Visual Universitätsmedizin Mainz

Jürgen Prochaska, MD

Prochaska, MD
Jürgen Prochaska, MD
Position: Junior group leader
Deputy Head Preventive Cardiology and Medical Prevention, Senior Physician Cardiology I
DZHK PI

06131 17-2594
juergen.prochaska@unimedizin-mainz.de
Further Information

Clinical Epidemiology Fellowship

Project Description


The goal of the „Fellowship Clinical Epidemiology“ within Module B “Clinical Epidemiology” of the Center for Thrombosis und Hemostasis (CTH) is the synergistic combination of epidemiological training („Master of Science in Epidemiology“ program) and scientific work on the field “Oral Anticoagulation” (OAC). OAC with vitamin K antagonists is an established therapy for decades, although evidence on the quality and management of anticoagulation with phenprocoumon – which is predominantly applied in Germany – is limited. In recent years, new direct oral anticoagulative drugs (factor Xa and thrombin inhibitors) have been successfully investigated in randomized clinical trials and are now available for clinical practice. Increasing life-expectancy and the demographic change will lead to a growing need for oral anticoagulation treatment in the future as most of the diseases like e.g. atrial fibrillation – the most frequent indication – and venous thromboembolism are more prevalent in the elderly. An expanding complexity of hemostaseology results in high demands on the physicians in charge: Multi-morbidity of older patients and new diversity of options for OAC available by novel anticoagulative drugs require a careful consideration of benefits and risks of the treatment. Major efforts are needed to provide scientific evidence to cope with these clinical challenges.

The main subject of this Epidemiology Fellowship application is to comprehensively evaluate oral anticoagulation therapy in the clinical setting. We aim to get insights from the thrombEVAL study program on the physicians´ perception of current oral anticoagulation therapy, the clinical application of bridging therapy and the long-term follow-up of anticoagulated patients. In addition, we will investigate (potential) effects of oral anticoagulants on hemostasis and the course of cardiovascular disease in an epidemiological study. This will contribute to enhance our current knowledge of the pathophysiological mechanisms involved in the development of cardiovascular diseases and the complex interplay between hemostasis, inflammation and immune system.

Research Interests

    • Epidemiology of oral anticoagulation therapy with vitamin K-antagonists and direct oral anticoagulants
    • Risk factors and long-term follow-up of patients receiving oral anticoagulation
    • Epidemiology and prevention of cardiovascular and thrombotic diseases

      Mentor

       

      Mentors of the Epidemiology-Fellow are Professor Philipp Wild, Head of the Module Clinical Epidemiology at the CTH and Head of Institute for Preventive Cardiology and Preventive Medicine, and Professor Hugo ten Cate, Professor of Clinical Thrombosis and Hemostasis at the Cardiovascular Research Institute (CARIM) Maastricht and Fellow of the Gutenberg Forschungskolleg (GFK) of the Johannes Gutenberg-University Mainz

      Team

        • Heidrun Lamparter (Data management)
        • Zaid Al-Bayati (Doctoral Candidate)
        • Christina Baer (Doctoral Candidate)
        • Christoph Hausner (Doctoral Candidate)
        • Torben Knöpfler (Doctoral Candidate)
        • Charlotte Kowitz (Doctoral Candidate)
        • Leonie Schleuter (Doctoral Candidate)
        • Kristina Papp (Research Assistant)
        • Vera Wilmesmeier-Marx (Research Assistant)
        • Julian Bassemir (Research Assistant)
        • Paul Ludolph (Doctoral Candidate)

          Curriculum vitae

          07/2001

          German secondary school diploma (Abitur)

          2001-2002

          Civil service, Hospital Pegnitz

          10/2002- 06/2009

          Medical studies, Julius-Maximilians-University Würzburg

          2005-2008

          Research assistant and Doctoral Fellow, AG Neuroimmunology, Department of Neurology, University-Hospital Würzburg

           

          Doctoral thesis: “Regulation of Junctional Adhesion Molecule A in cerebral endothelial cells under proinflammatory conditions”

          Since 09/2009

          Clinical resident at the Department of Medicine 2 (Cardiology / Angiology)

