Visual Universitätsmedizin Mainz

Professur für Klinische Studien

Univ.-Prof. Dr. Stavros Konstantinides
Ärztlicher Direktor des CTH

Das Modul C im CTH plant und koordiniert multizentrische klinische Studien zur Behandlung thrombotischer Erkrankungen. Im Fokus unseres Interesses steht die Optimierung des diagnostischen und therapeutischen Vorgehens bei Patienten mit venöser Thromboembolie (VTE). In laufenden prospektiven Kohorten- und interventionellen Studien evaluieren wir neue Strategien zur Risikostratifizierung der Patienten mit akuter Lungenembolie (LE). Weitere Studien befassen sich mit der ambulanten Behandlung ausgewählter LE-Patienten sowie mit dem Risiko der Entwicklung einer Chronisch-Thromboembolischen Pulmonalen Hypertension (CTEPH).

Abgesehen von individuellen Forschungsprojekten besteht die Mission unseres Moduls und des CTH darin, bei der Vernetzung europäischer Exzellenzzentren der Lungenembolie-Forschung und -Behandlung eine führende Rolle zu spielen. Mit der Unterstützung von Grundlagenforschern und klinischen Experten aus 15 europäischen Ländern und aus Nordamerika bauen wir derzeit das European Pulmonary Embolism Network (EPENet) auf.

Eine detaillierte Übersicht aller laufenden Projekte sowie Mitarbeiter der ‚Klinischen Studien’ finden Sie auf unseren Internetseiten www.unimedizin-mainz.de/cth-clinical-trials.

Forschungsschwerpunkte

  • Erarbeitung und prospektive Evaluierung neuer Multimarker-Strategien und Scores zur Risikostratifizierung von Patienten mit akuter Lungenembolie (Definition des intermediären Risikos)
  • Selektion von Lungenembolie-Patienten mit niedrigem Risiko zur frühen Entlassung und ambulanten Behandlung
  • Erforschung gemeinsamer kardiovaskulärer Risikofaktoren für arterielle und venöse Thrombosen
  • Langzeitverlauf nach einer akuten venösen Thromboembolie: Inzidenz und Pathogenese der CTEPH

Kooperationspartner

  • Einrichtungen der Universitätsmedizin Mainz: Prof. H. Binder, IMBEI; Prof. C. Espinola-Klein, II. Medizinische Klinik und Poliklinik, Abt. Angiologie; Prof. T. Münzel, II. Medizinische Klinik und Poliklinik; Prof. A. Kuhn, IZKS Mainz
  • Europäische Partner: Prof. C. Becattini, Perugia, IT; Prof. C. Binder, Vienna, AT; Prof. B. Brenner, Haifa, IL; Prof. P. Corris, Newcastle, UK; Prof. D. Jimenez, Madrid, ES; Dr. M. Kozak, Ljubljana, SLO; Prof. N. Kucher, Bern, CH; Prof. I. Lang, Vienna, AT; Prof. N. Meneveau, Besançon, FR; Prof. G. Meyer, Paris, FR; Prof. M. Monreal, Barcelona, ES; Prof. P. Pruszczyk, Warsaw, PL; Prof. M. Samarzija, Zagreb, HR; Prof. B. Stefanovic, Belgrade, SRB; Prof. A. Torbicki, Otwock, PL; Prof. T. Thum, Hannover, DE; Prof. D. Tziakas, Alexandroupolis, GR; Prof. F. Verschuren, Leuven, BE
  • Prof. S.Z. Goldhaber, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, US, and the North American Thrombosis Forum (NATF)

Drittmittelförderung

  • Bundesministerium für Bildung und Forschung (Klinische Studien 2015-2020)
  • Deutsche Gesellschaft für Kardiologie, Herz- und Kreislaufforschung
  • Pharmazeutische Industrie (Unterstützung von investigator initiated clinical trials)

