Visual Universitätsmedizin Mainz

Juniorgroup "Clinical Studies in Venous Thromboembolism"

Mareike Lankeit, MD, FESC
Leader Juniorgroup "Clinical Studies in Venous Thromboembolism"

The scientific focus of the Junior Group in the Module C “Clinical Trials” of the Center for Thrombosis and Hemostasis (CTH) is on optimizing the risk stratification of, and management strategies for, patients with acute pulmonary embolism (PE). In (mostly multicenter) prospective cohort studies, strategies for identification of patients with (i) intermediate-risk and (ii) low-risk PE are being tested and further developed. Besides the validation of established (laboratory) markers, clinical scores, and combination models, innovative concepts and biomarkers are being examined regarding their diagnostic, prognostic, and therapeutic implications in patients with acute PE. Furthermore, the clinical long-term outcome and quality of life of patients with acute PE are being investigated and analyzed. Thus, the work of the junior group is providing the scientific background and hypothesis to be subsequently tested in multicenter clinical trials of Module C. In most of its projects, the junior group collaborates closely with the Module B, “Clinical Epidemiology” of the CTH, and with renowned national and international partners. Beyond the scientific projects themselves, we place special emphasis on the support and mentoring of young talented researches, and on communicating the enthusiasm for clinical research.

Research Interests

  • Optimizing risk stratification and management strategies of patients with acute pulmonary embolism
  • Innovative biomarkers and strategies in acute pulmonary embolism
  • Long-term follow-up and patient satisfaction after acute pulmonary embolism

      External partners of Collaboration

      • Professor Gerd Hasenfuß, MD, Department  of  Cardiology and Pulmonology, Georg-August University of Göttingen (Scientific co-worker, Leader working group on "Right ventricular dysfunction and myocardial damage")
      • Professor Thomas Thum, MD, Medical University of Hannover, Transplantation, Institute of Molecular and Translational therapeutic strategies
      • Professor David Jiménez, Respiratory Department and Medicine Department, Ramón y Cajal Hospital and Alcalá de Henares University Madrid, Spain
      • Professor Piotr Pruszczyk, Department of Internal Medicine & Cardiology, Medical University of Warsaw, Poland
      • Professor Irene Lang, Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Austria
      • PD Mark Rosenberg, MD, Department of Internal Medicine III, Division of Cardiology and Angiology, University Hospital Schleswig-Holstein, Campus Kiel
      • Prof. Philipp Kümpers, Department of Medicine D, General Internal Medicine, Kidney and Hypertension diseases and Rheumatology, University Hospital of Münster
      • Professor Eckhard Mayer, Department of Thoracic Surgery, Kerckhoff-Klinik, Bad Nauheim
      • Professor Menno Huisman, Leiden Universiy Medical Center, The Netherlands

          Research Funding

          • Grant from Deutsche Gesellschaft für Kardiologie, Herz- und Kreislaufforschung e.V. (DGK)

          • BMBF                          

          Team - Juniorgroup Clinical Studies in Venous Thromboembolism

          Lankeit, MD
          Mareike Lankeit, MD
          Position: Junior group leader

          mlankeit@uni-mainz.de

          Hobohm, MD
          Lukas Hobohm, MD
          Position: Research Physician

          lukas.hobohm@unimedizin-mainz.de

          cand. med. Kölmel
          Sebastian Kölmel, cand. med.
          Position: MD student

          s.koelmel@students.uni-mainz.de

          cand. med. Krieg
          Valentin Krieg , cand. med.
          Position: MD student

