Visual Universitätsmedizin Mainz


  • Heinrich UR, Strieth S, Schmidtmann I, Li H, Helling K: Gentamicin alters Akt-expression and its activation in the guinea pig cochlea. Neuroscience. 2015,311:490-8.
  • Heinrich UR, Strieth S, Schmidtmann I, Stauber R, Helling K. Dexamethasone prevents hearing loss by restoring glucocorticoid receptor expression in the guinea pig cochlea. Laryngoscope. 2016, 126:E29-34.
  • Künzel J, Hainz M, Ziebart T, Pitz S, Ihler F, Strieth S, Matthias C: Head and neck solitary fibrous tumors: a rare and challenging entity. Eur Arch Otorhinolaryngol 2016, 273:1589-98.
  • Hussain T, Schneider M, Summer B, Strieth S: Pre-operative in vitro fibroblast coating of porous polyethylene compound grafts – cell survival in vivo and effects on biocompatibility. Biomed Mater and Eng 2016, 27:237-49.
  • Docter D, Strieth S, Westmeier D, Hayden O, Gao M, Knauer SK, Stauber RH: No king without a crown - impact of the nanomaterial-protein corona on nanobiomedicine. Nanomedicine (Lond). 2015;10: 503-19.
  • Künzel J, Hainz M, Ziebart T, Pitz S, Ihler F, Strieth S, Matthias C.: Head and neck solitary fibrous tumors: a rare and challenging entity. Eur Arch Otorhinolaryngol 2016, 273(6):1589-98 May.
  • Klotz LV, Clevert DA, Scheckinger S, Strieth S, Eichhorn ME: Contrast-enhanced ultrasound imaging of antiangiogenic tumor therapy. Anticancer Res 2015, 35(5): 2571-6.
  • Heinrich UR, Strieth S, Schmidtmann I, Stauber R, Helling K: Dexamethasone prevents hearing loss by restoring glucocorticoid receptor(GR)-expression in the lateral wall of the guinea pig cochlea. Laryngoscope 2015; in press.
  • Heinrich UR, Schmidtmann I, Strieth S, Helling K: Cell-specific accumulation patterns of gentamicin in the guinea pig cochlea. Hear Res 2015; in press.
  • Reichel CA, Hessenauer ME, Pflieger K, Rehberg M, Kanse SM, Zahler S, Krombach F, Berghaus A, Strieth S: Components of the Plasminogen Activation System Promote Engraftment of Porous Polyethylene Biomaterial via Common and Distinct Effects. PLoS One 2015; 10(2): e0116883
  • Strieth S, Dunau C, Michaelis U, Jäger, L, Gellrich D, Wollenberg B, Dellian M: Phase I/II clinical study on safety and antivascular effects of paclitaxel encapsulated in cationic liposomes for targeted therapy in advanced head and neck cancer. Head Neck 2014, 36:976-84.
  • Gellrich D, Becker S, Strieth S: Static magnetic fields increase tumor microvessel leakiness and improve antitumoral efficacy in combination with paclitaxel. Cancer Lett 2014, 343:107-14.
  • Strieth S, Siedek V*, Rytvina M, Gürkov R, Berghaus A, Clevert DA*: Dynamic contrast-enhanced ultrasound for differential diagnosis of submandibular gland disease. (*contributed equally to this study) Eur Arch Otorhinolaryngol 2014, 271:163-9.
  • Ihler F, Sharaf K, Bertlich M, Strieth S, Reichel CA, Berghaus A, Canis M: Etanercept prevents decrease of cochlear blood flow dose-dependently caused by tumor necrosis factor alpha. Ann Otol Rhinol Laryngol 2013, 122:468-73.
  • Arpornchayanon W, Canis M, Ihler F, Settevendemie C, Strieth S: TNF-α inhibition using etanercept prevents noise-induced hearing loss by improvement of cochlear blood flow in vivo. Int J Audiol 2013, 52:545-52.
