Visual Universitätsmedizin Mainz

Publications 2017

Müller WEG, Wang XH, Schröder HC (2017) New target sites for treatment of osteoporosis. In: W.E.G. Müller, XH Wang, HC Schröder (eds.) Blue Biotechnology, Progress in Molecular and Subcellular Biology 55, DOI 10.1007/978-3-319-51284-6_6

Schröder HC, Tolba E, Diehl-Seifert B, Wang XH, Müller WEG (2017) Electrospinning of bioactive wound healing nets. In: W.E.G. Müller, XH Wang, HC Schröder (eds.) Blue Biotechnology, Progress in Molecular and Subcellular Biology 55, DOI 10.1007/978-3-319-51284-6_8

Wang XH, Neufurth M, Tolba E, Wang SF, Schröder HC, Müller WEG (2017) Biocalcite and carbonic acid activators. In: W.E.G. Müller, XH Wang, HC Schröder (eds.) Blue Biotechnology, Progress in Molecular and Subcellular Biology 55, DOI 10.1007/978-3-319-51284-6_7

Müller WEG, Tolba E, Neufurth M, Wang SF, Ackermann M, Feng QL, Schröder HC, Wang XH (2017) Fabrication of amorphous strontium polyphosphate microparticles that induce mineralization of bone cells in vitro and in vivo. Acta Biomater, in press.

Publications 2016

Wang XH, Schröder HC, Müller WEG (2016) Polyphosphate as a metabolic fuel in Metazoa: A foundational breakthrough invention for biomedical applications. Biotechnol J 11: 11-30

Müller WEG, Schröder HC, Tolba E, Neufurth M, Diehl-Seifert B, Wang XH (2016) Mineralization of bone-related SaOS-2 cells under physiological hypoxic conditions. FEBS J 283: 74-87

Tolba E, Müller WEG, El-Hady BMA, Neufurth M, Wurm F, Wang S, Schröder HC, Wang XH (2016) High biocompatibility and improved osteogenic potential of amorphous calcium carbonate/vaterite. J Mat Chem B 4: 376-386

Müller WEG, Tolba E, Schröder HC, Muñoz-Espí R, Diehl-Seifert B, Wang XH (2016) Amorphous polyphosphate-hydroxyapatite: a morphogenetically active substrate for bone-related SaOS-2 cells in vitro. Acta Biomat 31: 358-367

Wang XH, Huang J, Wang K, Neufurth M, Schröder HC, Wang SF, Müller WEG (2016) The morphogenetically active polymer, inorganic polyphosphate complexed with GdCl3, as an inducer of hydroxyapatite formation in vitro. Biochem Pharmacol 102: 97-106

Daletos G, Liu Y, Kurtán T, Wang C, Lin WH, Orfali R, Müller WEG, Proksch P (2016) Cladosporinone, a new viriditoxin derivative from the hypersaline lake derived fungus Cladosporium cladosporioides. J Antibiotics 69: 702-706

Wang XH, Wang SF, He F, Tolba E, Schröder HC, Diehl-Seifert B, Müller WEG (2016) Polyphosphate a bioactive and biodegradable implant material: induction of bone regeneration in rats. Adv Engin Mater 18: 1406-1417

Müller WEG, Neufurth M, Tolba E, Wang SF, Geurtsen W, Feng QL, Schröder HC, Wang XH (2016) A biomimetic approach to ameliorate dental hypersensitivity by amorphous polyphosphate microparticles. Dent Mater 32: 775-783

Müller WEG, Neufurth M, Wang SF, Tolba E, Schröder HC, Wang XH (2016) Morphogenetically active scaffold for osteochondral repair (polyphosphate/alginate/N,O- carboxymethyl chitosan. Eur Cell Mater 31: 174-190

Schröder HC, Grebenjuk VA, Wang XH, Müller WEG (2016) Hierarchical architecture of sponge spicules: Biocatalytic and structure-directing activity of silicatein proteins as model for bioinspired applications. Bioinspir Biomim 11: 041002

Schröder HC, Wang XH, Müller WEG (2016) Potenzial für Medizin und Nanotechnologie: Multitalentierte Biominerale. Biol Unserer Zeit 46: 158-168

Wang XH, Ackermann M, Wang SF, Tolba E, Neufurth M, Feng QL, Schröder HC, Müller WEG (2016) Amorphous polyphosphate/amorphous calcium carbonate implant material with enhanced bone healing efficacy in a critical-size defect in rats. Biomed Mater 11: 035005

Müller WEG, Ackermann M, Tolba E, Neufurth M, Wang SF, Schröder HC, Wang XH (2016) A bio-imitating approach to fabricate an artificial matrix for cartilage tissue engineering using magnesium-polyphosphate and hyaluronic acid. RSC Adv 6: 88559-88570

Heller M, Bauer HK, Goetze E, Gielisch M, Ozbolath I, Moncal KK, Rizk E, Seitz H, Gelinsky M, Schröder HC, Wang XH, Müller WEG, Al-Nawas B (2016) Materials and scaffolds in medical 3D printing and bioprinting in the context of bone regeneration. Int J Comput Dent 19: 301-321

Heller M, Bauer HK, Goetze E, Gielisch M, Roth KE, Drees P, Maier GS, Dorweiler B, Ghazy A, Neufurth M, Müller WEG, Schröder HC, Wang XH, Vahl CF, Al-Nawas B (2016) Applications of patient-specific 3D printing in medicine. Int J Comput Dent 19: 323-339

Wang XH, Ackermann M, Tolba E, Neufurth M, Wurm F, Feng QL, Wang SF, Schröder HC, Müller WEG (2016) Artificial cartilage bio-matrix formed of hyaluronic acid and Mg2+-polyphosphate. Eur Cell Mater 32: 271-283

Müller WEG and Wang XH (2016) Evolution of the mineralized animal skeletons: Formation of bone hydroxyapatite via amorphous Ca-carbonate and Ca-phosphate. Eur Cells Mater 32 Suppl. 3: 1473

Müller WEG (2016) Schwämme und unsere Genetik. In: R. Schrott (Hrsg.) Erste Erde EPOS. Audiobook with MP3 Audio. Der Hörverlag, München. Artikel-Nr.: 9783446252820

Milano S, Schöne BR, Wang S, Müller WEG (2016) Impact of high pCO2 on shell structure of the bivalve Cerastoderma edule. Mar Environ Res 119: 144-155

Elnaggar MS, Ebada SS, Ashour ML, Ebrahim W, Müller WEG, Mándi A, Kurtán T, Singab A, Lin W, Liu Z, Proksch P (2016) Xanthones and sesquiterpene derivatives from a marine-derived fungus Scopulariopsis sp. Tetrahedron 72: 2411-2419

He W, Kienzle A, Liu XJ, Müller WEG, Elkhooly TA and Feng QL (2016) In vitro effect of 30 nm silver nanoparticles on adipogenic differentiation of human mesenchymal stem cells. J Biomedical Nanotechnol 12: 525-535

