Visual Universitätsmedizin Mainz

Tanja Falter, PhD

Falter, PhD
Tanja Falter, PhD
Position: Physician Dept. Med. III, Virchow Fellow

tanja.falter@unimedizin-mainz.de
Further Information

Project description

In our project, the ADAMTS13 activity and the ultra large von Willebrand factor multimers will be quantified in 50 stroke patients in the age cohort of < 50 years (in cooperation with Prof Zipp, Head of the Department of Neurology). Furthermore, different proinflammatory and proapoptotic cytokines (e.g. TNF alpha) will be analyzed.

In addition to the decreased ADAMTS13 activity and the evidence of ultra large multimers, we expect to find a specific marker in the plasma samples. This marker will then (in cooperation with Prof. Lackner, Head of the Institute of Clinical Chemistry and Laboratory Medicine), be further characterized in cell culture. In patients exhibiting a reduced ADAMTS13 activity, we plan an examination for mutations. In cooperation with PD Dr. Radsak, Assistant Laboratory Head, diagnostics/routine – cytological laboratory and immunocytological laboratory, the genesis of micro-vascular diseases will be explored in “knockout” mice.

Beyond that, we want to investigate juvenile myocardial infarction with the focus on ADAMTS13 and ultra large von Willebrand factor multimers. Thereby we would like to use the data of the Department of Cardiology and Angiology as well as hospital patients of these departments. The research results will be evaluated in the bio bank of the Platform for Translational Research. Additional testing on clinical use of recombinant ADAMTS13 on patients with IS and MI.

We hope that our findings will contribute to a further insight into the pathophysiology of ischemic strokes (IS) and myocardial infarction (MI) in juvenile patients and may result in a decrease of relapse-risk and in innovative therapeutic consequences.

 

Mentor

Mentor of the Virchow-Fellow is Professor Inge Scharrer, MD, Consultant of Internal Medicine, Hemastaseology at the Department of Medicine 3.

Team

  • Veronique Schmitt (PhD student)
  • Stephanie Herold (PhD student)

Curriculum vitae

09/1995 - 07/2004

Paracelsus–Gymnasium, Hohenheim

10/2004 - 03/2008

Academic study of Pharmacy, Martin Luther University, Halle-Wittenberg

08/2007 - 09/2007

Assistant at Boehringer Ingelheim, Ingelheim am Rhein

10/2008

Second State examination

11/2008 - 04/2009

Internship Hirsch Pharmacy, Mainz

05/2009 - 10/2009

Internship and diploma at Sanofi-Aventis Deutschland GmbH, R&D Chemical and Analytical Sciences, Frankfurt am Main

11/2009

Third State examination

12/2009

Approbation as pharmacist

04/2010

Diploma-pharmacist, Martin Luther University, Halle-Wittenberg

01/2010 - 01/2011

Doctoral candidate at the Depatment of Medicin 3 (Hematology) and Institut of Pharmacology, Mainz

expected in 06/2011

Doctor of Natural Science, Johannes Gutenberg-University, Mainz

References

  • Falter T, Kremer Hovinga JA, Lackner K, Fullemann HG, Lammle B, Scharrer I. Late onset and pregnancy-induced congenital thrombotic thrombocytopenic purpura. Hamostaseologie 34:244-248, 2014.
  • Falter T, Alber KJ, Scharrer I, Long term outcome and sequelae in patients after acute thrombotic thrombocytopenic purpura episodes. Hämostaseologie, 2013 May 29;33(2):113-20.