Bauer, M., M. Goldstein, M. Christmann, H. Becker, D. Heymann and B. Kaina (2011) Human monocytes are severely impaired in base and DNA double-strand break repair that renders them vulnerable to oxidative stress, Proc. Natl. Acad. Sci USA, in press

Christmann, M. and B. Kaina (2011) O6-Methylguanine-DNA methyltransferase (MGMT) in cancer protection and therapy, Buchbeitrag in press

Christmann M., B. Verbeek, W.P. Roos and B. Kaina (2011) O⁶-Methylguanine-DNA methyltransferase (MGMT) in normal tissues and tumors: Enzyme activity, promoter methylation and immunohistochemistry, Biochim. Biophys. Acta Rev. Cancer, 1816, 179-190

Christmann, M. and B. Kaina (2011) O⁶-Methylguanine-DNA methyltransferase: impact on cancer risk in response to tobacco smoke, Mutation Research, in press

Dietrich C. (2011) The AHR in the Control of Cell Cycle and Apoptosis, Buchbeitrag, in press

Kaina, B. and W.P. Roos (2011) DNA damage-induced apoptosis: from specific DNA lesions to the DNA damage response and apoptosis, Cancer Letters, invited review

Quiros S., W.P. Roos, B. Kaina (2011) Rad51 and BRCA2 – New Molecular Targets for Sensitizing Glioma Cells to Alkylating Anticancer Drugs, PLoS One, 6,27183 epub

Frank H., M. Funk, F. Oesch and K.L. Platt (2011) Synthesis, Absolute Configuration, and Bacterial Mutagenicity of the 8 Stereoisomeric Vicinal Diol Epoxides at the Terminal Benzo Ring of Carcinogenic Dibenz[a,h]anthracene, Chem. Res. Toxicol., in press

Köberle B. and A. Piee-Staffa (2011) The Molecular Basis of Cisplatin Resistance in Bladder Cancer Cells, Buchbeitrag, in press.

Hamalukic M., J. Hülsenbeck, A. Schad, S. Wirtz, B. Kaina, G. Fritz (2011) Rac1-regulated endothelial radiation response stimulates extravasation and metastasis that can be blocked by HMG-CoA reductase inhibitors, PLoS One, 6, e26413, 1-11

Berdelle N., T. Nikolova, S. Quiros, T. Efferth and B. Kaina (2011) Artesunate Induces Oxidative DNA Damage, Sustained DNA Double-Strand Breaks, and the ATM/ATR Damage Response in Cancer Cells, Mol. Cancer Ther., 10, 2224-2233

Huelsenbeck S.C., A. Rohrbeck, A. Handreck, G. Hellmich, E. Kiaei, I. Roettinger, C. Grothe, I. Just, K. Haastert-Talini (2011) C3 Peptide Promotes Axonal Regeneration and Functional Motor Recovery after Peripheral Nerve Injury, Neurotherapeutics, in press

Hülsenbeck J., C. Henninger, A. Schad, K.J. Lackner, B. Kaina and G. Fritz (2011) Inhibition of Rac1 signaling by lovastatin protects against anthracycline-induced cardiac toxicity, Cell Death Disease, 65, 1-10

Efferth, T. and B. Kaina (2011) Toxicities by herbal medicines with emphasis to traditional Chinese medicine, Current Drug Metabolism, epub

Olsen B.B., U. Fischer, T.L. Rasmussen, M. Montenarh, E. Meese, G. Fritz and O.-G. Issinger (2011) Lack of the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) is accompanied by increased CK2a’ levels, Mol Cell Biochem, in press

Cimbora-Zovko T., A. Brozovic, I. Piantanida, G. Fritz, A. Virag, B. Alic, V. Majce, M. Kocevar, S. Polanc and M. Osmak (2011) Synthesis and biological evaluation of 4-nitro-substituted 1,3-diaryltriazenes as a novel class of potent antitumor agents, Eur J Med Chem, 2971-83

Roos, W.P., E. Jöst, C. Belohlavek, G. Nagel, G. Fritz and B. Kaina (2011) Intrinsic anticancer drug resistance of malignant melanoma cells is abrogated by interferon-ß and valproic acid, Cancer Res., 71, 4150-4160

Kaina B., M. Christmann (2011) DNA-Schadensantwort und ihre pharmakologische Beeinflussung, Onkologe, 503-512

Reichert S., C. Rödel, J. Mirsch, P.N. Harter, M.T. Tomicic, M. Mittelbronn, B. Kaina and F. Rödel (2011) Survivin inhibition and DNA double-strand break repair: A molecular mechanism to overcome radioresistance in glioblastoma, Radiotherapy and Oncology, 101, 51-58

Helbig L., J. Damrot, J. Hülsenbek, B. Köberle, A. Brozovic, M. Osmak, Z. Fiket, B. Kaina and G. Fritz (2011) Late Activation of Stress-activated Protein Kinases/c-Jun N-terminal Kinases Triggered by Cisplatin-induced DNA Damage in Repair-defective Cells, J. Biol. Chem., 286, 12991-13001

Sciuscio, D., A.C. Diserens, K. van Dommelen, D. Martinet, G. Jones, R.C. Janzer, C. Pollo, M.F. Hamou, B. Kaina, R. Stupp, M. Levivier and M.E. Hegi (2011) Extent and patterns of MGMT promoter methylation in glioblastoma and respective derived spheres, Clin. Cancer Res., 17, 255-66

Tomicic, M.T., P. Reischmann, B. Rasenberger, R. Meise, B. Kaina and M. Christmann (2011) Delayed c-Fos activation in human cells triggers XPF induction and an adaptive response to UVC-induced DNA damage and cytotoxicity, Cell Mol. Life Sci., 68, 1785-98

Wiese C., T. Nikolova, I. Zahanich, S. Sulzbacher, J. Fuchs, S. Yamanaka, E. Graf, U. Ravens, K.R. Boheler, A.M. Wobus (2011) Differentiation induction of mouse embryonic stem cells into sinus node-like cells by suramin, Int. J. Cardiol., 147, 95-111

Albers A.E., C. Chen, B. Köberle, X. Qian, J.P. Klussmann, B. Wollenberg, A.M. Kaufmann (2011) Stem cells in squamous head and neck cancer, Critical Reviews Oncology/ Hematology, in press

Nilsson S., J. Hülsenbeck and G. Fritz (2011) Mevalonate pathway inhibitors affect anticancer drug-induced cell death and DNA damage response of human sarcoma cells, Cancer Letters, 304, 60-69

Fritz G., C. Henninger and J. Hülsenbeck (2011) Potential use of HMG-CoA reductase inhibitors (statins) as radioprotective agents, British Medical Bulletin, in press

Dietrich C. (2011) Dioxin, persistentes Risiko: Wirkungen und Mechanismen von Dioxin, Labor&More 1.11, 33-35

M. Küppers, D. Faust, B. Linz and C. Dietrich (2011) Regulation of ERK1/2 activity upon contact inhibition in fibroblasts, Biochem. Biophys. Res. Comm., 406, 483-487

Usanova, S., A. Piee-Staffa, U. Sied, J. Thomale, A. Schneider, B. Kaina and B. Köberle (2010) Cisplatin sensitivity of testis tumor cells is due to deficiency in interstrand-crosslink repair and low ERCC1-XPF expression, Mol. Cancer, 9, 248-259

Platt K.L., R. Edenharder, S. Aderhold, E. Muckel and H. Glatt (2010) Fruits and vegetables protect against the genotoxicity of heterocyclic aramatic amines activated by human xenobiotic-metabolizing enzymes expressed in immortal mammalian cells, Mutat. Res., 703, 90-98

Wortge S., L. Eshkind, N. Cabezas-Wallscheid, B. Lakaye, J. Kim, R. Heck, Y. Abassi, M. Diken, R. Sprengel and E. Bockamp (2010) Tetracycline-controlled transgene activation using the ROSA26-iM2-GFP knock-in mouse strain permits GFP monitoring of DOX-regulated transgene-expression, BMC Dev Biol., 10,95

Wirtz S., G. Nagel, L. Eshkind, M. Neurath, LD. Samson and B. Kaina (2010) Both base excision repair and O⁶-methylguanine-DNA methyltransferase protect against methylation-induced colon carcinogenesis, Carcinogenesis, 31, 2111-2117

