Monday, October 10, 2016


10.30 a.m.
Registration and Coffee


11.30 a.m.
WELCOME AND INTRODUCTORY REMARKS

HENRIKE HARTMANN, Volkswagen Foundation
CHRISTIAN BEHL, University Medical Center Mainz, Germany


12:00 p.m.
Re-imagining Alzheimer's disease – the diminishing importance of amyloid and a glimpse of what lies ahead
KARL HERRUP, Hong Kong University of Science and Technology, Hong Kong


12:45 p.m.
Lunch


1:50 p.m.
LIPID METABOLISM, INFLAMMATION AND VASCULAR ASPECTS
Chair: JOCHEN WALTER

Molecular basis of Alzheimer’s disease - role of ApoE and ApoE receptors
JOACHIM HERZ, UT Southwestern Medical Center, Dallas, USA

The role of local and systemic inflammation in Alzheimer’s disease
V. HUGH PERRY, University of Southampton, UK

Neurovascular and neurometabolic factors in Alzheimer’s disease: the plot thickens…COSTANTINO IADECOLA, Weill Cornell Medical College, New York, USA


3:50 p.m.
Coffee Break


4:20 p.m.
NOVEL FACETS OF PRESENILIN FUNCTION
Chair: ROLAND BRANDT

Effects of FAD mutants on neurotrophin-dependent neuroprotection and neovascularization
NIKOS ROBAKIS, Mount Sinai Medical Center, New York, USA

Function of gamma-secretase in glial cells
JOCHEN WALTER, University of Bonn, Germany

Loss of presenilin function in the pathogenesis of familial Alzheimer's disease
RAYMOND KELLEHER, Harvard Medical School, Boston, USA


6:20 p.m.
Dinner at Herrenhausen Palace

 

 

Tuesday, October 11, 2016


8:30 a.m.
Welcome Coffee


9:00 a.m.
PATHOBIOCHEMISTRY OF TAU AND ITS INTERACTING PROTEINS
Chair: THOMAS ARENDT

Microtubules, tau and the neurodegenerative triad of Alzheimer’s disease
ROLAND BRANDT, Osnabrück University, Germany

Role of the kinase Fyn in Alzheimer’s disease
JÜRGEN GÖTZ, University of Queensland, Brisbane, Australia

Prion-like spreading of tau aggregates
MICHEL GOEDERT, MRC Laboratory of Molecular Biology, Cambridge, UK


11:00 a.m.
Coffee Break


11:30 a.m.
CELL CYCLE AND NEURONAL ACTIVITY
Chair: KONSTANZE WINKLHOFER

Cell cycle activation and aneuploid neurons in Alzheimer's disease - an evolutionary perspective
THOMAS ARENDT, Paul Flechsig Institute of Brain Research, Leipzig University, Germany

An inverted hierarchies model of Alzheimer’s disease
BERND MOOSMANN, University Medical Center Mainz, Germany


12:50 p.m.
Lunch


1:50 p.m.
MITOCHONDRIAL AND VESICULAR DYNAMICS
Chair: JÜRGEN GÖTZ

Brain aging, Alzheimer's disease, and mitochondria
ANNE ECKERT, University of Basel, Switzerland

Cellular stress response pathways linked to neurodegenerative diseases
KONSTANZE WINKLHOFER, Ruhr University Bochum, Germany

The pathogenic role of defective endosomal-lysosomal function in Alzheimer's disease
RALPH NIXON, NYU Langone Medical Center, New York, USA


3:50 p.m.
Short Break


4:00 p.m.
PLENARY DISCUSSION
and
PANEL DISCUSSION ON FUNDING POLICY AND FUTURE STRATEGIES
Chair: CHRISTIAN BEHL

Panelists:
ULRICH DIRNAGL, Experimental Neurology, Charité Berlin, and DZNE Berlin site, Germany
KARSTEN GEORG, DLR Project Management Agency / Federal Ministry of Education and Research, Germany
MICHAEL MADEJA, Hertie Foundation, Neuroscience area, Frankfurt/Main, Germany


5:00 p.m.
Closing Reception


7:00 p.m.
Public Lecture (Herrenhausen Forum)