Visual Universitätsmedizin Mainz

Publications

Xia, N., Pautz, A., Wollscheid, U., Reifenberg, G., Forstermann, U. and Li, H. (2014) Artichoke, cynarin and cyanidin downregulate the expression of inducible nitric oxide synthase in human coronary smooth muscle cells. Molecules, 19, 3654-3668.

Henke, J., Erkel, G., Brochhausen, C., Kleinert, H., Schwarting, A., Menke, J. and Pautz, A. (2014) The fungal lactone oxacyclododecindione is a potential new therapeutic substance in the treatment of lupus-associated kidney disease. Kidney international, 86, 780-789.

Bollmann, F., Wu, Z., Oelze, M., Siuda, D., Xia, N., Henke, J., Daiber, A., Li, H., Stumpo, D.J., Blackshear, P.J. et al. (2014) Endothelial dysfunction in tristetraprolin-deficient mice is not caused by enhanced tumor necrosis factor-alpha expression. The Journal of biological chemistry, 289, 15653-15665.

Bollmann, F., Art, J., Henke, J., Schrick, K., Besche, V., Bros, M., Li, H., Siuda, D., Handler, N., Bauer, F. et al. (2014) Resveratrol post-transcriptionally regulates pro-inflammatory gene expression via regulation of KSRP RNA binding activity. Nucleic acids research, 42, 12555-12569.

Casper, I., Nowag, S., Koch, K., Hubrich, T., Bollmann, F., Henke, J., Schmitz, K., Kleinert, H. and Pautz, A. (2013) Post-transcriptional regulation of the human inducible nitric oxide synthase (iNOS) expression by the cytosolic poly(A)-binding protein (PABP). Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society, 33, 6-17.

Bollmann, F., Fechir, K., Nowag, S., Koch, K., Art, J., Kleinert, H. and Pautz, A. (2013) Human inducible nitric oxide synthase (iNOS) expression depends on chromosome region maintenance 1 (CRM1)- and eukaryotic translation initiation factor 4E (elF4E)-mediated nucleocytoplasmic mRNA transport. Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society, 30, 49-59.

Torzewski, M., Wenzel, P., Kleinert, H., Becker, C., El-Masri, J., Wiese, E., Brandt, M., Pautz, A., Twardowski, L., Schmitt, E. et al. (2012) Chronic inflammatory cardiomyopathy of interferon gamma-overexpressing transgenic mice is mediated by tumor necrosis factor-alpha. The American journal of pathology, 180, 73-81.

Siuda, D., Zechner, U., El Hajj, N., Prawitt, D., Langer, D., Xia, N., Horke, S., Pautz, A., Kleinert, H., Forstermann, U. et al. (2012) Transcriptional regulation of Nox4 by histone deacetylases in human endothelial cells. Basic research in cardiology, 107, 283.

Schmidt, N., Art, J., Forsch, I., Werner, A., Erkel, G., Jung, M., Horke, S., Kleinert, H. and Pautz, A. (2012) The anti-inflammatory fungal compound (S)-curvularin reduces proinflammatory gene expression in an in vivo model of rheumatoid arthritis. The Journal of pharmacology and experimental therapeutics, 343, 106-114.

Roggli, E., Gattesco, S., Pautz, A. and Regazzi, R. (2012) Involvement of the RNA-binding protein ARE/poly(U)-binding factor 1 (AUF1) in the cytotoxic effects of proinflammatory cytokines on pancreatic beta cells. Diabetologia, 55, 1699-1708.

Daiber, A., Oelze, M., Wenzel, P., Bollmann, F., Pautz, A. and Kleinert, H. (2012) Heme oxygenase-1 induction and organic nitrate therapy: beneficial effects on endothelial dysfunction, nitrate tolerance, and vascular oxidative stress. International journal of hypertension, 2012, 842632.