          vkrieg@students.uni-mainz.de

          Pohl
          cand. med. Kristina Pohl
          Position: MD student

          kpohl@students.uni-mainz.de

          JG Lankeit

          Reviews

          • Lankeit M. Always think of the right ventricle, even in "low-risk" pulmonary embolism. Eur Respir J 2017;50(6).
          • Lankeit M, Keller K, Tschöpe C, Pieske B (2017) [Medicinal treatment of tricuspid valve regurgitation]. Herz
          • Lankeit M, Held M. Incidence of venous thromboembolism in COPD: linking inflammation and thrombosis? The European respiratory journal 47:369-373. 2016.
          • Konstantinides SV, Barco S, Lankeit M, Meyer G. Management of Pulmonary Embolism: An Update. Journal of the American College of Cardiology 67:976-990. 2016.
          • Grove EL, Lankeit M, Hess K, Freynhofer M, Stojkovic S, Varenhorst C, Thomas M. CardioPulse: the 'Young Thrombosis Researchers Group' of the ESC Working Group on Thrombosis. European heart journal. 36:703-704. 2015.
          • Klok FA, Kooiman J, Huisman MV, Konstantinides S, Lankeit M. Predicting anticoagulant-related bleeding in patients with venous thromboembolism: a clinically oriented review. European Respiratory Journal. 45:201-210, 2015.
          • Konstantinides S, Torbicki A, … Lankeit M, … 2014 ESC Guidelines on the diagnosis and management of acute pulmonary embolism: The Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology (ESC). Endorsed by the European Respiratory Society (ERS). European Heart Journal. 35:3033-3073, 2014.
          • Wilkens H, Lang I, Blankenburg T, Grohe C, Guth S, Held M, Klepetko W, Konstantinides S, Kramm T, Kruger U, Lankeit M, Schafers HJ, Seyfarth HJ, Mayer E. Chronic thromboembolic pulmonary hypertension - A position paper. Deutsche Medizinische Wochenschrift. 139:2204-2206, 2014.
          • Marti C, John G, Konstantinides S, Combescure C, Sanchez O, Lankeit M, Meyer G, Perrier A. Systemic thrombolytic therapy for acute pulmonary embolism: a systematic review and meta-analysis. European Heart Journal. 2014.
          • Lankeit M, Konstantinides S. Aktuelle Therapie und Sekundärprävention der Lungenembolie (CME zertifizierte Fortbildung). Der Kardiologe. 7:217-230, 2013.
          • Konstantinides S, Lankeit M. Pulmonary embolism hotline 2012. Recent and expected trials. Hamostaseologie. 33:43-50, 2013.
          • Lankeit M, Konstantinides S. Is it time for home treatment of pulmonary embolism? European Respiratory Journal. 40:742-749, 2012.