Team - Modul Klinische Studien

Univ.-Prof. Dr. med. Konstantinides
Univ.-Prof. Dr. med. Stavros Konstantinides
Funktionen: Ärztlicher Direktor CTH, Professur "Klinische Studien", Stellvertretender Sprecher CTH, Medizinische Leitung der CTH-Ambulanz
Qualifikationen: Facharzt für Innere Medizin/Kardiologie

stavros.konstantinides@unimedizin-mainz.de

PD Dr. med. Lankeit
PD Dr. med. Mareike Lankeit
Funktionen: Nachwuchsgruppenleiterin

mareike.lankeit@unimedizin-mainz.de

Projektmanagement

Quitzau
Kurt Quitzau
Funktionen: Studienkoordinator

06131/17-8376
06131/17-8461
kurt.quitzau@unimedizin-mainz.de

Dr. rer. nat. Heydenreich
Dr. rer. nat. Nadine Heydenreich
Funktionen: Studienkoordinatorin

06131/17-8376
06131/17-8461
nadine.heydenreich@unimedizin-mainz.de

Dr. rer. nat. Becker
Dr. rer. nat. Dorothea Becker
Funktionen: Studienkoordinatorin

06131/17-8376
Dorothea.becker@unimedizin-mainz.de

Rump
Sabrina Rump
Funktionen: Projektkoordinatorin "Klinische Studien"

06131 17-8382
06131 17-8461
sabrina.rump@unimedizin-mainz.de

Forschung

Dr. med. Hobohm
Dr. med. Lukas Hobohm
Funktionen: Forschungsarzt

06131/17-8380
06131/17-8461
lukas.hobohm@unimedizin-mainz.de

Dr. Klok
Dr. Frederikus (Erik) Klok
Funktionen: Forschungsarzt, Virchow Fellow

06131/17-8380
06131/17-8461
Frederikus.Klok@unimedizin-mainz.de
Weitere Informationen

Dr. Barco
Dr. Stefano Barco
Funktionen: Wissenschaftlicher Mitarbeiter

06131-17 8251
06131 17 8461
s.barco@uni-mainz.de

Studienassistenz

Berghausen
Beate Berghausen
Funktionen: Studienassistenz

06131/17-8386
06131/17-47 1622
beate.berghausen@unimedizin-mainz.de

Fischer
Brunhilde Fischer
Funktionen: Studienassistenz, Vertretung Sekretariat

06131/17-8386
06131/17-8461
brunhilde.fischer@unimedizin-mainz.de

Otto
Silke Otto
Funktionen: Studienassistenz

06131/17-8252
silke.otto@unimedizin-mainz.de

Schöneberger
Doris Schöneberger
Funktionen: Studienassistenz

06131/17-8252
doris.schoeneberger@unimedizin-mainz.de

Reviews

  • Schulman S, Ageno W, Konstantinides SV (2017) Venous thromboembolism: Past, present and future. Thrombosis and haemostasis 117: 1219-1229
  • Barco S, Konstantinides S, Huisman MV, Klok FA (2017) Diagnosis of recurrent venous thromboembolism. Thrombosis research
  • Konstantinides SV (2017) Diagnosis of pulmonary embolism: progress after many YEARS. Lancet 390: 210-211