          Since 04/2010

          Head of project management of the thrombEVAL study program

          Since 2011

          Research fellow Gutenberg Health Study

          04/2013

          Chair of poster session „Cardiovascular risks” and member of the jury for the “Rudolf-Thauer-Posterpreis” at the annual meeting of the German Cardiac Society (DGK) 2013

          05/2013

          Young Investigator Grant for the “CTH Spring School on the Science and Practice of Venous Thromboembolism”

          Since 10/2013

          Postgradual studies “Master of Science in Epidemiology” at Institute for Medicinal Biometry, Epidemiology and Informatics (IMBEI) Mainz

          Since 02/2014

          Postodoctoral Fellowship Clinical Epidemiology

          Since 03/2014

          Member of the Working Group "Thrombosis" of the European Society of Cardiology

          Since 07/2014

          Scientific Advisor for CTH Platform Biodata Banking

          Since 10/2014

          Research Fellow of the German Center for Cardiovascular Research (DZHK)

          References

           

           

          • Frank B, Ariza L, Lamparter H, Grossmann V, Prochaska JH, Ullmann A, Kindler F, Weisser G, Walter U, Lackner KJ, Espinola-Klein C, Munzel T, Konstantinides SV, Wild PS, group VTs. Rationale and design of three observational, prospective cohort studies including biobanking to evaluate and improve diagnostics, management strategies and risk stratification in venous thromboembolism: the VTEval Project. BMJ open 5:e008157, 2015.
          • Keller K, Prochaska JH, Coldewey M, Gobel S, Ullmann A, Jünger C, Lamparter H, Ariza L, Bickel C, Lauterbach M, Konstantinides S, Rostock T, Münzel T, Wild PS. History of deep vein thrombosis is a discriminator for concomitant atrial fibrillation in pulmonary embolism. Thrombosis research 136:899-906, 2015.
          • Schnabel RB, Wild PS, Prochaska JH, Ojeda FM, Zeller T, Rzayeva N, Ebrahim A, Lackner KJ, Beutel ME, Pfeiffer N, Sinning CR, Oertelt-Prigione S, Regitz-Zagrosek V, Binder H, Münzel T, Blankenberg S, Gutenberg Health Study I. Sex Differences in Correlates of Intermediate Phenotypes and Prevalent Cardiovascular Disease in the General Population. Frontiers in cardiovascular medicine 2:15, 2015.

          • Michal M, Prochaska JH, Keller K, Göbel S, Coldewey M, Ullmann A, Schulz A, Lamparter H, Münzel T, Reiner I, Beutel ME, Wild PS. Symptoms of depression and anxiety predict mortality in patients undergoing oral anticoagulation: Results from the thrombEVAL study program. International journal of cardiology 187:614-619, 2015. (IF 6,175)
          • Zolfaghari S, Harenberg J, Frölich L, Weiss C, Wehling M, Wild P, Prochaska J, Beyer-Westendorf J, Koscielny J, Lip GY. Development of recommendations to continue anticoagulation with one of the two types of oral anticoagulants based on the identification of patients' preference. Seminars in thrombosis and hemostasis 41:166-177, 2015. (IF 3,693)
          • Prochaska JH, Göbel S, Keller K, Coldewey M, Ullmann A, Lamparter H, Jünger C, Al-Bayati Z, Baer C, Walter U, Bickel C, Ten Cate H, Münzel T, Wild PS. Quality of oral anticoagulation with phenprocoumon in regular medical care and its potential for improvement in a telemedicine-based coagulation service inverted question mark results from the prospective, multi-center, observational cohort study thrombEVAL. BMC medicine 13:14, 2015. (IF 7,276)
          • Michal M, Prochaska JH, Ullmann A, Keller K, Göbel S, Coldewey M, Münzel T, Wiltink J, Beutel ME, Wild PS. Relevance of depression for anticoagulation management in a routine medical care setting: Results from the ThrombEVAL study program. Journal of thrombosis and haemostasis, 2014. (IF 5,55)
          • Haarmann A, Deiss A, Prochaska J, Foerch C, Weksler B, Romero I, Couraud PO, Stoll G, Rieckmann P, Buttmann M. Evaluation of soluble junctional adhesion molecule-A as a biomarker of human brain endothelial barrier breakdown. PLoS One. 5(10):e13568, 2010. (IF 4,092)