Hepatol. 2009 Jun;50(6):1122-31. Epub 2009 Mar 31. PMID: 19395114 [PubMed - indexed for MEDLINE]

Safety and efficacy of sorafenib in patients with advanced hepatocellular carcinoma in consideration of concomitant stage of liver cirrhosis. Wörns MA, Weinmann A, Pfingst K, Schulte-Sasse C, Messow CM, Schulze-Bergkamen H, Teufel A, Schuchmann M, Kanzler S, Düber C, Otto G, Galle PR. J Clin Gastroenterol. 2009 May-Jun;43(5):489-95. PMID: 19247201 [PubMed - indexed for MEDLINE]

Incidence of HAV and HBV infections and vaccination rates in patients with autoimmune liver diseases. Wörns MA, Teufel A, Kanzler S, Shrestha A, Victor A, Otto G, Lohse AW, Galle PR, Höhler T. Am J Gastroenterol. 2008 Jan;103(1):138-46. Epub 2007 Oct 26. PMID: 17970833 [PubMed - indexed for MEDLINE]

Regulation of B cell homeostasis and activation by the tumor suppressor gene CYLD. Hövelmeyer N, Wunderlich FT, Massoumi R, Jakobsen CG, Song J, Wörns MA, Merkwirth C, Kovalenko A, Aumailley M, Strand D, Brüning JC, Galle PR, Wallach D, Fässler R, Waisman A. J Exp Med. 2007 Oct 29;204(11):2615-27. Epub 2007 Oct 8. PMID: 17923499 [PubMed - indexed for MEDLINE]

Hereditary liver diseases. Wörns MA, Weinmann A, Galle PR. Gastoenterologie up2date. 2007; 2:135-153

Efficacy of an escalating dose regimen of pegylated interferon alpha-2a plus ribavirin in the early phase of HCV reinfection after liver transplantation. Zimmermann T, Böcher WO, Biesterfeld S, Zimmermann A, Kanzler S, Greif-Higer G, Barreiros AP, Sprinzl MF, Wörns MA, Lohse AW, Mönch C, Otto G, Galle PR, Schuchmann M. Transpl Int. 2007 Jul;20(7):583-90. Epub 2007 Apr 13. PMID: 17433090 [PubMed - indexed for MEDLINE]

Single center experience over a 5-year period with sequential transarterial chemoembolization (TACE) in the treatment of hepatocellular carcinoma (HCC) Herber SC, Otto G, Wörns MA, Moench C, Kanzler S, Junginger T, Schneider J, Schuchmann M, Kummer I, Manzl N, Düber C, Pitton MB. Rofo. 2007 Mar;179(3):289-99. German. PMID: 17325996 [PubMed - indexed for MEDLINE]

Molecular pathogenesis of hepatocellular carcinoma. Wörns MA, Schuchmann M, Kanzler S, Weinmann A, Galle PR. Gastroenterologe. 2007;2:12-19

Genetic association of autoimmune hepatitis and human leucocyte antigen in German patients. Teufel A, Wörns MA, Weinmann A, Centner C, Piendl A, Lohse AW, Galle PR, Kanzler S. World J Gastroenterol. 2006 Sep 14;12(34):5513-6. PMID: 17006990 [PubMed - indexed for MEDLINE]

Genetic and environmental contributions to plasma C-reactive protein and interleukin-6 levels-a study in twins. Wörns MA, Victor A, Galle PR, Höhler T. Genes Immun. 2006 Oct;7(7):600-5. Epub 2006 Aug 10. PMID: 16900203 [PubMed - indexed for MEDLINE]

Five cases of de novo inflammatory bowel disease after orthotopic liver transplantation. Wörns MA, Lohse AW, Neurath MF, Croxford A, Otto G, Kreft A, Galle PR, Kanzler S. Am J Gastroenterol. 2006 Aug;101(8):1931-7. Epub 2006 Jun 22. PMID: 16790037 [PubMed - indexed for MEDLINE]

Histone deacetylase inhibition by valproic acid down-regulates c-FLIP/CASH and sensitizes hepatoma cells towards CD95- and TRAIL receptor-mediated apoptosis and chemotherapy. Schuchmann M, Schulze-Bergkamen H, Fleischer B, Schattenberg JM, Siebler J, Weinmann A, Teufel A, Wörns MA, Fischer T, Strand S, Lohse AW, Galle PR. Oncol Rep. 2006 Jan;15(1):227-30. PMID: 16328060 [PubMed - indexed for MEDLINE]

A genetic basis for IFN-gamma production and T-bet expression in humans. Höhler T, Reuss E, Adams P, Bartsch B, Weigmann B, Wörns MA, Galle PR, Victor A, Neurath MF. J Immunol. 2005 Oct 15;175(8):5457-62. PMID: 16210653 [PubMed - indexed for MEDLINE]