Kaina B., G. Margison and M. Christmann (2010) Targeting O⁶-methylguanine-DNA methyltransferase with specific inhibitors as a strategy in cancer therapy, Cell. Mol. Life Sci. 67, 3663-81

Köberle B., M.T. Tomicic, S. Usanova and B. Kaina (2010) Cisplatin resistance: Preclinical findings and clinical implications, Biochim Biophys Acta, 1806, 172-182

Chen C., B. Köberle, A. Kaufmann and A. Albers (2010) A Quest for Initiating Cells of Head and Neck Cancer and their Treatment, Cancers, 2, 1528-1554

Nikolova T., M. Ensminger, M. Löbrich and B. Kaina (2010) Homologous recombination protects mammalian cells from replication-associated DNA double-strand breaks arising in response to methyl methanesulfonate, DNA Repair, 9, 1050-63

Lemée F., V. Bergoglio, A. Fernandez-Vidal, A. Machado-Silva, M.J. Pillaire, A. Bieth, C. Gentil, L. Baker, A.L. Martin, C. Leduc, E. Lam, E. Magdaleine, T. Filleron, N. Oumouhou, B. Kaina, M. Seki, F. Grimal, M. Lacroix-Triki, A. Thompson, H. Roche, J.C. Bourdon, R. Wood, J.S. Hoffmann and C. Cazaux (2010) DNA Polymerase 0 up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability, Proc. Natl. Acad. Sci. USA, 107, 13390-5

Küppers M., C. Ittrich, D. Faust and C. Dietrich (2010) The Transcriptional Programme of Contact-Inhibition, J. Cell. Biochem., 110, 1234-1243

Jacob R., N. Shafiei, G. Nagel, HJ. Welkoborsky, W. Mann and B. Kaina (2010) MGMT Activity in Mucosal Epithelium and Squamous Cell Carcinoma of the Head and Neck, Anticancer Res., 30, 2561-6

Jöst E., WP. Roos, B. Kaina and H. Schmidberger (2010) Response of pancreatic cancer cells treated with interferon-a or ß and co-exposed to ionising radiation, Int. J. Radiat. Biol., 86, 732-41

Hamalukic M., J. Hülsenbeck, A. Schad, S. Wirtz, B. Kaina and G. Fritz (2010) Radiotherapy augments tumor cell extravasation and metastazation that can be blocked by lipid-lowering drugs, PLoS One, am 26.9., accepted

Usanova S, A. Piée-Staffa, U. Sied, J. Thomale, A. Schneider, B. Kaina and B. Köberle (2010) Cisplatin sensitivity of testis tumour cells is due to deficiency in interstrand-crosslink repair and low ERCC1-XPF expression, Mol Cancer, 9, 248

Eich M., WP. Roos, GL. Dianov, M. Digweed and B. Kaina (2010) Nijmegen breakage syndrome (NBN) protein causes resistance to methylating anticancer drugs like temozolomide., Mol Pharmacol., 78, 943-51

Christmann M., M., Tomicic, D. Aasland, N. Berdelle and B. Kaina (2010) Three prime exonuclease I (TREX1) is Fos/Ap-1 regulated by genotoxic stress and protects against ultraviolet light and benzo(a)pyrene-induced DNA damage, Nucleic Acids Res., 38, 6418-32

Dietrich C. and B. Kaina (2010) The aryl hydrocarbon receptor (AhR) in the regulation of cell-cell contact and tumor growth, Carcinogenesis, 31, 1319-28

Christmann M., G. Nagel, S. Horn, U. Krahn, D. Wiewrodt, C. Sommer and B. Kaina (2010) MGMT activity, promoter methylation and immunohistochemistry of pre-treatment and recurrent malignant gliomas: a comparative study on astrocytomas and glioblastomas, Int. J. Cancer, 127, 2106-18

Hoehme S., M. Brulport, A. Bauer, E. Bedawy, W. Schormann, M. Hermes, V. Puppe, R. Gebhardt, S. Zellmer, M. Schwarz, E. Bockamp, T. Timmel, J.G. Hengstler and D. Drasdo (2010) Prediction and validation of cell alignment along microvessels as order principle to restore tissue architecture in liver regeneration, Proc. Natl. Acad. Sci. USA, 107, 10371-6

Cimbora-Zovko T., G. Fritz, N. Mikac and M. Osmak (2010) Downregulation of RhoB GTPase confers resistance to cisplatin in human laryngeal carcinoma cells, Cancer Lett., 295, 182-90

Efferth T. and B. Kaina (2010) Toxicity of antimalarial artemisinin and its derivatives, Crit. Rev. in Toxicol., 40, 405-21

Dietrich C., C. Weiss, E. Bockamp, C. Brisken, T. Roskams, R. Morris, B. Oesch-Bartlomowicz and F. Oesch (2010) Stem cells in chemical carcinogenesis, Arch Toxicol, 84, 245-51

Köberle B., C. Ditz, I. Kausch, B. Wollenberg, R. Ferris and A. Albers (2010) Metastases of squamous cell carcinoma of the head and neck show increased levels of nucleotide excision repair protein XPF in vivo that correlate with increased chemoresistance ex vivo, Internat. J. Oncol., 36, 1277-84

Quiros S., WP. Roos and B. Kaina (2010) Processing of O⁶-methylguanine into DNA double-strand breaks requires two rounds of replication whereas apoptosis is also induced in subsequent cell cycles, Cell Cycle, 9, 168-78

Kaina B., WP. Roos and M. Christmann (2010) DNA damage response and the balance between cell survival and cell death, in: Z. Siddik (edt.) Checkpoint Response in Cancer Therapy, The Humana Press (Springer Science), pp. 95-108

Köberle B., W. Brenner, A. Albers, S. Usanova, J.W. Thüroff and B. Kaina (2010) ERCC1 and XPF expression in human testicular germ cell tumors, Oncol. Rep., 23, 223-7

Tomicic M., M. Christmann and B. Kaina (2010) Topotecan triggers apoptose in p53- deficient cells by forcing degradation of X-Chromosome-Linked Inhibitor of Apoptosis and surviving thereby activating caspase-3-mediated Bid cleavage, J. Pharmacol. Exp. Ther., 332, 316-25

Wiese C., T. Nikolova, I. Zahanich, S. Sulzbacher, J. Fuchs, S. Yamanaka, E. Graf, U. Ravens, K. Boehler and A. Wobus (2009) Differentiation induction of mouse embryonic stem cells into sinus node-like cells by suramin, Int. J. Cardiol, in press

Fritz G., OG. Issinger, BB. Olsen (2009) Selectivity analysis of protein kinase CK2 inhibitors DMAT, TBB and resorufin in cisplatin-induced stress responses. Int. J. Oncol., 35, 1151-1157  

Fritz G. (2009) Targeting the mevalonate pathway for improved anticancer thereapy, Curr Cancer Drug Targets, 9, 626-38

Oesch-Bartlomowicz B., C. Weiss, C. Dietrich and F. Oesch (2009) Circadian rythms and chemical carcinogenesis: Potential link. An overview, Mutat. Res., 680, 83-86

Bockamp E., C. Antunes, S. Liebner, S. Schmitt, N. Cabezas-Wallscheid, R. Heck, S. Ohngemach, B. Oesch-Bartlomowicz, C. Rickert, MJ. Sanchez, J. Hengstler, B. Kaina, A. Wilson, A. Trumpp and L. Eshkind (2009) In vivo fate mapping with SCL regulatory elements identifies progenitors for primitive and definitive hematopoiesis in mice, Mech. Dev. 126, 863-72

Roos WP., A. Tsaalbi-Shtylik, R. Tsaryk, F. Güvercin, N. de Wind and B. Kaina (2009) The translesion polymerase Rev3L in the tolerance of alkylating anticancer drugs, Mol. Pharmacol., 76, 927-34

Brozovic A., J. Damrot, R. Tsaryk, L. Helbig, T. Nikolova, C. Hartig, M. Osmak, W. P. Roos, B. Kaina and G. Fritz (2009) Cisplatin sensitivity is related to late DNA damage processing and checkpoint control rather than to the early DNA damage response, Mutat. Res., 670, 32-41

Finkenwirth P., U. Spelmeyer, G. Hommel, DM. Rose, D. Jung, B. Roßbach, O. Mayer-Popken, KL. Platt, F. Oesch, A. Muttray (2009) Effects of an acute exposure to toluene on the DNA repair activity of the human 8-oxoguanine DNA glycosylase 1 (hOGG1) in healthy subjects, Arch Toxicol, 83, 777-784

