Prof. Dr. Gregory Harms

My technical research interests are in Single Molecule Biophysics and Fluorescence Microscopy Techniques, including superresolution microscopy, deep tissue imaging by fluorescence microscopy and non-linear optical techniques, and my scientific research interests are in TGF-beta, Interleukin, and G-Protein coupled receptor signalling systems as drug targets to address cancer, inflammation and cardiovascular diseases and Alzheimer’s Disease neurodegeneration and Traumatic Brain Injury.

Training and professional experience

• 1987 - 1992: B.A./B.S. Biophysical Chemistry & German, Bethel College, KS USA
• 1989 - 1990: Exchange Student, Universität Marburg and Wuppertal, Germany
• 1992 - 1998: Ph.D. Biophysical Chemistry, University of Kansas, USA
• 1997 - 1998: Fulbright Scholar & Post-docETH Zürich (CH)
• 1998 - 2000: Post-doctoral fellow, Universitaet Leiden (NL) Universität Linz (A)
• 2001 - 2002: Post-doctoral Fellow, Pacific Northwest National Laboratory, USA
• 2002 - 2011: Professor of Microscopy and Biophysics, Rudolf-Virchow-Center, Institut für Physik und Astronomie, Universität Würzburg, Germany
• 2010 - present: Associate Professor, Wilkes University, Departments of Biology/Health Sciences and Physics/Engineering, USA

Selected publications

• Mooz, J., Oberoi-Khanuja, T.K., Harms, G.S., Wang, W., Jaiswal, B.S., Seshagiri, S., Tikkanen, R., Rajalingam, K. (2014) Dimerization of ARAF promotes MAPK pathway activation and cell migration. Science Signaling7, 337.
• Brede, C., Friedrich, M., Jordán-Garrote, AL., Riedel, S., Bäuerlein, C., Heinze, K., Bopp, T., Schulz, S., Mottok, A., Kiesel, C., Mattenheimer, K., Ritz, M., von Krosigk, V., Rosenwald, A., Einsele, H., Negrin, R., Harms, G.S., Beilhack, A. (2012) Mapping immunological processes in intact organs at the single cell level. The Journal of Clinical Investigation122(12):4439-46.
• Guzman A, Zelman-Femiak M, Boergermann JH, Paschkowsky S, Kreuzaler PA, Fratzl P, Knaus P, Harms GS. (2012) SMAD versus non-SMAD signaling is determined by lateral mobility of bone morphogenetic protein (BMP) receptors. J. Biol Chem.49(2), 574-579.
• Oberoi TK, Dogan T, Hocking JC, Scholz RP, Mooz J, Anderson CL, Karreman C, Meyer Zu Heringdorf D, Schmidt G, Ruonala M, Namikawa K, Harms GS, Carpy A, Macek B, Köster RW, Rajalingam K. (2011) IAPs regulate the plasticity of cell migration by directly targeting Rac1 for degradation.EMBO Journal 31 (1), 14 - 28.
• Ermolayev, V., Friedrich, M., Nozadze, R., Cathomen, T., Klein, M.A., Flechsig, E. and Harms, G.S. (2009) Ultramicroscopy reveals axonal transport impairments in cortical motor neurons at prion disease. Biophys J,96 (8), 3390-3398
• Dogan,T. , Harms, G.S., Hekman, M., Karremann, C., Alnemri, E.S., Rapp, U.R. and Rajalingam, K. (2008) X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility, Nature Cell Biol., 10(12), 1447 - 1455.
• Gromova, K., Friedrich, M., Noskov, A., Harms, G.S. (2007) Visualizing SMAD1/4 signaling response to Bone Morphogenetic Protein-4 activation by FRET biosensors. BBA Mol. Cell Res, 1773, 1759-1773.
• Friedl, P, Wolf, K., von Andrian, U., Harms, G.S. (2007) Biological second and third harmonic generation microscopy. Curr Prot Cell Biol, 4.15.1-4.15.21. 7
• Vilardaga, J.P., Steinmeyer, R., Harms, G.S., Lohse, M.J. (2005) Molecular basis of inverse agonism in a G protein-coupled receptor. Nat Chem Biol, 1, 25-28. 6