DRUCKEN

2014

Wagner T., Brand P., Heinzel T., Krämer O.H. (2014) Histone deacetylase 2 controls p53 and is a critical factor in tumorigenesis, Biochim Biophys Acta, 1846, 524-538


Roos W.P., Quiros S., Krumm A., Merz S., Switzeny O.J., Christmann M., Loquai C., Kaina B. (2014) B-Raf inhibitor vemurafenib in combination with temozolomide and fotemustine in the killing response of malignant melanoma cells, Oncotarget, 5, 12607-12620 

 

Tomicic M.T., Aasland D., Naumann S.C., Meise R., Barckhausen C., Kaina B., Christmann M. (2014) Translesion polymerase η Is upregulated by cancer therapeutics and confers anticancer drug resistance, Cancer Research, 74, 5585-5596


Krämer O.H., Mahboobi S., Sellmer A. (2014) Drugging the HDAC6-HSP90 interplay in malignant cells, Trends in Pharmacological Sciences, 35, 501-509

 

Wirth M., Stojanovic N., Christian J., Paul M.C., Stauber R.H., Schmid R.M., Häcker G., Krämer O.H., Saur D., Schneider G. (2014) MYC and EGR1 synergize to trigger tumor cell death by controlling NOXA and BIMtranscription upon treatment with the proteasome inhibitor bortezomib, Nucleic Acids Research, 42, 10433-10447

 

Heylmann D., Rödel F., Kindler T., Kaina B. (2014) Radiation sensitivity of human and murine peripheral blood lymphocytes, stem and progenitor cells, Biochimia et Biophysica Acta, 1846, 121-129

 

Ginter T., Fahrer J., Kröhnert U., Fetz V., Garrone A., Stauber R.H., Reichardt W., Müller-Newen G., Kosan C., Heinzel T., Krämer O.H. (2014) Arginine residues within the DNA binding domain of STAT3 promote intracellular shuttling and phosphorylation of STAT3, Cell Signal, 26, 1698-1706


Ensminger M., Iloff L., Ebel C., Nikolova T., Kaina B., Löbrich M. (2014) DNA breaks and chromosomal aberrations arise when replication meets base excision repair, Journal of Cell Biology, 206, 29-43



Nikolova T., Dvorak M., Jung F., Adam I., Krämer E., Gerhold-Ay A., Kaina B. (2014), The γH2AX Assay for Genotoxic and Nongenotoxic Agents: Comparison of H2AX Phosphorylation with Cell Death Response Toxicological Sciences, 140, 103-117

 

Fahrer J., Huelsenbeck J., Jaurich H., Dörsam B., Frisan T., Eich M., Roos W.P., Kaina B., Fritz G. (2014) Cytolethal distending toxin (CDT) is a radiomimetic agent and induces persistent levels of DNA double-strand breaks in human fibroblasts, DNA Repair (Amst), 18, 31-43


Müller S., Chen Y., Ginter T., Schäfer C., Buchwald M., Schmitz L.M., Klitzsch J., Schütz A., Haitel A., Schmid K., Moriggl R., Kenner L., Friedrich K., Haan C., Petersen I., Heinzel T., Krämer O.H. (2014) SIAH2 antagonizes TYK2-STAT3 signaling in lung carcinoma cells, Oncotarget, 5, 3184-3196

 

Treude F., Kappes F., Fahrenkamp D., Müller-Newen G., Dajas-Bailador F., Krämer O.H., Lüscher B., Hartkamp J. (2014) Caspase-8-mediated PAR-4 cleavage is required for TNFα-induced apoptosis, Oncotarget, 5, 2988-2998

 

Licht V., Noack K., Schlott B., Förster M., Schlenker Y., Licht A., Krämer O.H., Heinzel T. (2014) Caspase-3 and caspase-6 cleave STAT1 in leukemic cells, Oncotarget, 5, 2305-2317

 

Barckhausen C., Roos W.P., Naumann S.C., Kaina B. (2014) Malignant melanoma cells acquire resistance to DNA interstrand cross-linking chemotherapeutics by p53-triggered upregulation of DDB2/XPC-mediated DNA repair, Oncogene, 33, 1964-1974


Rauch A., Hennig D., Schäfer C., Wirth M., Marx C., Heinzel T., Schneider G., Krämer O.H. (2014) Survivin and YM155: How faithful is the liaison? Biochimica et Biophysica Acta, 1845, 202-220


Hähnel P.S., Enders B., Sasca D., Roos W.P., Kaina B., Bullinger L., Theobald M., Kindler T. (2014) Targeting components of the alternative NHEJ pathway sensitizes KRAS mutant leukemic cells to chemotherapy, Blood, 123, 2355-2366

 

Becker K., Thomas A.D., Kaina B. (2014) Does increase in DNA repair allow "tolerance-to-insult" in chemical carcinogenesis? Skin tumor experiments with MGM overexpressing mice, Environmental Molecular Mutagenesis, 55, 145-150


Kaina B., Thomas A.D., Hengstler J.G. (2014) Do carcinogens have a threshold dose? Pro and contra, Regulatory Toxicology397-406


Graf F., Fahrer J., Maus S., Morgenstern A., Bruchertseifer F., Venkatachalam S., Fottner C., Weber M.M., Huelsenbeck J., Schreckenberger M., Kaina B., Miederer M. (2014) DNA Double Strand Breaks as Predictor of Efficacy of the Alpha-Particle Emitter Ac-225 and the Electron Emitter Lu-177 for Somatostatin Receptor Targeted Radiotherapy, PLoS One, 9, e88239

 

Sonnemann J., Marx C., Becker S., Wittig S., Palani C. D., Kraemer O. H., Beck J. F. (2014) p53-dependent and p53-independent anticancer effects of different histone deacetylase inhibitors, British Journal of Cancer, 110, 656-667