  • Konstantinides SV, Barco S (2017) Prevention of early complications and late consequences after acute pulmonary embolism: Focus on reperfusion techniques. Thrombosis research
  • Schäfer K, Drosos I, Konstantinides S (2017) Perivascular adipose tissue: epiphenomenon or local risk factor? Int J Obes (Lond) 41(9):1311-1323
  • Schulman S, Ageno W, Konstantinides SV (2017) Venous thromboembolism: Past, present and future. Thrombosis and haemostasis 117: 1219-122
  • Barco S, Konstantinides SV (2017) Catheter-directed thrombolysis for acute pulmonary embolism: Where do we stand? Lung India 34: 221-222
  • Barco S, Konstantinides SV (2017) Risk-adapted management of pulmonary embolism. Thrombosis research 151 Suppl 1: S92-S96
  • Konstantinides SV, Barco S (2017) Systemic Thrombolytic Therapy for Acute Pulmonary Embolism: Who Is a Candidate? Semin Respir Crit Care Med 38: 56-65
  • Mazzolai L, Aboyans V, Ageno W, Agnelli G, Alatri A, Bauersachs R, Brekelmans MP, Buller HR, Elias A, Farge D, Konstantinides S, Palareti G, Prandoni P, Righini M, Torbicki A, Vlachopoulos C, Brodmann M (2017) Diagnosis and management of acute deep vein thrombosis: a joint consensus document from the European society of cardiology working groups of aorta and peripheral circulation and pulmonary circulation and right ventricular function. European heart journal 
  • Ponikowski P, et al. (2016) 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)Developed with the special contribution of the Heart Failure Association (HFA) of the ESCEuropean heart journal
  • Harjola VP, Mebazaa A, Celutkiene J, Bettex D, Bueno H, Chioncel O, Crespo-Leiro MG, Falk V, Filippatos G, Gibbs S, Leite-Moreira A, Lassus J, Masip J, Mueller C, Mullens W, Naeije R, Nordegraaf AV, Parissis J, Riley JP, Ristic A et al. (2016) Contemporary management of acute right ventricular failure: a statement from the Heart Failure Association and the Working Group on Pulmonary Circulation and Right Ventricular Function of the European Society of Cardiology. European journal of heart failure 18: 226-41
  • Konstantinides SV (2016) Trends in pregnancy outcomes in patients with pulmonary hypertension: still a long way to go. European journal of heart failure 18: 1129-31
  • Konstantinides SV (2016) Trends in incidence versus case fatality rates of pulmonary embolism: Good news or bad news? Thrombosis and haemostasis 115: 233-5