Bollmann, F., Casper, I., Henke, J. and Pautz, A. (2012) qRT-PCR: a method and its difficulties. Naunyn-Schmiedeberg's archives of pharmacology, 385, 949-951.

Witte, I., Altenhofer, S., Wilgenbus, P., Amort, J., Clement, A.M., Pautz, A., Li, H., Forstermann, U. and Horke, S. (2011) Beyond reduction of atherosclerosis: PON2 provides apoptosis resistance and stabilizes tumor cells. Cell death & disease, 2, e112.

Schuhmacher, S., Oelze, M., Bollmann, F., Kleinert, H., Otto, C., Heeren, T., Steven, S., Hausding, M., Knorr, M., Pautz, A. et al. (2011) Vascular dysfunction in experimental diabetes is improved by pentaerithrityl tetranitrate but not isosorbide-5-mononitrate therapy. Diabetes, 60, 2608-2616.

Oelze, M., Knorr, M., Schell, R., Kamuf, J., Pautz, A., Art, J., Wenzel, P., Munzel, T., Kleinert, H. and Daiber, A. (2011) Regulation of human mitochondrial aldehyde dehydrogenase (ALDH-2) activity by electrophiles in vitro. The Journal of biological chemistry, 286, 8893-8900.

Hausding, M., Tepe, M., Ubel, C., Lehr, H.A., Rohrig, B., Hohn, Y., Pautz, A., Eigenbrod, T., Anke, T., Kleinert, H. et al. (2011) Induction of tolerogenic lung CD4+ T cells by local treatment with a pSTAT-3 and pSTAT-5 inhibitor ameliorated experimental allergic asthma. International immunology, 23, 1-15.

Schmidt, N., Pautz, A., Art, J., Rauschkolb, P., Jung, M., Erkel, G., Goldring, M.B. and Kleinert, H. (2010) Transcriptional and post-transcriptional regulation of iNOS expression in human chondrocytes. Biochemical pharmacology, 79, 722-732.

Pautz, A., Art, J., Hahn, S., Nowag, S., Voss, C. and Kleinert, H. (2010) Regulation of the expression of inducible nitric oxide synthase. Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society, 23, 75-93.

Bros, M., Wiechmann, N., Besche, V., Art, J., Pautz, A., Grabbe, S., Kleinert, H. and Reske-Kunz, A.B. (2010) The RNA binding protein tristetraprolin influences the activation state of murine dendritic cells. Molecular immunology, 47, 1161-1170.

Altenhofer, S., Witte, I., Teiber, J.F., Wilgenbus, P., Pautz, A., Li, H., Daiber, A., Witan, H., Clement, A.M., Forstermann, U. et al. (2010) One enzyme, two functions: PON2 prevents mitochondrial superoxide formation and apoptosis independent from its lactonase activity. The Journal of biological chemistry, 285, 24398-24403.

Pautz, A., Rauschkolb, P., Schmidt, N., Art, J., Oelze, M., Wenzel, P., Forstermann, U., Daiber, A. and Kleinert, H. (2009) Effects of nitroglycerin or pentaerithrityl tetranitrate treatment on the gene expression in rat hearts: evidence for cardiotoxic and cardioprotective effects. Physiological genomics, 38, 176-185.

Pautz, A., Linker, K., Altenhofer, S., Heil, S., Schmidt, N., Art, J., Knauer, S., Stauber, R., Sadri, N., Pont, A. et al. (2009) Similar regulation of human inducible nitric-oxide synthase expression by different isoforms of the RNA-binding protein AUF1. The Journal of biological chemistry, 284, 2755-2766.

Wenzel, P., Muller, J., Zurmeyer, S., Schuhmacher, S., Schulz, E., Oelze, M., Pautz, A., Kawamoto, T., Wojnowski, L., Kleinert, H. et al. (2008) ALDH-2 deficiency increases cardiovascular oxidative stress--evidence for indirect antioxidative properties. Biochemical and biophysical research communications, 367, 137-143.

