Visual Universitätsmedizin Mainz

Juniorgroup "Experimental Research"

Markus Bosmann, MD
Leader Juniorgroup "Experimental Research"

Sepsis and lung injury (ALI, ARDS) are life-threatening diseases and frequently require treatment in critical care medicine. The annual incidence of sepsis and ARDS is estimated more than 150,000 cases in Germany. Immunocompromised patients are under increased risk for the development of infections such as pneumonia, which can progress to ARDS and/or sepsis. Additional complications can arise from severe disturbances in the blood clotting system (e.g. disseminated intravascular coagulopathy) during sepsis and ARDS.

Accumulating evidence suggests key roles of the coagulation system and innate immune responses during sepsis and lung injury. The release of a plethora of inflammatory mediators (e.g. IL-27, C5a) is accompanied by complex interactions of intracellular signaling cascades mediating down-stream effects on coagulation. The focus of our research projects is on the molecular interactions of blood coagulation and the innate immune responses. We study the immune-modulatory functions of platelets and role of coagulation factors in macrophages, neutrophils and type II alveolar epithelial cells. Additional projects are related to novel pathogen-associates molecular patterns (e.g. polyphosphates), signal transduction pathways (e.g. MAVS, MDA5, RIG-I) and neutrophil extracellular traps in the context of coagulopathies during sepsis and ARDS.

Our studies will contribute to a better understanding of the molecular pathogenesis of sepsis and lung injury, thereby helping to identify new avenues for therapeutic interventions.

Research Interests

  • Molecular pathogenesis of peritoneal sepsis and acute lung injury (ALI/ARDS)
  • Interactions of acute inflammation and the coagulation System
  • Cytokines (e.g. IL-27)
  • Cross-talk of the complement system and coagulation
  • Host-pathogen interactions and bacterial infections of epithelial-lined organs (gut, lung)
  • Novel pathogen-associated molecular patterns in homeostasis, immune-metabolism and infection
  • Neutrophil extracellular traps 

Partners of Collaboration

  • Peter A. Ward, MD (Godfrey D. Stobbe Professor, Department of Pathology, University of Michigan, Ann Arbor, USA)

  • Professor James H. Morrissey, PhD (Professor of Biochemistry, Molecular and Cellular Biology, Department of Biochemistry) and Stephanie A. Smith, PhD (Assistant Professor, Department of Biochemistry), University of Illinois, Urbana, USA

  • Heiko Mühl, PhD (Professor of Pharmacology and Toxicology, Center of Pharmacology, Johann Wolfgang Goethe-University, Frankfurt a.M., Germany)

  • Charles T. Esmon,  PhD (Adjunct Professor, Departments of Biochemistry & Molecular Biology and Pathology, University Oklahoma Health Science Center, USA)

Research Funding

  • CTH/BMBF (Federal Ministry of Education and Research, JG)

  • DFG (German Research Foundation)

Team - Juniorgroup Experimental Research

Bosmann, MD
Markus Bosmann, MD
Position: Juniorgroup leader, Internist, Adjunct Assistant Professor of Molecular Medicine
Associate Professor of Medicine, Pathology & Laboratory Medicine, Boston University

06131 17-8277
markus.bosmann@unimedizin-mainz.de

PhD Krenzlin
Viola Krenzlin, PhD
Position: Postdoc

06131 17-8281
06131 17-6238
viola.krenzlin@unimedizin-mainz.de

PhD Malinarich González
Frano Hernán Malinarich González , PhD
Position: Post Doc

f.malinarich@uni-mainz.de

Platten
Johannes Platten
Position: PhD student

06131 17-8281
06131 17-6238
joplatte@uni-mainz.de

Samangan
Foruzandeh Samangan
Position: Technical assistant

06131/17-8281
06131/17-6238
f.samangan@uni-mainz.de

Strüve
Marcel Strüve
Position: Graduate student

06131 17-8281
marcel.strueve@unimedizin-mainz.de

Dr. Walachowski
Sarah Walachowski, Dr.
Position: Post-Doc

06131 17-8281
swalacho@uni-mainz.de

Alumni

  • Dr. med. Norman Russkamp, Assistenzarzt, Zentrum für Hämatologie und Onkologie, UniversitätsSpital Zürich 
  • Dr. rer. nat. Dennis Riehl, Nationales Centrum für Tumorerkrankungen, Deutsches Krebsforschungszentrum, Heidelberg 
  • Dr. med. Robert Rümmler, Assistenzarzt, Klinik für Anästhesiologie
  • Dr. rer. nat. Julian Röwe, DKFZ Heidelberg
  • Dr. med. Max Higer, Assistenzarzt, III. Medizinische Klinik

