Visual Universitätsmedizin Mainz

PD Dr. med. Tim Zimmermann

Priv.-Doz. Dr. med. Zimmermann
Funktionen: Oberarzt der Station 5B1, der Lebertransplantationsambulanz und Leberambulanz
Qualifikationen: Facharzt für Innere Medizin, Gastroenterologe, Hepatologe,
Transplantationsmedizin, Ernährungsmedizin,
Strahlenkunde, DEGUM I
tim.zimmermann@unimedizin-mainz.de

Wissenschaftliche Schwerpunkte:

Komplikationen chronischer Hepatopathien vor und nach Lebertransplantation

Mitgliedschaften in Fachgesellschaften:

  • Deutsche Gesellschaft für Verdauungs- und Stoffwechselkrankheiten (DGVS)
  • German association for the study of the liver (GASL)
  • European association for the study of the liver (EASL)
  • Deutsche Transplantationsgesellschaft (DTG)
  • Deutsche Gesellschaft für Ernährungsmedizin (DGEM)
  • Deutsche Gesellschaft für Ultraschall in der Medizin (DEGUM)

Kooperationen:

Intern: Prof. Dr. M. Schuchmann, Prof. Dr. Dr. D. Schuppan, Prof. Dr. S. Strand, Dr. A. Lautem
Extern: Prof. Dr. D. Gründemann (Pharmakologisches Institut, Universität Köln), Prof. Dr. A. Schinkel (The Netherlands Cancer Institute, Amsterdam)

Preise:

Förderpreis der GARPS 2008 für experimentelle Gastroenterologie: „EGF supprimiert Hugl-2, das humane Homolog des Drosophila Lgl Tumorsuppressor-Gens.“Young Investigator Award – EASL 2011: “Recipient CYP2D6*4 poor metabolizer status associates with early fibrosis development after liver transplantation.”

Publikationen (PubMed):

1. Heise M, Lautem A, Knapstein J, Schattenberg JM, Hoppe-Lotichius M, Foltys D, Weiler N, Zimmermann A, Schad A, Gründemann D, Otto G, Galle PR, Schuchmann M, Zimmermann T. Downregulation of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) in human hepatocellular carcinoma and their prognostic significance. BMC Cancer 2012; 22(1): 382-385.

2. Schattenberg JM, Wörns MA, Zimmermann T, He YW, Galle PR, Schuchmann M. The role of death effector domain-containing proteins in acute oxidative cell injury in hepatocytes. Free Radical Biology and Medicine, in press.

3. Foltys DB, Kaths JM, Zimmermann T, Heise M, Hoppe-Lotichius M, Otto G. Ten years of simultaneous pancreas-kidney transplantation: a retrospective single-center analysis of prospectively obtained data. Transplantation Proceedings 2011; 43(9): 3267-3269.

4. Foltys D, Heise M, Hadian A, Lautem A, Wisser G, Zimmermann T, Weiler N, Hoppe-Lotichius M, Peixoto N, Symkange-Zeeb F, Otto G. Liver transplantation for hepatocellular carcinoma – is there a risk of recurrence caused by intraoperative blood salvage autotransfusion? European Surgical Research 2011; 47(3): 182-187.

5. Wehler TC, Graf C, Altherr K, Zimmermann T, Brenner W, Thüroff JW, Biesterfeld S, Gockel I, Theobald M, Galle PR, Schimanski CC. SDF1β expression in renal cell carcinoma correlates with grading and infiltration by CD8+ T-cells. Anticancer Research 2011; 31(9): 2797-2803.

6. Zimmermann T, Hoppe-Lotichius M, Körner A, Lautem A, Heise M, Foltys D, Weiler N, Biesterfeld S, Schmidtmann I, Galle PR, Otto G, Schuchmann M. The recipient CYP2D6 allele 4-associated poor metabolizer status correlates with an early fibrosis development after liver transplantation. Transplant international 2011; 24(11): 1059-1067.

7. Schattenberg J, Zimmermann T, Wörns M, Sprinzl MF, Kreft A, Kohl T, Nagel M, Siebler J, Bergkamen HS, He YW, Galle PR, Schuchmann M. Ablation of c-FLIP in hepatocytes enhances death-receptor mediated apoptosis and toxic liver injury in vivo. Journal of Hepatology 2011; 55(6): 1272-1280.

8. Zimmermann A*, Zimmermann T*, Schattenberg J, Pöttgen S, Lotz J, Rossmann H, Röddiger R, Biesterfeld S, Geiss CH, Schuchmann M, Galle PR, Weber MM. Alterations in lipid, carbohydrate and iron metabolism in patients with NASH and metabolic syndrome. European Journal of Internal Medicine 2011; 22(3): 305-310. * Co-Erstautor

9. Schimanski CC, Moehler M, Zimmermann T, Wörns MA, Steinbach A, Baum M, Galle PR. Cetuximab-induced skin exanthema: Improvement by a reactive skin therapy. Molecular Medicine Reports 2010; 3(5): 789-794.

10. Schimanski CC, Möhler M, Gockel I, Zimmermann T, Lang H, Galle PR, Berger MR. Expression of chemokine receptor CCR5 correlates with the presence of hepatic molecular metastases in K-ras positive human colorectal cancer. Journal of Cancer Research and Clinical Oncology 2011; 137(7): 1139-1345.

