Visual Universitätsmedizin Mainz

Selected publications

Bros, M., Wiechmann, N., Besche, V., Art, J., Pautz, A., Grabbe, S., Kleinert, H. and Reske-Kunz, A.B. (2010) The RNA binding protein tristetraprolin influences the activation state of murine dendritic cells. Molecular Immunology, 47, 1161-1170.

Daiber, A., Oelze, M., Kamuf, J., Schell, R., Pautz, A., Wenzel, P. and Kleinert, H. (2010) Updates on antioxidant properties of PETN and nitrate metabolism in isolated ALDH-2. Herz, 35, 24-35.

Pautz, A., Rauschkolb, P., Art, J., Voss, C., Karbach, S., Wenzel, P., Oelze, M., Forstermann, U., Daiber, A. and Kleinert, H. (2010) Regulation of gene expression by organic nitrates. Herz, 35, 56-66.

Pautz, A., Art, J., Hahn, S., Nowag, S., Voss, C. and Kleinert, H. (2010) Regulation of the expression of inducible nitric oxide synthase. Nitric Oxide, 23, 75-93.

Schmidt, N., Pautz, A., Art, J., Rauschkolb, P., Jung, M., Erkel, G., Goldring, M.B. and Kleinert, H. (2010) Transcriptional and post-transcriptional regulation of iNOS expression in human chondrocytes. Biochemical Pharmacology, 79, 722-732.

Daiber, A., Kamuf, J., Pautz, A., Oelze, M., Art, J., Heeren, T. and Kleinert, H. (2009) Effects of Pentaerithrityl Tetranitrate and Glyceryl Trinitrate on Activity of Purified Human Mitochondrial Aldehyde Dehydrogenase. Free Radical Biology and Medicine, 47, S73-S73.

Kleinert, H., Daiber, A., Pautz, A., Schmidt, N., Art, J., Wenzel, P., Oelze, M. and Forstermann, U. (2009) First results on the effects of a treatment with nitroglycerin (NTG) and pentaerithrityl tetranitrate (PETN) on the whole genome expression profile in cardiomyocytes - Is there evidence of "cardiotoxic" and "cardioprotective" mechanisms? Herz, 34, 19-26.

Pautz, A., Rauschkolb, P., Schmidt, N., Art, J., Oelze, M., Wenzel, P., Forstermann, U., Daiber, A. and Kleinert, H. (2009) Effects of nitroglycerin or pentaerithrityl tetranitrate treatment on the gene expression in rat hearts: evidence for cardiotoxic and cardioprotective effects. Physiological Genomics, 38, 176-185.

Pautz, A., Linker, K., Altenhofer, S., Heil, S., Schmidt, N., Art, J., Knauer, S., Stauber, R., Sadri, N., Pont, A. et al. (2009) Similar Regulation of Human Inducible Nitric-oxide Synthase Expression by Different Isoforms of the RNA-binding Protein AUF1. Journal of Biological Chemistry, 284, 2755-2766.

Stalleicken, D. and Kleinert, H. (2009) Regulation der Genexpression durch organische Nitrate - Evidenz für kardioprotektive Wirkungen von PETN? Perfusion, 22, 126-130.

Elzner, S., Schmidt, D., Schollmeyer, D., Erkel, G., Anke, T., Kleinert, H., Forstermann, U. and Kunz, H. (2008) Inhibitors of inducible NO synthase expression: Total synthesis of (S)-curvularin and its ring homologues. Chemmedchem, 3, 924-939.

Engels, K., Knauer, S.K., Loibl, S., Fetz, V., Harter, P., Schweitzer, A., Fisseler-Eckhoff, A., Kommoss, F., Hanker, L., Nekljudova, V. et al. (2008) NO signaling confers cytoprotectivity through the survivin network in ovarian carcinomas. Cancer Res, 68, 5159-5166.