  • Georgios Stavrides, Asssistenzarzt, Klinik für Chirurgie, Klinikum Frankfurt Hoechst

  • cand. med. Johannes Schoeche, Praktisches Jahr, Johannes Gutenberg Universität

Reviews

  • Ward PA, Fattahi F, Bosmann M. New Insights into Molecular Mechanisms of Immune Complex-Induced Injury in Lung. Frontiers in immunology 7:86. 2016.
  • Bosmann M, Ward PA. Protein-based therapies for acute lung injury: targeting neutrophil extracellular traps. Expert Opin Ther Targets. 18:703-714, 2014.
  • Bosmann M, Ward P. Modulation of inflammation by interleukin-27. Journal of Leukocyte Biology. 94(6):1159-65, 2013.
  • Bosmann M, Ward PA. Role of C3, C5 and anaphylatoxin receptors in acute lung injury and in sepsis (Review). Adv Exp Med Biol. 946:147-59, 2012.
  • Bosmann M., Ward P. A. The inflammatory response in sepsis. Trends Immunology. 1471-4906(12)00162-7, 2012.
  • Ward P. A., Bosmann M. A historical perspective on sepsis. The American Journal of Pathology. 181(1):2-7, 2012.

Original articles

  • Sharma A, Steven S, Bosmann M. The pituitary gland prevents shock-associated death by controlling multiple inflammatory mediators. Biochem Biophys Res Commun 2019;509(1):188-193.
  • Hansen M, Peltier J, Killy B, Amin B, Bodendorfer B, Hartlova A, Uebel S, Bosmann M, Hofmann J, Buttner C, Ekici AB, Kuttke M, Franzyk H, Foged C, Beer-Hammer S, Schabbauer G, Trost M, Lang R. Macrophage Phosphoproteome Analysis Reveals MINCLE-dependent and -independent Mycobacterial Cord Factor Signaling. Mol Cell Proteomics 2019;18(4):669-685.
  • Gawish R, Bulat T, Biaggio M, Lassnig C, Bago-Horvath Z, Macho-Maschler S, Poelzl A, Simonovic N, Prchal-Murphy M, Rom R, Amenitsch L, Ferrarese L, Kornhoff J, Lederer T, Svinka J, Eferl R, Bosmann M, Kalinke U, Stoiber D, Sexl V, Krmpotic A, Jonjic S, Müller M, Strobl B. Myeloid Cells Restrict MCMV and Drive Stress-Induced Extramedullary Hematopoiesis through STAT1. Cell Rep 2019;26(9):2394-2406 e2395.
  • Kröller-Schön S, Daiber A, Steven S, Oelze M, Frenis K, Kalinovic S, Heimann A, Schmidt FP, Pinto A, Kvandova M, Vujacic-Mirski K, Filippou K, Dudek M, Bosmann M, Klein M, Bopp T, Hahad O, Wild PS, Frauenknecht K, Methner A, Schmidt ER, Rapp S, Mollnau H, Münzel T. Crucial role for Nox2 and sleep deprivation in aircraft noise-induced vascular and cerebral oxidative stress, inflammation, and gene regulation. Eur Heart J 2018;39(38):3528-3539.
  • Alflen A, Prüfer S, Ebner K, Reuter S, Aranda Lopez P, Scharrer I, Banno F, Stassen M, Schild H, Jurk K, Bosmann M, Beckert H, Radsak MP (2017) ADAMTS-13 regulates neutrophil recruitment in a mouse model of invasive pulmonary aspergillosis. Scientific reports 7: 7184
  • Roewe J, Higer M, Riehl DR, Gericke A, Radsak MP, Bosmann M (2017) Neuroendocrine Modulation of IL-27 in Macrophages. Journal of immunology 199(7):2503-2514
  • Schütz E, Bochenek ML, Riehl DRBosmann M, Münzel T, Konstantinides S, Schäfer K. Absence of transforming growth factor beta 1 in murine platelets reduces neointima formation without affecting arterial thrombosis. Thromb Haemost 2017;117(9):1782-1797.
  • Kiouptsi K, Grill A, Mann A, Döhrmann M, Lillich M, Jäckel S, Malinarich F, Formes H, Manukyan D, Subramaniam S, Khandagale A, Karwot C, Thal SC, Bosmann M, Scharrer I, Jurk K, Reinhardt C (2017) Mice deficient in the anti-haemophilic coagulation factor VIII show increased von Willebrand factor plasma levels. PloS one 12: e0183590 