Nikolova T., M. Christmann and B. Kaina (2009) FEN1 is overexpressed in testis, lung and brain tumors, Anticancer Res., 29, 2453-9

Ostrau C., J. Hülsenbeck, M. Herzog, A. Schad, M. Torzewski, KJ. Lackner and G. Fritz (2009) Lovastatin attenuates ionizing radiation-induced normal tissue damage in vivo. Radiother. Oncol., 92, 492-9

Schreck I., D. Chudziak, S. Schneider, A. Seidel, KL. Platt, F. Oesch, C. Weiss (2009) Influence of aryl hydrocarbon- (Ah) receptor and genotoxins on DNA repair gene expression and cell survival of mouse hepatoma cells, Toxicology, 259, 91-96

Stebel A., C. Brachetti, M. Kunkel, M. Schmidt, G. Fritz (2009) Progression of breast tumors is accompanied by a decrease in expression of the Rho guanine exchange factor Tiam1, Oncol. Rep.,, 21, 217-222

Damrot J., L. Helbig, WP. Roos, S.Q. Barrantes, B. Kaina, G. Fritz (2009) DNA replication arrest in response to genotoxic stress provokes early activation of stress-activated protein kinases (SAPK/JNK), J. Mol. Biol., 385, 1409-1421

Batista LF, WP. Roos, B. Kaina and CF. Menck (2009) p53 mutant human glioma cells are sensitive to UV-C-induced apoptosis due to impaired cyclobutane pyrimidine dimer removal, Mol. Cancer Res., 7, 237-46

Efferth T. and B. Kaina (2009) Pharmacogenomics of Biotic and Abiotic Natural Products Derived from Traditional Chinese Medicine for Cancer Therapy, Novel Therapeutic Agents from Plants, Science Publishers, Enfield, Jersey Pymouth, 379-396

Naumann SC, WP. Roos, E. Jöst, C. Belohlavek, V. Lennerz, CW. Schmidt, M. Christmann and B. Kaina (2009) Temozolomide- and fotemustine-induced apoptosis in human malignant melanoma cells: response related to MGMT, MMR, DSBs, and p53, Br. J. Cancer, 100, 322-33

Roos WP., T. Nikolova, S. Quiros, SC. Naumann, O. Kiedron, MZ. Zdzienicka and B. Kaina (2009) Brca2/Xrcc2 dependent HR, but not NHEJ, is required for protection against O-6-methylguanine triggered apoptosis, DSBs and chromosomal aberrations by a process leading to SCEs, DNA Repair, 8, 72-86

Batista LF., B. Kaina, R. Meneghini, CF. Menck (2009) How DNA lesions are turned into powerful killing structures: Insights from UV-induced apoptosis, Mutat. Res., 681, 197-208

Oesch-Bartlomowicz B. and F. Oesch (2009) Role of camp in mediating AHR signalling, Biochem. Pharmacol., 627-641

Landsiegel R., MD. Kapp, M. Schulz, K. Wiench and F. Oesch (2009) Genotoxicity investigations on nanomaterials: Methods, preparation and characterization of test material, potential artefacts and liminations-Many questions, some answers, Mutat. Res., 681, 241-258

Wilson A., E. Laurenti, GM. Oser, RC. van der Wath, W. Blanco-Bose, S. Offner, C. Dunant, E. Bockamp, L. Eshkind, P. Liò, HR. MacDonald and A. Trumpp (2008) Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair, Cell, 13, 1118-1129

Brozovi´c A., D. Majhen, V. Roje, N. Mikack, S. Jakopec, G. Fritz, M. Osmak, A. Ambriovi´c-Ristov (2008) a_vß₃ Integrin-mediated drug resistance in human laryngeal carcinoma cells is caused by glutathione-dependent elimination of drug-induced reactive oxidative species, Mol. Pharmacol., 74, 298-306

Huber S., J. Schrader, G. Fritz, K. Presser, S. Schmitt, A. Waisman, S. Lüth, M. Blessing, J. Herkel, C. Schramm (2008) P38 MAP kinase signaling is required for the conversion of CD4+CD25- T cells into iTreg, PloS one, 10, e3302

Bockamp E., R. Sprengel, L. Eshkind, T. Lehmann, JM. Braun, F. Emmrich and JG. Hengstler (2008) Conditional transgenic mouse models; from the basics to genome-wide sets of knockouts and current studies of tissue regeneration, Regen Med., 3, 217-35

Sprengel R., L. Eshkind, J. Hengstler, E. Bockamp (2008) Improved models for animal research. (Aths. Conn, P. Michael; Eds. Conn, P. Michael), Humana Press, Totowa, NJ

Christmann M., M. Tomicic, C. Gestrich, WP. Roos, V. Bohr and B. Kaina (2008) WRN protects against topo I but not topo II inhibitors by preventing DNA break formation, DNA repair, 7, 1999-2009

Li PC, E. Lam, WP. Roos, B. Kaina and T. Efferth (2008) Artesunate derived from Traditional Chinese medicine induces DNA damage and repair, Cancer Res., 68, 4347-51

Staszewski O., T. Nikolova and B. Kaina (2008) Kinetics of g-H2AX focus formation upon treatment with UV-C light and alkylating agents, Env. Mol. Mutagen, 49, 734-40

Goldstein M., WP. Roos and B. Kaina (2008) Apoptotic death induced by mafosfamide in human lymphoblastoid cells: contribution of DNA replication, transcription inhibition and p53/Chk signalling, Toxicol. Applied Pharmacol. 15, 229, 20-32

Wiewrodt D., G. Nagel, N. Dreimüller, T. Hundsberger, A. Perneczky and B. Kaina  (2008) MGMT in primary and recurrent human glioblastomas after radiation and chemotherapy and comparison with p53 status and clinical outcome, Int. J. Cancer, 122, 1391-1399

Konkimalla VB., B. Kaina and T. Efferth (2008) Role of transporter genes in cisplatin resistance, In Vivo, 22, 279-283

Konkimalla VS., G. Wang, B. Kaina and T. Efferth (2008) Microarray-based expression of DNA repair genes does not correlate with growth inhibition of cancer cells by natural products derived from traditional Chinese medicine, Cancer Genomics Proteomics, 5, 79-84

Strik H., JH. Buhk, A. Wrede, A. Hoffmann, C. Bock, M.  Christmann and B. Kaina  (2008) Rechallenge with temozolomide with different scheduling is effective in recurrent malignant gliomas, Mol. Medicine Rep., 1, 863-867

Voelter V., AC. Diserens, A. Moulin, G. Nagel, B. Kaina, P. Yan, E. Migliavacca, D. Rimoldi, MF. Hamou, S. Leyvraz and E. Monika Hegi (2008) Infrequent promoter methylation of the MGMT gene and response to alkylating agent chemotherapy in uveal melanoma patients, Int. J. Cancer, 1, 123, 1215-8

Efferth T., S. Kahl, K. Paulus, M. Adams, R. Rauh, H. Boechzelt, X. Hao, B. Kaina and R. Bauer (2008) Phytochemistry and Pharmacogenomics of Natural Products derived from traditional Chinese Medicine and Chinese Materia Medica with activity against tumor cells, Mol. Cancer Ther., 7, 152-161

Platt KL., S. Aderhold, K. Kulpe, M. Fickler (2008) Unexpected DNA damage caused by polyclic aromatic hydrocarbons under standard laboratory conditions, Mutat. Res., 650, 96-103

Platt KL., S. Grupe and M. Fickler (2008) The 3,4-oxide is responsible for the DNA Binding of benzo[ghi]perylene, a polycyclic aromatic hydrocarbon without a “classic” bay-region, Chemico-Biological Interactions, 176, 179-187

Weiss C., D. Faust, I. Schreck, A. Ruff, T. Farwerck, A. Melenberg, S. Schneider, B. Oesch-Bartlomowicz, J. Zatloukalova, J. Vondrácek, F. Oesch and C. Dietrich (2008) TCDD deregulates contact inhibition in rat liver oval cells via Ah receptor, JunD and cyclin A, Oncogene, 27, 2198-207