  • Konstantinides SV (2016) Trends in Pulmonary Embolism Outcomes: Are We Really Making Progress? Journal of the American College of Cardiology 67: 171-3

  • Sista AK, Goldhaber SZ, Vedantham S, Kline JA, Kuo WT, Kahn SR, Kabrhel C, McLaughlin VV, White SB, Kim NH, Gray M, Simon MA, Benenati JF, Misra S, Sterling KM, Kee ST, Konstantinides SV, Jaff MR, Kearon C (2016) Research Priorities in Submassive Pulmonary Embolism: Proceedings from a Multidisciplinary Research Consensus Panel. Journal of vascular and interventional radiology : JVIR 27: 787-94
  • Konstantinides SV, Barco S, Lankeit M, Meyer G. Management of Pulmonary Embolism: An Update. Journal of the American College of Cardiology 67:976-990. 2016.
  • Konstantinides SV, Wärntges S. Acute phase treatment of venous thromboembolism: advanced therapy. Systemic fibrinolysis and pharmacomechanical therapy. Thrombosis and haemostasis 113. 2015.
  • Comerota AJ, Sandset PM, Konstantinides S, de Graaf R, Wakefield TW, Arnoldussen CW, Lam YL, van Gent WB, de Wolf MA, Catarinella FS, Kurstjens RL, Alshabatat A, Wittens CH. Theme 4: Invasive management of (recurrent) VTE and PTS. Thrombosis research 136 Suppl 1:S19-25. 2015.
  • Klok FA, Meyer G, Konstantinides S. Management of intermediate-risk pulmonary embolism: uncertainties and challenges. European journal of haematology. 2015.
  • Konstantinides S. [Coronary heart disease: Genetic score identifies risk patients]. Deutsche medizinische Wochenschrift. 140:1418. 2015.
  • Konstantinides SV, Wärntges S. Acute phase treatment of venous thromboembolism: advanced therapy. Systemic fibrinolysis and pharmacomechanical therapy. Thrombosis and haemostasis. 113. 2015.
  • Wärntges S, Konstantinides SV. Progress in the management of acute pulmonary embolism. Current opinion in pulmonary medicine. 2015.
  • Hellenkamp K, Käberich A, Schwung J, Konstantinides S, Lankeit M. Risk stratification of normotensive pulmonary embolism based on the sPESI - Does it work for all patients? International journal of cardiology. 197:162-163. 2015.
  • Konstantinides SV, Torbicki A, [...], Lankeit M, [...], Task Force for the D, Management of Acute Pulmonary Embolism of the European Society of C. 2014 ESC guidelines on the diagnosis and management of acute pulmonary embolism. European heart journal. 35:3033-3069, 3069a-3069k. 2014.
  • Wilkens H, Lang I, Blankenburg T, Grohe C, Guth S, Held M, Klepetko W, Konstantinides S, Kramm T, Kruger U, Lankeit M, Schafers HJ, Seyfarth HJ, Mayer E.  [Chronic thromboembolic pulmonary hypertension - A position paper.]. Deutsche medizinische Wochenschrift. 2014.
  • Lankeit M, Konstantinides S. Aktuelle Therapie und Sekundärprävention der Lungenembolie, p. 77-90, Gefässchirurgie - Zeitschrift für vaskuläre und endovaskuläre Medizin, vol. 19. 2014.
  • Lankeit M, Konstantinides, S. Thrombolyse bei akuter Lungenembolie – Risikostratifizierung, risikoadaptierte Diagnostik und Therapie, p. 6-11, Klinikarzt, vol. 433. 2014.
  • Clemens A, Strack A, Noack H, Konstantinides S, Brueckmann M, Lip GY.  Anticoagulant-related gastrointestinal bleeding--could this facilitate early detection of benign or malignant gastrointestinal lesions? Annals of medicine 46:672-678, 2014.
  • Käberich A, Wärntges S, Konstantinides S. Risk-adapted management of acute pulmonary embolism: recent evidence, new guidelines. Rambam Maimonides medical journal. 5:e0040, 2014.
  • Klok FA, Kooiman J, Huisman MV, Konstantinides S, Lankeit M. Predicting anticoagulant-related bleeding in patients with venous thromboembolism: a clinically oriented review. The European respiratory journal. 2014.
  • Klok FA, van der Hulle T, den Exter PL, Lankeit M, Huisman MV, Konstantinides S. The post-PE syndrome: a new concept for chronic complications of pulmonary embolism. Blood reviews. 2014.
  • Konstantinides S, Torbicki A. Management of venous thrombo-embolism: an update. European heart journal. 2014.
  • Konstantinides SV, Torbicki A. Management of pulmonary embolism: recent evidence and the new European guidelines. The European respiratory journal. 44:1385-1390, 2014.
  • Marti C, John G, Konstantinides S, Combescure C, Sanchez O, Lankeit M, Meyer G, Perrier A. Systemic thrombolytic therapy for acute pulmonary embolism: a systematic review and meta-analysis. European heart journal. 2014.
  • Konstantinides S, Lankeit M. Pulmonary embolism hotline 2012. Recent and expected trials. Hamostaseologie. 33(1):43-50. doi: 10.5482/HAMO-12-12-0024, 2013.
  • Konstantinides S, Goldhaber SZ. Pulmonary embolism: risk assessment and management. Eur Heart J. 33(24):3014-22, 2012.

