Visual Universitätsmedizin Mainz

Junior group 'Clinical and translational research in VTE'

Dr. Stefano Barco

Group leader


Medicine based on the evidence generated by randomized clinical trials is considered the gold standard in contemporary patient care. However, trials are not always the most appropriate or feasible way to address important open issues in thrombosis and hemostasis. These include the study of ´unusual´ inflammatory thrombotic diseases, long-term outcomes after venous thromboembolism (VTE), and anticoagulant-associated (bleeding) complications. In addition, new potential antithrombotic strategies and recently defined determinants of disease, such as the effects of diet and gut microbiota on thrombosis risk, are novel areas still poorly investigated and require clinical translation.

The Junior group Clinical and Early Translational Research in Venous Thromboembolism aims to expand the clinical research spectrum of the CTH and complement the Clinical Trial Professorship by setting up a working group able to host clinical research on acute VTE and anticoagulant treatment. The scientific goal of the group will be to focus on the pathophysiology and treatment of rare inflammatory (pro)thrombotic conditions as well as late VTE and anticoagulant-cassociated complications. Methodological aims will be the implementation of multistate modelling for more comprehensive time-to-event analyses and interventional studies in early clinical translation in humans adopting surrogate outcomes for confirming hypotheses generated in the CTH laboratory setting.

Research interest

  • Pathophysiology and treatment of rare inflammatory (pro)thrombotic conditions, such as Lemierre syndrome 
  • Late complications of acute pulmonary embolism and major bleeding
  • Interventional early translational studies in humans 

International collaboration partners

  • W. Ageno and F. Dentali (Varese, Italy)
  • M. Di Nisio (Chieti, Italy)
  • M. Huisman and F.A. Klok (Leiden, the Netherlands)
  • S. Middeldorp and M. Coppens, M. Serlie (Amsterdam, the Netherlands)
  • M. Monreal (Barcelona, Spain)
  • C. Ambaglio and A. Pecci (Pavia, Italy)
  • M. Righini (Geneve, Switzerland)
  • G. Meyer (Paris, France)

Research funding

  • BMBF (CTH, 01EO1503)

Team - Junior group 'Clinical and translational research in VTE'

MD, PhD Barco
Stefano Barco, MD, PhD
Position: Junior group leader

06131 17-8251
06131 17-8461
s.barco@uni-mainz.de

Curriculum Vitae (Pdf-file, 109,5 KB)

 

 

MD Valerio
Luca Valerio, MD
Position: Postdoctoral Fellow

06131 17-7490
lvalerio@uni-mainz.de

  • Marius Jankowski (MD student)
  • Sarah Krutmann (MD student)
  • Svenja Otten (HiWi)

Selected original articles

  • Barco S*, Valerio L*, Ageno W, Cohen AT, Goldhaber SZ, Hunt BJ, Iorio A, Jimenez D, Klok FA, Kucher N, Mahmoudpour SH, Middeldorp S, Münzel T, Tagalakis V, Wendelboe AM, Konstantinides SV. Age-sex specific pulmonary embolism-related mortality in the USA and Canada, 2000-18: an analysis of the WHO Mortality Database and of the CDC Multiple Cause of Death database. Lancet Respir Med 2020.

  • Valerio L, Zane F, Sacco C, Granziera S, Nicoletti T, Russo M, Corsi G, Holm K, Hotz MA, Righini C, Karkos PD, Mahmoudpour SH, Kucher N, Verhamme P, Di Nisio M, Centor RM, Konstantinides SV, Pecci A, Barco S. Patients with Lemierre syndrome have a high risk of new thromboembolic complications, clinical sequelae and death: an analysis of 712 cases. J Intern Med. 2020 May 22.

  • Lodigiani C, Iapichino G, Carenzo L, Cecconi M, Ferrazzi P, Sebastian T, Kucher N, Studt JD, Sacco C, Alexia B, Sandri MT, Barco S. Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Milan, Italy. Thromb Res 2020 Jul;191:9-14.

  • Hobohm L, Anušić T, Konstantinides SV, Barco S. Ambulatory Treatment of Low-risk Pulmonary Embolism in Fragile Patients: A Subgroup Analysis of the Multinational Home Treatment of Pulmonary Embolism (HoT-PE) Trial. Eur Respir J. 2020 May 7:2000663.

  • Barco S, Sollfrank S, Trinchero A, Adenaeuer A, Abolghasemi H, Conti L, Häuser F, Kremer Hovinga JA, Lackner KJ, Loewecke F, Miloni E, Vazifeh Shiran N, Tomao L, Wuillemin WA, Zieger B, Lämmle B, Rossmann H. Severe plasma prekallikrein deficiency: Clinical characteristics, novel KLKB1 mutations, and estimated prevalence. J Thromb Haemost 2020 Jul;18(7):1598-1617.

  • Barco S, Mahmoudpour  SH, Valerio L, Klok FA, Münzel T, Middeldorp S, Ageno W, Cohen AT, Hunt BJ, Konstantinides SV. Trends in mortality related to pulmonary embolism in the European Region, 2000-15: analysis of vital registration data from the WHO Mortality Database. Lancet Resp Med 2020 Mar;8(3):277-287.