He W, Liu XJ, Kienzle A, Müller WEG and Feng QL (2016) In vitro Uptake of silver nanoparticles and their toxicity in human mesenchymal stem cells derived from bone marrow. J Nanosc Nanotechnol 16: 219-228

Gardères J, Domart-Coulon I, Marie A, Hamer B, Batel R, Müller WEG and Bourguet-Kondracki ML (2016) Purification and partial characterization of a lectin protein complex, the clathrilectin, from the calcareous sponge Clathrina clathrus. Comp Biochem Physiol Part B 200: 17-27

Gardères J, Elkhooly TA, Link T, Markl JS, Müller WEG, Renkel J, Korzhev M and Wiens M (2016) Self-assembly and photocatalytic activity of branched silicatein/silintaphin filaments decorated with silicatein-synthesized TiO2 nanoparticles. Bioprocess Biosyst Eng 39: 1477-1486

Wang XH, Müller WEG (2016) Three-dimensional morphology and gene expression in animals. In: Encyclopedia of Molecular Cell Biology and Molecular Medicine. (Meyers RA, ed). WILEY-VCH Press, Weinheim, Vol 2/no 1:1-41; DOI: 10.1002/3527600906.mcb.200500041.pub2

Publications 2015

Al Tarabeen M, Daletos G, Ebrahim W, Müller WEG, Hartmann R, Lin W and Proksch P (2015) Ircinal E, a new manzamine derivative from the Indonesian marine sponge Acanthostrongylophora ingens. Natural Prod Commun 10: 1952-1953

He W, Kienzle A, Liu XJ, Müller WEG and Feng QL (2015) In vitro 30 nm silver nanoparticles promote chondrogenesis of human mesenchymal stem cells. RSC Adv 5: 49809–49818.

Uzor PF, Ebrahim W, Osadebe PO, Nwodo JN, Okoye FB, Müller WEG, Lin W, Liu Z and Proksch P (2015) Metabolites from Combretum dolichopetalum and its associated endophytic fungus Nigrospora oryzae - Evidence for a metabolic partnership. Fitoterapia 105: 147-150.

Wang XH, Schröder HC, Müller WEG (2015) Properties and applications of biosilica enzymatically synthesized by aquatic/marine sponges. In: Springer Handbook of Marine Biotechnology; Editor - Prof. Se-Kwon Kim. Heidelberg: Springer pp. 1265-1277

Li Qiang, Wang XH, Korzhev M, Schröder HC, Link T, Tahir MN, Diehl-Seifert B and Müller WEG (2015) Potential biological role of laccase from the sponge Suberites domuncula as an antibacterial defense component. Biochim Biophys – Gen Subj 1850: 118-128

Han G, Müller WEG, Wang XH, Lilja L, Shen Z (2015) Porous titania surfaces on titanium with hierarchical macro- and mesoporosities for enhancing cell adhesion, proliferation and mineralization. Mater Sci Eng C Mater Biol Appl 47:376-383

Chen AL, Müller WEG, Hou XG, Xiao S (2015) New articulated protospongiid sponges from the early Cambrian Chengjiang biota. Palaeoworld 24:46–54

Müller WEG, Schröder HC, Feng QL, Schloßmacher U, Link T and Wang XH (2015) Development of a morphogenetically active scaffold for three-dimensional growth of bone cells: biosilica/alginate hydrogel for SaOS-2 Cell cultivation. J Tissue Engin Regen Med 9:E39-50.

Wang XH and Müller WEG (2015) Involvement of aquaporin channels in water extrusion from biosilica during maturation of sponge siliceous spicules. Biol. Bull. 229: 24–37.

Müller WEG, Tolba E, Schröder HC, Neufurth M, Wang S, Link T, Al-Nawas B and Wang XH (2015) A new printable and durable N,O-carboxymethyl chitosan-Ca2+-polyphosphate complex with morphogenetic activity. J. Mat. Chem B 3:1722-1730

Müller WEG, Tolba E, Schröder HC, Wang S, Glaßer G, Muñoz-Espí R, Link T, Wang XH (2015) A new polyphosphate calcium material with morphogenetic activity. Materials Letters 148:163-166

Hammerschmidt L, Aly AH, Abdel-Aziz M, Müller WEG, Lin W, Daletos G and Proksch P (2015) Cytotoxic acyl amides from the soil fungus Gymnascella dankaliensis. Bioorg Med Chem 23:712-719.

Müller WEG, Tolba E, Schröder HC, Diehl-Seifert B and Wang XH (2015) Retinol encapsulated into amorphous Ca2+ polyphosphate nanospheres acts synergistically in MC3T3-E1 cells. Eur J Pharm Biopharm 93: 214-223

Wang XH, Schröder HC, Müller WEG (2015) Properties and applications of biosilica enzymatically synthesized by aquatic/marine sponges. In: Kim SK (ed.) Functional Marine Biomaterials. Woodhead Publishing Series in Biomaterials. Elsevier: Amsterdam Pp. 33-50.

Wang XH and Müller W.E.G. (2015) Molecular morphogenesis: gene expression patterns in animals. In: Meyers RA (Ed) Encyclopedia of Molecular Cell Biology and Molecular Medicine: Developmental Biology. Wiley-VCH Verlag: Weinheim; in press.

Müller WEG, Tolba E, Schröder HC and Wang XH (2015) Polyphosphate: a morphogenetically active implant material serving as metabolic fuel for bone regeneration. Macromolec Biosci 15:1182-1197.

Hammerschmidt L, Ola A, Müller WEG, Lin WH, Mándi A, Kurtán T, Proksch P and Aly AH (2015) Two new metabolites from the endophytic fungus Xylaria sp. Isolated from the medicinal plant Curcuma xanthorrhiza. Tetrahedron Letters 56:1193–1197.

Müller WEG, Neufurth M, Huang J, Wang K, Feng Q, Schröder HC, Diehl-Seifert B, Muñoz-Espí R, Wang XH (2015) Non-enzymatic transformation of amorphous CaCO3 into calcium phosphate mineral after exposure to sodium phosphate in vitro: Implications for in vivo hydroxyapatite bone formation. ChemBioChem 16:1323-1332.

Müller WEG, Tolba E, Feng Q, Schröder HC, Markl JS, Kokkinopoulou M and Wang XH (2015) Amorphous Ca2+ polyphosphate nanoparticles regulate the ATP level in bone-like SaOS-2 cells. J Cell Sci 128: 2202-2207.

