Visual Universitätsmedizin Mainz

Research group 'Platelet Physiology and Dysfunction'

Prof. Dr. Kerstin Jurk

Group Leader

Research topics

  • Regulatory mechanisms of platelet function
  • Platelet signaling
  • Crosstalk between platelets, leukocytes and the vascular compartment in inflammation-driven thrombotic diseases
  • Inherited and acquired platelet function disorders

Partners of Collaboration

Partners at the University Medical Center Mainz

  • Prof. Dr. Wolfram Ruf (CTH)
  • Dr. Charis von Auer (III. Medizinische Klinik, CTH Gerinnungsambulanz II)
  • Prof. Dr. Jörg Faber, Dr. Alexandra Russo (Center for Pediatric and Adolescent Medicine)
  • Prof. Dr. Christine Espinola-Klein (Center for Cardiology, Cardiology III - Angiology)
  • Prof. Dr. Markus Radsak ( III. Department of Medicine Hematology, Oncology, Pneumology)
  • Prof. Dr. Krishan Rajalingam (Cell Biology Unit)
  • Prof. Dr. Julia Weinmann-Menke (Department of Nephrology)
  • Prof. Dr. Stefan Tenzer (Institute for Immunology, Core Facility Mass Spectrometry)

National Partners

  • Prof. Dr. Albert Sickmann, Dr. René Zahedi (Leibniz–Institut für Analytische Wissenschaften – ISAS, Dortmund)
  • Prof. Dr. Beate Kehrel (Department of Anaesthesiology, Intensive Care and Pain Medicine, Experimental and Clinical Haemostasis Research, University Hospital Münster)
  • Prof. Dr. Barbara Zieger (Department of Pediatrics and Adolescent Medicine, Medical Center - University of Freiburg)
  • Dr. Manuela Krause (DKD Helios Klinik Wiesbaden)

International Partners

  • Prof. Dr. Johann Heemskerk (CARIM, Maastricht)
  • Prof. Dr. Tilman Hackeng (CARIM, Maastricht)
  • Dr. Stepan Gambaryan (Sechenov Institute of Evolutionary Physiology, St. Petersburg, Russia)
  • Dr. Albert Smolenski (Conway Institute of Biomolecular & Biomedical Research, University College Dublin, Ireland)
  • Prof. Dr. Stefan Chlopicki (Jagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University, Krakow, Polen)

Research Funding

  • CTH TRP X28, X43, X44

We are part of the TICARDIO Research Consortium (Project 8 + Project 9) funded through the Marie Skłodowska-Curie Innovative Training Network, Horizon 2020.

Biography - Kerstin Jurk

Positions:
Since 2020 – Group Leader 'Clinical Platelet Research', CTH, Center of Cardiology, University Medical Center of the Johannes Gutenberg-University, Mainz
Since 2015 – Group Leader 'Platelet Physiology and Dysfunction', CTH, University Medical Center of the Johannes Gutenberg-University, Mainz
Since 2012 – Head of the CTH Platform 'Platelet Function'
Since 2012 – Coordinator of the Experimental CTH Platforms

Research Career:
2006 - 2011 – Research Associate, Dept. of  Anaesthesiology and Intensive Care, Exp. and Clin. Haemostasis, University-Hospital, Münster
2004 - 2006 – Lise-Meitner Habilitation Fellow of North Rhine-Westphalia
1999 - 2004 – Postdoctoral Research Fellow, Dept. of  Anaesthesiology and Intensive Care, Exp. and Clin. Haemostasis, University-Hospital, Münster

Professional Education:
1999 – Dr. rer. nat. (PhD), Westfälische Wilhelms University, Münster
1994 – Diploma in Biology, Westfälische Wilhelms University, Münster

ORCID Researcher ID:
0000-0001-5313-4035

Team RG Jurk

Jurk, PhD
PD Kerstin Jurk, PhD
Position: Principal Investigator

06131 17-8278

Groß (neé Schwierczek)
Kathrin Groß (neé Schwierczek)
Position: Technician

06131 17-8296

Gutekunst
Melissa Gutekunst
Position: MD student

06131 17-8296

Platzhalterbild
Saskia von Ungern Sternberg, Dr.
Position: Postdoc

06131 17-8296

Zhang
Pengyu Zhang
Position: TICARDIO PhD student

06131 17-8296

MD students

  • Anna Walther
  • Tatjana Wiegand
  • Johannes Irle

Former team members

  • Mareike Döhrmann
  • Dr. rer. nat. Elena Kumm
  • Dr. rer. nat. Stephanie Makhoul
  • Dr. med. Karoline Rosenplänter 
  • Dr. med. vet. Katharina Trabold
  • Dr. med. Alice Huang
  • Dr. med. Charlotte Hutchinson
  • Dr. med. Dr. phil. nat. Daniele Pillitteri
  • Kehel Wohra
  • Alexandra Walter

