Visual Universitätsmedizin Mainz

Dr. med. Harald von Pein

Dr. med. Pein
Dr. med. Harald von Pein
Qualifikationen: Facharzt für Neuropathologie

06131 17-6718
06131 17-6606
Weitere Informationen

Studium und beruflicher Werdegang

Studium und beruflicher Werdegang


Studium der Humanmedizin an der Heinrich-Heine-Universität Düsseldorf


Promotion, Ruprecht-Karls-Universität Heidelberg


Arzt im Praktikum und Assistenzarzt im Pathologischen Institut der Ruprecht-Karls-Universität Heidelberg (Prof. Dr. Dr. h. c. H. F. Otto)


Assistenzarzt im Institut für Anatomie der Otto-von-Guericke-Universität Magdeburg (Prof. Dr. D. Wendler)


Assistenzarzt im Institut für Neuropathologie der RWTH Aachen (Prof. Dr. J. M. Schröder)


Facharzt für Neuropathologie


Assistenzarzt in der Prosektur und Abteilung für Neuropathologie am BKH Günzburg (Prof. Dr. P. Möller / Prof. Dr. C. Sommer)

seit 2005

Oberarzt des Instituts für Neuropathologie, Universitätsmedizin der Johannes Gutenberg-Universität Mainz



seit 1998

Anatomische Gesellschaft

seit 1998

Neurowissenschaftliche Gesellschaft

seit 1999

Deutsche Gesellschaft für Neuropathologie und Neuroanatomie


  • Neuromuskuläre Erkrankungen
  • Neuroprotektion nach zerebraler Ischämie

Ausgewählte Publikationen


Ridwan S, Bauer H, Frauenknecht K, Hefti K, von Pein H, Sommer C:
Distribution of the hematopoietic growth factor G-CSF and its receptor in the adult human brain with specific reference to Alzheimer's disease.
J Anat (2014) 224 (4): 377-91


Gramlich OW, Lueckner TC, Kriechbaum M, Teister J, Tao X, von Pein HD, Pfeiffer N, Grus FH:
Dynamics, alterations, and consequences of minimally invasive intraocular pressure elevation in rats.
Invest Ophthalmol Vis Sci (2014) 55 (1): 600-11


Goebel HH, Müller HD:
Storage diseases: diagnostic position.
Ultrastruct Pathol (2013) 37 (1): 19-22


Joachim SC, Gramlich OW, Laspas P, Schmid H, Beck S, von Pein HD, Dick HB, Pfeiffer N, Grus FH:
Retinal ganglion cell loss is accompanied by antibody despositions and increased levels of microglia after immunization with retinal antigens.
PLoS One (2012) 7 (7): e40616


Wolf J, Obermaier-Kusser B, Jacobs M, Milles C, Mörl M, von Pein HD, Grau AJ, Bauer MF:
A new mitochondrial point mutation in the transfer RNA(Lys) gene associated with progressive external ophthalmoplegia with impaired respiratory regulation.
J Neurol Sci (2012) 316 (1-2): 108-11


Laspas P, Gramlich OW, Müller HD, Cuny CS, Gottschling PF, Pfeiffer N, Dick HB, Joachim SC, Grus FH:
Autoreactive antibodies and loss of retinal ganglion cells in rats induced by immunization with ocular antigens.
Invest Ophthalmol Vis Sci (2011) 52 (12): 8835-48


Gockel HR, Gockel I, Drescher DG, Müller H, Schad A, Kittner JM, Rossmann H, Lang H:
Achalasia in a patient with HIV/HCV coinfection: detection of HCV in the esophageal tissue.
Chirurg (2011) 82 (11): 1021-6


Tschan CA, Keiner D, Müller HD, Schwabe K, Gaab MR, Krauss JK, Sommer C, Oertel J:
Waterjet dissection of peripheral nerves: an experimental study of the sciatic nerve of rats.
Neurosurgery (2010) 67 (2 Suppl Operative): 368-376


Müller HD, Berger C, Schwab S, Sommer C:
Pravastatin treatment causes a shift in the balance of hippocampal neurotransmitter binding densities towards inhibition.
Brain Res (2010) 1316: 17-26


Müller HD, Landeghem FK, Schmidt PF, Sommer C, Goebel HH:
Macrophagic myofasciitis plus (distinct types of muscular dystrophy).
Neuropediatrics (2009) 40 (4): 174-178


Müller HD, Neder A, Sommer C, Schäbitz WR:
Different postischemic protein expression of the GABAA receptor alpha2 subunit and the plasticity-associated protein MAP1B after treatment with BDNF versus G-CSF in the rat brain.
Restor Neurol Neurosci (2009) 27 (1): 27-39


Luessi F, Sollors J, Müller H, Stoeter P, Sommer C, Vogt T, Birklein F, Thömke F:
Infliximab in the treatment of rheumatoid meningoencephalitis.
J Neurol (2009) 256: 2094-2096


