Publikationen des Institutes für Toxikologie_2020

Haas B., Ciftcioglu J., Jermar S., Weickhardt S., Eckstein N., Kaina B. (2020) Methadone-mediated sensitization of glioblastoma cells is drug and cell line dependent, Journal of Cancer Research and Clinical Oncology, doi.org/10.1007/s00432-020-03485-3

Dzulko M., Pons M., Henke A., Schneider G., Krämer O.H. (2020) The PP2A subunit PR130 is a key regulator of cell development and oncogenic transformation, BBA - Reviews on Cancer, 188453

Allmann S., Meyer L., Olma J., Kaina B., Hofmann T.G., Tomicic M.T., Christmann M. (2020) Benzo[a]pyrene represses DNA repair through altered E2F1/E2F4 function marking an early event in DNA damage-induced cellular senescence, Nucleic Acids Research, doi: 10.1093/nar/gkaa965

Matos-Rodrigues G., Grigaravicius P., Lopez B.S., Hofmann T.G., Frappart P.-O., Martins R. (2020) ATRIP protects progenitor cells against DNA damage in vivo, Cell Death and Disease, 11:923

Schmalohr B.F., Mustafa, A.M., Krämer O.H., Imhof D. (2020) Structural insights into the interaction of heme with protein tyrosine kinase JAK2, ChemBioChem, 21, 1-5

Lankes K., Hassan Z., Doffo M.J., Schneeweis C., Lier S., Öllinger R., Rad R., Krämer O.H., Keller U., Saur D., Reichert M., Schneider G., Wirth M. (2020) Targeting the ubiquitin-proteasome system in a pancreatic cancer subtype with hyperactive MYC, Molecular Oncology, doi: 10.002/1878-0261.12835

Bergholz L., Grimminger P., Dikeoulia E., Rossmann H., Weinmann A., Möhler M., Zimmermann T., Weber M.M., Galle P.R., Kaina B., Zimmermann A. (2020) Pilot study on malnutrition and DNA damage in patients with newly diagnosed gastrointestinal tumors: is DNA damage reversible by early individualized nutritional support? Journal of Gastrointestinal and Liver Diseases, doi: 10.15403/jgld-2589

Taubmann A., Willershausen I., Walter C., Al-Maawi S., Kaina B., Gölz L. (2020) Genotoxic and cytotoxic potential of methacrylate-based orthodontic adhesives, Clinical Oral Investigations

Seiwert N., Wecklein S., Demuth P., Hasselwander S., Kemper T.A., Schwerdtle T., Brunner T., Fahrer J. (2020) Heme oxygenase 1 protects human colonocytes against ROS formation, oxidative DNA damage and cytotoxicity induced by heme iron, but not inorganic iron, Cell Death & Disease, 11 (9), 787

Frappart P.-O., Hofmann T. (2020) Pancreatic ductal adenocarcinoma (PDAC) organoids: the shining light at the end of the tunnel for drug response prediction and personalized medicine, MDPI, Cancers, 12 (10), 2750

Kaina B., Beltzig L., Piee-Staffa A., Haas B. (2020) Cytotoxic and Senolytic effects of methadone in combination with temozolomide in glioblastoma cells, International Journal of Molecular Sciences, 21, 7006, doi: 10.3390/ijms21197006

Kaina B. (2020) A genome-wide screening for DNA repair genes: much more players than hitherto known, Signal Transduction and Targeted Therapy, 5:204

Matos-Rodrigues G.E., Tan Pedro B., Rocha-Martins M., Charlier C.F., Gomes A.L., Cabral-Miranda F., Grigaravicius P., Hofmann T.G., Frappart P-O., Martins R.A.P. (2020) Progenitor death drives retinal dysplasia and neuronal degeneration in a mouse model of Atrip-Seckel syndrome, Disease Models & Mechanisms, 1-34

Gout J., Perkhofer L., Morawe M., Arnold F., Ihle M., Biber S., Lange S., Roger E., Kraus J.M:, Stifter K., Hahn S.A., Zamperone A., Engleitner T., Müller M., Walter K., Rodriguez-Aznar E., Sainz Jr B., Hermann P.C., Hessmann E., Müller S., Azoitei N., Lechel A., Liebau S., Wagner M., Simeone D.M., Kestler H.A., Seufferlein T., Wiesmüller L., Rad R., Frappart P-O, Kleger A. (2020) Synergistic targeting and resistance to PARP inhibition in DNA damage repair-deficient pancreatic cancer, BMJ Journal, 0:1-18