Oesch F., C. Dietrich, H. Naegeli, M. Schwarz, G. van der Horst, U. Zanger, B. Oesch and C. Weiss (2008) New aspects on mechanisms of chemical carcinogenesis: emphasis on species and gender/sex differences and development/aging determinants, Arch. Toxicol. 82, 875-880

Köberle B., V. Roginskaya, K. Zima, J. Masters and R. Wood (2008) Elevation of XPA Protein Level in Testis Tumor Cells Without Increasing Resistance to Cisplatin or UV Radiation, Mol. Carcinog., 47, 580-586

Andrysik Z., J. Vondracek, M. Machala, P. Krcmar, L. Svihalkova-Sindlerova, A. Kranz, C. Weiss, D. Faust, A. Kozubik and C. Dietrich (2007) The aryl hydrocarbon receptor-dependent deregulation of cell cycle control induced by polycyclic aromatic hydrocarbons in rat liver epithelial cells, Mutat. Res. 615:87-97

Batista LFZ, WP. Roos, B. Kaina and CFM Menck (2007) UV-induced lesions trigger apoptosis in p53-mutated glioma cells, Naunyn Schmiedebergs Arch. Pharmacol., 403:82

Cabezas-Wallscheid N., L. Eshkind, C. Antunes, S. Schmitt, R. Heck, G. Nagel, S. Ohngemach, B. Kaina and E. Bockamp (2007) Protection of haematopoietic stem cells (HSC) against high-dose chemotherapy by virtue of the O6-methylguanine- DNA-methyltransferase (MGMT) repair enzyme, Naunyn Schmiedebergs Arch. Pharmacol., 375: 85

Carmo H., M. Brulport, M. Hermes, F. Oesch, D. de Boer, F. Remiao, F. Carvalho, MR. Schön, N. Krebsfänger, J. Doehmer, MD. Bastos, JG. Hengstler (2007) CYP2D6 increases toxicity of the designer drug 4-methylthioamphetamine (4-MTA), Toxicology, 229:236-244

Christmann M., MT. Tomicic-Christmann, J. Origer and B. Kaina (2007) A role for c-Fos in the regulation of DNA repair and protection against ultraviolet light-induced cell death, Naunyn Schmiedebergs Arch. Pharmacol., 375:84

Damrot J., B. Kaina and G. Fritz (2007) Involvement of DNA repair factors in late activation of stress kinases (SAPK/JNK) by DNA cross-linking agents, Naunyn Schmiedebergs Arch. Pharmacol., 375:84

Faust D., I. Schreck, F. Oesch, C. Weiss and C. Dietrich (2007) Identification of the JunD-Interaction partner in AhR-dependent regulation of cyclin A expression, Naunyn Schmiedebergs Arch. Pharmacol., 375:88

Fritz G., T. Brachetti and B. Kaina (2007) Genotoxin-induced DNA replication blockage is involved in the regulation of stress kinases (SAPK/JNK), Naunyn Schmiedebergs Arch. Pharmacol., 375:91

Gestrich C., M. Christmann and B. Kaina (2007) Involvement of WRN helicase in the resistance too topoisomerase I and II inhibitors, Naunyn Schmiedebergs Arch. Pharmacol., 375:85

Goldstein M., WP. Roos and B. Kaina (2007) Mafosfamide induced apoptosis in human lymphoblastoid cells: Role of DNA replication, RNA transcription, p53 and Chk1/Chk2, Naunyn Schmiedebergs Arch. Pharmacol., 402:82

Hengstler JG., M. Brulport, M. Hermes, A. Bauer, W. Schormann, D. Drasdo and E. Bockamp (2007) Mathematical modeling of liver regeneration after intoxication with CC14. Naunyn Schmiedebergs Arch. Pharmacol., 375:85

Hülsenbeck J., S. Dreger, R. Gerhard, G. Fritz, I. Just and H. Genth (2007) Up-regulation of the immediate early gene product RhoB by exoenzyme C3 from Clostridium limosum and toxin B from Clostridium difficile, Biochemistry, 46:4932-4931

Jöst E., WP. Roos, H. Schmidberger and B. Kaina (2007) IFN induced cell kill in pancreatic cancer cell lines on its own and sensitizes these cells in combination with ionizing radiation, Naunyn Schmiedebergs Arch. Pharmacol., 417:84

Köberle B., H. Dürk, S. Schmitt, RD. Wood and B. Kaina (2007) Low levels of XPA protein do not account for the sensitivity of testis tumor cells to cisplatin and UV irradiation, Naunyn Schmiedebergs Arch. Pharmacol., 375:84

Kunkel M., M. Moergel, M. Stockinger, JH. Jeong, G. Fritz, HA. Lehr and TL. Whiteside (2007) Overexpression of GLUT-1 is associated with resistance to radiotherapy and adverse prognosis in squamous cell carcinoma of the oral cavity, Oral Oncol, 43:76-803

Meyer HJ., S. Dreger, G. Fritz, K. Aktories, G. Schmidt and H. Genth (2007) Up-regulation of RhoB by cytotoxic necrotizing factor 1 from Escherichia coli, Naunyn Schmiedebergs Arch. Pharmacol., 375:38

Nagel G., D. Wiewrodt, A. Perneczky, C. Sommer, M. Christmann and B. Kaina (2007) Comparing MGMT activity and promoter methylation in glioblastomas as predictive tools, Naunyn Schmiedebergs Arch. Pharmacol., 375:85

Naumann SC., WP. Roos, M. Christmann and B. Kaina (2007) Role of E2F-1/p73 apoptosis signaling in fotemustine treated malignant melanoma cells, Naunyn Schmiedebergs Arch. Pharmacol., 401:82

Oesch F., E. Fabian, B. Oesch-Bartlomowicz, C. Werner and R. Landsiegel (2007) Drug metabolizing enzymes in the skin of man, rat and pig, Drug Metab. Rev., 39:659-698

Oesch-Bartlomowicz B. and F. Oesch (2007) Mechanisms of toxication and detoxication which challenge drug candidates and drugs, Beitrag in: Comprehensive Medical Medicine, Herausgeber: D. Triggle and J. Taylor, Elsevier Philadelphia, S. 193-214

Randel G., M. Balzer, S. Grupe, S. Drusch, B. Kaina, KL. Platt and K. Schwarz (2007) Degradation of heterocyclic aromatic amines in oil under storage and frying conditions and reduction of their mutagenic potential, Food Chem. Toxicol., 45:2245-2253

Schulz F., J. Hülsenbeck, R. Gerhard, A. Kotlyarov, G. Fritz, I. Just and H. Genth (2007) P38 MAP kinase and the cytotoxic effect of clostridium difficile toxin B, Naunyn Schmiedebergs Arch. Pharmacol., 375:38

Tomicic-Christmann M., M. Christmann and B. Kaina (2007) Topotecan-driven degradation of topoisomerase I is p53-dependent affecting cell survival: Role of gamma-H2AX-phosphorylation, caspase activation and survival, Naunyn Schmiedebergs Arch. Pharmacol., 375:85

Wiewrodt D., G. Nagel, N. Dreimüller, T. Hundsberger, A. Perneczky and B. Kaina (2007) MGMT in primary and recurrent human glioblastomas after radiation and chemotherapy and comparison with p53 status and clinical outcome, Int. J. Cancer, 122:1391-1399.