Rodriguez-Pascual, F., Redondo-Horcajo, M., Magan-Marchal, N., Lagares, D., Martinez-Ruiz, A., Kleinert, H. and Lamas, S. (2008) Glyceraldehyde-3-Phosphate Dehydrogenase Regulates Endothelin-1 Expression by a Novel, Redox-Sensitive Mechanism Involving mRNA Stability. Molecular and Cellular Biology, 28, 7139-7155.

Wenzel, P., Muller, J., Zurmeyer, S., Schuhmacher, S., Schulz, E., Oelze, M., Pautz, A., Kawamoto, T., Wojnowski, L., Kleinert, H. et al. (2008) ALDH-2 deficiency increases cardiovascular oxidative stress - Evidence for indirect antioxidative properties. Biochemical and Biophysical Research Communications, 367, 137-143.

Wohlfart, P., Xu, H., Endlich, A., Habermeier, A., Closs, E.I., Hubschle, T., Mang, C., Strobel, H., Suzuki, T., Kleinert, H. et al. (2008) Antiatherosclerotic effects of small-molecular-weight compounds enhancing endothelial nitric-oxide synthase (eNOS) expression and preventing eNOS uncoupling. Journal of Pharmacology and Experimental Therapeutics, 325, 370-379.

Dragoni, S., Gori, T., Lisi, M., Di Stolfo, G., Pautz, A., Kleinert, H. and Parker, J.D. (2007) Pentaerythrityl tetranitrate and nitroglycerin, but not isosorbide mononitrate, prevent endothelial dysfunction induced by ischemia and reperfusion. Arteriosclerosis Thrombosis and Vascular Biology, 27, 1955-1959.

Korhonen, R., Linker, K., Pautz, A., Forstermann, U., Moilanen, E. and Kleinert, H. (2007) Post-transcriptional regulation of human inducible nitric-oxide synthase expression by the jun N-terminal kinase. Molecular Pharmacology, 71, 1427-1434.

Reifenberg, K., Lehr, H.A., Torzewski, M., Steige, G., Wiese, E., Kupper, I., Becker, C., Ott, S., Nusser, P., Yamamura, K.I. et al. (2007) Interferon-gamma induces chronic active myocarditis and cardiomyopathy in transgenic mice. American Journal of Pathology, 171, 463-472.

Ziesche, E., Bachmann, M., Kleinert, H., Pfeilschifter, J. and Muhl, H. (2007) The interleukin-22/STAT3 pathway potentiates expression of inducible nitric-oxide synthase in human colon carcinoma cells. Journal of Biological Chemistry, 282, 16006-16015.

Pautz, A., Linker, K., Hubrich, T., Korhonen, R., Altenhofer, S. and Kleinert, H. (2006) The polypyrimidine tract-binding protein (PTB) is involved in the post-transcriptional regulation of human inducible nitric oxide synthase expression. Journal of Biological Chemistry, 281, 32294-32302.

Fechir, M., Linker, K., Pautz, A., Hubrich, T. and Kleinert, H. (2005) The RNA binding protein TIAR is involved in the regulation of human iNOS expression. Cellular and Molecular Biology, 51, 299-305.

Fechir, M., Linker, K., Pautz, A., Hubrich, T., Forstermann, U., Rodriguez-Pascual, F. and Kleinert, H. (2005) Tristetraprolin regulates the expression of the human inducible nitric-oxide synthase gene. Molecular Pharmacology, 67, 2148-2161.

Linker, K., Pautz, A., Fechir, M., Hubrich, T., Greeve, J. and Kleinert, H. (2005) Involvement of KSRP in the post-transcriptional regulation of human iNOS expression-complex interplay of KSRP with TTP and HuR. Nucleic Acids Research, 33, 4813-4827.

Kleinert, H., Pautz, A., Linker, K. and Schwarz, P.M. (2004) Regulation of the expression of inducible nitric oxide synthase. European Journal of Pharmacology, 500, 255-266.

Tedeschi, E., Menegazzi, M., Yao, Y., Suzuki, H., Forstermann, U. and Kleinert, H. (2004) Green tea inhibits human inducible nitric-oxide synthase expression by down-regulating signal transducer and activator of transcription-1 alpha activation. Molecular Pharmacology, 65, 111-120.

