Visual Universitätsmedizin Mainz

Dr. Malvika Pompaiah

PostDoc

I was born in a city called Bangalore. Bangalore is located in South India and is the capital of Karnataka. I completed my Bachelor in Science from Bangalore. After completing my Bachelor, I moved to Sydney, Australia and did my Master in Applied Science from the University of Western Sydney.

During my Master studies I decided to shift my focus of research from fermentation technology to infection related diseases. I was fortunate and got accepted for my PhD at the Max Planck Institute for Infection Biology, Berlin. During my PhD I focused my work on Helicobacter pylori, a pathogen known to cause stomach cancer. In November 2015, I joined the group of Dr. Sina Bartfeld as a post-doctoral researcher and lab manager at the Institute of Molecular Infection Biology, University of Würzburg, I acquired substantial knowledge and experience by establishing and optimizing the organoid pipeline for stomach and intestine (murine and human). We started to establish a living biobank of healthy and diseased tissue from the patients. Also, using organoids from healthy patients I studied pathogenesis of H. pylori, the project aimed to identify functional insights that contribute to carcinogenesis. Working on a collaboration project and using single cell RNA technology, we identified that H. pylori has a great affinity to a subtype of epithelial pit cells which was not known previously. Since August 2018, I joined Prof. Krishnaraj Rajalingam's group as a Postdoctoral Fellow.

Professional Appointments

  • 08/2018 - till present: PostDoc in Prof. Rajalingam's group
  • 11/2015 - 07/2018 Postdoctoral Research Scientist and Lab Manager, Research Centre for Infectious Diseases, Institute for Molecular Infection Biology (IMIB), Würzburg. Laboratory of Dr. Sina Bartfeld
  • 11/2010 - 06/2013 Postdoctoral Research Fellow, Max-Planck Institute for Infection Biology, Department of Molecular Biology, Berlin

Publications

  • Kayisoglu O, Weiss F, Niklas C, Pierotti I, Pompaiah M, Wallaschek N, Germer CT, Wiegering A, Bartfeld S. Location-specific cell identity rather than exposure to GI microbiota defines many innate immune signalling cascades in the gut epithelium. Gut. 2020.
  • Bogucka K, Pompaiah M, Marini F, Binder H, Harms G, Kaulich M, Klein M, Michel C, Radsak MP, Rosigkeit S, Grimminger P, Schild H, Rajalingam K. ERK3/MAPK6 controls IL-8 production and chemotaxis. Elife. 2020;9.
  • Wallaschek N, Niklas C, Pompaiah M, Wiegering A, Germer CT, Kircher S, Brändlein S, Maurus K, Rosenwald A, Yan HHN, Leung SY, Bartfeld S. Establishing Pure Cancer Organoid Cultures: Identification, Selection and Verification of Cancer Phenotypes and Genotypes. J Mol Biol. 2019 May 29. pii: S0022-2836(19)30315-8.
  • Pompaiah M, Bartfeld S.Gastric Organoids: An Emerging Model System to Study Helicobacter pylori Pathogenesis. Curr Top Microbiol Immunol. 2017;400:149-168. doi: 10.1007/978-3-319-50520-6_7.
  • ​Churin Y, Roderfeld M, Würger T, Schröder D, Matono T, Mollenkopf HJ, Montalbano R, Pompaiah M, Reifenberg K, Zahner D, Ocker M, Gerlich W, Glebe D, Roeb E. Pathological Impact of Hepatitis B Virus Surface Proteins on the Liver Is Associated with the Host Genetic Background. PLoS One. 2015 May 1;10(5):e0127375. doi: 10.1371/journal.pone.0127375. eCollection 2015.​
  • Belogolova E¶, Bauer B¶ , Pompaiah M¶, Asakura H¶, Brinkman V, Ertl C, Bartfeld S, Nechitaylo TY, Haas R, Machuy N, Salama N, Churin Y, Meyer TF. Helicobacter pylori outer membrane protein HopQ identified as a novel T4SS-associated virulence factor. Cell Microbiol. 2013 Jun 20. doi: 10.1111/cmi.12158. ¶ These authors contributed equally.
  • Boettcher JP, Kirchner M, Churin Y, Kaushansky A, Pompaiah M, Thorn H, Brinkmann V, Macbeath G, Meyer TF. Tyrosine-phosphorylated caveolin-1 blocks bacterial uptake by inducing Vav2-RhoA-mediated cytoskeletal rearrangements. PLoS Biol. 2010 Aug 24;8(8). pii: e1000457. doi: 10.1371/journal.pbio.1000457.