Gomes A.L., Matos-Rodrigues G.E., Frappart P-O., Martins R. (2020) RINT1 loss impairs retinogenesis through TRP53-mediated apoptosis, Frontiers in cell and developmental biology, vol.8, article 711, doi:10.3389/fcell.2020.00711

Göder A., Ginter T., Kröhnert U., Kosan C., Krämer O.H. (2020) Impact of the STAT1 N-terminal domain for fibrosarcoma cell responses to gama-irradiation, Experimental Results, 1, e20, 1-9, Cambridge University Press

Volcic M., Sparrer K.M.J., Koepke  L., Hotter D., Sauter D., Stürzel C.M., Scherer M., Stamminger T., Hofmann T.G., Arhel N.J., Wiesmüller L., Kirchhoff F. (2020) Vpu modulates DNA repair to suppress innate sensing and hyper-integration of HIV-1, Nature Microbiology, doi.org/10.1038/s41564-020-0753-6

Kaina B. (2020) Woher kommt SARS-CoV-2? Bekanntes, Unbekanntes und Überlegungen zur Herkunft des Virus, Naturwissenschaftliche Rundschau (Pdf , 10,6 MB), 864 (6), 285-296

Friedrich A., Assmann A.-S., Schumacher L., Stuijvenberg J.v., Kassack M.U., Schulz W.A., Roos W.P., Hansen F.K., Pflieger M., Kurz T., Fritz G. (2020) In vitro assessment of the genotoxic hazard of novel hydroxamic acid- and benzamide-type histone deacetylase inhibitors (HDACi), MDPI International Journal of Molecular Sciences, 21, 4747, doi: 10.3390/ijms21134747

Rodriguez-Alvarez M., Kim D., Khobta A. (2020) EGFP reporters for direct and sensitive detection of mutagenic bypass of DNA lesions, MDPI Biomolecules, 10, 902, DOI: 10.3390/biom10060902

Sellmer A., Pilsl B., Beyer M., Pongratz H., Wirth L., Elz S., Dove S., Henninger S.J., Spiekermann K., Polzer H., Klaeger S., Kuster B., Böhmer F.D., Fiebig H-H., Krämer O.H., Mahboobi S (2020) A series of novel aryl-methanone derivatives as inhibitors of FMS-like tyrosine kinase 3 (FLT3) in FLT3-ITD-positive acute myeloid leukemia, European Journal of Medicinal Chemistry, 193, 112232

Ziegler V., Deußen M., Schumacher L., Roos WP., Fritz G (2020) Anticancer drug and ionizing radiation-induced DNA damage differently influences transcription activity and DDR-related stress responses of an endothelial monolayer. Molecular Cell Research, volume 1867, issue 6, 118678

Seiwert N., Heylmann D., Hasselwander S., Fahrer J. (2020) Mechanism of colorectal carcinogenesis triggered by heme iron from red meat. Biochim Biophys Acta Rev. Cancer, 26: 188334

Beyer M., Romanski A., Mustafa Al-Hassan M., Pons M., Büchler I., Vogel A., Pautz A., Sellmer A., Schneider G., Bug G., Krämer O.H. (2020) HDAC3 Activity is Essential for Human Leukemic Cell Growth and the Expression of B-catenin, MYC, and Wt1, MDPI Cancers 11,1436; doi:10.3390/cancers11101436

Nikolova T., Krämer O.H. (2020) Targeting DNA double-strand break repair for glioblastoma chemotherapy.  Science World Journal of Cancer Science and Therapy, 1(1), 1-4

Kiweler N., Wünsch D., Wirth M., Mahendrarajah N., Schneider G., Stauber R.H., Brenner W., Butter F., Krämer O.H. (2020) Histone deacetylase inhibitors dysregulate DNA repair proteins and antagonize metastasis-associated processes. Journal of Cancer Research and Clinical Oncology, doi.org/10.1007/s00432-019-03118-4