Kang TB, Ben-Moshe T, Varfolomeev EE, Pewzner-Jung Y, Yogev N, Jurewicz A, Waisman A, Brenner O, Haffner R, Gustafsson E, Ramakrishnan P, Lapidot T, Wallach D. Caspase-8 serves both apoptotic and nonapoptotic roles. J Immunol 2004;173(5):2976-84. Pubmed

Weigmann B, Nemetz A, Becker C, Schmidt J, Strand D, Lehr HA, Galle PR, Ho IC, Neurath MF. A critical regulatory role of leucin zipper transcription factor c-Maf in Th1-mediated experimental colitis. J Immunol 2004;173(5):3446-55. Pubmed

Kiesslich R, Burg J, Vieth M, Gnaendiger J, Enders M, Delaney P, Polglase A, McLaren W, Janell D, Thomas S, Nafe B, Galle PR, Neurath MF. Confocal laser endoscopy for diagnosing intraepithelial neoplasias and colorectal cancer in vivo. Gastroenterology 2004;127(3):706-13. Pubmed

Kiesslich R, Neurath MF. Chromoendoscopy: an evolving standard in surveillance for ulcerative colitis. Inflammatory bowel diseases 2004;10(5):695-6. Pubmed

Kiesslich R, Neurath MF. Endoscopic mucosal resection: an evolving therapeutic strategy for non-polypoid colorectal neoplasia. Gut 2004;53(9):1222-4. Pubmed

Schramm C, Huber S, Protschka M, Czochra P, Burg J, Schmitt E, Lohse AW, Galle PR, Blessing M. TGFbeta regulates the CD4+CD25+ T-cell pool and the expression of Foxp3 in vivo. International immunology 2004;16(9):1241-9. Pubmed

Becker C, Fantini MC, Schramm C, Lehr HA, Wirtz S, Nikolaev A, Burg J, Strand S, Kiesslich R, Huber S, Ito H, Nishimoto N, Yoshizaki K, Kishimoto T, Galle PR, Blessing M, Rose-John S, Neurath MF. TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling. Immunity 2004;21(4):491-501. Pubmed

Helisch A, Forster GJ, Reber H, Buchholz HG, Arnold R, Goke B, Weber MM, Wiedenmann B, Pauwels S, Haus U, Bouterfa H, Bartenstein P. Pre-therapeutic dosimetry and biodistribution of 86Y-DOTA-Phe1-Tyr3-octreotide versus 111In-pentetreotide in patients with advanced neuroendocrine tumours. European journal of nuclear medicine and molecular imaging 2004;31(10):1386-92. Pubmed

Holtmann MH, Galle PR. Current concept of pathophysiological understanding and natural course of ulcerative colitis. Langenbeck's archives of surgery / Deutsche Gesellschaft fur Chirurgie 2004;389(5):341-9. Pubmed

Tavakoli S, Schwerin W, Rohwer A, Hoffmann S, Weyer S, Weth R, Meisel H, Diepolder H, Geissler M, Galle PR, Lohr HF, Bocher WO. Phenotype and function of monocyte derived dendritic cells in chronic hepatitis B virus infection. The Journal of general virology 2004;85(Pt 10):2829-36. Pubmed

Grifoni D, Garoia F, Schimanski CC, Schmitz G, Laurenti E, Galle PR, Pession A, Cavicchi S, Strand D. The human protein Hugl-1 substitutes for Drosophila lethal giant larvae tumour suppressor function in vivo. Oncogene 2004;23(53):8688-94. Pubmed

Mannon PJ, Fuss IJ, Mayer L, Elson CO, Sandborn WJ, Present D, Dolin B, Goodman N, Groden C, Hornung RL, Quezado M, Yang Z, Neurath MF, Salfeld J, Veldman GM, Schwertschlag U, Strober W. Anti-interleukin-12 antibody for active Crohn's disease. The New England journal of medicine 2004;351(20):2069-79. Pubmed

Mosler P, Mergener K, Denzer U, Kiesslich R, Galle PR, Kanzler S. Current practice in managing patients on anticoagulants and/or antiplatelet agents around the time of gastrointestinal endoscopy -- a nation-wide survey in Germany. Zeitschrift fur Gastroenterologie 2004;42(11):1289-93. Pubmed

