The work program includes the following scientific studies: At the LysMCreiDTR mouse model, where myelomonocytic cells are depleted, a heart attack should be induced by ligation of the anterior coronary artery and ischemia / reperfusion should be established. Following echocardiography examinations are arranged to determine the left ventricular function, to evaluate the valvular assessment and the contraction behavior. Furthermore, various studies, such as Western blot and real time PCR analysis, immunohistochemical sections and reactive oxygen species measurements for a more detailed characterization of the animals and to clarify the pathophysiological role of myelomonocytic cells in myocardial infarction can be performed in these animals.
Mentor of the Virchow-Fellow is Philip Wenzel, MD, Consultant of preclinical research at the Department of Medicine 2.
08/1987 – 06/1991 | Loretto Grundschule, Freiburg |
08/1991 – 06/2000 | Rotteck-Gymnasium, Freiburg, Abitur |
08/2000 – 12/2007 | Karls-Ruprecht-University Heidelberg, State examination 12/2007 |
06/2003 – 12/2006 | Molecular Experimental Cardiology, Ruprecht-Karls-University, Professor N. Frey, MD |
12/2007 | Dissertation: „Mögliche Bedeutung eines latenten Energiedefizites in der Pathogenese der hypertrophischen Kardiomyopathie“ (magna cum laude) |
01/2008 – 12/2008 | Department of Medicine 2, University Medical Center Mainz; Cardiology ward |
01/2009 – 06/2009 | Hematology, University Medical Center Mainz; Hematology ward |
07/2009 – 06/2010 | Fellowship by the Foundation Heart of Mainz: „Beeinflussung der Gefässfunktion und der arteriellen Hypertonie im Rahmen einer Angiotensin II Infusion durch in vivo-Ablation von myelomonozytären Zellen“ |
seit 07/2010 | Department of Medicine 2, University Medical Center Mainz; Intensiv Care Unit |
Wenzel P, Rossmann H, Müller C, Kossmann S, Oelze M, Schulz A, Arnold N, Simsek C, Lagrange J, Klemz R, Schönfelder T, Brandt M, Karbach SH, Knorr M, Finger S, Neukirch C, Häuser F, Beutel ME, Kröller-Schön S, Schulz E, Schnabel RB, Lackner K, Wild PS, Zeller T, Daiber A, Blankenberg S, Münzel T. Heme oxygenase-1 suppresses a pro-inflammatory phenotype in monocytes and determines endothelial function and arterial hypertension in mice and humans. European heart journal 36:3437-3446. 2015.
Hinkel R, Lange P, Petersen B, Gottlieb E, Ng JK, Finger S, Horstkotte J, Lee S, Thormann M, Knorr M, El-Aouni C, Boekstegers P, Reichart B, Wenzel P, Niemann H, Kupatt C. Heme Oxygenase-1 Gene Therapy Provides Cardioprotection Via Control of Post-Ischemic Inflammation: An Experimental Study in a Pre-Clinical Pig Model. Journal of the American College of Cardiology 66:154-165. 2015.