  • Siedek V, Rytvina M, Ihrler S, Klotz L, Berghaus A, Clevert DA*, Strieth S*: Validation of contrast-enhanced ultrasound-derived intensity-time gradients in submandibular gland sialolithotomy patients. (*contributed equally to this study) Eur Arch Otorhinolaryngol 2013, 270:1941-6.
  • Tschiesner, Stier-Jarmer M, Strieth S, Singer S, Dietz A, Fietkau R, Wollenberg B, Mast G, Cieza A, Harréus U: [Development of an ICF-based clinical practice guideline for the assessment of function in patients with head and neck cancer] Laryngorhinootologie 2013, 92:314-25.
  • Strieth S, Dunau C, Kolbow K, Knuechel R, Michaelis U, Ledderose H, Eichhorn ME, Strelczyk D, Tschiesner U, Wollenberg B, Dellian M: Phase I clinical study of vascular targeting fluorescent cationic liposomes in head and neck cancer. Eur Arch Otorhinolaryngol 2013, 270:1481-7.
  • Ihler F, Bertlich M, Sharaf K, Strieth S, Strupp M, Canis M: Betahistine exerts a dose-dependent effect on cochlear stria vascular blood flow in guinea pigs in vivo. PLoS One 2012, 7(6):e39086. Epub 2012 Jun 20
  • Siedek V*, Clevert DA*, Rytvina M, Ihrler S, Klotz LV, Berghaus A, Strieth S: Contrast-enhanced ultrasound for monitoring effects of extracorporeal shock wave sialolithotripsy in sialolithiasis. (*contributed equally to this study) Laryngoscope 2012, 122:1301-5
  • Ihler F, Strieth S, Pieri N, Göhring P, Canis M: Acute hyperfibrinogenaemia impairs blood flow and hearing function in vivo. Int J Audiol 2012, 51:210-5
  • Tschiesner U, Schuster L, Strieth S, Harréus U: Functional outcome in patients with advanced head and neck cancer: surgery and reconstruction with free flaps versus primary radiochemotherapy. Eur Arch Otorhinolaryngol 2012, 269:629-38
  • Strassen U, Deppe C, Mees K, Plesnila N, Canis M, Strieth S, Olzowy B: Diagnostic potential of distortion product otoacoustic emissions (DPOAEs) in non-invasive assessment of elevated intracranial pressure: different patterns of DPOAE alterations in the guinea pig. ISRN Anesthesiology Volume 2011, Article ID 596848, 6 pagesdoi:10.5402/2011/596848
  • Arpornchayanon W*, Canis M*, Suckfuell M, Ihler F, Olzowy B, Strieth S: Modeling the measurements of cochlear microcirculation and hearing function after loud noise. (*contributed equally to this study) Otolaryngol Head Neck Surg 2011, 145:463-9
  • Scherer EQ, Yang J, Canis M, Reimann K, Ivanov K, Diehl CD, Backx PH, Wier WG, Strieth S, Wangemann P, Voigtlaender-Bolz J, Lidington D, Bolz SS: Tumor necrosis factor-α enhances microvascular tone and reduces blood flow in the cochlea via enhanced sphingosine-1-phosphate signaling. Stroke 2010, 41:2618-24
  • Olzowy B, Deppe C, Arpornchayanon W, Canis M, Strieth S, Kummer P: Quantitative estimation of minor conductive hearing loss with distortion product otoacoustic emissions in the guinea pig. J Acoust Soc Am 2010, 128:1845-52
  • Becker S, Strieth S, Canis M, Preissler G, Eichhorn ME: Automated assessment of tumour microvascular architecture in vivo. Anticancer Res 2010, 30:2597-602
  • Eichhorn ME, Klotz LV, Luedemann S, Strieth S, Kleespies A, Preissler G, Lindner M, Jauch KW, Reiser MF, Clevert DA: Vascular targeting tumor therapy: Non-invasive Contrast enhanced ultrasound for quantitative assessment of tumor microcirculation. Cancer Biol Ther 2010, 9: 794-802