Schubert M, Minnemann T, Hubler D, Rouskova D, Christoph A, Oettel M, Ernst M, Mellinger U, Krone W, Jockenhovel F. Intramuscular testosterone undecanoate: pharmacokinetic aspects of a novel testosterone formulation during long-term treatment of men with hypogonadism. The Journal of clinical endocrinology and metabolism 2004;89(11):5429-34. Pubmed

Tehrani M, Krummenauer F, Mann WJ, Pitz S, Dick HB, Kahaly GJ. Disease-specific assessment of quality of life after decompression surgery for Graves' ophthalmopathy. European journal of ophthalmology 2004;14(3):193-9. Pubmed

Schuchmann M, Hermann F, Herkel J, van der Zee R, Galle PR, Lohse AW. HSP60 and CpG-DNA-oligonucleotides differentially regulate LPS-tolerance of hepatic Kupffer cells. Immunology letters 2004;93(2-3):199-204. Pubmed

Taniai M, Grambihler A, Higuchi H, Werneburg N, Bronk SF, Farrugia DJ, Kaufmann SH, Gores GJ. Mcl-1 mediates tumor necrosis factor-related apoptosis-inducing ligand resistance in human cholangiocarcinoma cells. Cancer research 2004;64(10):3517-24. Pubmed

Fantini MC, Becker C, Monteleone G, Pallone F, Galle PR, Neurath MF. Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7. J Immunol 2004;172(9):5149-53. Pubmed

Kahaly GJ. [Managing Graves' orbitopathy]. Z Arztl Fortbild Qualitatssich 2004;98 Suppl 5:63-6. Pubmed

Otto C, Geiss HC, Empen K, Parhofer KG. Long-term reduction of C-reactive protein concentration by regular LDL apheresis. Atherosclerosis 2004;174(1):151-6. Pubmed

Finotto S, Siebler J, Hausding M, Schipp M, Wirtz S, Klein S, Protschka M, Doganci A, Lehr HA, Trautwein C, Khosravi-Far R, Strand D, Lohse A, Galle PR, Blessing M, Neurath MF. Severe hepatic injury in interleukin 18 (IL-18) transgenic mice: a key role for IL-18 in regulating hepatocyte apoptosis in vivo. Gut 2004;53(3):392-400. Pubmed

Kahaly GJ. Recent developments in Graves' ophthalmopathy imaging. Journal of endocrinological investigation 2004;27(3):254-8. Pubmed

Schulze-Bergkamen H, Brenner D, Krueger A, Suess D, Fas SC, Frey CR, Dax A, Zink D, Buchler P, Muller M, Krammer PH. Hepatocyte growth factor induces Mcl-1 in primary human hepatocytes and inhibits CD95-mediated apoptosis via Akt. Hepatology (Baltimore, Md 2004;39(3):645-54. Pubmed

Strand S, Strand D, Seufert R, Mann A, Lotz J, Blessing M, Lahn M, Wunsch A, Broering DC, Hahn U, Grischke EM, Rogiers X, Otto G, Gores GJ, Galle PR. Placenta-derived CD95 ligand causes liver damage in hemolysis, elevated liver enzymes, and low platelet count syndrome. Gastroenterology 2004;126(3):849-58. Pubmed

Schumm-Draeger PM, Diederich S, Doren M, Fassbender WJ, Mann B, Raue F, Schilling T, Weber MM, Pfeiffer AF. [Endocrinology--I]. Med Klin (Munich) 2004;99(6):293-308. Pubmed

Fottner C, Hoeflich A, Wolf E, Weber MM. Role of the insulin-like growth factor system in adrenocortical growth control and carcinogenesis. Hormone and metabolic research Hormon- und Stoffwechselforschung 2004;36(6):397-405. Pubmed

Holtmann MH, Neurath MF. Differential TNF-signaling in chronic inflammatory disorders. Current molecular medicine 2004;4(4):439-44. Pubmed

Lange-Asschenfeldt C, Boor S, Kahaly GJ, Thomke F. [Autoimmune functional disorders of the thyroid during interferon-beta-1b treatment in patients with multiple sclerosis. Case report and literature review]. Der Nervenarzt 2004;75(6):589-94. Pubmed

