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NeuroKine Projects

The members of the NeuroKine consortium use different models and cover different aspects of research and methods.  In this way, they can provide a unique opportunity for both research and education of immunological diseases of the central nervous system (CNS).  These are the projects they are working on:

 

The profile of infiltrating T cells in the CNS

 Further information (Pdf , 271,0 KB)  (271 KB)

Supervisor:     Ari Waisman
Researcher:    Alma Mohebiany
Partner:          University Medical Center Mainz, Germany

Generation of novel mouse lines to elucidate the role of interleukin-23 in inflammatory disease of the CNS

 Further information (Pdf , 256,9 KB)  (257 KB)

Supervisor:     Ari Waisman
Researcher:    Maja Kitic
Partner:          University Medical Center Mainz, Germany  

Identification of IL-23 responsive cell populations and their impact on inflammation using IL-23R- conditional mice

 Further information (Pdf , 241,2 KB)  (241 KB)

Supervisor:     Burkhard Becher
Researcher:    Tom Hartwig
Partner:          University of Zurich, Switzerland

IL-23 in autoimmune neuroinflammation

 Further information (Pdf , 204,0 KB)  (204 KB)

Supervisor:     Burkhard Becher
Researcher:    Melania Balzarolo
Partner:          University of Zurich, Switzerland

Nature of the inflammatory response in Multiple Sclerosis lesions

 Further information (Pdf , 202,4 KB)  (202 KB)

Supervisor:     Hans Lassmann
Researcher:    Joana Machado Dos Santos
Partner:          University of Vienna, Austria

Analysing the immune targeting of neurons by autoreactive T cells in autoimmune diseases of the central nervous system

 Further information (Pdf , 221,4 KB)  (221 KB)

Supervisor:     Roland Liblau
Researcher:    Christina Gebauer
Partner:          INSERM Toulouse, France

Effect of multiple antigens cross-reacting TCRs on pathogenesis of central nervous system autoimmunity

Further information coming soon

Supervisor:     Roland Liblau
Researcher:    Manish Malviya
Partner:          INSERM Toulouse, France

Impact of inflammation on neural stem cells and tissue repair

 Further information (Pdf , 235,6 KB)  (236 KB)

Supervisor:     Gianvito Martino
Researcher:    Hélène Descamps
Partner:          San Raffaele Hospital Milan, Italy

Cytokines driving innate and adaptive immunity in the non-human primate marmoset EAE model for MS

 Further information (Pdf , 209,8 KB)  (210 KB)

Supervisor:     Jon Laman and Bert ‘t Hart
Researcher:    Jordon Dunham
Partner:          University Medical Center Groningen, The Netherlands

Cellular targets and downstream effector mechanisms of IL-12/IL-23 signalling in Alzheimer´s disease

 Further information (Pdf , 220,7 KB)  (221 KB)

Supervisor:     Frank Heppner
Researcher:    Pascale Eede
Partner:          Charité - University Berlin, Germany

Function and role of astrocytes in CNS inflammation

 Further information (Pdf , 213,0 KB)  (213 KB)

Supervisor:     Melanie Jungblut
Researcher:    Hui Zhang
Partner:          Miltenyi Biotec GmbH, Bergisch-Gladbach, Germany

Antigen-specific immunotherapy

 Further information (Pdf , 185,5 KB)  (185 KB)

Supervisor:     David Wraith
Researcher:    Anja Wegner
Partner:          Apitope Technology Ltd, Bristol, United Kingdom

Project title tbc

Further information coming soon

Supervisor:     Thomas Hoffmann
Researcher:    Elisa Colombo
Partner:          Phenex Pharmaceuticals AG, Mainz, Germany

Development of a novel single-cell T cell receptor profiling platform using next-generation sequencing (NGS)

 Further information (Pdf , 289,3 KB)  (289 KB)

Supervisor:     Tana Omokoko
Researcher:    Shaheer El-Bardisy
Partner:          BioNTech AG, Mainz, Germany

Understanding the regulatory mechanism at the choroid plexus in a transgenic model of Alzheimer's disease

 Further information (Pdf , 243,2 KB)  (243 KB)

Supervisor:     Michal Schwartz
Researcher:    Alaa Sharif
Partner:          Weizmann Institute of Science, Rehovot, Israel