Originalarbeiten

  • Schütz E, Bochenek ML, Riehl DR, Bosmann M, Münzel T, Konstantinides S, Schäfer K (2017) Absence of transforming growth factor beta 1 in murine platelets reduces neointima formation without affecting arterial thrombosis. Thrombosis and haemostasis 117: 1782-1797
  • Lankeit MKrieg V, Hobohm L, Kölmel S, Liebetrau C, Konstantinides S, Hamm CW, Mayer E, Wiedenroth CB, Guth S (2017) Pulmonary endarterectomy in chronic thromboembolic pulmonary hypertension. J Heart Lung Transplant
  • Chrysanthopoulou A, Kambas K, Stakos D, Mitroulis I, Mitsios A, Vidali V, Angelidou I, Bochenek M, Arelaki S, Arampatzioglou A, Galani IE, Skendros P, Couladouros EA, Konstantinides S, Andreakos E, Schäfer K, Ritis K (2017) Interferon lambda1/IL-29 and inorganic polyphosphate are novel regulators of neutrophil-driven thromboinflammation. J Pathol 243(1):111-122
  • Kaymaz C, Öztürk S, Akbal Ö, Tanboga IH, Yilmaz F, Poci N, Turkday S, Hakgör A, Yildiz C, Aktemur T, Özdemir N, Konstantinides S (2017) Ultrasound-Assisted Catheter-Directed Thrombolysis in High-Risk and Intermediate-High-Risk Pulmonary Embolism: Results From a Single-Center Cohort. Angiology 68: 433-440
  • Klok FA, Barco S, Konstantinides SV (2017) External validation of the VTE-BLEED score for predicting major bleeding in stable anticoagulated patients with venous thromboembolism. Thrombosis and haemostasis 117: 1164-1170
  • Konstantinides SV, Vicaut E, Danays T, Becattini C, Bertoletti L, Beyer-Westendorf J, Bouvaist H, Couturaud F, Dellas C, Duerschmied D, Empen K, Ferrari E, Galie N, Jimenez D, Kostrubiec M, Kozak M, Kupatt C, Lang IM, Lankeit M, Meneveau N et al. (2017) Impact of Thrombolytic Therapy on the Long-Term Outcome of Intermediate-Risk Pulmonary Embolism. Journal of the American College of Cardiology 69: 1536-1544
  • Ragia G, Kolovou V, Kolovou G, Konstantinides S, Maltezos E, Tavridou A, Tziakas D, Maitland-van der Zee AH, Manolopoulos VG (2017) A novel acenocoumarol pharmacogenomic dosing algorithm for the Greek population of EU-PACT trial. Pharmacogenomics 18: 23-34
  • Barco S, Corti M, Trinchero A, Picchi C, Ambaglio C, Konstantinides SV, Dentali F, Barone M (2017) Survival and recurrent venous thromboembolism in patients with first proximal or isolated distal deep vein thrombosis and no pulmonary embolism. Journal of thrombosis and haemostasis  
  • Bochenek ML, Rosinus NS, Lankeit M, Hobohm L, Bremmer F, Schutz E, Klok FA, Horke S, Wiedenroth CB, Münzel T, Lang IM, Mayer E, Konstantinides S, Schäfer K (2017) From thrombosis to fibrosis in chronic thromboembolic pulmonary hypertension. Thrombosis and haemostasis 117: 769-783
  • Hoeper MM, Lam CS, Vachiery JL, Bauersachs J, Gerges C, Lang IM, Bonderman D, Olsson KM, Gibbs JS, Dorfmuller P, Guazzi M, Galie N, Manes A, Handoko ML, Vonk-Noordegraaf A, Lankeit M, Konstantinides S, Wachter R, Opitz C, Rosenkranz S (2017) Pulmonary hypertension in heart failure with preserved ejection fraction: a plea for proper phenotyping and further research. European heart journal 7;38(38):2869-2873
  • Keller K, von Bardeleben RS, Ostad MA, Hobohm L, Münzel T, Konstantinides S, Lankeit M (2017) Temporal Trends in the Prevalence of Infective Endocarditis in Germany Between 2005 and 2014. Am J Cardiol 119: 317-322
  • Klok FA, Barco S, Konstantinides SV (2017) External validation of the VTE-BLEED score for predicting major bleeding in stable anticoagulated patients with venous thromboembolism. Thrombosis and haemostasis 