Liu Y, Marmann A, Abdel-Aziz MS, Wang CY, Müller WEG, Lin WH, Mándi A, Kurtán T, Daletos G and Proksch P (2015) Tetrahydroanthraquinone derivatives from the endophytic fungus Stemphylium globuliferum. Eur J Org Chem 2015: 2646-2653

Neufurth M, Wang XH, Tolba E, Dorweiler B, Schröder HC, Link T, Diehl-Seifert B, Müller WEG (2015) Modular small diameter vascular grafts with bioactive functionalities. PLoS ONE; DOI:10.1371/journal.pone.0133632

Uzor PF, Ebrahim W, Osadebe PO, Nwodo JN, Okoye FB, Müller WEG, Lin W, Liu Z, Proksch P (2015) Metabolites from Combretum dolichopetalum and its associated endophytic fungus Nigrospora oryzae - Evidence for a metabolic partnership. Fitoterapia 105:147-150.

Müller WEG, Tolba E, Dorweiler B, Schröder HC, Diehl-Seifert B, Wang XH (2015) Electrospun bioactive mats enriched with Ca-polyphosphate/retinol nanospheres as potential wound dressing. Biochem Biophys Rep 3:150-160

Gardères J, Bourguet-Kondracki ML, Hamer B, Batel R, Schröder HC., Müller WEG (2015) Porifera lectins: Diversity, physiological roles and biotechnological potential. Mar. Drugs, 13, 5059-5101.
Müller WEG, Tolba E, Schröder HC, Wang S, Glasser G, Diehl-Seifert B, Wang XH (2015) Biologizing titanium alloy implant material with morphogenetically active polyphosphate. RSC Advances 5: 75465–75473

Uzor PF, Ebrahim W, Osadebe PO, Nwodo JN, Okoye FB, Müller WEG, Lin W, Liu Z, Proksch P (2015) Metabolites from Combretum dolichopetalum and its associated endophytic fungus Nigrospora oryzae - Evidence for a metabolic partnership. Fitoterapia 105:147-150.

Li Q, Hu Q, Zhang C, Müller WEG., Schröder HC., Li Z, Zhang Y, Liu C, Jin Z (2015) The effect of toxicity of heavy metals contained in tailing sands on the organic carbon metabolic activity of soil microorganisms. from different land use types in the karst region. Environ Earth Sci 74:6747–6756

AlTarabeen M, Daletos G, Ebrahim W, Müller WEG, Hartmann R, Lin W and Proksch P (2015) Ircinal E, a new manzamine derivative from the Indonesian marine sponge Acanthostrongylophora ingens. Natural Prod Commun 10: 1952-1953

Publications 2014

Daletos G, de Voogd NJ, Müller WEG, Wray V, Lin WH, Feger D, Kubbutat M, Aly AH, Proksch P (2014) Cytotoxic and protein kinase inhibiting Nakijiquinones and Nakijiquinols from the sponge Dactylospongia metachromia. J Nat Prod 77: 218–226.

Draenert FG, Hützen D, Neff A, Müller WEG (2014) Vertical bone augmentation procedures: Basics and techniques in dental implantology. J Biomed Mater Res Part A 102A:1605-1613.

Fang Z, Wang Y, Feng Q, Kienzle A, Müller WEG (2014) Hierarchical structure and cytocompatibility of fish scales from Carassius auratus. Mater Sci Engineer C 43: 145–152.

Finkenwirth C, Roßbach B, Schröder HC, Emser A, Muttray A (2014): In-vivo ozone exposure does not lead to an increase of single-strand-breaks in human peripheral lymphocytes. Hum Exp Toxicol 33: 517-521.

Gardères J, Henry J, Bernay B, Ritter A, Zatylny-Gaudin C, Wiens M, Müller WEG, LePennec G (2014) Cellular effects of bacterial N-3-oxo-dodecanoyl-L-homoserine lactone on the sponge Suberites domuncula (Olivi, 1792): insights into an intimate inter-kingdom dialogue. PLoS ONE 9: e97662. doi:10.1371/journal.pone.0097662

Gardères J, Wang XH, Müller WEG (2014) Molecular evolution of defense pathways in sponges: Self-self-recognition and fight against the non-self. In: Roitt I (Main Editor), Delves P (Editor-in-Chief) and Ratcliffe M, and Rolink A, Colona M, Guidos C, Martin A, Elliott T, Miyasaka M, Mosmann T, Clark E, Mantovani A, DeFranco T, Hein W, Kaye P, Biron C, Cooke A, Finn O, Cavazzana M. Encyclopedia of Immunobiology. Amsterdam: Elsevier.

Liu YS, Huang QL, Kienzle A, Müller WEG, Feng QL (2014) In vitro degradation of porous PLLA/pearl powder composite scaffolds. Mater Sci Engineer C 38: 227-234.

Müller WEG, Albert O, Schröder HC, Wang XH (2014) Bio-inorganic nanomaterials for biomedical applications (Bio-silica and Polyphosphate). In: Bhushan B, Luo D, Schricker S, Sigmund W, Zauscher S (eds) Handbook of Nanomaterials Properties. Berlin Heidelberg: Springer-Press; pp 389–408.

Müller WEG, Li Q, Schröder HC, Hönig N, Yuan DX, Grebenjuk VA, Mussino F, Giovine M, Wang XH (2014) Carbonic anhydrase: A key regulatory and detoxifying enzyme for Karst plants. Planta 239:213–229.

Müller WEG, Link T, Schröder HC, Korzhev M, Neufurth M, Brandt D, Wang XH (2014) Dissection of the structure-forming from the structure-guiding activity of silicatein: a biomimetic molecular approach to print optical fibers. J Mater Chem B 2:5368-5377.

Müller WEG, Neufurth M, Schlossmacher U, Schröder HC, Pisignano D, Wang XH (2014) The sponge silicatein-interacting protein silintaphin-2 blocks calcite formation of calcareous sponge spicules at the vaterite stage. RSC Adv 4: 2577–2585.

Müller WEG, Schlossmacher U, Schröder HC, Lieberwirth I, Glasser G, Korzhev M, Neufurth M, Wang XH (2014) Enzyme-accelerated and structure-guided crystallization of Ca-carbonate: role of the carbonic anhydrase in the homologous system. Acta Biomater 10: 450–462.

Müller WEG, Schröder HC, Shen ZJ, Feng QL and Wang XH (2014) Inorganic polymers: Morphogenic inorganic biopolymers for rapid prototyping chain. In: Müller WEG, Wang XH and Schröder HC (eds) Biomedical Inorganic Polymers, Progress in Molecular and Subcellular Biology vol. 54; pp 235–259.

Müller WEG, Tolba E, Schröder HC, Diehl-Seifert B, Link T, Wang XH (2014) Biosilica-loaded poly(Ɛ-caprolactone) nanofibers mats provide a morphogenetically active surface scaffold for the growth and mineralization of the osteoclast-related SaOS-2 cells. Biotechnology J 9:1312-1321

Neufurth M, Wang XH, Schröder HC, Feng QL, Diehl-Seifert B, Ziebart T, Steffen R, Wang SF, Müller WEG (2014) Engineering a morphogenetically active hydrogel for bioprinting of bioartificial tissue derived from human osteoblast-like SaOS-2 cells. Biomaterials 35:8810-8819.

