Visual Universitätsmedizin Mainz

Research group 'Platelet Physiology and Dysfunction'

Kerstin Jurk, PhD PD

Research topics

  • Regulatory mechanisms of platelet function
  • Platelet signaling
  • Crosstalk between platelets, leukocytes and the vascular compartment in inflammation-driven thrombotic diseases
  • Inherited and acquired platelet function disorders

Partners of Collaboration

  • Prof. Dr. W. Ruf (CTH, University Medical Center Mainz)
  • Prof. Dr. T. Gori (2nd Medical Clinic, University Medical Center Mainz)
  • Dr. C. von Auer (3rd Medical Clinic, University Medical Center Mainz, CTH Outpatient Clinic for Coagulopathies)
  • Prof. Dr. J. Faber, Dr. Alexandra Russo (Children’s Hospital, University Medical Center Mainz)
  • Prof. Dr. H. Binder (IMBEI, University Medical Center Mainz)
  • PD Dr. M. Sibbing (DZHK Munich)
  • Prof. Dr. A. Sickmann, Dr. René Zahedi (Leibniz – Institut für Analytische Wissenschaften – ISAS, Dortmund)
  • Prof. Dr. B. Kehrel (Dept. of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Muenster)
  • Prof. Dr. B. Zieger (Dept. of Paediatrics and Adolescent Medicine, University Medical Center Freiburg)
  • PD Dr. C. Kirchmaier (DKD Helios Klinik Wiesbaden)
  • Prof. Dr. J. Heemskerk (CARIM, Maastricht, The Netherlands)
  • Prof. Dr. T. Hackeng (CARIM, Maastricht, The Netherlands)
  • Dr. Stepan Gambaryan (Sechenov Institute of Evolutionary physiology S. Petersburg, Russia)
  • Dr. Albert Smolenski (Conway Institute of Biomolecular & Biomedical Research, University College Dublin, Ireland)

Research Funding

  • CTH TRP X3, X4
  • CTH P PF
  • Boehringer Ingelheim
  • DFG JU 2735/2-1
  • Säule B Projekt – Deutsches Zentrum für Herz-Kreislauf-Forschung e.V. (DZHK)

Team RG Jurk

Jurk, PhD
PD Kerstin Jurk, PhD
Position: Principal Investigator

06131 17-8278
kerstin.jurk@unimedizin-mainz.de

Groß (neé Schwierczek, on maternity leave)
Kathrin Groß (neé Schwierczek, on maternity leave)
Position: Technician