          Original articles

          • von Bardeleben RS, Hobohm L, Kreidel F, Ostad MA, Schulz E, Konstantinides S, Lankeit M, Feldman T, Münzel T, Keller K. Incidence and in-hospital safety outcomes of patients undergoing percutaneous mitral valve edge-to-edge repair using MitraClip: five-year German national patient sample including 13,575 implants. EuroIntervention 2019;14(17):1725-1732.
          • Kresoja KP, Ebner M, Rogge NIJ, Sentler C, Keller K, Hobohm L, Hasenfuss G, Konstantinides SV, Pieske B, Lankeit M. Prediction and prognostic importance of in-hospital major bleeding in a real-world cohort of patients with pulmonary embolism. Int J Cardiol 2019;290:144-149.
          • Kostrubiec M, Plywaczewska M, Jimenez D, Lankeit M, Ciurzynski M, Konstantinides S, Pruszczyk P. The Prognostic Value of Renal Function in Acute Pulmonary Embolism-A Multi-Centre Cohort Study. Thromb Haemost 2019;119(1):140-148.
          • Barco S, Russo M, Vicaut E, Becattini C, Bertoletti L, Beyer-Westendorf J, Bouvaist H, Couturaud F, Danays T, Dellas C, Duerschmied D, Empen K, Ferrari E, Galie N, Jimenez D, Klok FA, Kostrubiec M, Kozak M, Kupatt C, Lang IM, Lankeit M, Meneveau N, Palazzini M, Pruszczyk P, Rugolotto M, Salvi A, Sanchez O, Schellong S, Sobkowicz B, Meyer G, Konstantinides SV. Incomplete echocardiographic recovery at 6 months predicts long-term sequelae after intermediate-risk pulmonary embolism. A post-hoc analysis of the Pulmonary Embolism Thrombolysis (PEITHO) trial. Clin Res Cardiol 2019;108(7):772-778.
          • Wilkens H, Konstantinides S, Lang IM, Bunck AC, Gerges M, Gerhardt F, Grgic A, Grohe C, Guth S, Held M, Hinrichs JB, Hoeper MM, Klepetko W, Kramm T, Kruger U, Lankeit M, Meyer BC, Olsson KM, Schafers HJ, Schmidt M, Seyfarth HJ, Ulrich S, Wiedenroth CB, Mayer E. Chronic thromboembolic pulmonary hypertension (CTEPH): Updated Recommendations from the Cologne Consensus Conference 2018. Int J Cardio l 2018;272S:69-78.
          • Barco S, Ende-Verhaar YM, Becattini C, Jimenez D, Lankeit M, Huisman MV, Konstantinides SV, Klok FA. Differential impact of syncope on the prognosis of patients with acute pulmonary embolism: a systematic review and meta-analysis. Eur Heart J 2018;39(47):4186-4195.Barco S, Vicaut E, Klok FA, Lankeit M, Meyer G, Konstantinides SV, Investigators P. Improved identification of thrombolysis candidates amongst intermediate-risk pulmonary embolism patients: implications for future trials. Eur Respir J 2018;51(1).
          • Dellas C, Lobo JL, Rivas A, Ballaz A, Portillo AK, Nieto R, Del Rey JM, Zamorano JL, Lankeit M, Jimenez D. Risk stratification of acute pulmonary embolism based on clinical parameters, H-FABP and multidetector CT. Int J Cardiol 2018;265:223-228.
          • Hellenkamp K, Pruszczyk P, Jimenez D, Wyzgal A, Barrios D, Ciurzynski M, Morillo R, Hobohm L, Keller K, Kurnicka K, Kostrubiec M, Wachter R, Hasenfuss G, Konstantinides S, Lankeit M. Prognostic impact of copeptin in pulmonary embolism: a multicentre validation study. Eur Respir J 2018;51(4).
          • Klok FA, Ageno W, Barco S, Binder H, Brenner B, Duerschmied D, Empen K, Faggiano P, Ficker JH, Galiè N, Ghuysen A, Held M, Heydenreich N, Huisman MV, Jiménez D, Kozak M, Lang IM, Lankeit M, Münzel T, Petris A, Pruszczyk P, Quitzau K, Schellong S, Schmidt KH, Stefanovic BS, Verschuren F, Wolf-Puetz A, Meyer G, Konstantinides SV, Investigators P-. Dabigatran after Short Heparin Anticoagulation for Acute Intermediate-Risk Pulmonary Embolism: Rationale and Design of the Single-Arm PEITHO-2 Study. Thromb Haemost 2017;117(12):2425-2434.
          • Lankeit MKrieg V, Hobohm L, Kölmel S, Liebetrau C, Konstantinides S, Hamm CW, Mayer E, Wiedenroth CB, Guth S (2017) Pulmonary endarterectomy in chronic thromboembolic pulmonary hypertension. J Heart Lung Transplant
          • Bochenek ML, Rosinus NS, Lankeit MHobohm L, Bremmer F, Schutz E, Klok FA, Horke S, Wiedenroth CB, Münzel T, Lang IM, Mayer E, Konstantinides S, Schäfer K (2017) From thrombosis to fibrosis in chronic thromboembolic pulmonary hypertension. Thrombosis and haemostasis 117: 769-783