Ren DN, Albert O, Müller WEG, Feng QL (2014) Primary cell culture of fresh water Hyriopsis cumingii mantle/pearl sac tissues and its effect on calcium carbonate mineralization. Cryst Growth Des 14: 1149–1157.

Schröder HC, Wang XH, Schloßmacher U, Wiens M and Müller WEG (2014) Biogenic inorganic polysilicates (biosilica): Formation and biomedical applications. In: Müller WEG, Wang XH and Schröder HC (eds) Biomedical Inorganic Polymers, Progress in Molecular and Subcellular Biology vol. 54; pp 197–234.

Wang XH, Schröder HC, Grebenjuk V, Diehl-Seifert B, Mailänder V, Steffen R, Schloßmacher U, Müller WEG (2014) The marine sponge-derived inorganic polymers, biosilica and polyphosphate, as morphogenetically active matrices/scaffolds for differentiation of human multipotent stromal cells: Potential application in 3D printing and distraction osteogenesis. Mar Drugs 12:1131-1147.

Wang XH, Schröder HC, Feng Q, Diehl-Seifert B, Grebenjuk VA, Müller WEG (2014) Isoquercitrin and polyphosphate co-enhance mineralization of human osteoblast-like SaOS-2 cells via separate activation of two RUNX2 cofactors AFT6 and Ets1. Biochem Pharmacol 89:413–421.

Wang XH, Schröder HC, Müller WEG (2014) Biocalcite, a multifunctional inorganic polymer: Building block for calcareous sponge spicules and bioseed for the synthesis of calcium phosphate-based bone. Beilstein J Nanotechnol 5: 610–621.

Wang XH, Schröder HC, Müller WEG (2014) Enzyme-based biosilica and biocalcite: biomaterials for the future in regenerative medicine. Trends Biotechnol 32:441-447

Wang XH, Schröder HC, Müller WEG (2014) Enzymatically synthesized inorganic polymers as morphogenetically active bone scaffolds: application in regenerative medicine. Int Rev Cell Mol Biol 313: 27-77.

Wang XH, Schröder HC, Schloßmacher U, Müller WEG (2014) Inorganic polyphosphates: Biologically active biopolymers for biomedical applications. In: Müller WEG, Wang XH and Schröder HC (eds) Biomedical Inorganic Polymers, Progress in Molecular and Subcellular Biology vol. 54; pp 261–294.

Wang XH, Schröder HC, Schloßmacher U, Neufurth M, Feng Q, Diehl-Seifert B, Müller WEG (2014) Modulation of the initial mineralization process of SaOS-2 cells by carbonic anhydrase activators and polyphosphate. Calcif Tissue Int 94:495–509.

Wang S, Wang XH, Draenert FG, Albert O, Schröder HC, Mailänder V, Mitov G, Müller WEG (2014) Bioactive and biodegradable silica biomaterial for bone regeneration. Bone 67: 292–304.

Wiens M, Elkhooly TA, Schröder HC, Mohamed THA, Müller WEG (2014) Characterization and osteogenic activity of a silicatein/biosilicacoated chitosan-graft-polycaprolactone. Acta Biomater 10:4456-4464.

Publications 2013

Adányi N, Bori Z, Szendrö I, Erdélyi K, Wang X, Schröder HC, Müller WEG (2013) Biosilica-based immobilization strategy for label-free OWLS sensors. Sens Actuat B Chem l 177:1– 7.

Adányi N, Bori Z, Szendrő I, Erdélyi K, Wang XH, Schröder HC, Müller WEG (2013) Bacterial sensors based on biosilica immobilization for label-free owls detection. N Biotechnol 30:493–499.

Link T, Wang XH, Schloßmacher U, Feng QL, Schröder HC and Müller WEG (2013) An approach to a biomimetic bone scaffold: Increased expression of BMP-2 and of osteoprotegerin in SaOS-2 cells grown onto silica-biologized 3D printed scaffolds. RSC Adv 3:11140–11147.

Müller WEG, Mugnaioli E, Schröder HC, Schloßmacher U, Giovine M, Kolb U and Wang XH (2013) Hierarchical composition of the axial filament from spicules of the siliceous sponge Suberites domuncula: From biosilica-synthesizing nanofibrils to structure- and morphology-guiding triangular stems. Cell Tissue Res 351:49–58.

Müller WEG, Schröder HC, Burghard Z, Pisignano D and Wang XH (2013) Silicateins - A novel paradigm in bioinorganic chemistry: Enzymatic synthesis of inorganic polymeric silica. Chem Eur J 19:5790–5804.

Müller WEG, Schröder HC, Markl JS, Grebenjuk VA, Korzhev M, Steffen R and Wang XH (2013) Cryptochrome in sponges: a key molecule linking photoreception with phototransduction. J Histochem Cytochem 61:814–832.

Müller WEG, Schröder HC, Muth S, Gietzen S, Korzhev M, Grebenjuk VA, Wiens M, Schloßmacher U and Wang XH (2013) The silicatein-propeptide acts as inhibitor/modulator of self-organization during spicule axial filament formation. FEBS J 280:1693–1708.

Müller WEG, Schröder HC, Pisignano D, Markl J and Wang XH (2013). Metazoan circadian rhythm: Toward an understanding of a light-based Zeitgeber in sponges. Integr Comp Biol 53:103–117.

Müller WEG, Schröder HC, Schlossmacher U, Grebenjuk VA, Ushijima H and Wang XH (2013) Induction of carbonic anhydrase in SaOS-2 cells, exposed to bicarbonate and consequences for calcium phosphate crystal formation. Biomaterials 34:8671–8680.

Müller WEG, Schröder HC, Schlossmacher U, Neufurth M, Geurtsen W, Korzhev M and Wang XH (2013) The enzyme carbonic anhydrase as an integral component of biogenic Ca-carbonate formation in sponge spicules. FEBS Open Bio 3:357–362.

Müller WEG, Wang XH, Grebenjuk V, Diehl-Seifert B, Steffen R, Schloßmacher U, Trautwein A, Neumann S and Schröder HC (2013) Silica as a morphogenetically active inorganic polymer: effect on the BMP-2-dependent and RUNX2-independent pathway in osteoblast-like SaOS-2 cells. Biomaterials Sci. 1:669–678.

Müller WEG, Wang XH, Jochum KP and Schröder HC (2013) Self-healing, an intrinsic property of biomineralization processes. IUBMB Life 65:382–396.

Müller WEG, Wang XH, Proksch P, Perry CC, Osinga R, Gardères J, Schröder HC (2013) Principles of biofouling protection in marine sponges: A model for the design of novel biomimetic and bio-inspired coatings in the marine environment? Mar Biotechnol 15:375–398.