  • Strieth S, Weger T, Bartesch C, Bittmann P, Stelter K, Berghaus A: Biocompatibility of porous polyethylene implants tissue-engineered by extracellular matrix and VEGF. J Biomed Mater Res A 2010, 93:1566-73
  • Schneider M, Mandal PK, Arpornchayanon W, Jannasch K, Förster H, Alves F, Strieth S, Conrad S, Beck H: Absence of glutathione peroxidase 4 promotes tumor angiogenesis through deregulated 12/15-lipoxygenase activity. Neoplasia 2010, 12:254-63
  • Olzowy B, von Gleichenstein G, Canis M, Plesnila N, Strieth S, Deppe C, Mees K: Level alterations of the 2f (1)-f (2) distortion product due to hypoxia in the guinea pig depend on the stimulus frequency. Eur Arch Otorhinolaryngol 2010, 267:351-5
  • Eichhorn ME, Ischenko I, Luedemann S, Strieth S, Papyan A, Werner A, Bohnenkamp H, Guenzi E, Preissler G, Michaelis U, Jauch KW, Bruns CJ, Dellian M: Vascular targeting by EndoTAG-1 enhances therapeutic efficacy of conventional chemotherapy in lung and pancreatic cancer. Int J Cancer 2010, 126:1235-45
  • Canis M, Arpornchayanon W, Messmer C, Suckfuell M, Olzowy B, Strieth S: An animal model for the analysis of cochlear blood flow disturbance and hearing threshold in vivo. Eur Arch Otorhinolaryngol 2010, 267:197-203
  • Strelczyk D, Eichhorn ME, Luedemann S, Brix G, Dellian M, Berghaus A, Strieth S: Static magnetic fields impair angiogenesis and growth of solid tumors in vivo. Cancer Biol Ther 2009, 8:1756-62
  • Strieth S, Eichhorn ME, Werner A, Sauer B, Teifel M, Michaelis U, Berghaus A, Dellian M: Liposomal paclitaxel increases tumor microvessel leakiness and improves therapeutic efficacy in combination with cisplatin. Clin Cancer Res 2008, 14: 4603-11
  • Eichhorn ME, Strieth S, Luedemann S, Kleespies A, Noeth U, Passon A, Brix G, Jauch KW, Bruns CJ, Dellian M: Contrast enhanced MRI and intravital fluorescence microscopy indicate improved tumor microcirculation in highly vascularized melanomas upon short-term anti-VEGFR treatment. Cancer Biol Ther 2008, 7:1006-13
  • Strieth S, Strelczyk D, Eichhorn ME, Marc Dellian M, Lüdemann S, Griebel J, Bellemann M, Berghaus A, Brix G: Static magnetic fields induce blood blow decrease and platelet adherence in tumor microvessels. Cancer Biol Ther 2008, 7:814-819
  • Brix G*, Strieth S*, Strelczyk D, Dellian M, Griebel J, Eichhorn ME, Andrä W, Bellemann ME: Static magnetic fields affect capillary flow of red blood cells in striated skin muscle. (*contributed equally to this study) Microcirculation 2008, 15:15-26
  • Strieth S*, Nussbaum CF*, Eichhorn ME, Fuhrmann M, Teifel M, Michaelis U, Berghaus A, Dellian M: Tumor-selective vessel occlusions by platelets after vascular targeting chemotherapy using paclitaxel encapsulated in cationic liposomes. (*contributed equally to this study) Int J Cancer 2008, 122:452-60
  • Stelter K, Strieth S, Berghaus A: Porous polyethylene implants in revision rhinoplasty: Chances and risks. Rhinology 2007, 45:325-31
  • Suckfuell M, Canis M, Strieth S, Scherer H, Haisch H: Intratympanic treatment of acute acoustic trauma with a cell-permeable JNK ligand: a prospective randomized phase-I/II study. Acta Otolaryngolocica 2007, 127:938-42.
