English
PD Dr. Ernesto Bockamp
Ernesto Bockamp ist Wissenschaftlicher Angestellter am Institut für Translationale Immunologie in Mainz. Er promovierte an der Eberhard-Karls-Universität in Tübingen und arbeitete während seiner Promotion am Zentrum für Molekulare Biologie “Severo Ochoa” in Madrid (Landesgraduirtenförderung des Landes Baden-Württemberg und Stipendiat der Dr. Duisberg Stiftung). Danach war Herr Bockamp Postdoc und Senior Research Fellow am Medical Research Centre in Cambridge, UK (Fellow der Leukaemia Research Foundation). Im Jahr 2002 habilitierte sich Herr Bockamp im Fach Molekulare Medizin an der Johannes Gutenberg-University in Mainz. Am Institut für Translationale Immunologie arbeitet Herr Bockamp auf dem Gebiet der translationalen Krebsforschung mit Schwerpunkt Lungenkrebs. Weitere Forschungsschwepunkte sind konditionale Mausmodelle und die Aufklärung molekularer und zellulärer Inflammationsmechanismen.
| Studium |
1973-79 | Master’s (Diploma) in Biology (main topic Biochemistry and Microbiology), Eberhard-Karls-University Tübingen, Germany |
1989 | Ph.D. in Molecular Biology, Center for Molecular Biology “Severo Ochoa”, Madrid, Spain |
1992 | Postdoctoral Degree in Molecular Medicine (Habilitation), University Medical Center, Johannes Gutenberg-University, Mainz, Germany |
| Wissenschaftliche Karriere |
2015 | Reader, (Wissenschaftlicher Angestellter), Institute of Translational Immunology, University Medical Center, Johannes Gutenberg-University, Mainz, Germany |
2010-2014 | Reader, (Wissenschaftlicher Angestellter), Department of Internal Medicine III, Division of Translational and Experimental Oncology (TRON), University Medical Center, Johannes Gutenberg-University, Mainz, Germany |
1999-2010 | Reader (Wissenschaftlicher Angestellter), Institute of Toxicology, University Medical Center, Johannes Gutenberg-University, Mainz, Germany |
1994-98 | Senior Research Fellow, Medical Research Centre Cambridge, Department of Haematology, Cambridge, England |
1991-1994 | Postdoctoral Fellow, Medical Research Centre Cambridge, Department of Haematology, Cambridge, England |
1991 | Postdoctoral Fellow, Center for Molecular Biology “Severo Ochoa”, Madrid, Spain |
Originalpublikationen
1: Rosigkeit S, Kruchem M, Thies D, Kreft A, Eichler E, Boegel S, Jansky S,
Siegl D, Kaps L, Pickert G, Haehnel P, Kindler T, Hartwig UF, Guerra C, Barbacid
M, Schuppan D, Bockamp E. Definitive evidence for Club cells as progenitors for
mutant Kras/Trp53-deficient lung cancer. Int J Cancer. 2021 Jul 31. doi:
10.1002/ijc.33756. PMID: 34331774.
2: Bockamp E, Rosigkeit S, Siegl D, Schuppan D. Nano-Enhanced Cancer
Immunotherapy: Immunology Encounters Nanotechnology. Cells. 2020 Sep
15;9(9):2102. doi: 10.3390/cells9092102. PMID: 32942725.
3: Yurugi H, Zhuang Y, Siddiqui FA, Liang H, Rosigkeit S, Zeng Y, Abou-Hamdan H,
Bockamp E, Zhou Y, Abankwa D, Zhao W, Désaubry L, Rajalingam K. A subset of
flavaglines inhibits KRAS nanoclustering and activation. J Cell Sci. 2020 Jun
24;133(12):jcs244111. doi: 10.1242/jcs.244111. PMID: 32501281.