Natalio F, Corrales TP, Panthöfer M, Schollmeyer D, Müller WEG, Kappl M, Butt HJ, Tremel W (2013) Flexible minerals: Self-assembled calcite spicules with extreme bending strength. Science 339:1298–1302.

Nosenko T, Schreiber F, Adamska M, Adamski M, Eitel M, Hammel J, Maldonado M, Müller WEG, Nickel M, Schierwater B, Vacelet J, Wiens M, Wörheide G (2013) Deep metazoan phylogeny: When different genes tell different stories, Molec Phylog Evol 67:223–233.

Schloßmacher U, Schröder HC, Wang XH, Feng Q, Diehl-Seifert B, Neumann S, Trautwein A, Müller WEG (2013) Alginate/silica composite hydrogel as a potential morphogenetically active scaffold for three-dimensional tissue engineering. RSC Adv 3:11185–11194.

Tahir MN, Ali M, Andre R, Müller WEG, Schröder HC, Tremel W, Ensinger W (2013) Silicatein conjugation inside nanoconfined geometries through immobilized NTA-Ni(II) chelates. Chem Commun (Camb) 49:2210–2212.

Wang XH, Brandt D, Thakur NL, Wiens M, Batel R, Schröder HC, Müller WEG (2013) Molecular cross-talk between sponge host and associated microbes. Phytochem Rev 12:369–390.

Wang XH, Schloßmacher U, Schröder HC, and Müller WEG (2013) Biologically-induced transition of bio-silica sol to mesoscopic gelatinous flocs: a biomimetic approach to a controlled fabrication of bio-silica structures. Soft Matter 9:654–664.

Wang XH, Schröder HC, Diehl-Seifert B, Kropf K, Schlossmacher U, Wiens M and Müller WEG (2013) Dual effect of inorganic polymeric phosphate/polyphosphate on osteoblasts and osteoclasts in vitro. J Tissue Engin Regen Med 7:767–776.

Wang XH, Schröder HC, Feng QL, Draenert F and Müller WEG (2013) The deep-sea natural products, biogenic polyphosphate (Bio-PolyP) and biogenic silica (Bio-Silica), as biomimetic scaffolds for bone tissue engineering: fabrication of a morphogenetically-active polymer. Mar Drugs 11:718–746.

Wang XH, Schröder HC, Schloßmacher U, Jiang L, Korzhev M and Müller WEG (2013) Biosilica aging: From enzyme-driven gelation via syneresis to chemical/biochemical hardening. Biochim Biophys Acta 1830: 3437–3446.

Wiens M, Niem T, Elkhooly TA, Steffen R, Neumann S, Schloßmacher U and Müller WEG (2013) Osteogenic potential of a biosilica-coated P(UDMA-co-MPS) copolymer. J Mater Chem B 1: 3339–3343.

Publications 2012

Jiang CS, Müller WEG, Schröder HC and Guo YW (2012) Disulfide- and multisulfide-containing metabolites from marine sources. Chem Rev 112:2179–2207.

Jochum KP, Wang XH, Vennemann TW, Sinha1 B, and Müller WEG (2012) Siliceous deep-sea sponge Monorhaphis chuni: A potential paleoclimate archive in ancient animals. Chem Geol 300–301:143–151.

Müller WEG and Wang XH (2012) Silicatein: from chemical through enzymatic silica formation, to synthesis of biomimetic nanomaterials. FEBS J (Minireview Series) [A short overview of the series] 279:1709.

Müller WEG, Wang XH, Binder M, von Lintig J, Wiens M and Schröder HC (2012) Differential expression of the demosponge (Suberites domuncula) carotenoid oxygenases in response to light: Protection mechanism against the self-produced toxic protein (Suberitine). Mar Drugs 10:177–199.

Müller WEG, Wang XH, Guo YW, Schröder HC (2012) Potentiation of the cytotoxic activity of copper by polyphosphate on biofilm-producing bacteria: A bioinspired approach. Mar Drugs 10:2369–2387.

Müller WEG, Wang XH, Grebenjuk VA, Korzhev M, Wiens M, Schloßmacher U, Schröder HC (2012) Nocturnin in the demosponge Suberites domuncula: a potential circadian clock protein controlling glycogenin synthesis in sponges. Biochem J 448:233–242.

Müller WEG, Wang XH, Grebenjuk VA, Korzhev M, Wiens M, Schloßmacher U and Schröder HC (2012) Common genetic denominators for Ca++-based skeleton in Metazoa: Role of osteoclast-stimulating factor and of carbonic anhydrase in a calcareous sponge. PLoS ONE 7:e34617. doi:10.1371/journal.pone.0034617.

Pagliara S, Polini A, Camposeo A, Schröder HC, Müller WEG, and Pisignano D (2012) Electrical properties of in vitro biomineralized recombinant silicatein deposited by microfluidics. Appl Physics Lett 101:193702.

Polini A, Pagliara S, Camposeo A, Cingolani R, Wang XH, Schröder HC, Müller WEG, Pisignano D (2012) Optical properties of in-vitro biomineralised silica. Sci Rep (Nature group) 2:607; DOI: 10.1038/srep00607.

Schröder HC, Wang XH, Manfrin A, Yu SH, Grebenjuk VA, Korzhev M, Wiens M, Schloßmacher U, Müller WEG (2012) Silicatein: acquisition of structure-guiding and structure-forming properties during maturation from the pro-silicatein to the silicatein form. J Biol Chem 287:22196–22205.

Schröder HC, Wang XH, Wiens M, Diehl-Seifert B, Kropf K, Schloßmacher U, Müller WEG (2012) Silicate modulates the cross-talk between osteoblasts (SaOS-2) and osteoclasts (RAW 264.7 cells): inhibition of osteoclast growth and differentiation. J Cell Biochem 113:3197–3206

Schröder HC, Wiens M, Schloßmacher U, Brandt D, Müller WEG (2012) Silicatein-mediated polycondensation of orthosilicic acid: Modeling of catalytic mechanism involving ring formation. Silicon 4:33–38.

Wang XH, Gan L, Wiens M, Schloßmacher U, Schröder HC, Müller WEG (2012) Distribution of Microfossils Within Polymetallic Nodules: Biogenic Clusters Within Manganese Layers. Mar Biotechnol 14:96–105.

Wang XH, Schröder HC, Wang K, Kaandorp JA and Müller WEG (2012) Genetic, biological and structural hierarchies during sponge spicule formation: From soft sol-gels to solid 3D silica composite structures. Soft Matter 8:9501–9518

Wang XH, Schloßmacher U, Wiens M, Batel R, Schröder HC, Müller WEG (2012) Silicateins, silicatein interactors, and cellular interplay in sponge skeletogenesis: Formation of glass fiber-like spicules. FEBS J 279:1721–1736.

Wang XH, Schröder HC, Wiens M, Ushijima H, Müller WEG (2012) Bio-silica and bio-polyphosphate: applications in biomedicine (bone formation). Curr Opin Biotechnol 23:570–578.