  • Eichhorn ME, Luedemann S, Strieth S, Papyan A, Ruhstorfer H, Haas H, Michaelis U, Sauer B, Teifel M, Enders G, Brix G, Jauch KW, Bruns CJ, Dellian M: Cationic Lipid Complexed Camptothecin (EndoTAG®-2) Improves Antitumoral Efficacy by Tumor Vascular Targeting. Cancer Biol Ther 2007, 6:920-9
  • Strieth S, Eichhorn ME, Sutter A, Jonczyk A, Berghaus A, Dellian M: Anti-angiogenic combination tumor therapy blocking av-integrins and VEGF-receptor-2 increases therapeutic effects in vivo. Int J Cancer 2006, 119:423-431
  • Eichhorn ME, Becker S, Strieth S, Werner A, Sauer B, Ruhstorfer H, Michaelis U, Griebel J, Brix G, Jauch KW, Dellian M: Dynamic magnetic resonance tomography for monitoring the efficacy of an anti-vascular tumor therapy by paclitaxel encapsulating cationic lipid complexes. Cancer Biol Ther 2006, 5:89-96
  • Strieth S, v. Johnston V, Eichhorn ME, Enders G, Krasnici S, Thein E, Hammer C, Dellian M: A new animal model to assess angigogenesis and endocrine function of parathyroid heterografts in vivo. Transplantation 2005, 79:392-400
  • Eichhorn ME, Strieth S, Dellian M: Anti-vascular tumor therapy: Recent advances, pitfalls and clinical perspectives. Drug Resist Updat 2004, 7: 125-138
  • Eichhorn ME, Strieth S, Krasnici S, Sauer B, Teifel M, Schulze B, Michaelis U, Naujoks K, Dellian M: Protamine enhances uptake of cationic liposomes in solid tumors. Angiogenesis 2004, 7:133-141
  • Strieth S, Eichhorn ME, Sauer B, Schulze B, Teifel M, Michaelis U, Dellian M: Neovascular targeting chemotherapy: paclitaxel encapsulated in cationic liposomes impairs functional tumor microvasculature. Int J Cancer 2004, 110:117-124
  • Schmitt-Sody M*, Strieth S*, Krasnici S, Sauer B, Schulze, Teifel M, Michaelis U, Naujoks K, Dellian M: Neovascular targeting therapy: paclitaxel encapsulated in cationic liposomes improves antitumor efficacy. (*contributed equally to this study) Clin Cancer Res 2003, 9:2335-2341
  • Dellian M, Eichhorn ME, Strieth S: Antivaskuläre Strategien – ein neues Konzept zur Diagnose und Therapie von Kopf-. Hals-Tumoren. Laryngorhinootologie 2002, 81:509-515
  • Strieth S, Hartschuh H, Pilz L, Fusenig NE: Carcinoma-like vascular density in atypic keratoacanthoma suggests malignant progression. Br J Cancer 2002, 87: 1301-1307
  • Strieth S, Hartschuh H, Pilz L, Fusenig NE: Angiogenic switch occurs late in squamous cell carcinomas of human skin. Br J Cancer 2000, 82: 591-600

Prof. Dr. med. Dr. med. habil. S. Strieth

Hals-, Nasen-, Ohrenklinik und Poliklinik - Plastische Operationen
Johannes-Gutenberg-Universität Mainz
Tel: (+49) 6131 - 177361
Email:  Prof. Strieth




PD Dr. med. K. Helling
Hals-, Nasen-, Ohrenklinik und Poliklinik
Johannes Gutenberg-Universität Mainz
Langenbeckstraße 1
55101 Mainz

Tel: +49 (0) 6131 - 17 6871
Fax: +49 (0) 6131 - 17 6637