06131 17-8296
kathrin.gross@unimedizin-mainz.de

Gutekunst
Melissa Gutekunst
Position: MD student

06131 17-8296
cgutekun@students.uni-mainz.de

PhD Kumm (née Walter)
Elena Kumm (née Walter), PhD
Position: Graduate student

06131 17-8296
elena.kumm@unimedizin-mainz.de

PhD Makhoul
Stephanie Makhoul, PhD
Position: Graduate student

06131 17-8296
stephanie.makhoul@unimedizin-mainz.de

Wohra
Kehel Wohra
Position: BTA

06131 17-8296
kehel.wohra@unimedizin-mainz.de

Former team members

Mareike Döhrmann

Dr. med. Karoline Rosenplänter 

Dr. med. vet. Katharina Trabold

Original articles

  • Urbahn MA, Kaup SC, Reusswig F, Kruger I, Spelleken M, Jurk K, Klier M, Lang PA, Elvers M. Phospholipase D1 regulation of TNF-alpha protects against responses to LPS. Sci Rep 2018;8(1):10006.
  • Klatt C, Kruger I, Zey S, Krott KJ, Spelleken M, Gowert NS, Oberhuber A, Pfaff L, Luckstadt W, Jurk K, Schaller M, Al-Hasani H, Schrader J, Massberg S, Stark K, Schelzig H, Kelm M, Elvers M. Platelet-RBC interaction mediated by FasL/FasR induces procoagulant activity important for thrombosis. J Clin Invest 2018;128(9):3906-3925.
  • van Geffen JP, Brouns SLN, Batista J, McKinney H, Kempster C, Nagy M, Sivapalaratnam S, Baaten C, Bourry N, Frontini M, Jurk K, Krause M, Pillitteri D, Swieringa F, Verdoold R, Cavill R, Kuijpers MJE, Ouwehand WH, Downes K, Heemskerk JWM. High-throughput elucidation of thrombus formation reveals sources of platelet function variability. Haematologica 2019;104(6):1256-1267.
  • Ebert J, Wilgenbus P, Teiber JF, Jurk K, Schwierczek K, Döhrmann M, Xia N, Li H, Spiecker L, Ruf W, Horke S. Paraoxonase-2 regulates coagulation activation through endothelial tissue factor. Blood 2018;131(19):2161-2172.
  • Makhoul S, Walter E, Pagel O, Walter U, Sickmann A, Gambaryan S, Smolenski A, Zahedi RP, Jurk K. Effects of the NO/soluble guanylate cyclase/cGMP system on the functions of human platelets. Nitric Oxide 2018;76:71-80.
  • Steven S, Jurk K, Kopp M, Kröller-Schön S, Mikhed Y, Schwierczek K, Roohani S, Kashani F, Oelze M, Klein T, Tokalov S, Danckwardt S, Strand S, Wenzel P, Münzel T, Daiber A. Glucagon-like peptide-1 receptor signalling reduces microvascular thrombosis, nitro-oxidative stress and platelet activation in endotoxaemic mice. Br J Pharmacol 2017;174(12):1620-1632.
  • Gowert NS, Krüger I, Klier M, Donner L, Kipkeew F, Gliem M, Bradshaw NJ, Lutz D, Köber S, Langer H, Jander S, Jurk K, Frotscher M, Korth C, Bock HH, Elvers M. Loss of Reelin protects mice against arterial thrombosis by impairing integrin activation and thrombus formation under high shear conditions. Cell Signal 2017;40:210-221.
  • Kiouptsi K, Gambaryan S, Walter E, Walter U, Jurk K, Reinhardt C. Hypoxia impairs agonist-induced integrin alphaIIbbeta3 activation and platelet aggregation. Sci Rep 2017;7(1):7621.
  • Kiouptsi K, Grill A, Mann A, Döhrmann M, Lillich M, Jäckel S, Malinarich F, Formes H, Manukyan D, Subramaniam S, Khandagale A, Karwot C, Thal SC, Bosmann M, Scharrer I, Jurk K, Reinhardt C. Mice deficient in the anti-haemophilic coagulation factor VIII show increased von Willebrand factor plasma levels. PLoS One 2017;12(8):e0183590.
  • Alflen A, Prüfer S, Ebner K, Reuter S, Aranda Lopez P, Scharrer I, Banno F, Stassen M, Schild H, Jurk K, Bosmann M, Beckert H, Radsak MP (2017) ADAMTS-13 regulates neutrophil recruitment in a mouse model of invasive pulmonary aspergillosis. Scientific reports 7: 7184
  • Jäckel S, Kiouptsi K, Lillich M, Hendrikx T, Khandagale A, Kollar B, Hörmann N, Reiss C, Subramaniam S, Wilms E, Ebner K, von Brühl ML, Rausch P, Baines JF, Haberichter S, Lämmle B, Binder CJ, Jurk K, Ruggeri ZM, Massberg S, Walter U, Ruf W, Reinhardt C (2017) Gut microbiota regulate hepatic von Willebrand Factor synthesis and arterial thrombus formation via Toll-like receptor-2. Blood
  • Beck F, Geiger J, Gambaryan S, Solari FA, Dell'Aica M, Loroch S, Mattheij NJ, Mindukshev I, Potz O, Jurk K, Burkhart JM, Fufezan C, Heemskerk JW, Walter U, Zahedi RP, Sickmann A (2017) Temporal quantitative phosphoproteomics of ADP stimulation reveals novel central nodes in platelet activation and inhibition. Blood 129: e1-e12
  • Kossmann S, Lagrange J, Jäckel S, Jurk K, Ehlken M, Schönfelder T, Weihert Y, Knorr M, Brandt M, Xia N, Li H, Daiber A, Oelze M, Reinhardt C, Lackner K, Gruber A, Monia B, Karbach SH, Walter U, Ruggeri ZM, Renné T, Ruf W, Münzel T, Wenzel P (2017) Platelet-localized FXI promotes a vascular coagulation-inflammatory circuit in arterial hypertension. Sci Transl Med 9
  • Loroch S, Trabold K, Gambaryan S, Reiss C, Schwierczek K, Fleming I, Sickmann A, Behnisch W, Zieger B, Zahedi RP, Walter U, Jurk K (2017) Alterations of the platelet proteome in type I Glanzmann thrombasthenia caused by different homozygous delG frameshift mutations in ITGA2B. Thrombosis and haemostasis 117: 556-569