Luessi F, Sollors J, Torzewski M, Müller HD, Siegel E, Blum J, Sommer C, Vogt T, Thömke F:
Eosinophilic meningitis due to Angiostrongylus cantonensis in Germany.
J Travel Med (2009) 16 (4): 292-4


Goebel HH, Müller HD, Schröder R:
Congenital and other myopathies.
Pathologe (2009) 30 (5): 365-9


Geber C, Baumgärtner U, Schwab R, Müller H, Stoeter P, Dieterich M, Sommer C, Birklein F, Treede RD:
Revised definition of neuropathic pain and its grading system: an open case series illustrating its use in clinical practice.
Am J Med (2009) 122 (10 Suppl): S3-12


Clemen CS, Fischer D, Reimann J, Eichinger L, Müller CR, Müller HD, Goebel HH, Schröder R:
How much mutant protein is needed to cause a protein aggregate myopathy in vivo? Lessons from an exceptional desminopathy.
Hum Mutat (2009) 30 (3): E490-9


Bauer R, Hudson J, Müller HD, Sommer C, Dekomien G, Bourke J, Routledge D, Bushby K, Klepper J, Straub V:
Does delta-sarcoglycan-associated autosomal-dominant cardiomyopathy exist?
Eur J Hum Genet (2009) 17 (9): 1148-53


Schomacher M, Müller HD, Sommer C, Schwab S, Schäbitz WR:
Endocannabinoids mediate neuroprotection after transient focal cerebral ischemia.
Brain Res (2008) 1240: 213-20


Müller HD, Hanumanthiah KM, Diederich K, Schwab S, Schäbitz WR, Sommer C:
Brain-derived neurotrophic factor but not forced arm use improves long-term outcome after photothrombotic stroke and transiently upregulates binding densities of excitatory glutamate receptors in the rat brain.
Stroke (2008) 39 (3): 1012-21


Jacobi C, Müller HD, Korporal M, Back T, Wildemann B:
Mononeuropathy multiplex as a result of treatment with interferon-alpha and ribavirin in a patient with hepatitis C.
Eur J Neurol (2008) 15 (6): e55-6


Gockel I, Musholt TJ, Eckardt V, Mildenberger P, Müller H, Lang H:
Two-stage esophageal resection with ischemic preconditioning of the gastric tube in decompensated dolichomegaesophagus and end-stage achalasia.
Z Gastroenterol (2008) 46 (11): 1278-82


Neumaier B, Deidenhofer S, Fürst D, von Arnim CA, Thees S, Buck AK, Glatting G, Landwehrmeyer GB, Krause BJ, Müller HD, Sommer C, Reske SN, Mottaghy FM:
Radiosynthesis and evaluation of [(11)C]BTA-1 and [(11)C]3’-MeBTA-1 as potential radiotracers for in vivo imaging of beta-amyloid plaques
Nuklearmedizin (2007) 46 (6): 271-280


Sommer C, Schomacher M, Berger C, Kuhnert H, Müller HD, Schwab S, Schäbitz W-R:
Neuroprotective cannabinoid receptor antagonist SR141716A prevents downregulation of excitotoxic NMDA receptors in the ischemic penumbra
Acta Neuropathol (2006) 112: 277-28


Schomacher M, Müller HD, Sommer C
Short-term ischemia usually used for ischemic preconditioning down-regulates central cannabinoid receptors in the gerbil hippocampus
Acta Neuropathol (2006) 111: 8-14


Goebel HH, Müller HD
Protein aggregate myopathies
Semin Pediatr Neurol (2006) 13:96-103


Schäbitz WR, Schade H, Heiland S, Kollmar R, Bardutzky J, Henninger N, Müller H, Carl U, Toyokuni S, Sommer C, Schwab S:
Neuroprotection by hyperbaric oxygenation after experimental focal cerebral ischemia monitored by MRI
Stroke (2004) 35: 1175-9


Berger C, Schäbitz WR, Wolf M, Müller H, Sommer C, Schwab S:
Hypothermia and brain-derived neurotrophic factor reduce glutamate synergistically in acute stroke
Exp Neurol (2004) 185:305-12


Müller HD, Beckmann A, Schröder JM:
Inflammatory infiltrates in the spinal cord of patients with Guillain-Barre syndrome
Acta Neuropathol (2003) 106: 509-17


Müller HD, Vielhaber S, Brunn, Schröder JM:
Dominantly inherited myopathy with novel tubular aggregates containing 1-21 tubulofilamentous structures
Acta Neuropathol (2001) 102: 27-35


Müller HD, Mugler M, Ramaekers VT, Schröder JM:
Hereditary motor and sensory neuropathy with absence of large myelinated fibers due to absence of large neurons in dorsal root ganglia and anterior horns, clinically associated with deafness, mental retardation, and epilepsy (HMSN-ADM)
J Peripher Nerv Syst (2000) 5: 147-57