  • Konstantinides SV, Vicaut E, Danays T, Becattini C, Bertoletti L, Beyer-Westendorf J, Bouvaist H, Couturaud F, Dellas C, Duerschmied D, Empen K, Ferrari E, Galie N, Jimenez D, Kostrubiec M, Kozak M, Kupatt C, Lang IM, Lankeit M, Meneveau N et al. (2017) Impact of Thrombolytic Therapy on the Long-Term Outcome of Intermediate-Risk Pulmonary Embolism. Journal of the American College of Cardiology 69: 1536-1544
  • Ragia G, Kolovou V, Kolovou G, Konstantinides S, Maltezos E, Tavridou A, Tziakas D, Maitland-van der Zee AH, Manolopoulos VG (2017) A novel acenocoumarol pharmacogenomic dosing algorithm for the Greek population of EU-PACT trial. Pharmacogenomics 18: 23-34
  • Becattini C, Agnelli G, Lankeit M, Masotti L, Pruszczyk P, Casazza F, Vanni S, Nitti C, Kamphuisen P, Vedovati MC, De Natale MG, Konstantinides S (2016) Acute pulmonary embolism: mortality prediction by the 2014 European Society of Cardiology risk stratification model. The European respiratory journal 
  • Bleker SM, Buchmuller A, Chauleur C, Ainle FN, Donnelly J, Verhamme P, Jacobsen AF, Ganzevoort W, Prins M, Beyer-Westendorf J, DeSancho M, Konstantinides S, Pabinger I, Rodger M, Decousus H, Middeldorp S (2016) Low-molecular-weight heparin to prevent recurrent venous thromboembolism in pregnancy: Rationale and design of the Highlow study, a randomised trial of two doses. Thrombosis research 144: 62-68
  • Drosos I, Chalikias G, Pavlaki M, Kareli D, Epitropou G, Bougioukas G, Mikroulis D, Konstantinou F, Giatromanolaki A, Ritis K, Münzel T, Tziakas D, Konstantinides S, Schäfer K (2016) Differences between perivascular adipose tissue surrounding the heart and the internal mammary artery: possible role for the leptin-inflammation-fibrosis-hypoxia axis. Clinical research in cardiology : official journal of the German Cardiac Society 
  • Kaymaz C, Öztürk S, Akbal Ö, Tanboga IH, Yilmaz F, Poci N, Türkday S, Hakgör A, Yildiz C, Aktemur T, Özdemir N, Konstantinides S (2016) Ultrasound-Assisted Catheter-Directed Thrombolysis in High-Risk and Intermediate-High-Risk Pulmonary Embolism: Results From a Single-Center Cohort. Angiology 
  • Klok FA, Hösel V, Clemens A, Yollo WD, Tilke C, Schulman S, Lankeit M, Konstantinides SV (2016) Prediction of bleeding events in patients with venous thromboembolism on stable anticoagulation treatment. The European respiratory journal 
  • Konstantinides SV, Barco S, Rosenkranz S, Lankeit M, Held M, Gerhardt F, Bruch L, Ewert R, Faehling M, Freise J, Ghofrani HA, Grünig E, Halank M, Heydenreich N, Hoeper MM, Leuchte HH, Mayer E, Meyer FJ, Neurohr C, Opitz C et al. (2016) Late outcomes after acute pulmonary embolism: rationale and design of FOCUS, a prospective observational multicenter cohort study. Journal of thrombosis and thrombolysis 
  • Koc M, Kostrubiec M, Elikowski W, Meneveau N, Lankeit M, Grifoni S, Kuch-Wocial A, Petris A, Zaborska B, Stefanovic BS, Hugues T, Torbicki A, Konstantinides S, Pruszczyk P, Ri HI. Outcome of patients with right heart thrombi: the Right Heart Thrombi European Registry. The European respiratory journal 47:869-875. 2016.
  • Klok FA, Niemann C, Dellas C, Hasenfuss G, Konstantinides S, Lankeit M. Performance of five different bleeding-prediction scores in patients with acute pulmonary embolism. Journal of thrombosis and thrombolysis 41:312-320. 2016.
  • Klok FA, Dzikowska-Diduch O, Kostrubiec M, Vliegen HW, Pruszczyk P, Hasenfuss G, Huisman MV, Konstantinides S, Lankeit M. Derivation of a clinical prediction score for chronic thromboembolic pulmonary hypertension after acute pulmonary embolism. Journal of thrombosis and haemostasis 14:121-128. 2016.
  • Jimenez D, Lobo JL, Fernandez-Golfin C, Portillo AK, Nieto R, Lankeit M, Konstantinides S, Prandoni P, Muriel A, Yusen RD, investigators P. Effectiveness of prognosticating pulmonary embolism using the ESC algorithm and the Bova score. Thrombosis and haemostasis 115:827-834. 2016.
