Jan Moritz Brandt, MD

• Project description
• Mentor
• Curriculum vitae
• References

Project description

Despite its many advantages, sonographic methods require considerable theoretical knowledge, technical skill and practical experience to yield reproducible result. The first aim is to conduct echocardiography and vascular sonography in mice as a standard procedure and central method. The method can later be employed by other research groups within and outside the CTH. Several proposed projects with potential overlap, which could benefit from this method, have been identified within the CTH.

Consequent to the first part, the candidate attends a research fellowship at the laboratory of J. P. Cooke (Stanford University) beginning in July 2012.

 

Mentor

Mentor of the Virchow-Fellow is Philip Wenzel, MD, Consultant of preclinical research at the Department of Medicine 2.

Publications

• Wenzel P, Rossmann H, Müller C, Kossmann S, Oelze M, Schulz A, Arnold N, Simsek C, Lagrange J, Klemz R, Schönfelder T, Brandt M, Karbach SH, Knorr M, Finger S, Neukirch C, Häuser F, Beutel ME, Kröller-Schön S, Schulz E, Schnabel RB, Lackner K, Wild PS, Zeller T, Daiber A, Blankenberg S, Münzel T. Heme oxygenase-1 suppresses a pro-inflammatory phenotype in monocytes and determines endothelial function and arterial hypertension in mice and humans. European heart journal 36:3437-3446. 2015.

• Brandt M, Schönfelder T, Schwenk M, Becker C, Jäckel S, Reinhardt C, Stark K, Massberg S, Münzel T, von Brühl ML, Wenzel P. Deep vein thrombus formation induced by flow reduction in mice is determined by venous side branches. Clin Hemorheol Microcirc 56:145-152, 2014.

• Kossmann S, Hu H, Steven S, Schönfelder T, Fraccarollo D, Mikhed Y, Brahler M, Knorr M, Brandt M, Karbach SH, Becker C, Oelze M, Bauersachs J, Widder J, Münzel T, Daiber A, Wenzel P. Inflammatory monocytes determine endothelial nitric-oxide synthase uncoupling and nitro-oxidative stress induced by angiotensin II. The Journal of biological chemistry 289:27540-27550, 2014.

• Kossmann S, Schwenk M, Hausding M, Karbach SH, Schmidgen MI, Brandt M, Knorr M, Hu H, Kröller-Schön S, Schönfelder T, Grabbe S, Oelze M, Daiber A, Münzel T, Becker C, Wenzel P. Angiotensin II-induced vascular dysfunction depends on interferon-gamma-driven immune cell recruitment and mutual activation of monocytes and NK-cells. Arteriosclerosis, thrombosis, and vascular biology 33:1313-1319, 2013.

• Torzewski, M., Wenzel, P., Kleinert, H., Becker C., El-Masri, J., Wiese, E., Brandt, M., Pautz, A., Twardowski, L., Schmitt, E., Münzel, T., Reifenberg, K., Chronic Inflammatory Cardiomyopathy of Interferon gamma-Overexpressing Transgenic Mice Is Mediated by Tumor Necrosis Factor-alpha. Am J Pathol 180, 73-81 (2012).

• Wenzel, P., Hink, U., Oelze, M., Seeling, A., Isse, T., Bruns, K., Steinhoff, L., Brandt, M., Kleschyov, A. L., Schulz, E., Lange, K., Weiner, H., Lehmann, J., Lackner, K. J., Kawamoto, T., Munzel, T. and Daiber, A., Number of nitrate groups determines reactivity and potency of organic nitrates: a proof of concept study in ALDH-2-/- mice, Br J Pharmacol, 2007, 150: 526-533.
  
  
• Wenzel, P., Daiber, A., Oelze, M., Brandt, M., Closs, E., Xu, J., Thum, T., Bauersachs, J., Ertl, G., Zou, M. H., Forstermann, U. and Munzel, T., Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus, Atherosclerosis, 2008, 198: 65-76.