Wang Y, Schattenberg JM, Rigoli RM, Storz P, Czaja MJ. Hepatocyte resistance to oxidative stress is dependent on protein kinase C-mediated down-regulation of c-Jun/AP-1. The Journal of biological chemistry 2004;279(30):31089-97. Pubmed

Teufel A, Steinmann S, Siebler J, Zanke C, Hohl H, Adami B, Schroeder M, Klein O, Hohler T, Galle PR, Heike M, Moehler M. Irinotecan plus folinic acid/continuous 5-fluorouracil as simplified bimonthly FOLFIRI regimen for first-line therapy of metastatic colorectal cancer. BMC cancer [electronic resource] 2004;4:38. Pubmed

Schumm-Draeger PM, Diederich S, Doren M, Fassbender WJ, Mann B, Raue F, Schilling T, Weber MM, Pfeiffer AF. [Endocrinology. II]. Med Klin (Munich) 2004;99(7):372-82. Pubmed

Denzer U, Hoffmann S, Helmreich-Becker I, Kauczor HU, Thelen M, Kanzler S, Galle PR, Lohse AW. Minilaparoscopy in the diagnosis of peritoneal tumor spread: prospective controlled comparison with computed tomography. Surgical endoscopy 2004;18(7):1067-70. Pubmed

Linnemann U, Schimanski CC, Gebhardt C, Berger MR. Prognostic value of disseminated colorectal tumor cells in the liver: results of follow-up examinations. International journal of colorectal disease 2004;19(4):380-6. Pubmed

Schimanski CC, Burg J, Mohler M, Hohler T, Kanzler S, Otto G, Galle PR, Lohse AW. Phenprocoumon-induced liver disease ranges from mild acute hepatitis to (sub-) acute liver failure. Journal of hepatology 2004;41(1):67-74. Pubmed

Higuchi H, Grambihler A, Canbay A, Bronk SF, Gores GJ. Bile acids up-regulate death receptor 5/TRAIL-receptor 2 expression via a c-Jun N-terminal kinase-dependent pathway involving Sp1. The Journal of biological chemistry 2004;279(1):51-60. Pubmed

Bayer EM, Schramm C, Kanzler S, Lohse AW. [Autoimmune liver disease: diagnosis and therapy]. Zeitschrift fur Gastroenterologie 2004;42(1):19-30. Pubmed

Holtmann MH, Neurath MF. Anti-TNF strategies in stenosing and fistulizing Crohn's disease. International journal of colorectal disease 2005;20(1):1-8. Pubmed

Kiesslich R, Jung M, DiSario JA, Galle PR, Neurath MF. Perspectives of chromo and magnifying endoscopy: how, how much, when, and whom should we stain? Journal of clinical gastroenterology 2004;38(1):7-13. Pubmed

Klingel R, Schaefer M, Schwarting A, Himmelsbach F, Altes U, Uhlenbusch-Korwer I, Hafner G. Comparative analysis of procoagulatory activity of haemodialysis, haemofiltration and haemodiafiltration with a polysulfone membrane (APS) and with different modes of enoxaparin anticoagulation. Nephrol Dial Transplant 2004;19(1):164-70. Pubmed

Rose-John S, Neurath MF. IL-6 trans-signaling: the heat is on. Immunity 2004;20(1):2-4. Pubmed

Iijima H, Neurath MF, Nagaishi T, Glickman JN, Nieuwenhuis EE, Nakajima A, Chen D, Fuss IJ, Utku N, Lewicki DN, Becker C, Gallagher TM, Holmes KV, Blumberg RS. Specific regulation of T helper cell 1-mediated murine colitis by CEACAM1. The Journal of experimental medicine 2004;199(4):471-82. Pubmed

Okouoyo S, Herzer K, Ucur E, Mattern J, Krammer PH, Debatin KM, Herr I. Rescue of death receptor and mitochondrial apoptosis signaling in resistant human NSCLC in vivo. International journal of cancer 2004;108(4):580-7. Pubmed