  • Barco S, Russo M, Vicaut E, Becattini C, Bertoletti L, Beyer-Westendorf J, Bouvaist H, Couturaud F, Danays T, Dellas C, Duerschmied D, Empen K, Ferrari E, Galie N, Jimenez D, Klok FA, Kostrubiec M, Kozak M, Kupatt C, Lang IM, Lankeit M, Meneveau N, Palazzini M, Pruszczyk P, Rugolotto M, Salvi A, Sanchez O, Schellong S, Sobkowicz B, Meyer G, Konstantinides SV. Incomplete echocardiographic recovery at 6 months predicts long-term sequelae after intermediate-risk pulmonary embolism. A post-hoc analysis of the Pulmonary Embolism Thrombolysis (PEITHO) trial. Clin Res Cardiol 2019;108(7):772-778.
  • Barco S, Mahmoudpour SH, Planquette B, Sanchez O, Konstantinides SV, Meyer G. Prognostic value of right ventricular dysfunction or elevated cardiac biomarkers in patients with low-risk pulmonary embolism: a systematic review and meta-analysis. Eur Heart J 2019;40(11):902-910.
  • Barco S, Granziera S, Coppens M, Douxfils J, Nijkeuter M, Riva N, Vanassche T, Zhang G, Lin M, Kamphuisen PW, Cohen AT, Beyer-Westendorf J. Determinants of the Quality of Warfarin Control after Venous Thromboembolism and Validation of the SAMe-TT2-R2 Score: An Analysis of Hokusai-VTE. Thromb Haemost 2019;119(4):675-684.
  • Barco S, Ende-Verhaar YM, Becattini C, Jimenez D, Lankeit M, Huisman MV, Konstantinides SV, Klok FA. Differential impact of syncope on the prognosis of patients with acute pulmonary embolism: a systematic review and meta-analysis. Eur Heart J 2018;39(47):4186-4195.
  • Barco S, Vicaut E, Klok FA, Lankeit M, Meyer G, Konstantinides SV, PEITHO Investigators. Improved identification of thrombolysis candidates amongst intermediate-risk pulmonary embolism patients: implications for future trials. Eur Respir J. 2018 Jan 18;51(1).
  • Barco S, Corti M, Trinchero A, Picchi C, Ambaglio C, Konstantinides SV, Dentali F, Barone M (2017) Survival and recurrent venous thromboembolism in patients with first proximal or isolated distal deep vein thrombosis and no pulmonary embolism. Journal of Thrombosis and Haemostasis 15: 1436-1442
  • Barco S, Woersching AL, Spyropoulos AC, Piovella F, Mahan CE (2016) European Union-28: An annualised cost-of-illness model for venous thromboembolism. Thrombosis and Haemostasis 115: 800-808
  • * indicates equal contribution of the authors

Selected reviews

  • Valerio L, Corsi G, Sebastian T, Barco S. Lemierre syndrome: Current evidence and rationale of the Bacteria-Associated Thrombosis, Thrombophlebitis and LEmierre syndrome (BATTLE) registry. Thromb Res 2020;196:494-499.

  • Valerio L, Riva N. Head, Neck, and Abdominopelvic Septic Thrombophlebitis: Current Evidence and Challenges in Diagnosis and Treatment. Hamostaseologie. 2020 Aug; 40(03):301-310.

  • Barco S, Konstantinides SV; CORE‐THROMBOSIS Investigators. Thrombosis and thromboembolism related to COVID-19: A clarion call for obtaining solid estimates from large-scale multicenter data. Res Pract Thromb Haemost. 2020 Jun 12;4(5):741-743.

  • Barco S. The Millennial Generation of Thrombosis and Hemostasis. Hamostaseologie. 2020 Aug;40(3):259-261.

  • Barco S, Sebastian T. Death from, with, and without pulmonary embolism. Eur J Intern Med. 2020 Mar;73:25-26.

  • Valerio L, Klok FA, Barco S. Immediate and late impact of reperfusion therapies in acute pulmonary embolism. Eur Heart J Suppl. 2019 Nov;21(Suppl I):I1-I13.

  • Barco S. What's the Matter with Distal Deep Vein Thrombosis? Thromb Haemost. 2019 Oct;119(10):1547-1549. d1696983.

  • Huisman MV, Barco S, Cannegieter SC, Le Gal G, Konstantinides SV, Reitsma PH, Rodger M, Vonk Noordegraaf A, Klok FA. Pulmonary embolism. Nat Rev Dis Primers 2018;4:18028.
  • Barco S (2016) Edoxaban for pulmonary embolism with right ventricular dysfunction. The Lancet Haematology 3: e405-406
  • Konstantinides SV, Barco S, Lankeit M, Meyer G. Management of Pulmonary Embolism: An Update. Journal of the American College of Cardiology 2016;67: 976-990