Markus Bosmann, MD
Leader Juniorgroup "Experimental Research"
Sepsis and acute lung injury (ALI, ARDS) are life-threatening diseases and frequently require treatment in critical care medicine. The annual incidence of sepsis and ALI is approximately 150,000 cases in Germany. Immunocompromised patients are under increased risk for the development of infections, which can progress to sepsis or/and ALI. Additional complications can arise from severe disturbances in the blood clotting system (e.g. disseminated intravascular coagulopathy) during sepsis and ALI.
Accumulating evidence suggests key roles of the coagulation system and innate immune responses during sepsis and ALI. The release of a plethora of inflammatory mediators (e.g. IL-27, C5a) is observed and accompanied by complex interactions of intracellular signaling cascades and down-stream effects on coagulation. The focus of our research projects is on the molecular interactions of blood coagulation and the innate immune responses. In detail, the roles of plasmatic and cellular components of coagulation are investigated. We study the immune-modulatory functions of platelets and role of coagulation factors in macrophages and type II alveolar epithelial cells. Additional projects are related to novel pathogen-associates molecular patterns (e.g. polyphosphates), signal transduction pathways (e.g. MAVS, MDA5, RIG-I) and neutrophil extracellular traps in the context of coagulopathies during sepsis and ALI.
Our studies will contribute to a better understanding of the molecular pathogenesis of sepsis and acute lung injury, thereby helping to identify new avenues for therapeutic interventions.
Molecular pathogenesis of sepsis and acute lung injury (ALI)
Interactions of acute inflammation and the coagulation system
Role of inflammatory mediators (e.g. IL-27) during innate immune responses
Cross-talk of the complement system and coagulation
Peter A. Ward, MD (Godfrey D. Stobbe Professor, Department of Pathology, University of Michigan, Ann Arbor, USA)
Professor James H. Morrissey, PhD (Professor of Biochemistry, Molecular and Cellular Biology, Department of Biochemistry) and Stephanie A. Smith, PhD (Assistant Professor, Department of Biochemistry), University of Illinois, Urbana, USA
Heiko Mühl, PhD (Professor of Pharmacology and Toxicology, Center of Pharmacology, Johann Wolfgang Goethe-University, Frankfurt a.M., Germany)
Peter J. Murray, PhD (Associate Member, St. Jude Faculty, Departments of Infectious Diseases and Immunology, St. Jude Children’s Research Hospital, Memphis, USA)
CTH/BMBF (Federal Ministry of Education and Research, Modul A, JG)
DFG (German Research Foundation, BO 3482/3-1)
B. Braun Foundation
Internal university research funding, Level I
EU Marie Curie Career Integration Grant (CIG)
EHA Clinical Research Fellowship
Bosmann M, Ward P. Modulation of inflammation by interleukin-27. Journal of Leukocyte Biology. 94(6):1159-65, 2013.
Alflen A, Prüfer S, Ebner K, Reuter S, Aranda Lopez P, Scharrer I, Banno F, Stassen M, Schild H, Jurk K, Bosmann M, Beckert H, Radsak MP (2017) ADAMTS-13 regulates neutrophil recruitment in a mouse model of invasive pulmonary aspergillosis. Scientific reports 7: 7184
Roewe J, Higer M, Riehl DR, Gericke A, Radsak MP, Bosmann M (2017) Neuroendocrine Modulation of IL-27 in Macrophages. Journal of immunology 199(7):2503-2514
Schaefer K, Schütz E, Bochenek ML, Riehl DR, Bosmann M, Münzel T, Konstantinides S (2017) Absence of transforming growth factor beta 1 in murine platelets reduces neointima formation without affecting arterial thrombosis. Thrombosis and haemostasis 117(9):1782-1797
Kiouptsi K, Grill A, Mann A, Döhrmann M, Lillich M, Jäckel S, Malinarich F, Formes H, Manukyan D, Subramaniam S, Khandagale A, Karwot C, Thal SC, Bosmann M, Scharrer I, Jurk K, Reinhardt C (2017) Mice deficient in the anti-haemophilic coagulation factor VIII show increased von Willebrand factor plasma levels. PloS one 12: e0183590
Bosmann M, Grailer JJ, Ruemmler R, Russkamp NF, Zetoune FS, Sarma JV, Standiford TJ, Ward PA. Extracellular histones are essential effectors of C5aR- and C5L2-mediated tissue damage and inflammation in acute lung injury. FASEB Journal. 27(12):5010-21, 2013.
Bosmann M, Meta F, Ruemmler R, Haggadone MD, Sarma JV, Zetoune FS, Ward PA. Regulation of IL-17 Family Members by Adrenal Hormones During Experimental Sepsis in Mice. American Journal of Pathology. 182(4):1124-30, 2013.