The coagulation system is an integral part of the innate immune defense against tissue injuries. During tumor diseases, systemic changes affect coagulation, platelet-leukocyte interaction, and immune responses. The cellular receptors of the coagulation proteases are "Tissue Factor (TF)" and the "Endothelial Protein C Receptor (EPCR)". They are structurally related to interleukin, CD1d and toll-like receptors (TLR) and are expressed e.g. by tumor, immune and vascular cells. They interact with the coagulation factors FX, FVII and protein C. In addition to their synthesis in the liver, FVII and FX are also expressed by macrophages and dendritic cells and influence their phenotypes. As a result, they also modulate anti-tumor immune responses.
We are interested in the control of macrophage and DC phenotypes mediated by coagulation proteases and platelet-leukocyte interaction. We are investigating this in the context of chronic inflammatory processes, especially malignancies, using mouse models that show special alterations in the expression or signaling of coagulation proteases. Translational relevance results from the synergistic effects of anticoagulants and checkpoint inhibitors observed in preclinical models on reducing tumor growth and improving the anti-tumor immune response.
since 2018 - Junior Group Leader „Coagulation Proteases in Inflammation“, CTH, University Medical Center, Johannes Gutenberg-University, Mainz
since 2020 - Scientific Management of the GTH-Mediathek
since 2020 - Reviewer for ISTH
2018 - Habilitation in Internal Medicine
2009 - PhD, GRK 1043 „antigen-specific immunotherapy“, Univ.-Prof. Thomas Wölfel, University Medical Center, Johannes Gutenberg-University, Mainz; Title: Analysis of autologous T-cell responses against neoepitopes generated by FLT3 internal tandem duplications (FLT3-ITD), Grade: magna cum laude
2005 - MD, Univ.-Prof. Thomas Wölfel, University Medical Center, Johannes Gutenberg-University, Mainz; Title: Identification of peptide antigens of the vaccinia virus that are recognized by CD8+ T lymphocytes; Grade: summa cum laude
2018 - Qualification for Specialised Genetic Counseling
2017 - Certification as Hemostaseologist
2013 - Certification as Physician in Palliative Care
2013 - ESMO Certification
2013 - Specialist for Internal Medicine, Hematology and Oncology
2005 - License to practice medicine
1998 – 2005 - Medical studies at the University Medical Center, Johannes Gutenberg-University, Mainz
ORCID Researcher ID:
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