  • Hobohm L, Hellenkamp K, Hasenfuss G, Münzel T, Konstantinides S, Lankeit M. Comparison of risk assessment strategies for not-high-risk pulmonary embolism. The European respiratory journal 47:1170-1178. 2016.
  • Barco S, Lankeit M, Binder H, Schellong S, Christ M, Beyer-Westendorf J, Duerschmied D, Bauersachs R, Empen K, Held M, Schwaiblmair M, Fonseca C, Jimenez D, Becattini C, Quitzau K, Konstantinides S. Home treatment of patients with low-risk pulmonary embolism with the oral factor Xa inhibitor rivaroxaban. Rationale and design of the HoT-PE Trial. Thrombosis and haemostasis 116. 2016.
  • Stakos DA, Kambas K, Konstantinidis T, Mitroulis I, Apostolidou E, Arelaki S, Tsironidou V, Giatromanolaki A, Skendros P, Konstantinides S, Ritis K. Expression of functional tissue factor by neutrophil extracellular traps in culprit artery of acute myocardial infarction. European heart journal. 36:1405-1414. 2015.
  • Klok FA, Tesche C, Rappold L, Dellas C, Hasenfuss G, Huisman MV, Konstantinides S, Lankeit M.  External validation of a simple non-invasive algorithm to rule out chronic thromboembolic pulmonary hypertension after acute pulmonary embolism. Thrombosis research 135:796-801. 2015.
  • Klok FA, Niemann C, Dellas C, Hasenfuss G, Konstantinides S, Lankeit M. 2015. Performance of five different bleeding-prediction scores in patients with acute pulmonary embolism. Journal of thrombosis and thrombolysis. 2015.
  • Klok FA, Dzikowska-Diduch O, Kostrubiec M, Vliegen HW, Pruszczyk P, Hasenfuss G, Huisman MV, Konstantinides S, Lankeit M. 2015. Derivation of a clinical prediction score for chronic thromboembolic pulmonary hypertension after acute pulmonary embolism. Journal of thrombosis and haemostasis : JTH.
  • Hellenkamp K, Schwung J, Rossmann H, Kaeberich A, Wachter R, Hasenfuss G, Konstantinides S, Lankeit M. Risk stratification of normotensive pulmonary embolism: prognostic impact of copeptin. The European respiratory journal. 2015.
  • Fernandez C, Bova C, Sanchez O, Prandoni P, Lankeit M, Konstantinides S, Vanni S, Fernandez-Golfin C, Yusen RD, Jimenez D. Validation of a Model for Identification of Patients at Intermediate to High Risk for Complications Associated with Acute Symptomatic Pulmonary Embolism. Chest. 2015.
  • Käeberich A, Seeber V, Jimenez D, Kostrubiec M, Dellas C, Hasenfuss G, Giannitsis E, Pruszczyk P, Konstantinides S, Lankeit M. Age-adjusted hsTnT cut-off value for risk stratification of pulmonary embolism. The European respiratory journal. 2015.
  • Prochaska JH, Coldewey M, Gobel S, Keller K, Hendelmeier M, Konstantinides S, Münzel T, Wild PS, for the thromb ESG. Evaluation of oral anticoagulation therapy: rationale and design of the thrombEVAL study programme. Eur J Prev Cardiol. 2014. 
  • Meyer G, Vicaut E, [...] Lankeit M, [...] Konstantinides SV. Fibrinolysis for patients with intermediate-risk pulmonary embolism. N Engl J Med. 370:1402-1411, 2014.
  • Lankeit M, Jimenez D, Kostrubiec M, Dellas C, Kuhnert K, Hasenfuss G, Pruszczyk P, Konstantinides S. Validation of N-terminal pro-brain natriuretic peptide cut-off values for risk stratification of pulmonary embolism. The European respiratory journal. 43:1669-1677, 2014.
  • Jimenez D, Kopecna D, Tapson V, Briese B, Schreiber D, Lobo JL, Monreal M, Aujesky D, Sanchez O, Meyer G, Konstantinides S, Yusen RD, On Behalf Of The Protect I. Derivation and validation of multimarker prognostication for normotensive patients with acute symptomatic pulmonary embolism. Am J Respir Crit Care Med. 189:718-726, 2014.