Wang XH, Wiens M, Schloßmacher U, Jochum KP, Schröder HC, Müller WEG (2012) Bio-sintering/bio-fusion of silica in sponge spicules: a review. Adv Biomat 14:B4–B12.

Wiens M, Link T, Elkhooly TA, Isbert S and Müller WEG (2012) Formation of a micropatterned titania photocatalyst by microcontact printed silicatein on gold surfaces. ChemComm 48:11331–11333.

Publications 2011

André R, Natálio F, Humanes M, Leppin J, Heinze K, Wever R, Schröder HC, Müller WEG, Tremel W (2011) V2O5 Nanowires with an Intrinsic Peroxidase-Like Activity. Adv Funct Mater 21:501–509.

André R, Tahir MN, Link T, Jochum FD, Kolb U, Theato P, Berger R, Wiens M, Schröder HC, Müller WEG, and Tremel W (2011) Chemical mimicry: Hierarchical 1D TiO2@ZrO2 core - shell structures reminiscent of sponge spicules by the synergistic effect of silicatein-α and silintaphin-1. Langmuir 27:5464–5471.

Andre R, Tahir MN, Schröder HC, Müller WEG, Tremel W (2011) Enzymatic synthesis and surface deposition of tin dioxide using silicatein-α. Chem Mater 23:5358–5365.

Châtel A, Hamer B, Jakšić Z, Vucelić V, Talarmin H, Dorange G, Schröder HC, Müller WEG (2011) Induction of apoptosis in mussel Mytilus galloprovincialis gills by model cytotoxic agents. Ecotoxicol 20:2030–2041.

Châtel A, Talarmin H, Hamer B, Schröder HC, Müller WEG, Dorange G (2011) MAP kinase cell signaling pathway as biomarker of environmental pollution in the sponge Suberites domuncula. Ecotoxicol 20:1727–1740.

Chianese G, Fattorusso E, Aiyelaagbe OO, Luciano P, Schröder HC, Müller WEG, Taglialatela-Scafati O (2011) Spirocurcasone, a Diterpenoid with a Novel Carbon Skeleton from Jatropha curcas. Org Lett 13:316–319.

Lukic-Bilela L, Perovic-Ottstadt S, Walenta S, Natalio F, Plese B, Link T and Müller WE G (2011) ATP distribution and localization of mitochondria in Suberites domuncula (Olivi 1792) tissue. J Exp Biol 214:1748–1753.

Luthringer B, Isbert S, Müller WEG, Zilberberg C, Thakur NL, Wörheide G, Stauber RH, Kelve M, Wiens M (2011) Poriferan survivin exhibits a conserved regulatory role in the interconnected pathways of cell cycle and apoptosis. Cell Death Diff 18, 201–213.

Müller WEG, Binder M, von Lintig J, Guo YW, Wang XH, Kaandorp JA, Wiens M, Schröder HC (2011) Interaction of the retinoic acid signaling pathway with spicule formation in the marine sponge Suberites domuncula through activation of bone morphogenetic protein-1. Biochim Biophys Acta 1810:1178–1194.

Müller WEG, Wang XH, Diehl-Seifert B, Kropf K, Schloßmacher U, Lieberwirth I, Glasser G, Wiens M and Schröder HC (2011) Inorganic polymeric phosphate/polyphosphate as an inducer of alkaline phosphatase and a modulator of intracellular Ca2+ level in osteoblasts (SaOS-2 cells) in vitro. Acta Biomater 7; 2661–2671.

Müller WEG, Wang XH, Wiens M, Schloßmacher U, Jochum KP, Schröder HC (2011) Hardening of bio-silica in sponge spicules involves an aging process after its enzymatic polycondensation: Evidence for an aquaporin-mediated water absorption. Biochim Biophys Acta 1810:713–726.

Polini A, Pagliara S, Camposeo A, Biasco A, Schröder HC, Müller WEG, Pisignano D (2011) Biosilica electrically-insulating layers by soft lithography-assisted biomineralisation with recombinant silicatein. Adv Mater 23:4674–4678.

Schlossmacher U, Wiens M, Schröder HC, Wang XH, Jochum KP and Müller WEG (2011) Silintaphin-1: Interaction with silicatein during structureguiding biosilica formation. FEBS J 278:1145–1155.

Wang XH, Peine F, Schmidt A, Schröder HC, Wiens M, Schloßmacher U, Müller WEG (2011) Concept of biogenic ferromanganese crust formation: Coccoliths as bio-seeds in crusts from central Atlantic Ocean (Senghor Seamount/Cape Verde). Nat Prod Commun 6:679–688.

Wang XH, Schröder HC, Brandt D, Wiens M, Lieberwirth I, Glasser G, Schloßmacher U, Wang SF, Müller WEG (2011) Sponge bio-silica formation involves syneresis following polycondensation in vivo. ChemBioChem 12, 2316–2324.

Wang XH, Wiens M, Divekar M, Grebenjuk VA, Schröder HC, Batel R, Müller WEG (2011) Isolation and characterization of a Mn(II)-oxidizing bacillus strain from the demosponge Suberites domuncula. Mar Drugs 9:1–28.

Wang XH, Wiens M, Schröder HC, Jochum KP, Schloßmacher U, Götz H, Duschner H, Müller WEG (2011) Circumferential spicule growth by pericellular silica deposition in the hexactinellid sponge Monorhaphis chuni. J. Exp Biol 214:2047–2056.

Wang XH, Zeng L, Wiens M, Schloßmacher U, Jochum KP, Schröder HC, Müller WEG (2011) Evidence for a biogenic, microorganismal origin of rock varnish from the Gangdese Belt of Tibet. Micron 42:401–411.

Wiens M, Schröder HC, Wang XH, Link T, Steindorf D and Müller WEG (2011) Isolation of the silicatein-α interactor Silintaphin-2 by a novel solid-phase pull-down assay. Biochemistry 50:1981–1990.

Wang XH, Gan L, Wiens M, Schloßmacher U, Schröder HC, Müller WEG (2012) Distribution of Microfossils Within Polymetallic Nodules: Biogenic Clusters Within Manganese Layers. Mar Biotechnol 14:96–105.

Wang XH, Wiens M, Schröder HC, Schloßmacher U, Pisignano D, Jochum KP, and Müller WEG (2011) Evagination of cells controls bio-silica formation and maturation during spicule formation in sponges. PLoS ONE 6:e20523. doi:10.1371/journal.pone.0020523.

Wiens M, Schröder HC, Korzhev M, Wang XH, Batel R and Müller WEG (2011) Inducible ASABF-type antimicrobial peptide from the sponge : microbicidal and hemolytic activity and toxic effect on molluscs . Mar Drugs 9:1969–1994.

Publications 2010

Aiello A, Fattorusso E, Imperatore C, Menna M, Müller WEG (2010) Iodocionin, a cytotoxic iodinated metabolite from the Mediterranean ascidian Ciona edwardsii. Mar Drugs 8:285–291.