Rebillard A., X. Tekpli, O. Meurette, O. Sergent, G. LeMoigne-Muller, L. Vernhet, M. Gorria, M. Chevanne, M. Christmann, B. Kaina, L. Counillon, E. Gulbins, D. Lagadic-Gossmann and MT. Dimanche-Boitrel (2007) Cisplatin-Induced Apoptosis Involves Membrane Fluidification via Inhibition of NHE1 in Human Colon Cancer Cells, Cancer Res., 67, 7865-7874

Batista LFZ., WP. Roos, M. Christmann, CFM. Menck and B. Kaina (2007) Differential sensitivity of malignant glioma cells to methylating and chloroethylating anticancer drugs: p53 determines the switch by regulating xpc, ddb2 and DNA double-strand breaks, Cancer Res., 67, 11886-11895

Kaina B. (2007) DNA damage- induced apoptosis, Encyclopedia of Cancer, in press

Christmann M., WP. Roos and B. Kaina (2007), DNA Methylation Damage: Formation, Repair and Biological Consequences in: Chromosomal Alterations: Methods, Results and Importance in Human Health, Eds. Günter Obe and Vijayalaxmi, Springer Verlag Berlin Heidelberg, S.99-122

Rauh R., S. Kahl, H. Boechzelt, R. Bauer, B. Kaina and T. Efferth (2007) Molecular Biology of cantharidin in cancer cells, Chinese Medicine, 2, 1-9

Efferth T., PC. Li, VS. Konkimalla and B. Kaina (2007) From traditional Chinese medicine to rational cancer therapy, Trends Mol. Medicine, 13, 353-361

Kaina B., M. Christmann, S. Naumann and WP. Roos (2007) MGMT: key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents, DNA Repair, 6, 1079-1099

Bockamp E., C. Christel, D. Hameyer, A. Khobata, M. Maringer, M. Reis, R. Heck, N. Cabazas-Wallscheid, B. Epe, B. Oesch-Bartolowicz, B. Kaina, S. Schmitt and L. Eshkind (2007) Generation and characterization of tTS-H4: a novel transcriptional repressor that is compatible with the reverse tetracycline-controlled TET-ON system, J. Gene Med., 9, 308-318

Hameyer D., A. Loonstra, L. Eshkind, S. Schmitt, C. Antunes, A. Groen, E. Bindels, J. Jonkers, P. Krimpenfort, R. Meuwissen, L. Rijswijk, A. Bex, A. Berns, E. Bockamp (2007) Toxicity of ligand-dependent Cre recombinases and generation of a conditional Cre deleter mouse allowing mosaic recombination in peripheral tissues, Physiol Genomics. 31, 32-4

Weiss C., D. Faust, I. Schreck, A. Ruff, T. Farwerck, A. Melenberg, S. Schneider, B. Oesch-Bartlomowicz, J. Zatloukalov, J. Vondro´cek, F. Oesch, C. Dietrich (2007) TCDD deregulates contact inhibition in rat liver oval cells via Ah receptor, JunD and cyclin A. Oncogene, 1-10

Koch D., T. Hundsberger, S. Boor and B. Kaina (2007) Local intracerebral administration of O⁶-benzylguanine combined with systemic chemotherapy with temozolomide of a patient suffering from a recurrent glioblastoma, J. Neurooncology, 82, 85-89

Efferth T. and B. Kaina (2007) Chemical Carcinogenesis: Genotoxic and Non-genotoxic Mechanisms. In: H. Greim and R. Snyder (edts), Introduction to Toxicology and Risk Assessment, John Wiley & Sons Ltd., S.151-179

Christmann M., M. Tomicic, D. Aasland and B. Kaina (2007) A role for UV-light-induced c-Fos: stimulation of nucleotide excision repair and protection against sustained JNK activation and apoptosis, Carcinogenesis, 28, 183-190

Briegert M. and B. Kaina (2007) Human monocytes, but not dendritic cells derived from them, are defective in base excision repair and hypersensitive to methylating agents, Cancer Res., 67, 26-31

Briegert M., A. Enk and B. Kaina (2007) Change in expression of MGMT during maturation of monocytes into dendritic cells, DNA Repair, 6, 1255-1263

Roos WP., M. Christmann, ST. Fraser and B. Kaina (2007) Mouse embryonic stem cells are hypersensitive to apoptosis triggered by the DNA damage O⁶-methylguanine due to high E2F1 regulated mismatch repair, Cell Death Diff., 14, 1422-1432

Roos WP., L. Batista, S. Naumann, W. Wick, M. Weller, C. Menck and B. Kaina (2007) Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O⁶-methylguanine, Oncogene, 26, 186-197

Roos WP., LFZ Batista, SC Naumann, O. Kiedron, M. Christmann and B. Kaina (2007) Mechanism of methylating agent induced cell death: Roles of MGMT, mismatch repair and DNA double-strand break repair, Naunyn Schmiedebergs Arch. Pharmacol, 404:82

Christmann M., G. Fritz and B. Kaina (2007) Induction of DNA repair genes in mammalian cells in response to genotoxic stress, in Lankenau, D. (Edt.)Genome Intergrity: Facets and Perspectives, Springer Verlag Berlin-Heidelberg, 383-398

Brahler E., H. Muehlan, C. Albani and S. Schmidt (2007) Teststatistische Prüfung und Nominierung der deutschen Versionen des EUROHIS-QOL Lebensquallität-Index und des WHO-5 Wohlbefinden-Index, Diagnostica, 53, 83-96

Holthöfer B., L. Eshkind, R. Windoffer and RE. Leube (2007) Generation of conditional tissue-specific desmoglein 2 null mutant mice, Eur. J. Cell Biol., 86S1, 37

Simeoni MC., S. Schmidt, H. Muehlan, D. Debensason and M. Bullinger (2007) Field testing of a European quality of life instrument for children and adolescents with chronic conditions: the 37-item DISABKIDS Chronic Generic Module, Qual. Life Res., 16, 881-893

Steiner E., K. Plata, C. Interthal, M. Schmidt, A. Faldum, JG. Henglster, N. Sakuragi, H. Watari, R. Yamamoto and H. Koelbl (2007) Diabetes mellitus is a multivariante independent prognostic factor in endometrial carcinoma; a clinicopathologic study on 313 patients, Eur. J. Gynaecol. Oncol., 28, 95-7

Steiner E., K. Pollow, D. Hasenclever, W. Schormann, M. Hermes, M. Schmidt, A. Puhl, M. Brulport, A. Bauer and H. Koelbl (2007) Role of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor type 1 (PAI-1) for prognosis in endometrial cancer, Gnyecol. Oncol., 108, 569-76

Carmo H., M. Brulport, M. Hermes, F. Oesch, R. Silva, LM. Ferreira, PS. Branco, DD. Boer, F. Remiao, F. Carvalho, MR. Schön, N. Krebsfänger, J. Doehmer, MD. Bastos and JG. Hengstler (2006) Influence of CYP2D6 polymoriphism on 3,4-methylenedioxymethamphetamine (Ecstasy) cytotoxicity, Pharmacogenet Genomics, 789-799

Cummings M., K. Higginbottom, CJ. McGurk, OG. Wong, B. Köberle, RT. Oliver, JR. Masters (2006) XPA versus ERCC1 as chemosensitising agents to cisplatin and mitomycin C in prostate cancer cells: role of ERCC1 in homologous recombination repair, Biochem. Pharmacol., 72:166-75

Hausherr K., IB. Schiffer, S. Gebhard, A. Banic, B. Tanner, H. Kölbl, E. Thoenes, T. Beckers, C. Spangenberg, D. Prawitt, T. Trost, B. Zabel, F. Oesch, M. Hermes and JG. Hengstler (2006) Dephosphorylation of p-ERK-1/2 in relation to tumor remission after HER-2 and Raf1 blocking therapy in a conditional mouse model, Mol. Carcinog., 45:302-308

McGurk CJ., M. Cummings, B. Köberle, JA. Hartley, RT. Oliver and JR. Masters (2006) Regualtion of DNA repair gene expression in human cancer cell lines, J. Cell Biochem., 97:1121-36

Schulte-Hermann R., GN. Wogan, C. Berry, NA. Brown, A. Czeizel, E. Giavini, LB. Holmes, R. Kroes, H. Nau, D. Neubert, F. Oesch, T. Ott, O. Pelkonen, E. Robert-Gnasia and FM. Sullivan (2006) Analysis of reproductive toxicity and classification of glufosinate ammonium, Regul. Toxicol. Pharmaco.l, 44:1-76

Spangenberg C., EU. Lausch, TM. Trost, D. Prawitt, A. May, R. Keppler, SA. Fees, D. Reutzel, C. Bell, S. Schmitt, IB. Schiffer, A. Weber, W. Brenner, M. Hermes, U. Sahin, O. Tureci, H. Kölbl, JG. Hengstler and BU. Zabel (2006) ERBB2-mediated transcriptional up-regulation of the alpha5beta1 integrin fibronectin receptor promotes tumor cell survival under adverse conditions, Cancer Res,, 66:3715-3725

Tsaryk R., K. Fabian, J. Thacker and B. Kaina (2006) XRCC2 deficiency sensitizes cells to apoptosis by MNNG and the alkylating anticancer drugs temozolomide, fotemustine and mafosfamide, Cancer Lett., 239:305-313

Vodicka P., M. Koskinen, A. Naccarati, B. Oesch-Bartlomowicz, L. Vodickova, K. Hemminki and F. Oesch (2006) Styrene metabolism, genotoxicity and potential carcinogenicity, Drug Metab. Rev., 38:805-53