  • Dellas C, Tschepe M, Seeber V, Zwiener I, Kuhnert K, Schäfer K, Hasenfuss G, Konstantinides S, Lankeit M. A novel H-FABP assay and a fast prognostic score for risk assessment of normotensive pulmonary embolism. Thrombosis and haemostasis. 111:996-1003, 2014.
  • Bova C, Sanchez O, Prandoni P, Lankeit M, Konstantinides S, Vanni S, Jimenez D. Identification of intermediate-risk patients with acute symptomatic pulmonary embolism. The European respiratory journal. 2014.
  • Raskob GE, Angchaisuksiri P, Blanco AN, Buller, Gallus A; Hunt BJ,  Hylek EM, Kakkar A, Konstantinides SV, McCumber M, Ozaki Y, Wendelboe A, Weitz JI. Thrombosis: a major contributor to global disease burden. Thrombosis and haemostasis 112:843-852, 2014.
  • Schroeter MR, Leifheit-Nestler M, Hubert A, Schumann B, Gluckermann R, Eschholz N, Kruger N, Lutz S, Hasenfuss G, Konstantinides S, Schäfer K. Leptin promotes neointima formation and smooth muscle cell proliferation via NADPH oxidase activation and signalling in caveolin-rich microdomains. Cardiovasc Res. 99:555-565, 2013.
  • Schroeter MR, Eschholz N, Herzberg S, Jerchel I, Leifheit-Nestler M, Czepluch FS, Chalikias G, Konstantinides S, Schafer K. Leptin-dependent and leptin-independent paracrine effects of perivascular adipose tissue on neointima formation. Arteriosclerosis, thrombosis, and vascular biology. 33:980-987, 2013.
  • Leifheit-Nestler M, Wagner NM, Gogiraju R, Didie M, Konstantinides S, Hasenfuss G, Schäfer K. Importance of leptin signaling and signal transducer and activator of transcription-3 activation in mediating the cardiac hypertrophy associated with obesity. J Transl Med. 11:170, 2013.
  • Lankeit M, Dellas C, Benz V, Hasenfuss G, Konstantinides S. The predictive value of heart-type fatty acid-binding protein is independent from symptom duration in normotensive patients with pulmonary embolism. Thromb Res. 132:543-547, 2013.
  • Dellas C, Lankeit M, Reiner C, Schäfer K, Hasenfuss G, Konstantinides S. BMI-independent inverse relationship of plasma leptin levels with outcome in patients with acute pulmonary embolism. Int J Obes (Lond). 37(2):204-10, 2013.
  • Lankeit M, Gómez V, Wagner C, Aujesky D, Recio M, Briongos S, Moores L, Yusen R, Konstantinides S, Jiménez D on behalf of the IRYCIS Pulmonary Embolism Study Group. A strategy combining imaging and laboratory biomarkers in comparison to a simplified clinical score for risk stratification of patients with acute pulmonary embolism. Chest. 141:916-922, 2012.
  • Konstantinides S, for the PEITHO Steering Committee. Single-bolus tenecteplase plus heparin compared with heparin alone for normotensive patients with acute pulmonary embolism who have evidence of right ventricular dysfunction and myocardial injury: rationale and design of the Pulmonary Embolism Thrombolysis (PEITHO) trial. Am Heart J. 163:33-38.e1, 2012.
  • Vedovati MC, Becattini C, Agnelli G, Kamphuisen PW, Masotti L, Pruszczyk P, Casazza F, Salvi A, Grifoni S, Carugati A, Konstantinides S, Schreuder M, Golebiowski M, Duranti M. Multidetector computed tomography for acute pulmonary embolism: embolic burden and clinical outcome. Chest. 142(6):1417-24, 2012.
  • Lankeit M, Jiménez D, Kostrubiec M, Dellas C, Hasenfuß G, Pruszczyk P, Konstantinides S. Predictive value of the highly sensitive troponin T assay and the simplified Pulmonary Embolism Severity Index in hemodynamically stable patients with acute pulmonary embolism: a prospective validation study. Circulation. 124:2716-2724, 2011.
AKTUELLES

Neue Leitlinien der ESC/ERS zur Diagnostik und Therapie der Lungenembolie (Pdf , 2.6 MB) (Chair der Task Force: Stavros Konstantinides) auf dem Kongress der European Society of Cardiology in Barcelona vorgestellt!
Zusammenfassung als PDF. (Pdf , 198.5 KB)