4: Pickert G, Wirtz S, Matzner J, Ashfaq-Khan M, Heck R, Rosigkeit S, Thies D,
Surabattula R, Ehmann D, Wehkamp J, Aslam M, He G, Weigert A, Foerster F, Klotz
L, Frick JS, Becker C, Bockamp E, Schuppan D. Wheat Consumption Aggravates
Colitis in Mice via Amylase Trypsin Inhibitor-mediated Dysbiosis.
Gastroenterology. 2020 Jul;159(1):257-272.e17. doi:
10.1053/j.gastro.2020.03.064. Epub 2020 Apr 3. PMID: 32251667.
5: Chapeau EA, Mandon E, Gill J, Romanet V, Ebel N, Powajbo V, Andraos-Rey R,
Qian Z, Kininis M, Zumstein-Mecker S, Ito M, Hynes NE, Tiedt R, Hofmann F,
Eshkind L, Bockamp E, Kinzel B, Mueller M, Murakami M, Baffert F, Radimerski T.
A conditional inducible JAK2V617F transgenic mouse model reveals
myeloproliferative disease that is reversible upon switching off transgene
expression. PLoS One. 2019 Oct 10;14(10):e0221635. doi:
10.1371/journal.pone.0221635. PMID: 31600213.
6: Luther J, Yorgan TA, Rolvien T, Ulsamer L, Koehne T, Liao N, Keller D,
Vollersen N, Teufel S, Neven M, Peters S, Schweizer M, Trumpp A, Rosigkeit S,
Bockamp E, Mundlos S, Kornak U, Oheim R, Amling M, Schinke T, David JP. Wnt1 is
an Lrp5-independent bone-anabolic Wnt ligand. Sci Transl Med. 2018 Nov
7;10(466):eaau7137. doi: 10.1126/scitranslmed.aau7137. PMID: 30404864.
7: Rosigkeit S, Meng M, Grunwitz C, Gomes P, Kreft A, Hayduk N, Heck R, Pickert
G, Ziegler K, Abassi Y, Röder J, Kaps L, Vascotto F, Beissert T, Witzel S, Kuhn
A, Diken M, Schuppan D, Sahin U, Haas H, Bockamp E. Monitoring Translation
Activity of mRNA-Loaded Nanoparticles in Mice. Mol Pharm. 2018 Sep
4;15(9):3909-3919. doi: 10.1021/acs.molpharmaceut.8b00370. Epub 2018 Aug 9.
PMID: 30028629.
8: Foerster F, Hess M, Gerhold-Ay A, Marquardt JU, Becker D, Galle PR, Schuppan
D, Binder H, Bockamp E. The immune contexture of hepatocellular carcinoma
predicts clinical outcome. Sci Rep. 2018 Mar 29;8(1):5351. doi:
10.1038/s41598-018-21937-2. PMID: 29599491.
9: Cabezas-Wallscheid N, Eichwald V, de Graaf J, Löwer M, Lehr HA, Kreft A,
Eshkind L, Hildebrandt A, Abassi Y, Heck R, Dehof AK, Ohngemach S, Sprengel R,
Wörtge S, Schmitt S, Lotz J, Meyer C, Kindler T, Zhang DE, Kaina B, Castle JC,
Trumpp A, Sahin U, Bockamp E. Instruction of haematopoietic lineage choices,
evolution of transcriptional landscapes and cancer stem cell hierarchies derived
from an AML1-ETO mouse model. EMBO Mol Med. 2013 Dec;5(12):1804-20. doi:
10.1002/emmm.201302661. Epub 2013 Oct 4. PMID: 24124051.
10: Wilson A, Laurenti E, Oser G, van der Wath RC, Blanco-Bose W, Jaworski M,
Offner S, Dunant CF, Eshkind L, Bockamp E, Lió P, Macdonald HR, Trumpp A.
Hematopoietic stem cells reversibly switch from dormancy to self-renewal during
homeostasis and repair. Cell. 2008 Dec 12;135(6):1118-29. doi:
10.1016/j.cell.2008.10.048. Erratum in: Cell. 2009 Jul 10;138(1):209. PMID:19062086.