Kaina B. and WP. Roos (2006) Apoptosis induced by DNA-damaging agents. Beitrag in: Apoptosis and Cancer Therapy – Frim Cutting-edge Science to Novel Therapeutic Concepts. Herausgeber: K.M. Debatin and S. Fulda, Wiley-VHC Weinheim, S. 799-821

Köberle B., V. Roginskaya and RD. Wood (2006) XPA protein as a limiting factor for nucleotide excision repair and UV sensitivity in human cells, DNA Repair (Amst), 5:641-8

Roos WP. and B. Kaina (2006) DNA damage-induced cell death by apoptosis, Trends Mol. Medicine, 12, 440-450

Christmann M., M. Tomicic, J. Origer, D. Aasland and B. Kaina (2006) c-Fos is required for excision repair of UV-light induced DNA lesions by triggering the resynthesis of XPF, Nucleic Acids Res., 34, 6530-6539

Christmann M., G. Fritz and B. Kaina (2006) Induction of DNA repair genes in mammalian cells in response to genotoxic stress, in Lankenau, D., Genome Dynamics and Stability, Springer Verlag Berlin-Heidelberg, online available

Bockamp E., C. Antunes, M. Maringer, R. Heck, K. Presser, S. Beilke, S. Ohngemach, R. Alt, M. Cross, R. Sprengel, U. Hartwig, B. Kaina, S. Schmitt, L. Eshkind (2006) Tetracycline-controlled transgenic targeting from the SCL locus directs conditional expression to erythrocytes, megakaryocytes, granulocytes and c-kit expressing lineage negative hematopoietic cells, Blood, 108, 1533-1541

Hermisson M. Klumpp, W. Wick, J. Wischhusen, G. Nagel, WP. Roos, B. Kaina and M. Weller (2006) O⁶methylguanine-DNA methyltransferase and p53 status predict temozolomide sensitivity in human malignant glioma cells, J. Neurochem., 96, 766-776

Damrot J., T. Nübel, B. Epe, WP. Roos, B. Kaina and G. Fritz (2006) Lovastatin protects human endothelial cells from the genotoxic and cytotoxic effects of the anticancer drugs doxorubicin and etoposide, Br. J. Cancer, 149, 988-997

Kaina B. and G. Fritz (2006) DNA Damaging Agents. In: Ganten (edt), Encyclopedic Reference of Genomic and Proteomics in Molecular Medicine, Springer Verlag, online available

Kaina B. and M. Christmann (2006) O⁶-Methylguanine-DNA methyltransferases (alkyltransferases). In: Ganten (edt), Encyclopedic Reference of Genomic and Proteomics in Molecular Medicine, Springer Verlag, online available

Fritz G. and B. Kaina, (2006) Rho GTPases: promising cellular targets for novel anticancer drugs, Curr. Cancer Drug Targets, 6, 1-14

Fritz G. and B. Kaina (2006) Late activation of stress kinases (SAPK/JNK) by genotoxins requires the DNA repair proteins DNA-PKcs and CSB, Mol. Biol. Cell, 17, 851-861

Nübel T., J. Damrot, WP. Roos, B. Kaina and G. Fritz (2006) Lovastatin protects human endothelial cells from killing by ionizing radiation without impairing induction and repair of DNA double-strand breaks, Clin. Cancer Res., 12, 933-939

Mühlhausen U., R. Schirrmacher, M. Piel, B. Lecher, M. Briegert, A. Piee-Staffa, B. Kaina, F. Rösch (2006) Synthesis of (131) I-Labeled Glucose-Conjugated Inhibitors of O(6)-Methylguanine-DNA Methyltransferase (MGMT) and Comparison with Nonconjugated Inhibitors as Potential Tools for in Vivo MGMT Imaging, J. Med. Chemistry, 49, 263-272

Holtmann M., B. Kaina and F. Poustka (2006) Zytogenetische Veränderungen durch Methylphenidat? Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie, 34, 215-220

Tsaryk R., K. Fabian, J. Thacker and B. Kaina (2006) XRCC2 deficiency sensitizes cells to apoptosis by MNNG and the alkylating anticancer drugs temozolomide, fotemustine and mafosfamide, Cancer Lett., 239, 305-313

Hengstler JG., E. Bockamp, M. Hermes, M. Brulport, A. Bauer, W. Schormann, IB. Schiffer, C. Hausherr, L. Eshkind, C. Antunes, A. Franzen, K. Krishnamurthi, E. Lausch, R. Lessig, T. Chakrabarti, D. Prawitt, B. Zabel, C. Spangenberg (2006) Oncogeneblocking therarpies: new insights from conditional mouse tumor models, Curr Cancer Drug Targets, 6, 603-12

Poppe D., I. Tiede, G. Fritz, C. Becker, B. Bartsch, S. Wirtz, D. Strand, S. Tanaka, PR. Galle, XR. Bustelo, MF. Neurath (2006) Azathioprine suppresses ezrin-radixin-moesin-dependent T cell-APC conjugation through inhibition of Vav guanosine exchange activity on Rac proteins, J. Immunology 176, 640-651

Oesch-Bartlomowicz B. and F. Oesch (2005) Phosphorylation of cytochrome P450: First discovery of a posttranslational modification of a drug metabolizing enzyme, Biochem Biophys Res. Commun., 338, 446-449

Nübel T., S. Schmidt B. Kaina and G. Fritz (2005) Lovastatin stimulates p75 TNF receptor (TNFR2) expression in primary human endothelial cells, Int. J. Mol. Med, 16, 1139-1145

Oesch-Bartlomowicz B., M. Arand, HG. Hengstler, IB. Schiffer and F. Oesch (2005) Carcinogenesis control: From chemically reactive species to interference with proliferation. Beitrag in: Controversies in Gynecological Oncology, Herausgeber: J. Kotarski, IZT Lublin, Poland, S. 13-18

Oesch-Bartlomowicz B., A. Huelster, O. Wiss, P. Antoniou-Lipfert, C. Dietrich, M. Arand, C. Weiss, E. Bockamp and F. Oesch (2005) Aryl hydrocarbon receptor activation by camp vs. dioxin: divergent signalling pathways, Proc. Natl. Acad. Sci. USA, 102, 9218-9223

Oesch-Bartlomowicz B., F. Oesch (2005) Phosphorylation of cytochromes P450: First discovery of posttranslational modification of a drug metabolizing enzyme, Biochem. Biophys. Res. Commun., 338, 446-9

Tomicic MT., M. Christmann and B. Kaina (2005) Topotecan-triggered degradation of topoisomerase I is p53-dependent and impacts cell survival, Cancer Res., 65, 8920-8926.

Tomicic MT., M. Christmann, B. Kaina (2005) Apoptosis in UV-C light irradiated p53 wild-type, apaf-1 and p53 knockout mouse fibroblasts: Interplay of receptor and mitochondrial pathway, Apoptosis, 10, 1295-1304

Schwarzl SM., JC. Smith, B. Kaina and T. Efferth, (2005) Molecular modeling of O⁶methylguanine-DNA methyltransferase mutant proteins encoded by single nucleotide polymorphisms, Int. J. Mol. Med. 16, 553-557

Tomicic MT., M. Christmann, K. Fabian and B. Kaina (2005) Apaf-1 deficient mouse fibroblasts are resistant to MNNG and MMS-induced apoptotic death without attenuation of Bcl-2 decline, Toxicol. Appl. Pharmacol, 207, 117-122

Kaina B. (2005) Chemische Kanzerogenese, Lehrbuchbeitrag in: K. Aktories, U. Förstermann, F. Hofmann und K. Starke, Urban&Fischer Verlag, München, Jena, 9. Auflage, 976-1000

Christmann M., MT. Tomicic, J. Origer, and B. Kaina (2005) Fen1 is induced p53 dependently and involved in the recovery from UV-light- induced replication inhibition, Oncogene, 24, 8304-8313

Schirrmacher R., E. Schirrmacher, U. Mühlhausen, B. Kaina and B. Wängler (2005) Synthetic strategies towards O⁶-substituted guanine derivatives and their application in medicine, Current Organic Synthesis, 2, 215-230

Ringel M., von Mach MA, R. Santos, PJ Feilen, M. Brulport, M. Hermes, AW. Bauer, W. Schormann, B. Tanner, MR. Schön, F. Oesch, J.G. Hengstler (2005) Hepatocytes cultured in alginate microspheres; an optimized technique to study enzyme induction, Toxicology 2005 Jan 5, 206, 153-67

Platt KL. and S. Grupe (2005) Microsomal biotransformation of benzo(ghi)perylene, a mutagenic polycyclic aromatic hydrocarbon without a “classic” bay-region, Chem. Res Toxicol., 18, 700-710

Muttray A., U. Spelmeyer, G. Hommel, F. Oesch, D. Jung, DM. Rose, O. Mayer-Popken, B. Roßbach and S. Letzel (2005) Acute exposure to 50 ppm toluene does not increase sleepiness, Environ Toxicol. Phar., 19, 665-669

Köberle B., JP. Wittschieben and RD. Wood 2005) DNA repair and cancer. Beitrag in: Cellular and Molecular Biology of Cancer, Herausgeber: Margaret Knowles and Peter Selby, Oxford University Press, 4. Aufl.