  • Subramaniam S, Jurk K, Hobohm L, Jäckel S, Saffarzadeh M, Schwierczek K, Wenzel P, Langer F, Reinhardt C, Ruf W (2017) Distinct contributions of complement factors to platelet activation and fibrin formation in venous thrombus development. Blood 129: 2291-2302
  • Steven S, Jurk K, Kopp M, Kröller-Schön S, Mikhed Y, Schwierczek K, Roohani S, Kashani F, Oelze M, Klein T, Tokalov S, Danckwardt S, Strand S, Wenzel P, Münzel T, Daiber A (2016) Glucagon-like peptide-1 receptor signalling reduces microvascular thrombosis, nitro-oxidative stress and platelet activation in endotoxaemic mice. British journal of pharmacology 
  • Manukyan D, Müller-Calleja N, Jäckel S, Luchmann K, Monnikes R, Kiouptsi K, Reinhardt C, Jurk K, Walter U, Lackner KJ. Cofactor-independent human antiphospholipid antibodies induce venous thrombosis in mice. Journal of thrombosis and haemostasis 14:1011-1020. 2016.
  • Larmann J, Jurk K, Janssen H, Müller M, Herzog C, Lorenz A, Schmitz M, Nofer JR, Theilmeier G. Hepatic Overexpression of Soluble Urokinase Receptor (uPAR) Suppresses Diet-Induced Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient (LDLR-/-) Mice. PloS one. 10:e0131854, 2015.
  • de Witt SM, Swieringa F, Cavill R, Lamers MM, van Kruchten R, Mastenbroek T, Baaten C, Coort S, Pugh N, Schulz A, Scharrer I, Jurk K, Zieger B, Clemetson KJ, Farndale RW, Heemskerk JW, Cosemans JM. Identification of platelet function defects by multi-parameter assessment of thrombus formation. Nat Commun. 2014;5:4257
  • Anaraki PK, Patecki M, Larmann J, Tkachuk S, Jurk K, Haller H, Theilmeier G, Dumler I. Urokinase receptor mediates osteogenic differentiation of mesenchymal stem cells and vascular calcification via the complement c5a receptor. Stem Cells Dev. 2014;23:352-362
  • Knorr M, Hausding M, Pfeffer A, Jurk K, Jansen T, Schwierczek K, Oelze M, Kroller-Schon S, Schulz E, Wenzel P, Gori T, Burgin K, Sartor D, Scherhag A, Munzel T, Daiber A. In vitro and in vivo characterization of a new organic nitrate hybrid drug covalently bound to pioglitazone. Pharmacology. 2014;93:203-215
  • Schnorbus B, Daiber A, Jurk K, Warnke S, Konig J, Krahn U, Lackner K, Munzel T, Gori T. Effects of clopidogrel, prasugrel and ticagrelor on endothelial function, inflammatory and oxidative stress parameters and platelet function in patients undergoing coronary artery stenting for an acute coronary syndrome. A randomised, prospective, controlled study. BMJ Open. 2014;4:e005268
  • Hausding M, Jurk K, Daub S, Kroller-Schon S, Stein J, Schwenk M, Oelze M, Mikhed Y, Kerahrodi JG, Kossmann S, Jansen T, Schulz E, Wenzel P, Reske-Kunz AB, Becker C, Munzel T, Grabbe S, Daiber A. Cd40l contributes to angiotensin ii-induced pro-thrombotic state, vascular inflammation, oxidative stress and endothelial dysfunction. Basic Res Cardiol. 2013;108:386
  • Fehrmann C, Jurk K, Bertling A, Seidel G, Fegeler W, Kehrel BE, Peters G, Becker K, Heilmann C. Role for the fibrinogen-binding proteins coagulase and efb in the staphylococcus aureus-candida interaction. Int J Med Microbiol. 2013;303:230-238
  • Bertling A, Niemann S, Hussain M, Holbrook L, Stanley RG, Brodde MF, Pohl S, Schifferdecker T, Roth J, Jurk K, Muller A, Lahav J, Peters G, Heilmann C, Gibbins JM, Kehrel BE. Staphylococcal extracellular adherence protein induces platelet activation by stimulation of thiol isomerases. Arterioscler Thromb Vasc Biol. 2012;32:1979-1990
  • Horn M, Bertling A, Brodde MF, Muller A, Roth J, Van Aken H, Jurk K, Heilmann C, Peters G, Kehrel BE. Human neutrophil alpha-defensins induce formation of fibrinogen and thrombospondin-1 amyloid-like structures and activate platelets via glycoprotein iib/iiia. J Thromb Haemost. 2012;10:647-661
  • Bohm M, Apel M, Sugawara K, Brehler R, Jurk K, Luger TA, Haas H, Paus R, Eiz-Vesper B, Walls AF, Ponimaskin E, Gehring M, Kapp A, Raap U. Modulation of basophil activity: A novel function of the neuropeptide alpha-melanocyte-stimulating hormone. J Allergy Clin Immunol. 2012;129:1085-1093

Reviews

  • Jurk K, Walter U. New Insights into Platelet Signalling Pathways by Functional and Proteomic Approaches. Hamostaseologie 2018.
  • Lutz J, Jurk K (2017) Antiplatelet Agents and Anticoagulants in Patients with Chronic Kidney Disease - from Pathophysiology to Clinical Practice. Current pharmaceutical design 23: 1366-1376
  • Lutz J, Jurk K, Schinzel H (2017) Direct oral anticoagulants in patients with chronic kidney disease: patient selection and special considerations. Int J Nephrol Renovasc Dis 10: 135-143
  • Pagel O, Walter E, Jurk K, Zahedi RP (2017) Taking the stock of granule cargo: Platelet releasate proteomics. Platelets 28: 119-128
  • Jurk K (2017) Platelet granules - secretory and secretive. Hamostaseologie 37(3):208-210
  • Jurk K (2015) Analysis of platelet function and dysfunction. Hamostaseologie 35: 60-72
  • Burkhart JM, Gambaryan S, Watson SP, Jurk K, Walter U, Sickmann A, Heemskerk JWM, Zahedi RP (2014) What Can Proteomics Tell Us About Platelets? Circ Res 114: 1204-1219