Visual Universitätsmedizin Mainz

Welcome to the 9th European Conference on Tetraspanins

September 04 – September 06, 2019

Tetraspanins are transmembrane proteins that have the ability to form extended subdomains by means of their strong tendency to associate laterally with one another and with adhesion and signalling molecules, proteases and immunoglobulins. Thereby they anchor specific proteins to one site of the cell membrane forming microclusters, which then organize further to larger assemblies, referred to as tetraspanin enriched microdomains (TEMs). These TEMs are involved in numerous physiological processes but also in pathophysiological processes including cancer, diabetes, Alzheimer's and infectious diseases. Therefore, tetraspanins have emerged as important therapeutic targets in cancer, hematological malignancy autoimmune and virus infections. Tetraspanins play additional roles in intercellular communication regulating the content and function of extracellular vesicles, specifically of exosomes – a new rapidly developing field of research, in both, fundamental and translational branches.

Moreover, it appears that unravelling basic molecular mechanism underlying the tetraspanin function and networking is at reach. A recent paper in Cell reported on the crystal structure of full-length tetraspanin suggesting a conformational switch that may regulate tetraspanin function. Other studies apply approaches as super-resolution imaging or molecular dynamics simulations for understanding key mechanisms on the pathway of TEM formation and thereby expand the field in the direction of biophysics. With over 5,000 publications since 1985, tetraspanin biology has developed into a hot topic with several interfaces between a variety of diseases and structural molecular biology.

 

The aim of these conferences is to promote the growing field of tetraspanin research and to support both established and early career researchers working in this field.

 

The organising committee is looking forward to seeing you in Mainz

 

Luise Florin, Mainz

Thorsten Lang, Bonn

Michael Christie, Lincoln

Irina Nazarenko, Freiburg

 

For all questions regarding the conference please contact  lflorin@uni-mainz.de

Symposium Venue

Waldthausen Castle

Im Wald 1

55257 Budenheim Germany

Symposium Flyer

  • Symposium flyer (pdf (Pdf , 260,0 KB))

Registration

Early bird registration deadline: June 25th 2019

  • Workshop Registration Form (pdf (Pdf , 97,1 KB), Word (Word , 15,3 KB))
  • Accommodation Reservation Form (pdf (Pdf , 122,3 KB)Word (Word , 20,4 KB))

Travel Grants

We offer travel grants to outstanding PhD students and postdocs covering conference registration fees and accommodation at Castle Waldthausen.

To be considered for a travel grant, applications should be submitted by email to
 thorsten.lang@uni-bonn.de and must contain the following attachments in form of a single pdf:

  • Short motivation letter
  • CV with grades
  • Abstract

Application deadline is August 8th 2019.

Travel grants are supported by the Boehringer Ingelheim Foundation.

 

 

 

 

 

Sponsored by


Publications

SPECIAL ISSUE  "Tetraspanins in Infection and Immunity" of the journal

Medical Microbiology and Immunology (Springer)

Submission deadline: 30. November 2019

Speakers are invited to submit manuscripts in the formats REVIEW or ORIGINAL INVESTIGATION.

All manuscripts will be peer reviewed.