Finotto S, Glimcher L. T cell directives for transcriptional regulation in asthma. Springer seminars in immunopathology 2004;25(3-4):281-94. Pubmed

Katzburg S, Hendel D, Waisman A, Posner GH, Kaye AM, Somjen D. Treatment with non-hypercalcemic analogs of 1,25-dihydroxyvitamin D3 increases responsiveness to 17beta-estradiol, dihydrotestosterone or raloxifene in primary human osteoblasts. The Journal of steroid biochemistry and molecular biology 2004;88(2):213-9. Pubmed

Kiesslich R, Neurath MF. Surveillance colonoscopy in ulcerative colitis: magnifying chromoendoscopy in the spotlight. Gut 2004;53(2):165-7. Pubmed

Luft C, Hausding M, Finotto S. Regulation of T cells in asthma: implications for genetic manipulation. Current opinion in allergy and clinical immunology 2004;4(1):69-74. Pubmed

Meining A, Rosch T, Kiesslich R, Muders M, Sax F, Heldwein W. Inter- and intra-observer variability of magnification chromoendoscopy for detecting specialized intestinal metaplasia at the gastroesophageal junction. Endoscopy 2004;36(2):160-4. Pubmed

Neurath MF. Mucosal immunity in Crohn's disease. Inflammatory bowel diseases 2004;10 Suppl 1:S29-31. Pubmed

Schattenberg JM, Wang Y, Rigoli RM, Koop DR, Czaja MJ. CYP2E1 overexpression alters hepatocyte death from menadione and fatty acids by activation of ERK1/2 signaling. Hepatology (Baltimore, Md 2004;39(2):444-55. Pubmed

Schuchmann M, Galle PR. Sensitizing to apoptosis--sharpening the medical sword. Journal of hepatology 2004;40(2):335-6. Pubmed

Schulze-Bergkamen H, Krammer PH. Apoptosis in cancer--implications for therapy. Seminars in oncology 2004;31(1):90-119. Pubmed

Kuball J, Theobald M, Ferreira EA, Hess G, Burg J, Maccagno G, Barreiros AP, Luth S, Schimanski CC, Schuchmann M, Schwarting A, Neurath M, Otto G, Galle PR, Lohse AW. Control of organ transplant-associated graft-versus-host disease by activated host lymphocyte infusions. Transplantation 2004;78(12):1774-9. Pubmed

Rotmann A, Strand D, Martine U, Closs EI. Protein kinase C activation promotes the internalization of the human cationic amino acid transporter hCAT-1. A new regulatory mechanism for hCAT-1 activity. The Journal of biological chemistry 2004;279(52):54185-92. Pubmed

Huber S, Schramm C, Lehr HA, Mann A, Schmitt S, Becker C, Protschka M, Galle PR, Neurath MF, Blessing M. Cutting edge: TGF-beta signaling is required for the in vivo expansion and immunosuppressive capacity of regulatory CD4+CD25+ T cells. J Immunol 2004;173(11):6526-31. Pubmed

Hausding M, Ho IC, Lehr HA, Weigmann B, Lux C, Schipp M, Galle PR, Finotto S. A stage-specific functional role of the leucine zipper transcription factor c-Maf in lung Th2 cell differentiation. European journal of immunology 2004;34(12):3401-12. Pubmed

Ritter M, Ali MY, Grimm CF, Weth R, Mohr L, Bocher WO, Endrulat K, Wedemeyer H, Blum HE, Geissler M. Immunoregulation of dendritic and T cells by alpha-fetoprotein in patients with hepatocellular carcinoma. Journal of hepatology 2004;41(6):999-1007. Pubmed

Rutter M, Bernstein C, Matsumoto T, Kiesslich R, Neurath M. Endoscopic appearance of dysplasia in ulcerative colitis and the role of staining. Endoscopy 2004;36(12):1109-14. Pubmed

Sienz M, Zilly M, Ebigbo A, Knipper A, Winzer R, Klinker H, Langmann P. Follow-up measurements of Nevirapine plasma levels over a prolonged period. European journal of medical research 2004;9(8):412-6. Pubmed