          • Keller K, von Bardeleben RS, Ostad MA, Hobohm L, Münzel T, Konstantinides S, Lankeit M (2017) Temporal Trends in the Prevalence of Infective Endocarditis in Germany Between 2005 and 2014. Am J Cardiol 119: 317-322
          • Konstantinides SV, Vicaut E, Danays T, Becattini C, Bertoletti L, Beyer-Westendorf J, Bouvaist H, Couturaud F, Dellas C, Duerschmied D, Empen K, Ferrari E, Galie N, Jimenez D, Kostrubiec M, Kozak M, Kupatt C, Lang IM, Lankeit M, Meneveau N et al. (2017) Impact of Thrombolytic Therapy on the Long-Term Outcome of Intermediate-Risk Pulmonary Embolism. Journal of the American College of Cardiology 69: 1536-1544
          • Hoeper MM, Lam CS, Vachiery JL, Bauersachs J, Gerges C, Lang IM, Bonderman D, Olsson KM, Gibbs JS, Dorfmuller P, Guazzi M, Galie N, Manes A, Handoko ML, Vonk-Noordegraaf A, Lankeit MKonstantinides S, Wachter R, Opitz C, Rosenkranz S (2017) Pulmonary hypertension in heart failure with preserved ejection fraction: a plea for proper phenotyping and further research. European heart journal 7;38(38):2869-2873
          • Becattini C, Agnelli G, Lankeit M, Masotti L, Pruszczyk P, Casazza F, Vanni S, Nitti C, Kamphuisen P, Vedovati MC, De Natale MG, Konstantinides S (2016) Acute pulmonary embolism: mortality prediction by the 2014 European Society of Cardiology risk stratification model. The European respiratory journal 48: 780-6
          • Klok FA, Hösel V, Clemens A, Yollo WD, Tilke C, Schulman S, Lankeit M, Konstantinides SV (2016) Prediction of bleeding events in patients with venous thromboembolism on stable anticoagulation treatment. The European respiratory journal 
          • Konstantinides SV, Barco S, Rosenkranz S, Lankeit M, Held M, Gerhardt F, Bruch L, Ewert R, Faehling M, Freise J, Ghofrani HA, Grünig E, Halank M, Heydenreich N, Hoeper MM, Leuchte HH, Mayer E, Meyer FJ, Neurohr C, Opitz C et al. (2016) Late outcomes after acute pulmonary embolism: rationale and design of FOCUS, a prospective observational multicenter cohort study. Journal of thrombosis and thrombolysis 
          • Koc M, Kostrubiec M, Elikowski W, Meneveau N, Lankeit M, Grifoni S, Kuch-Wocial A, Petris A, Zaborska B, Stefanovic BS, Hugues T, Torbicki A, Konstantinides S, Pruszczyk P, Ri HI. Outcome of patients with right heart thrombi: the Right Heart Thrombi European Registry. The European respiratory journal 47:869-875. 2016.
          • Klok FA, Niemann C, Dellas C, Hasenfuss G, Konstantinides SLankeit M. Performance of five different bleeding-prediction scores in patients with acute pulmonary embolism. Journal of thrombosis and thrombolysis 41:312-320. 2016.
          • Klok FA, Dzikowska-Diduch O, Kostrubiec M, Vliegen HW, Pruszczyk P, Hasenfuss G, Huisman MV, Konstantinides S, Lankeit M. Derivation of a clinical prediction score for chronic thromboembolic pulmonary hypertension after acute pulmonary embolism. Journal of thrombosis and haemostasis 14:121-128. 2016.
          • Jimenez D, Lobo JL, Fernandez-Golfin C, Portillo AK, Nieto R, Lankeit M, Konstantinides S, Prandoni P, Muriel A, Yusen RD, investigators P. Effectiveness of prognosticating pulmonary embolism using the ESC algorithm and the Bova score. Thrombosis and haemostasis 115:827-834. 2016.
          • Hobohm L, Hellenkamp K, Hasenfuss G, Münzel T, Konstantinides S, Lankeit M. Comparison of risk assessment strategies for not-high-risk pulmonary embolism. The European respiratory journal 47:1170-1178. 2016.
          • Barco S, Lankeit M, Binder H, Schellong S, Christ M, Beyer-Westendorf J, Duerschmied D, Bauersachs R, Empen K, Held M, Schwaiblmair M, Fonseca C, Jimenez D, Becattini C, Quitzau K, Konstantinides S. Home treatment of patients with low-risk pulmonary embolism with the oral factor Xa inhibitor rivaroxaban. Rationale and design of the HoT-PE Trial. Thrombosis and haemostasis 116. 2016.
          • Keller K, Beule J, Balzer JO, Dippold W (2016) Right bundle branch block and SQ-type patterns for risk stratification in acute pulmonary embolism. Journal of electrocardiology 
          • Keller K, Beule J, Balzer JO, Dippold W (2016) Syncope and collapse in acute pulmonary embolism. The American journal of emergency medicine 