11. Hartmann I, Schuchmann M, Zimmermann T. Posttransplant lymphoproliferative disease in liver transplant patients. Current Infectious Disease Reports 2011; 13: 53-59. 

12. Weiler N, Thrun I, Hoppe-Lotichius M, Zimmermann T, Kraemer I, Otto G. Early steroid-free immunosuppression with FK506 after liver transplantation: long-term results of a prospectively randomized double-blinded trial. Transplantation 2010; 90(12): 1562-1566.

13. Zimmermann T, Hoppe-Lotichus M, Tripkovic V, Barreiros AP, Wehler TC, Zimmermann A, Schattenberg JM, Heise M, Biesterfeld S, Galle PR, Otto G, Schuchmann M. Liver transplanted patients with preoperative autoimmune hepatitis and immunological disorders are at increased risk for Post-Transplant Lymphoproliferative Disease (PTLD). European Journal of Internal Medicine 2010; 21(3): 208-215.

14. Schimanski CC, Moehler M, Zimmermann T, Gockel I, Lang H, Arbogast R, Jäger D, Galle PR, Berger MR. [Detection of hepatic micrometastases in the context of adjuvant chemotherapy and surgery for hepatic metastases.] Deutsche Medizinische Wochenschrift 2010; 135(21): 1078-1082.

15. Zimmermann A, Grigorescu Sido P, AlKhzouz C, Patberg K, Bucerzan S, Schulze E, Zimmermann T, Roßmann H, Geiss Ch, Lackner KJ, Weber MM. Alterations in lipid and carbohydrate metabolism in patients with classic CAH due to 21-hydroxylase deficiency. Hormone Research in Paediatrics 2010; 74(1):41-9. 

16. Zimmermann T, Moehler M, Gockel I, Sgourakis GG, Biesterfeld S, Müller M, Berger MR, Lang H, Galle PR, Schimanski CC. Low expression of chemokine receptor CCR5 in human colorectal cancer correlates with lymphatic dissemination and reduced CD8+ T-cell infiltration. International Journal of Colorectal Disease 2010; 25(4): 417-424.  

17. Schimanski CC, Zimmermann T, Schmidtmann I, Gockel I, Lang H, Galle PR, Moehler M, Berger MR. K-ras mutation status correlates with the expression of VEGFR1, VEGFR2, and PDGFRalpha in colorectal cancer. International Journal of Colorectal Disease 2010; 25(2):181-186.

18. Zimmermann T, Otto C, Biesterfeld  S, Zimmermann A, Barreiros AP, Sprinzl MF, Otto G, Galle PR, Schuchmann M . Risk factors in patients with rapid recurrent HCV related cirrhosis within one year after liver transplantation. Transplantation Proceedings 2009; 41(6): 2549-2556.

19. Zimmermann T, Kashyap A, Hartmann U, Otto G, Galle PR, Strand S, Strand D. Cloning and characterization of the promoter of Hugl-2, the human homologue of Drosophila lethal giant larvae (lgl) polarity gene. Biochemical and Biophysical Research Communications 2008; 366(4): 1067-1073.

20. Zimmermann A, Schenk JP,  Grigorescu Sido P, Pfäffle R, Lazea C, Zimmermann T, Heinrich U, Weber MM, Bettendorf M. MRI findings and genotype analysis in patients with childhood onset growth hormone deficiency. Correlation with severity of hypopituitarism. Journal of Pediatric  Endocrinology and Metabolism 2007; 20(5):587-96. 

21. Zimmermann T, Böcher WO, Biesterfeld S, Zimmermann A, Kanzler S, Greif-Higer G, Barreiros AP, Sprinzl MF, Wörns MA, Lohse AW, Mönch C, Otto G, Galle PR, Schuchmann M. Efficacy of an escalating dose regimen of pegylated interferon alpha-2a plus ribavirin in the early phase of HCV reinfection after liver transplantation. Transplant International 2007; 20(7): 583-590.      

22. Lazar A*, Zimmermann T*, Koch W, Gründemann D, Schömig A, Kastrati A, Schömig E. Lower prevalence of the OCT2 Ser270 allele in patients with essential hypertension. Clinical and Experimental Hypertension 2006; 28: 645-653.   * Co-Erstautor          

23. Zimmermann T, Maccagno G, Galle PR, Otto G, Hitzler WE, Schuchmann M. Alloimmune hemolytic anemia after liver transplantation from an ABO-identical and Rh-nonidentical donor in a patient with postpartum Budd-Chiari syndrome. Transplant international 2006; 19(6): 514-515.

24. Lazar A, Gründemann D, Berkels R, Taubert D, Zimmermann T, Schömig E. Genetic variability of the extraneuronal monoamine transporter EMT (SLC22A3). Journal of Human Genetics 2003; 48: 226-230.

25. Gründemann D, Koschker AC, Haag C, Honold C, Zimmermann T, Schömig E. Activation of the extraneuronal monoamine transporter (EMT) from rat expressed in 293 cells. British Journal of Pharmacology 2002; 137(6): 910-918.