Hoelper P., D. Faust, F. Oesch and C. Dietrich (2005) Transforming growth factor beta-1 is not involved in 2,3,7,8-tetrachlorodibenzo-p-dioxin-dependent release from contact-inhibition in WB-F344 cells, Arch. Toxicol, 79, 31-36

Hoelper P., D. Faust, F. Oesch and C. Dietrich (2005) Evaluation of the role of c-Src and ERK in TCDD-dependent release from contact-inhibition in WB-F344 cells, Arch. Toxicol, 79, 201-207

Hengstler JG., M. Brulport, W. Schormann, A. Bauer, M. Hermes, AK. Nussler, F. Fandrich, M. Ruhnke, H. Ungefroren, L. Griffin, E. Bockamp, F. Oesch und MA. von Mach (2005) Generation of human hepatocytes by stem cell technology: definition of the hepatocyte, Expert Opin Drug Metab. Toxicol, 1, 61-74

Gerhard R., H. Tatge, H. Genth, T. Thum, J. Borlak, G. Fritz and I. Just (2005) Clostridium difficile toxin A induces expression of the stress-induced early gene product RhoB, J. Biol. Chem., 280, 1499-1505

Fritz G. and B. Kaina (2005) HMG-CoA reductase inhibitors (statins) as anticancer drugs, Int. J. Oncol., 27, 1401-1409

Trost TM., EU. Lausch, SA. Fees, S. Schmitt, T. Enklaar, D. Reutzel, LR. Brixel, P. Schmidtke, M. Maringer, IB. Schiffer, CK Heimerdinger, JG. Hengstler, G. Fritz, EO Bockamp, D. Prawitt, BU. Zabel and C. Spangenberg (2005) Premature senescence is a primary fail-safe mechanism of ERBB-2- driven tumorgenesis in breast carcinoma cells, Cancer Res., 65, 840-849

Finkenwirth P., U. Spelmeyer, G. Hommel, DM. Rose, D. Jung, B. Roßbach, O. Mayer-Popken, S. Letzel, K. Janßen, KL. Platt, B. Oesch and A. Muttray (2005) Unverminderte DNA-Reparaturaktivität der menschlichen 8-Oxoguanin-Glykosylase 1 (hOGG1) bei toluolexponierten Probanden. Beitrag in: Tagungsband der 45. Jahrestagung der Deutschen Gesellschaft für Arbeitsmedizin und Umweltmedizin in Bochum (CD-Dokumentation), Gentner Verlag, S. 738-740

Faust D., I. Dolado, A. Cuadrado, F. Oesch, C. Weiss, AR. Nebreda and C. Dietrich (2005) p38alpha MAPK is required for contact inhibition, Oncogene, 24, 7941-7945

Efferth T., Z. Chen, B. Kaina and G. Wang (2005) Molecular determinants of response of tumor cells to berberine, Cancer Genomics Proteomics, 2, 115-124

Efferth T., R. Rauh, S. Kahl, M. Tomicic, H. Böchzelt, ME.Tome, MM. Briehl, R. Bauer and B. Kaina (2005) Molecular modes of action of cantharidin in tumor cells, Biochem. Pharmacol., 69, 811-818

Carmo H., JG. Hengstler, D. de Boer, M. Ringel, F. Remiao, F. Carvalho, E. Fernandes, L.A. dos Reys, F. Oesch, M. de Lourdes Bastos (2005) Metabolic pathways of 4-bromo-2.5-dimethoxy-phenethylamine (2C-B): analysis of phase I metabolism with hepatocytes of six species including human, Toxicology, 206, 75-89

Weiss C., D. Faust, H. Dürk, SK. Kolluri, A. Pelzer, C. Dietrich, F. Oesch and M. Göttlicher (2005) TCDD induces c-jun expression via a novel Ah (dioxin) receptor mediated p38-MAPK dependent pathway, Oncogene, 24, 4975-83

Vondracek J., V. Bryja, K. Chramostova, P. Krcmar, C. Dietrich, F. Oesch and M. Göttlicher (2005) Aryl hydrocarbon-receptor-activating polychlorinated biphenyis and their hydroxylated metabolites induce cell proliferation in contact-inhibited rat liver epithelial cells, Toxicol. Sci., 83, 53-63

Arand M., A. Cronin, M. Adamska and F. Oesch (2005) Epoxide hydrolases: structure, function, mechanism and assay, Methods Enzymol, 400, 569-588

Brendler-Schwaab S., A. Czich, B. Epe, E. Gocke, B. Kaina, L. Müller, D. Pollet and D. Utesch (2004) Photochemical genotoxicity: principles and test methods. Report of a GUM task force, Mutat. Res., 566, 65-91

Kaina B. and J. Hengstler (2004) Haben Karzinogene eine Schwellendosis? Pro und Contra. In: F.X. Reichl, M. Schwenk (Edts.), Regulatorische Toxikologie, Springer Verlag, pp. 254-261

Nübel T., W. Dippold, H. Kleinert, B. Kaina and G. Fritz (2004) Lovastatin inhibits Rho-regulated expression of E-selectin by TNFa and attenuates tumor cell adhesion, FASEB Journal, 18, 140-142

Tanner B., S. Grimme, I. Schiffer, C. Heimerdinger, M. Schmidt, P. Dutkowski, S. Neubert, F. Oesch, A. Franzen, H. K?lbl, G. Fritz, B. Kaina and JG. Hengstler (2004) Nuclear expression of apurinic/apyrimidinic endonuclease increases with progression of ovarian carcinomas, Gynecologic Oncology, 92, 568-577

Brozovic A, G. Fritz, M. Christmann, J. Zisowsky, U. Jaehde, M. Osmak and B. Kaina (2004) Long-term activation of SAPK/JNK, p38 kinase and fas-L expression by cisplatin is attenuated in human carcinoma cells that acquired drug resistance, Int. J. Cancer, 112, 974-985

Thust R., MT. Tomicic, R. Gräbner, C. Friedrichs, P. Wutzler and B. Kaina (2004) Cytogenetic detection of a trans-species bystander effect: induction of sister chromatid exchanges in murine 3T3 cells by ganciclovir metabolised in HSV thymidine kinase gene-transfected Chinese hamster ovary cells, Mutagenesis, 19, 27-33

Roos W., M. Baumgartner and B. Kaina (2004) Apoptosis triggered by DNA damage O6-methylguanine in human lymphocytes requires DNA replication and is mediated by p53 and Fas/CD95/Apo-1, Oncogene, 23, 359-367

Debiak M., T. Nikolova and B. Kaina (2004) Loss of ATM sensitizes against O6-methylguanine triggered apoptosis, SCEs and chromosomal aberrations, DNA Repair, 3, 359-368

Nübel T., W. Dippold, B. Kaina and G. Fritz (2004) Ionizing radiation-induced E-selectin gene expression and tumor cell adhesion is inhibited by lovastatin and all-trans retinoic acid, Carcinogenesis, 1335-1344

Kaina B., U. Mühlhausen, A. Piee-Staffa, M. Christmann, R. Garcia Boy, F. R?sch and R. Schirrmacher (2004) Inhibition of O6-methylguanine-DNA methyltransferase by glucose-conjugated inhibitors: comparison with non-conjugated inhibitors and effect on fotemustine and temozolomide-induced cell death, J. Pharmacol. Expt. Therap., 311, 585-593

