Visual Universitätsmedizin Mainz

Selected Publications

  • Kühn MWM, Song E, Feng Z, Sinha A, Chen CW, Deshpande AJ, Cusan M, Rahnamay Farnoud N, Mupo A, Grove C, Koche R, Bradner JE, de Stanchina E, McGeehan G, Vassiliou GS, Hoshii T, and Armstrong SA. Targeting Chromatin Regulators Inhibits Leukemogenic Gene Expression in NPM1 Mutant Leukemia. Cancer Discov. 2016 Oct;6(10):1166-1181. 
     
  • Kühn MWM and Armstrong SA. Designed to kill: Novel menin-MLL inhibitors target MLL-rearranged leukemia. Cancer Cell. 2015 Apr 13;27(4):431-3, Preview Article
     
  • Kühn MWM*, Hadler MJ*, Daigle SR, Koche RP, Krivtsov AV, Olhava EJ, Caligiuri MA, Huang G, Bradner JE, Pollock RM, Armstrong SA. MLL-PTD leukemia cells are sensitive to small molecule DOT1L inhibition. Haematologica. 2015 May;100(5):e190-3 *equal contribution
     
  • Kühn MWM, Bullinger L, Gröschel S, Krönke J, Edelmann J, Rücker FG, Eiwen K, Paschka P, Gaidzik VG, Holzmann K, Schlenk RF, Döhner H, Döhner K. Genome-wide genotyping of acute myeloid leukemia with translocation t(9;11)(p22;q23) reveals novel recurrent genomic alterations. Haematologica. 2014 Aug;99(8):e133-5.
     
  • Krönke J, Bullinger L, Teleanu V, Tschürtz F, Gaidzik VI, Kühn MWM, Rücker FG, Holzmann K, Paschka P, Kapp-Schwörer S, Späth D, Kindler T, Schittenhelm M, Krauter J, Ganser A, Göhring G, Schlegelberger B, Schlenk RF, Döhner H, Döhner K. Clonal evolution in relapsed NPM1 mutated acute myeloid leukemia. Blood. 2013 Jul 4;122(1):100-8.
     
  • Gröschel S, Schlenk RF, Engelmann J, Rockova V, Teleanu V, Kühn MWM, Eiwen K, Erpelinck C, Havermans M, Lübbert M, Germing U, Schmidt-Wolf IGH, Berna Beverloo H, Schuurhuis GJ, Ossenkoppele GJ, Schlegelberger B, Krauter J, Ganser A, Valk PJM, Löwenberg B, Döhner K, Döhner H*, Delwel R*. Deregulated expression of EVI1 defines a poor prognostic subset of MLL-rearranged acute myeloid leukemias: a study of the German-Austrian AMLSG and Dutch-Belgian HOVON groups. J Clin Oncol. 2013 Jan 1;31(1):95-103.
     
  • Kühn MWM, Blagieva R, Beha D, Hänle M, Reister F, Henne-Bruns D, Pilcher C, Böhm BO, von Wichert G. 31-year-old pregnant women with refractory hypercalcemia. Internist (Berl). 2012 Dec;53(12):1490-5. Casuistics 
     
  • Edelmann J, Holzmann K, Miller F,Winkler D, Bühler A,Zenz T, Bullinger L, Kühn MWM, Gerhardinger A, Blöhdorn J, Radtke I, Su X, Ma J, Pounds S, Hallek M, Lichter P, Korbel J, Busch R, Mertens D, Downing JR, Stilgenbauer S, and Döhner H. High-resolution genomic profiling of chronic lymphocytic leukemia reveals new recurrent genomic alterations. Blood. 2012 Dec 6;120(24):4783-94.
     
  • Dolnik A, Engelmann JC, Scharfenberger-Schmeer M, Mauch J, Kelkenberg-Schade S, Haldemann B, Fries T, Krönke J, Kühn MWM, Paschka P, Kayser, Wolf S, Gaidzik VI, Schlenk RF, Rücker FG, Döhner H, Lottaz C, Döhner K, and Bullinger L. Commonly altered genomic regions in acute myeloid leukemia are enriched for somatic mutations involved in chromatin-remodeling and splicing. Blood. 2012 Nov 1;120(18):e83-92.
     
  • Kühn MWM*, Radtke I*, Bullinger L, Goorha S, Cheng J, Edelmann J, Gohlke J, Su X, Paschka P, Pounds S, Krauter J, Ganser A, Quessar A, Ribeiro R, Gaidzik VI, Shurtleff S, Krönke J, Holzmann K, Ma J, Schlenk RF, Rubnitz JE, Döhner K, Döhner H*, Downing JR*. High resolution genomic profiling of adult and pediatric Core-Binding Factor Acute Myeloid Leukemia reveals new recurrent alterations. Blood. 2012 Mar 8;119(10):e67-75. *equal contribution
     
  • Hummel M, Bentik S, Berger H, Klapper W, Wessendorf S, Barth TFE, Bernd HW, Cogliatti, SB, Dierlamm J, Feller AC, Hansmann ML, Haralambieva E, Harder L, Kühn M, Lenze D, Lichter P, Ignacio MS, Möller P, Müller-Hermelink HK, Ott G, Parwaresch RM, Pott C, Rosenwald A, Rosolowski M, Schwaenen C, Stürzenhofecker B, Szcepanowski M, Trautmann H, Wacker HH, Spang R, Loeffler M, Stein H, Siebert R. A biologic definition of Burkitt’s Lymphoma from transcriptional and genomic profiling. N Engl J Med 2006; 354:2419-30.