Professor for Pathobiochemical Adaptation
Project group leader
Phone +49 6131 39 24552
Fax 39 24743
The research group „Cellular Adaptation and Metabolism” investigates metabolic and biomolecular adaptation mechanisms in different paradigms of cellular and organismal stress. To this end, we employ state-of-the-art analytical, biochemical, genetic and bioinformatics tools studying in vitro models (cell culture) and in vivo models (Caenorhabditis elegans, rodents, and human specimens).
Various physiological and pathogenetic challenges have a strong influence on cellular function, including challenges like mitochondrial impairment, oxidative stress, nutrient shortage or oxygen deprivation. In general, these challenges induce diverse stress response pathways; however, only some of them are indeed compensatory and render the cells more resistant and enhance cell survival. Our aim is to identify those specific early adaptive pathways that are most important in counter-balancing stress and thereby, for example, help to maintain cellular bioenergetics and cellular functioning in degenerative diseases.
Weckmann K, Diefenthäler P, Baeken MW, Yusifli K, Turck CW, Asara JM, Behl C, Hajieva P. Metabolomics profiling reveals differential adaptation of major energy metabolism pathways associated with autophagy upon oxygen and glucose reduction. Sci Rep. 2018 Feb 5;8(1):2337.
Hajieva P, Baeken WM, Moosmann B. The Role of Plasma Membrane Calcium ATPases (PMCAs) in Neurodegenerative Disorders. Neurosci. Lett. 2018;663:29-38.
Granold M, Hajieva P, Tosa M, Irimie FD, Moosmann B. Modern diversification of the amino acid repertoire driven by oxygen. Proc Natl Acad Sci U S A. 2018;115(1):41-46.
Hajieva P. The Effect of Polyphenols on Protein Degradation Pathways: Implications for Neuroprotection. Molecules 2017; 22(1).
Granold M, Moosmann B, Staib-Lasarzik I, Arendt T, Del Rey A, Engelhard K, Behl C, Hajieva P. High membrane protein oxidation in the human cerebral cortex. Redox Biology 2015; 4: 200-207.
Hajieva P, Moosmann B. Brain protein oxidation: what does it reflect? Neural Regen Res 2015; 10(11):1729-1730.
Hajieva P, Bayatti N, Granold M, Behl C, Moosmann B. Membrane protein oxidation determines neuronal degeneration. J Neurochem 2015; 133: 352-367.
Renziehausen J, Hiebel C, Nagel H, Kundu A, Kins S, Kögel D, Behl C, Hajieva P. The cleavage product of amyloid precursor protein sAβPPα modulates BAG3-dependent aggresome formation and enhances cellular proteasomal activity. J Alzheimers Dis 2015; 44: 879-896.
Journal of Alzheimer’s Disease
Journal of Neurochemistry
European Journal of Biochemistry
Journal of Neuroscience
Free Radicals in Biology and Medicine
Neurobiology of Aging
Journal of Psychiatry
Journal of Visualized Experiments
German Network for Mitochondrial Disorders (mitoNET)
Gesellschaft für Biochemie und Molekularbiologie (GBM)