Akool, E.S., Kleinert, H., Hamada, F.M.A., Abdelwahab, M.H., Forstermann, U., Pfeilschifter, J. and Eberhardt, W. (2003) Nitric oxide increases the decay of matrix metalloproteinase 9 mRNA by inhibiting the expression of mRNA-stabilizing factor HuR. Molecular and Cellular Biology, 23, 4901-4916.

Kleinert, H., Schwarz, P.M. and Forstermann, U. (2003) Regulation of the expression of inducible nitric oxide synthase. Biological Chemistry, 384, 1343-1364.

Nubel, T., Dippold, W., Kleinert, H., Kaina, B. and Fritz, G. (2003) Lovastatin inhibits Rho-regulated expression of E-selectin by TNF-alpha and attenuates tumor cell adhesion. Faseb Journal, 17, 140-+.

Tedeschi, E., Menegazzi, M., Margotto, D., Suzuki, H., Forstermann, U. and Kleinert, H. (2003) Anti-inflammatory actions of St. John's wort: Inhibition of human inducible nitric-oxide synthase expression by down-regulating signal transducer and activator of transcription-1 alpha (STAT-1 alpha) activation. Journal of Pharmacology and Experimental Therapeutics, 307, 254-261.

Witteck, A., Yao, Y., Fechir, M., Forstermann, U. and Kleinert, H. (2003) Rho protein-mediated changes in the structure of the actin cytoskeleton regulate human inducible NO synthase gene expression. Experimental Cell Research, 287, 106-115.

Yao, Y., Hausding, M., Erkel, G., Anke, T., Forstermann, U. and Kleinert, H. (2003) Sporogen, S14-95, and S-curvularin, three inhibitors of human inducible nitric-oxide synthase expression isolated from fungi. Molecular Pharmacology, 63, 383-391.

Suschek, C.V., Bonmann, E., Kapsokefalou, A., Hemmrich, K., Kleinert, H., Forstermann, U., Kroncke, K.D., Mahotka, C. and Kolb-Bachofen, V. (2002) Revisiting an old antimicrobial drug: Amphotericin B induces interleukin-1-converting enzyme as the main factor for inducible nitric-oxide synthase expression in activated endothelia. Molecular Pharmacology, 62, 936-946.

Suschek, C.V., Bruch-Gerharz, D., Kleinert, H., Forstermann, U. and Kolb-Bachofen, V. (2001) Ultraviolet A(1) radiation induces nitric oxide synthase-2 expression in human skin endothelial cells in the absence of proinflammatory cytokines. Journal of Investigative Dermatology, 117, 1200-1205.

Hausding, M., Witteck, A., Rodriguez-Pascual, F., von Eichel-Streiber, C., Forstermann, U. and Kleinert, H. (2000) Inhibition of small G proteins of the Rho family by statins or Clostridium difficile toxin B enhances cytokine-mediated induction of NO synthase II. British Journal of Pharmacology, 131, 553-561.

Rodriguez-Pascual, F., Hausding, M., Ihrig-Biedert, I., Furneaux, H., Levy, A.P., Forstermann, U. and Kleinert, H. (2000) Complex contribution of the 3 '-untranslated region to the expressional regulation of the human inducible nitric-oxide synthase gene - Involvement of the RNA-binding protein HuR. Journal of Biological Chemistry, 275, 26040-26049.

Sirsjo, A., Gidlof, A.C., Olsson, A., Torma, H., Ares, M., Kleinert, H., Forstermann, U. and Hansson, G.K. (2000) Retinoic acid inhibits nitric oxide synthase-2 expression through the retinoic acid receptor-alpha. Biochemical and Biophysical Research Communications, 270, 846-851.

Suschek, C.V., Bonmann, E., Kleinert, H., Wenzel, M., Mahotka, C., Kolb, H., Forstermann, U., Gerharz, C.D. and Kolb-Bachofen, V. (2000) Amphotericin B severely affects expression and activity of the endothelial constitutive nitric oxide synthase involving altered mRNA stability. British Journal of Pharmacology, 131, 473-481.