  • Fattahi F, Kalbitz M, Malan EA, Abe E, Jajou L, Huber-Lang MS, Bosmann M, Russell MW, Zetoune FS, Ward PA (2017) Complement-induced activation of MAPKs and Akt during sepsis: role in cardiac dysfunction. FASEB journal 31(9):4129-4139
  • Russkamp NF, Ruemmler R, Roewe J, Moore BB, Ward PA, Bosmann M. Experimental design of complement component 5a-induced acute lung injury (C5a-ALI): a role of CC-chemokine receptor type 5 during immune activation by anaphylatoxin. FASEB journal. pii: fj.15-271635, 2015.
  • Kalbitz M, Grailer JJ, Fattahi F, Jajou L, Herron TJ, Campbell KF, Zetoune FS, Bosmann M, Sarma JV, Huber-Lang M, Gebhard F, Loaiza R, Valdivia HH, Jalife J, Russell MW, Ward PA. Role of extracellular histones in the cardiomyopathy of sepsis. FASEB journal. 29:2185-2193. 2015.
  • Taddonio MA, Dolgachev V, Bosmann M, Ward PA, Su G, Wang SC, Hemmila MR. Influence of lipopolysaccharide-binding protein on pulmonary inflammation in gram-negative pneumonia. Shock. 43:612-619. 2015.
  • Prüfer S, Weber M, Stein P, Bosmann M, Stassen M, Kreft A, Schild H, Radsak MP. Oxidative burst and neutrophil elastase contribute to clearance of Aspergillus fumigatus pneumonia in mice. Immunobiology. 219:87-96. 2014.
  • Weber M, Rudolph B, Stein P, Yogev N, Bosmann M, Schild H, Radsak MP. 2014. Host-derived CD8(+) dendritic cells protect against acute graft-versus-host disease after experimental allogeneic bone marrow transplantation. Biology of blood and marrow transplantation. 20:1696-1704. 2014.
  • Bosmann M, Russkamp NF, Strobl B, Roewe J, Balouzian L, Pache F, Radsak MP, van Rooijen N, Zetoune FS, Sarma JV, Nunez G, Muller M, Murray PJ, Ward PA. Interruption of macrophage-derived IL-27(p28) production by IL-10 during sepsis requires STAT3 but not SOCS3. Journal of immunology. 193:5668-5677, 2014.
  • Bosmann M, Strobl B, Kichler N, Rigler D, Grailer JJ, Pache F, Murray PJ, Muller M, Ward PA. Tyrosine kinase 2 promotes sepsis-associated lethality by facilitating production of interleukin-27. J Leukoc Biol. doi:10.1189/jlb.3A1013-541R, 2014.
  • Bosmann M, Grailer JJ, Ruemmler R, Russkamp NF, Zetoune FS, Sarma JV, Standiford TJ, Ward PA. Extracellular histones are essential effectors of C5aR- and C5L2-mediated tissue damage and inflammation in acute lung injury. FASEB Journal. 27(12):5010-21, 2013.
  • Bosmann M, Meta F, Ruemmler R, Haggadone MD, Sarma JV, Zetoune FS, Ward PA. Regulation of IL-17 Family Members by Adrenal Hormones During Experimental Sepsis in Mice. American Journal of Pathology. 182(4):1124-30, 2013.
  • Bosmann M, Zhu K, Grailer JJ, Matthay MA, Sarma JV, Zetoune FS, Ward PA. Anti-inflammatory Effects of ß2 Adrenergic Receptor Agonists in Experimental Acute Lung Injury. FASEB Journal. 26(5):2137-44, 2012.
  • Bosmann M, Sarma JV, Atefi G, Zetoune FS, Ward PA. Evidence for anti-inflammatory effects of C5a on the innate IL-17A/IL-23 axis. FASEB Journal. 26(4):1640-51, 2012.
  • Bosmann M, Haggadone MD, Hemmila MR, Zetoune FS, Sarma JV, Ward PA. Complement activation product C5a is a selective suppressor of TLR4-induced, but not TLR3-induced, production of IL-27(p28) from macrophages. Journal of Immunology. 188(10):5086-93, 2012.
  • Bosmann M, Patel VR, Russkamp NF, Pache F, Zetoune FS, Sarma JV, Ward PA. MyD88-dependent production of IL-17F is modulated by the anaphylatoxin C5a: Role of the Akt signaling pathway. FASEB Journal. 25(12):4222-32, 2011.