Efferth T., A. Benakis, MR. Romero, M. Tomicic, R. Rauth, D. Steinbach, R. Häfer, T. Stamminger, F. Oesch, B. Kaina and M. Marschall (2004) Enhancement of cytotoxicity of artemisinins toward cancer cells by ferrous iron, Free Radic. Biol. Med, 37, 998-1009

Kaina B. (2004) Mechanisms and consequences of methylating agent-induced SCEs and chromosomal aberrations: a long road traveled and still a far way to go, Cytogenet. Genome Res., 104, 77-86

Platt K L., HP. Dienes, M. Tommasone, A. Luch (2004) Tumor formation in the neonatal mouse bioassay indicates that the potent carcinogen dibenzo[def,p]chrysene (dibenzo[a,l]pyrene) is activated in vivo via its trans-11,12-dihydrodiol. Chem.-Biol. Interact., 148, 27-36

Hoelper P., D. Faust, F. Oesch and C. Dietrich (2004) Transforming growth factor b1 is not involved in 2,3,7,8-tetrachlorodibenzo-p-dioxin-dependent release from contact-inhibition in WB-F344 cells, Arch. Toxicol., 78, 643-648

Kaina B. (2004) Was ist MGMT? Neues zur Wirkung von Alkylanzien und zellul?ren Resistenzmechanismen, Onkologie (Service Aktuell, Springer Verlag), 1, 14-16

Efferth T. and B. Kaina (2004) Microarray-based prediction of cytotoxicity of tumor cells to arsenic trioxide, Cancer Genomics Proteomics, 1, 363-370

Tomicic MT., M. Christmann, K. Fabian and B. Kaina (2005) Apaf-1 deficient mouse fibroblasts are resistant to MNNG and MMS-induced apoptotic death without attenuation of Bcl-2 decline, Toxicol. Appl. Pharmacol., online available

Hoelper P., D. Faust, F. Oesch and C. Dietrich (2005) Evaluation of the role of c-Src and ERK in TCDD-dependent release from contact-inhibition in WB-F344 cells, Arch. Toxicol., 79, 201-207

Su C., G. Gao, S. Schneider, C. Helt, C. Weiss, MA. O'Reilly, D. Bohmann and J. Zhao (2004) DNA damage induces downregulation of histone gene expression through the G(1) checkpoint pathway, EMBO J. 10, 1133-43

Weiss C. and D. Bohmann (2004) Deregulated repression of c-Jun provides a potential link to its role in tumorigenesis, Cell Cycle, 3, 111-113

Petry C., G. Fritz, J. Pfeilschifter, A. Huwiler (2004) Inhibition of Rho modulates cytokine-induced prostaglandin E2 formation in renal mesangial cells, Biochim. Biophys. Acta 1636, 108-118.

Prawitt D., L. Brixel, C. Spangenberg, L. Eshkind, R. Heck, F. Oesch, B. Zabel and E. Bockamp (2004) RNAi knock-down mice: an emerging technology for post-genomic functional genetics, Cytogenet. Genome Res., 105, 412-421

Eger K., M. Hermes, K. Uhlemann, S. Rodewald, J. Ortwein, M. Brulport, AW. Bauer, W. Schormann, F. Lupatsch, IB. Schiffer, CK. Heimerdinger, S. Gebhard, C. Spangenberg, D. Prawitt, T. Trost, B. Zabel, C. Sauer, B. Tanner, H. Kolbl, U. Krugel, H. Franke, P. Illes, P. Madaj-Sterba, E. Bockamp, T. Beckers and JG. Hengstler (2004) 4-Epidoxycycline: an alternative to doxycycline to control gene expression in conditional mouse models, Biochem. Biophys. Res. Communc., 323, 979-986

Oesch-Bartlomowicz B., K. Jansen, O. Wiss, F. Oesch (2004) Guanine 6-0-methylation pattern within the dioxin responsive element of the CYP1A1 enhancer shows two critical guanines for AhR/ARNT binding, Chemistry and Biodiversity, 1, 473-480

Oesch-Bartlomowicz B. and F. Oesch (2004) Modulation of mutagenicity by phosphorylation of mutagen-metabolizing enzymes, Arch. Biochem. Biophys., 423, 31-36

Dunkern TR., I. Wedemeyer, M. Baumgartner, G. Fritz and B. Kaina (2003) Resistance to doxorubicin of p53 knockout cells is related to reduced formation of DNA breaks rather than impaired apoptotic signaling, DNA Repair, 2, 49-60

Tomicic MT., C. Friedrichs, M. Christmann, P. Wutzler, R. Thust and B. Kaina (2003) Apoptosis induced by (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) in varicella zoster virus thymidine kinase-expressing cells is driven by activation of c-Jun/AP-1 and FasL/caspase-8, Mol. Pharmacol., 63, 439-449

Huber WW., G. Scharf,, G. Nagel, S. Prustomersky, R. Schulte-Hermann and B. Kaina (2003) Coffee and its chemopreventive components Kahweol and Cafestol increase the activity of O6-methylguanine-DNA methyltransferase in rat liver ? comparison with phase II xenobiotic metabolism, Mutat. Res., 522, 57-68

Becker K., C. Gregel, C. Fricke, D. Komitowsky, J. Dosch and B. Kaina (2003) DNA repair protein MGMT protects against N-methyl-N-nitrosourea-induced conversion of benign into malignant tumors, Carcinogenesis, 24, 541-546

Margison GP., AC. Povey,  B. Kaina and MF. Santibanez Koref (2003) Variability and regulation of O6-alkylguanine-DNA alkyltransferase, Carcinogenesis, 24, 625-635

Kaina B. (2003) DNA damage-triggered apoptosis: critical role of DNA repair, replication, double-strand breaks and signaling, Biochem, Pharmacology, 66, 1547-1554

Bardeleben RV., B. Kaina and G. Fritz (2003) Ultraviolet light-induced apoptotic death is impaired by the HMG-CoA reductase inhibitor lovastatin, Biochem. Biophys. Res. Comm., 307, 401-407

Fritz G., C. Brachetti and B. Kaina (2003) Lovastatin sensitizes HeLa cells to ionizing radiation-induced apoptosis by abrogating G2 blockage, Int. J. Radiat. Biol., 79, 601-610

Christmann M., M. Tomicic-Christmann, WP. Roos and B. Kaina (2003) Mechanisms of human DNA repair ? an update, Toxicology, 193, 3-34

Fritz G., S. Grösch, M. Tomicic and B. Kaina (2003) Human apurinic endonuclease (APE/Ref-1) and the eukaryotic response to genotoxic stress, Toxicology, 193, 67-78

Nagel G., W. Brenner, K. Johnsson and B. Kaina (2003) DNA repair protein O6-methylguanine-DNA methyltransferase in testis and testicular tumors as determined by a novel nonradioactive assay, Analyt. Biochem., 321, 38-43

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Edenharder R., H. Krieg, V. Köttgen, KL. Platt (2003) Inhibition of clastogenicity of benzo[a]pyrene and of its trans-7,8-dihydrodiol in mice in vivo by fruits, vegetables, and flavonoids, Mutat. Res., 537, 169-181

Dietrich C., D. Faust, M. Moskwa, A. Kunz, KW. Bock and F. Oesch (2003) TCDD-dependent downregulation of -catenin in rat liver epithelial cells, Int. J. Cancer, 103, 435-439

Hengstler JG., U. Bolm-Audorff, A. Faldum, K. Janssen, M. Reifenrath, W. Gotte, D. Jung, O. Mayer-Popken, J. Fuchs, S. Gebhard, HG. Bienfait,  K. Schlink, C. Dietrich, D. Faust, B. Epe and F. Oesch (2003). Occupational exposure to heavy metals: DNA  damage induction and DNA repair inhibition prove co-exposures to cadmium, cobalt and lead as more dangerous than hitherto expected, Carcinogenesis, 24, 63-73

Weiss C., S. Schneider, EF. Wagner, X. Zhang, E. Seto and D. Bohmann (2003) JNK phosphorylation relieves HDAC3-dependent suppression of the transcriptional activity of c-Jun, EMBO J., 22, 3686-3695

Tiede I., G. Fritz, S. Strand, MF. Neurath et al. (2003) CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes: A mechanism for azathioprin-mediated immunosuppression in Crohn?s disease based on the induction of T cell apoptosis, J. Clin. Invest. 111, 1133-1145

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