Châtel A, Hamer B, Talarmin H, Dorange G, Schröder HC, Müller WEG (2010) Activation of MAP kinase signaling pathway in the mussel Mytilus galloprovincialis as biomarker of environmental pollution. Aquat Toxicol 96:247–255.

Gong N, Wiens M, Schröder HC, Mugnaioli E, Kolb U, MüllerWEG (2010) Biosilicification of loricate choanoflagellates: Organic composition of the nanotubular siliceous costal strips of Stephanoeca diplocostata. J Exp Biol 213, 3575–3585.

Harcet M, Roller M, Cetkovic H, Perina D, Wiens M, Müller WEG, Vlahovicek K (2010) Demosponge EST sequencing reveals a complex genetic toolkit of the simplest metazoans. Molec Biol Evol 27:2747–2756.

Müller WEG, Wang XH, Schröder HC, Korzhev M, Grebenjuk VA, Markl JS, Jochum KP, Pisignano D, Wiens M (2010) A cryptochrome-based photosensory system in the siliceous sponge Suberites domuncula (Demospongiae). FEBS J 277:1182–1201.

Müller WEG, Wang XH, Sinha B, Wiens M, Schröder HC, Jochum KP (2010) NanoSIMS: Insights into the organization of the proteinaceous scaffold within hexactinellid sponge spicules. ChemBioChem 11:1077–1082.

Natalio F, Link T, Müller WEG, Schröder HC, Cui FZ, Wang X, Wiens M (2010) Bioengineering of the silica-polymerizing enzyme silicatein-α for a targeted application to hydroxyapatite. Acta Biomater 6:3720–3728.

Natalio F, Mugnaioli E, Wiens M, Wang XH, Schröder HC, Tahir MN, Tremel W, Kolb U, Müller WEG (2010) Silicatein-mediated incorporation of titanium into spicules from the demosponge Suberites domuncula. Cell Tissue Res 339:429–436.

Schladt TD, Schneider K, Shukoor MI, Natalio F, Bauer H, Tahir MN, Weber S, Schreiber LM, Schröder HC, Müller WEG, Tremel W (2010) Highly soluble multifunctional MnO nanoparticles for simultaneous optical and MRI imaging and cancer treatment using photodynamic therapy. J Mater Chem 20:8297–8304.

Schladt TD, Shukoor MI, Tahir MN, Natalio F, Schneider K, Ament I, Becker J, Jochum F, Weber S, Theato P, Schreiber LM, Sönnichsen C, Schröder HC, Müller WEG, Tremel W (2010) Au@MnONanoflowers - hybrid nanocomposites for selective dual functionalization and imaging. Angew Chem Int Ed 49:3976–3980.

Wang XH, Hu S, Gan L, Wiens M, Müller WEG (2010) Sponges (Porifera) as living metazoan witnesses from the Neoproterozoic: biomineralization and the concept of their evolutionary success. Terra Nova 22, 1–11.

Wang XH, Schloßmacher U, Jochum KP, Stoll B, Uriz I, Müller WEG (2010) Silica-protein composite layers of the giant basal spicules from Monorhaphis: Basis for their mechanical stability. Pure Appl Chem 82:175–192.

Wang XH, Wiens M, Schröder HC, Hu S, Mugnaioli E, Kolb U, Tremel W, Pisignano D, Müller WEG (2010) Morphology of sponge spicules: silicatein a structural protein for bio-silica formation. Adv Biomater/Adv Engineer Mat 12:B422–B437.

Wiens M, Wang XH, Natalio F, Schröder HC, Schloßmacher U, Wang S, Korzhev M, Geurtsen W, Müller WEG (2010) Bioinspired fabrication of bio-silica-based bone substitution materials. Adv Engin Mat 12:B438–B450.

Wiens M, Wang XH, Schloßmacher U, Lieberwirth I, Glasser G, Ushijima H, Schröder HC, Müller WEG (2010) Osteogenic potential of bio-silica on human osteoblast-like (SaOS-2) cells. Calcif Tissue Int 87:513–524.

Wiens M, Wang XH, Schröder HC, Kolb U, Schloßmacher U, Ushijima H, Müller WEG (2010) The role of biosilica in the osteoprotegerin/RANKL ratio in human osteoblastlike cells. Biomaterials 31:7716–7725.

Wiens M, Wang XH, Unger A, Schröder HC, Grebenjuk VA, Pisignano D, Jochum KP, Müller WEG (2010) Flashing light signaling circuit in sponges: endogenous light generation after tissue ablation in Suberites domuncula. J Cell Biochem 111:1377–1389.

Wolf SE, Schlossmacher U, Pietuch A, Mathiasch B, Schröder HC, Müller WEG and Tremel W (2010) Formation of silicones mediated by the sponge enzyme silicatein-α. Dalton Trans 39:9245–9249.

Publications 2009

Mugnaioli E, Natalio F, Schloßmacher U, Wang XH, Müller WEG, Kolb U (2009) Crystalline nanorods as possible templates for the synthesis of amorphous biosilica during spicule formation in Demospongiae. ChemBioChem 10:683–689.

Müller WEG, Kasueske M, Wang XH, Schröder HC, Wang Y, Pisignano D, Wiens M (2009) Luciferase a light source for the silica-based optical waveguides (spicules) in the demosponge Suberites domuncula. Cell Mol Life Sci 66:537–552.

Müller WEG, Wang XH, Burghard Z, Bill J, Krasko A, Boreiko A, Schloßmacher U, Schröder HC, Wiens M (2009) Bio-sintering processes in hexactinellid sponges: Fusion of bio-silica in giant basal spicules from Monorhaphis chuni. J Struct Biol 168:548–561.

Müller WEG, Wang XH, Cui FZ, Jochum KP, Tremel W, Bill J, Schröder HC, Natalio F, Schloßmacher U, Wiens M (2009) Sponge spicules as blueprints for the biofabrication of inorganic-organic composites and biomaterials. Appl Microbiol Biotechnol 83:397–413.

Plese B, Schröder HC, Grebenjuk VA, Wegener G, Brandt D, Natalio F, Müller WEG (2009) Strombine dehydrogenase in the demosponge Suberites domuncula: characterization and kinetic properties of the enzyme crucial for an anaerobic metabolism. Comp Biochem Physiol - Part B 154:102–107.

Shukoor MI, Natalio F, Tahir MN, Wiens M, Tarantola M, Therese HA, Barz M, Weber S, Terekhov M, Schröder HC, Müller WEG, Janshoff A, Theato P, Zentel R, Schreiber LM, Tremel W (2009) Pathogen-mimicking MnO nanoparticles for selective activation of the TLR9 pathway and imaging of cancer cells. Adv Funct Mater 19:3717–3725.

