Visual Universitätsmedizin Mainz

Publikationen der AG Spessert

Marie-Paule Felder-Schmittbuhl, Ethan D. Buhr, Ouria Dkhissi-Benyahya, David Hicks, Stuart N. Peirson, Christophe P. Ribelayga, Cristina Sandu, Rainer Spessert, Gianluca Tosini
Ocular clocks: adapting mechanisms for eye functions and health, Invest Ophthalmol Vis Sci. (IOVS), accepted

Vancura P, Csicsely E, Leiser A, Iuvone PM, Spessert R.
Rhythmic Regulation of Photoreceptor and RPE Genes Important for Vision and Genetically Associated With Severe Retinal Diseases. Invest Ophthalmol Vis Sci. (IOVS) 2018 59(10):3789-3799. doi: 10.1167/iovs.18-24558.

Patrick Vancura, Shaima Abdelhadi, Erika Csicsely, Kenkichi Baba, Gianluca Tosini, P. Michael Iuvone, Rainer Spessert (2017) Gnaz couples the circadian and dopaminergic system to G protein-mediated signaling in mouse photoreceptors, PLOS Published: October 31, 2017,

Vancura, P., Wolloscheck, T., Baba, K., Tosini, G., Iuvone, P.M., Spessert, R. (2016) Circadian and Dopaminergic Regulation of Fatty Acid Oxidation Pathway Genes in Retina and Photoreceptor Cells, PLoS ONE, 11(10): e0164665, doi: 10.1371/Journal.pone.0164665

Kunst, S., Wolloscheck, T., Kelleher, D.K., Wolfrum, U., Sargsyan, S.A., Iuvone, P.M., Baba, K., Tosini, G., Spessert, R., Pgc-1α and Nr4a1 are target genes of circadian melatonin and dopamine release in murine retina. IOVS, Invest Ophthalmol Vis Sci. 2015 56(10):6084-94. doi: 10.1167/iovs.15-17503

Kunst, S., Wolloscheck, T., Grether, M., Trunsch, P., Wolfrum, U., Spessert, R., Photoreceptor cells display a daily rhythm in the orphan receptor estrogen-related receptor β. Mol. Vis., v.21; 2015, PMC4337357

Wolloscheck, T., Kunst, S., Kelleher, D.K., Spessert, R., Transcriptional regulation of nucleoredoxin-like genes takes place on a daily basis in the retina and pineal gland of rats. Vis. Neuroscience (2015), 32, doi:10.1017/S0952523814000352

Hiragaki, S., Baba, K., Coulson, E., Kunst, S., Spessert, R., Tosini, G., Melatonin signaling modulates clock genes expression in the mouse retina. PLOS One 9(9):e106819 (2014)

Spiwoks-Becker, I., Lamberti, R., tom Dieck, S., Spessert, R., Evidence for synergistic and complementary roles of Bassoon and darkness in organizing the ribbon synapse. Neuroscience. 236 (2013) 149-159. doi: 10.1016/j.neuroscience.2012.12.031

Kunst, S., Wolloscheck, T., Hölter, P., Wengert, A., Grether, M., Sticht, C., Weyer, V., Wolfrum, U., Spessert, R., Transcriptional analysis of rat photoreceptor cells reveals daily regulation of genes important for visual signaling and light damage susceptibility. J Neurochem. (2013) 124, 757-769. doi: 10.1111/jnc.12089.

Hölter, P., Kunst, S., Wolloscheck, T., Kelleher, D.K., Sticht, C., Wolfrum, U., Spessert, R., The retinal clock drives the expression of Kcnv2, a channel essential for visual function and cone survival. Invest Ophthalmol Vis Sci., 53:6947-6954 (2012). doi: 10.1167/iovs.12-10234

Koch, D., Spiwoks-Becker, I., Sabanov, V., Sinning, A., Dugladze, T., Stellmacher, A., Ahuja, R., Grimm J., Schüler, S., Müller, A., Angenstein, F., Ahmed T., Diesler, A., Moser, M., tom Dieck, S., Spessert, R., Boeckers, T.M., Faessler, R., Hübner, C.A., Balschun, D., Gloveli, T., Kessels, M.M., Qualmann, B., Proper synaptic vesicle formation and neuronal network activity critically rely on syndapin I. EMBO J. 30(24): 4955-69 (2011); v.30(24); 2011 Dec 14, PMC3243622