Reifenberg, K., Lehr, H.A., Torzewski, M., Steige, G., Wiese, E., Kupper, I., Becker, C., Ott, S., Nusser, P., Yamamura, K. et al. (2007) Interferon-gamma induces chronic active myocarditis and cardiomyopathy in transgenic mice. The American journal of pathology, 171, 463-472.

Korhonen, R., Linker, K., Pautz, A., Forstermann, U., Moilanen, E. and Kleinert, H. (2007) Post-transcriptional regulation of human inducible nitric-oxide synthase expression by the Jun N-terminal kinase. Molecular pharmacology, 71, 1427-1434.

Dragoni, S., Gori, T., Lisi, M., Di Stolfo, G., Pautz, A., Kleinert, H. and Parker, J.D. (2007) Pentaerythrityl tetranitrate and nitroglycerin, but not isosorbide mononitrate, prevent endothelial dysfunction induced by ischemia and reperfusion. Arteriosclerosis, thrombosis, and vascular biology, 27, 1955-1959.

Pautz, A., Linker, K., Hubrich, T., Korhonen, R., Altenhofer, S. and Kleinert, H. (2006) The polypyrimidine tract-binding protein (PTB) is involved in the post-transcriptional regulation of human inducible nitric oxide synthase expression. The Journal of biological chemistry, 281, 32294-32302.

Mollnau, H., Wenzel, P., Oelze, M., Treiber, N., Pautz, A., Schulz, E., Schuhmacher, S., Reifenberg, K., Stalleicken, D., Scharffetter-Kochanek, K. et al. (2006) Mitochondrial oxidative stress and nitrate tolerance--comparison of nitroglycerin and pentaerithrityl tetranitrate in Mn-SOD+/- mice. BMC cardiovascular disorders, 6, 44.

Linker, K., Pautz, A., Fechir, M., Hubrich, T., Greeve, J. and Kleinert, H. (2005) Involvement of KSRP in the post-transcriptional regulation of human iNOS expression-complex interplay of KSRP with TTP and HuR. Nucleic acids research, 33, 4813-4827.

Fechir, M., Linker, K., Pautz, A., Hubrich, T. and Kleinert, H. (2005) The RNA binding protein TIAR is involved in the regulation of human iNOS expression. Cellular and molecular biology, 51, 299-305.

Fechir, M., Linker, K., Pautz, A., Hubrich, T., Forstermann, U., Rodriguez-Pascual, F. and Kleinert, H. (2005) Tristetraprolin regulates the expression of the human inducible nitric-oxide synthase gene. Molecular pharmacology, 67, 2148-2161.

Kleinert, H., Pautz, A., Linker, K. and Schwarz, P.M. (2004) Regulation of the expression of inducible nitric oxide synthase. European journal of pharmacology, 500, 255-266.

Bros, M., Ross, X.L., Pautz, A., Reske-Kunz, A.B. and Ross, R. (2003) The human fascin gene promoter is highly active in mature dendritic cells due to a stage-specific enhancer. Journal of immunology, 171, 1825-1834.

Pautz, A., Franzen, R., Dorsch, S., Boddinghaus, B., Briner, V.A., Pfeilschifter, J. and Huwiler, A. (2002) Cross-talk between nitric oxide and superoxide determines ceramide formation and apoptosis in glomerular cells. Kidney international, 61, 790-796.

Huwiler, A., Boddinghaus, B., Pautz, A., Dorsch, S., Franzen, R., Briner, V.A., Brade, V. and Pfeilschifter, J. (2001) Superoxide potently induces ceramide formation in glomerular endothelial cells. Biochemical and biophysical research communications, 284, 404-410.

Franzen, R., Pautz, A., Brautigam, L., Geisslinger, G., Pfeilschifter, J. and Huwiler, A. (2001) Interleukin-1beta induces chronic activation and de novo synthesis of neutral ceramidase in renal mesangial cells. The Journal of biological chemistry, 276, 35382-35389.