Benesic A, Zilly M, Kluge F, Weissbrich B, Winzer R, Klinker H, Langmann P. Lipid lowering therapy with fluvastatin and pravastatin in patients with HIV infection and antiretroviral therapy: comparison of efficacy and interaction with indinavir. Infection 2004;32(4):229-33. Pubmed

Fritzsche C, Zeller G, Knaup KX, Roemer K. No anti-apoptotic effects of single copies of mutant p53 genes in drug-treated tumor cells. Anti-cancer drugs 2004;15(7):679-88. Pubmed

Geiss HC, Bremer S, Barrett PH, Otto C, Parhofer KG. In vivo metabolism of LDL subfractions in patients with heterozygous FH on statin therapy: rebound analysis of LDL subfractions after LDL apheresis. Journal of lipid research 2004;45(8):1459-67. Pubmed

Holtmann MH, Neurath MF. T helper cell polarisation in coeliac disease: any (T-)bet ? Gut 2004;53(8):1065-7. Pubmed

Strand S, Vollmer P, van den Abeelen L, Gottfried D, Alla V, Heid H, Kuball J, Theobald M, Galle PR, Strand D. Cleavage of CD95 by matrix metalloproteinase-7 induces apoptosis resistance in tumour cells. Oncogene 2004;23(20):3732-6. Pubmed

Staib F, Distler M, Bethke K, Schmitt U, Galle PR, Heike M. Cross-presentation of human melanoma peptide antigen MART-1 to CTLs from in vitro reconstituted gp96/MART-1 complexes. Cancer Immun 2004;4:3. Pubmed

Pohl J, Ring A, Ehehalt R, Schulze-Bergkamen H, Schad A, Verkade P, Stremmel W. Long-chain fatty acid uptake into adipocytes depends on lipid raft function. Biochemistry 2004;43(14):4179-87. Pubmed

Gerth AJ, Lin L, Neurath MF, Glimcher LH, Peng SL. An innate cell-mediated, murine ulcerative colitis-like syndrome in the absence of nuclear factor of activated T cells. Gastroenterology 2004;126(4):1115-21. Pubmed

Whybra C, Kampmann C, Krummenauer F, Ries M, Mengel E, Miebach E, Baehner F, Kim K, Bajbouj M, Schwarting A, Gal A, Beck M. The Mainz Severity Score Index: a new instrument for quantifying the Anderson-Fabry disease phenotype, and the response of patients to enzyme replacement therapy. Clinical genetics 2004;65(4):299-307. Pubmed

Kiesslich R, Kanzler S, Vieth M, Moehler M, Neidig J, Thanka Nadar BJ, Schilling D, Burg J, Nafe B, Neurath MF, Galle PR. Minimal change esophagitis: prospective comparison of endoscopic and histological markers between patients with non-erosive reflux disease and normal controls using magnifying endoscopy. Digestive diseases (Basel, Switzerland) 2004;22(2):221-7. Pubmed

Kiesslich R, Neurath MF, Galle PR. Chromoendoscopy and magnifying endoscopy in patients with gastroesophageal reflux disease. Useful or negligible? Digestive diseases (Basel, Switzerland) 2004;22(2):142-7. Pubmed

Klingel R, Schwarting A, Lotz J, Eckert M, Hohmann V, Hafner G. Safety and efficacy of single bolus anticoagulation with enoxaparin for chronic hemodialysis. Results of an open-label post-certification study. Kidney & blood pressure research 2004;27(4):211-7. Pubmed

Moehler M, Schimanski CC, Gockel I, Junginger T, Galle PR. (Neo)adjuvant strategies of advanced gastric carcinoma: time for a change? Digestive diseases (Basel, Switzerland) 2004;22(4):345-50. Pubmed

Pfutzner A, Kann PH, Pfutzner AH, Kunt T, Larbig M, Weber MM, Forst T. Intact and total proinsulin: new aspects for diagnosis and treatment of type 2 diabetes mellitus and insulin resistance. Clinical laboratory 2004;50(9-10):567-73. Pubmed

Schramm C, Kriegsmann J, Protschka M, Huber S, Hansen T, Schmitt E, Galle PR, Blessing M. Susceptibility to collagen-induced arthritis is modulated by TGFbeta responsiveness of T cells. Arthritis research & therapy 2004;6(2):R114-9. Pubmed