Our research focusses on axonal damage and repair. Points of interest are differences between peripheral axons that are well capable of regeneration and central axons that mostly regenerate badly, as well as immunological mechanisms involved in axon repair. The role of ribosome/RNA transport in axons in regeneration will be studied as well as retrograde signalling mechanisms in response to treatment strategies.
The relation between ribosome transport and the regenerative capacity of central and peripheral axons using viral transduction and two-photon imaging.
A role for IL-4 in axon repair after spinal cord injury and during the chronic phase of multiple sclerosis.
Involvement of signalling in the early response to spinal cord injury and treatment.