          • Keller K, Stelzer K, Münzel T, Ostad MA (2016) Hypertension is strongly associated with false-positive bicycle exercise stress echocardiography testing results. Blood pressure: 1-9
          • Fernandez C, Bova C, Sanchez O, Prandoni P, Lankeit M, Konstantinides S, Vanni S, Fernandez-Golfin C, Yusen RD, Jimenez D. Validation of a Model for Identification of Patients at Intermediate to High Risk for Complications Associated with Acute Symptomatic Pulmonary Embolism. Chest. 2015.
          • Hellenkamp K, Schwung J, Rossmann H, Kaeberich A, Wachter R, Hasenfuss G, Konstantinides S, Lankeit M. Risk stratification of normotensive pulmonary embolism: prognostic impact of copeptin. The European respiratory journal. 2015.
          • Klok FA, Dzikowska-Diduch O, Kostrubiec M, Vliegen HW, Pruszczyk P, Hasenfuss G, Huisman MV, Konstantinides S, Lankeit M. Derivation of a clinical prediction score for chronic thromboembolic pulmonary hypertension after acute pulmonary embolism. Journal of thrombosis and haemostasis. 2015.
          • Klok FA, Niemann C, Dellas C, Hasenfuss G, Konstantinides S, Lankeit M. Performance of five different bleeding-prediction scores in patients with acute pulmonary embolism. Journal of thrombosis and thrombolysis. 2015.
          • Klok FA, Tesche C, Rappold L, Dellas C, Hasenfuß G, Huisman MV, Konstantinides SLankeit M. External validation of a simple non-invasive algorithm to rule out chronic thromboembolic pulmonary hypertension after acute pulmonary embolism. Thrombosis Research. 2015.
          • Kaeberich ASeeber V, Jiménez D, Kostrubiec M, Dellas C, Hasenfuss G, Giannitsis E, Pruszczyk P, Konstantinides S, Lankeit M. Age-adjusted hsTnT cut-off value for risk stratification of pulmonary embolism. European Respiratory Journal. 2015.
          • Meyer G, Vicaut E, Danays T, .... Lankeit M, .... and Konstantinides SV for the PEITHO Investigators. Fibrinolysis for Patients with Acute Intermediate-Risk Pulmonary Embolism. New England Journal of Medicine. 370:1402-11, 2014.
          • Lankeit M, Jiménez D, Kostrubiec M, Dellas C, Kuhnert K, Hasenfuß G, Pruszczyk P, Konstantinides S. Validation of NT-proBNP cut-off values for risk stratification of acute non-high-risk pulmonary embolism. European Respiratory Journal. 43:1669-77, 2014.
          • Dellas C, Tschepe M, Seeber V, Zwiener I, Kuhnert K, Schäfer K, Hasenfuß G, Konstantinides S, Lankeit M. A novel H-FABP assay and a fast prognostic score for risk assessment of normotensive pulmonary embolism. Thrombosis and Haemostasis-. 111:996-1003, 2014.
          • Lankeit M, Dellas C, Benz V, Hasenfuß G, Konstantinides S. The predictive value of heart-type fatty acid-binding protein is independent from the symptom duration in normotensive patients with pulmonary embolism. Thrombosis Research. 132:543-7, 2013.
          • Lankeit M, Friesen D, Schäfer K, Hasenfuß G, Konstantinides S, Dellas C. A simple score for rapid risk assessment of non-high-risk pulmonary embolism. Clinical Research in Cardiology. 102:73:80, 2013.

          Book and book chapters

          PD DR. Mareike Lankeit (Hrsg.), Medizinische Klinik mit Schwerpunkt Kardiologie, Charité - Universitätsmedizin Berlin, unter Mitarbeit von  Prof. Dr. Stavros Konstantinides et al.
          UNI-MED Science, 2., neubearb. Auflage 2017, 96 Seiten, 18 Abb., Hardcover, ISBN 978-3-8374-2372-3

           

          • Lankeit M, Opitz C. Zustand nach Lungenembolie (CME zertifizierte Fortbildung). Der Kardiologe 2017; 11:125-138.
          • Lankeit M. Management des Rechtsherzversagens bei akuter Lungenembolie. Herzmedizin 2017; 1:25-32.
          • Wilkens H, Guth S, Lankeit M. Chronisch Thromboembolische Pulmonale Hypertonie. Klinikarzt 2017; 46: 396-403. 
          May 2017

          Dr. Lukas Hobohm is awarded with Young Investigator Award “Pulmonary Embolism“ of the 3rd European Spring School on Venous Thromboembolism 2017 for the project 'Performance of the modified FAST score for risk stratification of normotensive pulmonary embolism – a validation study'.