Spiwoks-Becker, I., Wolloscheck, T., Rickes, O., Kelleher, D., Rohleder, N., Weyer, V., Spessert, R., (2011) Phosphodiesterase10A in the rat pineal gland: Localization, daily and seasonal regulation of expression and influence on signal transduction. Neuroendocrinology, 94:113-123 (2011)

Wolloscheck, T., Spiwoks-Becker, I., Rickes, O., Holthues, H., Spessert, R., (2011) Phosphodiesterase10A: Abundance and circadian regulation in the retina and photoreceptor of the rat. Brain Res. 1376: 42-50

Schneider, K., Tippmann, S., Spiwoks-Becker, I., Holthues, H., Wolloscheck, T., Spatkowski, G., Engel, L., Frederiksen, U., Spessert, R., (2010) Unique clockwork in photoreceptor of rat., J. Neurochem. 115: 585-594

Spiwoks-Becker, I., Maus, C., tom Dieck, S., Fejtová, A., Engel, L., Wolloscheck, T., Wolfrum, U., Vollrath, L., Spessert, R., (2008) Active zone proteins are dynamically associated with synaptic ribbons in rat pinealocytes. Cell Tissue Res. 333: 185-195

Bai, L., Zimmer, S., Rickes, O., Rohleder, N., Holthues, H., Engel, L., Leube, R., Spessert, R., (2008) Daily oscillation of gene expression in the retina is phase-advanced with respect to the pineal gland. Brain Res. 1203: 89-96

Mathes, A., Engel, L., Holthues, H., Wolloscheck, T., Spessert, R., (2007) Daily profile in melanopsin transcripts depends on seasonal lighting conditions in rat retina. J. Neuroendocrinol. 19: 952-957

Spessert, R., Gupta, B.B.P., Rohleder, N., Gerhold, S., Engel, L., (2006) Cyclic AMP-inducible genes respond uniformly to seasonal lighting conditions in the rat pineal. Neuroscience 143: 607-613

Rohleder, N., Langer, C., Maus, C., Spiwoks-Becker, I., Emser, A., Engel, L., Spessert, R., (2006) Influence of photoperiodic history on clock genes and the circadian pacemaker in the rat retina. Eur. J. Neurosci. 23: 105-111

Peschke, E., Frese, T., Chankiewitz, E., Peschke, D., Preiss, U., Schneyer, U., Spessert, R., Mühlbauer, E., (2006) Diabetic Goto Kakizaki rats as well as type 1- and type 2-diabetic patients show a decreased diurnal serum melatonin level and an increased pancreatic melatonin receptor status. J. Pineal Res. 40: 135-143

Engel, L., Lorenzkowski, V., Langer, C., Rohleder, N., Spessert, R., (2005) The photoperiod entrains the molecular clock of the rat pineal gland. Eur. J. Neurosci. 21: 2297-2304

Engel, L., Gupta, B.B.P., Lorenzkowski, V., Heinrich, B., Schwerdtle, I., Gerhold, S., Holthues, H., Vollrath, L., Spessert, R., (2005) Fos-related antigene 2 (Fra-2) memorizes photoperiod in the rat pineal gland. Neuroscience 132: 511-518

Spessert, R. (2005) Photoperiodismus beim Säuger: Die Rolle von Melatonin. Abhandlungen der Sächsischen Akademie der Wissenschaften zu Leibzig, Band 63, Heft 2: 57-75

Holthues, H., Engel, L., Spessert, R., Vollrath, L., (2005) Circadian gene expression patterns of melanopsin and pinopsin in the chick pineal gland. Biochem. Biophys. Res. Commun. 326: 160-165

Gupta, B.B.P., Spessert, R., Vollrath, L., (2005) Molecular components and mechanism of adrenergic signal transduction in mammalian pineal gland: regulation of melatonin synthesis. Indian J. Exp. Biol. 43: 115-149

Engel, L., Vollrath, L., Spessert, R., (2004) Arylalkylamine N-acetyltransferase gene expression in retina and pineal gland of rats under various photoperiods. Biochem. Biophys. Res. Commun. 318(4): 983-6

Engel, L., Mathes, A., Schwerdtle, I., Heinrich, B., Pogorzelski, B., Holthues, H., Vollrath, L., Spessert, R., (2004) Rat pineal arylalkylamine-N-acetyltransferase: cyclic AMP inducibility of its gene depends on prior entrained photoperiod. Brain Res. Mol. Brain Res. 123(1-2): 45-55