Tahir MN, Natalio F, Berger R, Balz M, Theato P, Schröder HC, Müller WEG, Tremel W (2009) Growth of fibrous aggregates of silica nanoparticles: Fibre growth by mimicking the biogenic silica patterning processes. Soft Matter 5:3657–3662.

Tahir MN, Natalio F, Therese HA, Yella A, Metz N, Shah MR, Mugnaioli E, Berger R, Theato P, Schröder HC, Müller WEG, Tremel W (2009) Enzyme-mediated deposition of a TiO2 coating onto biofunctionalized WS2 chalcogenide nanotubes. Adv Funct Mater 19:285–291.

Wang XH, Müller WEG (2009) Marine biominerals: perspectives and challenges for polymetallic nodules and crusts. Trends Biotechnol 27:375–383.

Wang XH, Schloßmacher U, Natalio F, Schröder HC, Wolf SE, Tremel W, Müller WEG (2009) Evidence for biogenic processes during formation of ferromanganese crusts from the Pacific Ocean: implications of biologically induced mineralization. Micron 40:526–535.

Wang XH, Schloßmacher U, Wiens M, Schröder HC, Müller WE G (2009) Biogenic origin of polymetallic nodules from the Clarion-Clipperton zone in the Eastern Pacific Ocean: electron microscopic and EDX evidence. Mar Biotechnol 11:99–108.

Wang XH, Schröder HC, Müller WEG (2009) Giant siliceous spicules from the deep-sea glass sponge Monorhaphis chuni: morphology, biochemistry and molecular biology. Int Rev Cell Mol Biol 273:69–115.

Wang XH, Schröder HC, Schloßmacher U, Müller WEG. (2009) Organized bacterial assemblies in manganese nodules: evidence for a role of S-layers in metal deposition. Geo-Mar Lett 29:85–91.

Wang XH, Schröder HC, Wiens M, Schloßmacher U, Müller WEG (2009) Manganese/polymetallic nodules: Micro-structural characterization of exolithobiontic- and endolithobiontic microbial biofilms by scanning electron microscopy. Micron 40:350–358.

Wiens M, Bausen M, Natalio F, Link T, Schlossmacher U, Müller WEG (2009) The role of the silicatein-α interactor silintaphin-1 in biomimetic biomineralization. Biomaterials 30:1648–1656.

Publications 2008

Kaandorp JA, Blom JG, Verhoef J, Filatov M, Postma M, Müller WEG (2008) Modelling genetic regulation of growth and form in a branching sponge. Proc Royal Soc B 275:2569–2575.

Lukić-Bilela L, Brandt D, Pojskić N, Wiens M, Gamulin V, Müller WEG (2008) Mitochondrial genome of Suberites domuncula: palindromes and inverted repeats are abundant in non-coding regions. Gene 412:1–11.

Müller WEG, Boreiko A, Schloßmacher U, Wang XH, Eckert C, Kropf K, Li J, Schröder HC (2008) Identification of a silicatein(-related) protease in the giant spicules of the deep sea hexactinellid Monorhaphis chuni. J Exp Biol 211:300–309.

Müller WEG, Engel S, Wang XH, Wolf SE, Tremel W, Thakur NL, Krasko A, Divekar M, Schröder HC (2008) Bioencapsulation of living bacteria (Escherichia coli) with poly(silicate) after transformation with silicatein-α gene. Biomaterials 29:771–779.

Müller WEG, Jochum K, Stoll B, Wang XH (2008) Formation of giant spicule from quartz glass by the deep sea sponge Monorhaphis. Chem Mater 20:4703–4711.

Müller WEG, Schloßmacher U, Wang XH, Boreiko A, Brandt D, Wolf SE, Tremel W, Schröder HC (2008) Poly(silicate)-metabolizing silicatein in siliceous spicules and silicasomes of demosponges comprises dual enzymatic activities (silica-polymerase and silica-esterase). FEBS J 275:362–370.

Müller WEG, Wang XH, Kropf K, Boreiko A, Schloßmacher U, Brandt D, Schröder HC, Wiens M (2008) Silicatein expression in the hexactinellid Crateromorpha meyeri: the lead marker gene restricted to siliceous sponges. Cell Tissue Res 333:339–351.

Müller WEG, Wang XH, Kropf K, Ushijima H, Geurtsen W, Eckert C, Tahir MN, Tremel W, Boreiko A, Schloßmacher U, Li J, Schröder HC (2008) Bioorganic/inorganic hybrid composition of sponge spicules: Matrix of the giant spicules and of the comitalia of the deep sea hexactinellid Monorhaphis. J Struct Biol 161:188–203.

Plese B, Grebenjuk VA, Schröder HC, Breter H-J, Müller IM, Müller WEG (2008) Cloning and expression of a tauropine dehydrogenase from the marine sponge Suberites domuncula. Mar Biol 153:1219–1232.

Schröder HC, Natalio F, Wiens M, Tahir MN, Shukoor MI, Tremel W, Belikov SI, Krasko A, Müller WEG (2008) The 2’-5’-oligoadenylate synthetase in the lowest Metazoa: Isolation, cloning, expression and functional activity in the sponge Lubomirskia baicalensis. Molec Immunol 45:945–953.

Schröder HC, Wang XH, Tremel W, Ushijima H, Müller WEG (2008) Biofabrication of biosilica-glass by living organisms. Nat Prod Rep 25:455–474.

Shukoor MI, Natalio F, Glube N, Tahir MN, Therese HA, Ksenofontova V, Theato P, Langguth P, Boissel J-P, Schröder HC, Müller WEG, and Tremel W (2008) dsRNA functionalized multifunctional γ-Fe2O3 nanocrystals: a tool for targeting cell surface receptors. Angew Chem Int Ed. 47:4748–4752.

Shukoor MI, Natalio F, Glube N, Tahir MN, Therese HA, Ksenofontova V, Theato P, Langguth P, Boissel J-P, Schröder HC, Müller WEG, and Tremel W (2008) Multifunctional polymer-derivatized γ-Fe2O3 nanocrystals as a methodology for the biomagnetic separation of recombinant His-tagged proteins. J Magn Magn Mater 320:2339–2344.

Thakur NL, Jain R, Natalio F, Hamer B, Thakur AN, Müller WEG (2008) Marine molecular biology: An emerging field of biological sciences. Biotechnol Adv 26:233–245.

Wang XH, Boreiko A, Schloßmacher U, Brandt D, Schröder HC, Li J, Kaandorp JA, Götz H, Duschner H, Müller WEG (2008) Axial growth of hexactinellid spicules: formation of cone-like structural units in the giant basal spicules of the hexactinellid Monorhaphis. J Struct Biol 164:270–280.

Wiens M, Belikov SI, Kaluzhnaya OV, Adell T, Schröder HC, Perovic-Ottstadt S, Kaandorp JA, Müller WEG. (2008) Regional and modular expression of morphogenetic factors in the demosponge Lubomirskia baicalensis. Micron 39:447–460.

Further Information about the Research Group