Miscellaneous

We are looking forward to applications from highly motivated students for Master-Thesis Projects.   Email.

Original articles

  • Baidildinova G, Ten Cate V, Nagler M, Panova-Noeva M, Rapp S, Köck T, Prochaska JH, Heitmeier S, Gerdes C, Schwers S, Konstantinides SV, Münzel T, Espinola-Klein C, Lackner KJ, Spronk HMN, Ten Cate H, van der Meijden PEJ, Leineweber K, Wild PS, Jurk K. Subtype-specific plasma signatures of platelet-related protein releasate in acute pulmonary embolism. Thromb Res. 2022 Dec;220:75-87
  • Jurk K, Adenaeuer A, Sollfrank S, Groß K, Häuser F, Czwalinna A, Erkel J, Fritsch N, Marandiuc D, Schaller M, Lackner KJ, Rossmann H, Bergmann F. Novel GATA1 Variant Causing a Bleeding Phenotype Associated with Combined Platelet α-/δ-Storage Pool Deficiency and Mild Dyserythropoiesis Modified by a SLC4A1 Variant. Cells. 2022 Sep 29;11(19):3071
  • da Costa Marques R, Simon J, d'Arros C, Landfester K, Jurk K, Mailänder V. Proteomics reveals differential adsorption of angiogenic platelet lysate proteins on calcium phosphate bone substitute materials. Regen Biomater. 2022 Jul 5;9:rbac044.
  • Eckelt A, Wichmann F, Bayer F, Eckelt J, Groß J, Opatz T, Jurk K, Reinhardt C, Kiouptsi K. Ethyl Hydroxyethyl Cellulose-A Biocompatible Polymer Carrier in Blood. Int J Mol Sci. 2022 Jun 9;23(12):6432.
  • Jurk K, Rothenaicher KF, Groß K, Rossmann H, Weißer G, Schmidtmann I, Münzel T, Espinola-Klein C. Differential Inhibition of Platelet Reactivity by Dual Therapy With Aspirin and Low-Dose Rivaroxaban in Peripheral Arterial Disease: A Pilot Study. Front Cardiovasc Med. 2022 May 6;9:865166.
  • Leberzammer J, Agten SM, Blanchet X, Duan R, Ippel H, Megens RTA, Schulz C, Aslani M, Duchene J, Döring Y, Jooss NJ, Zhang P, Brandl R, Stark K, Siess W, Jurk K, Heemskerk JWM, Hackeng TM, Mayo KH, Weber C, von Hundelshausen P. Targeting platelet-derived CXCL12 impedes arterial thrombosis. Blood. 2022 Apr 28;139(17):2691-2705.
  • Hrdinova J, Fernández DI, Ercig B, Tullemans BME, Suylen DPL, Agten SM, Jurk K, Hackeng TM, Vanhoorelbeke K, Voorberg J, Reutelingsperger CPM, Wichapong K, Heemskerk JWM, Nicolaes GAF. Structure-Based Cyclic Glycoprotein Ibα-Derived Peptides Interfering with von Willebrand Factor-Binding, Affecting Platelet Aggregation under Shear. Int J Mol Sci. 2022 Feb 12;23(4):2046.
  • Schnorbus B, Jurk K, Lackner KJ, Welk C, Münzel T, Gori T. Effects of Clopidogrel, Prasugrel and Ticagrelor on Microvascular Function and Platelet Reactivity in Patients With Acute Coronary Syndrome Undergoing Coronary Artery Stenting. A Randomized, Blinded, Parallel Group Trial. Front Cardiovasc Med. 2021 Dec 13;8:780605.
  • Shiravand Y, Walter U, Jurk K. Fine-Tuning of Platelet Responses by Serine/Threonine Protein Kinases and Phosphatases-Just the Beginning. Hamostaseologie. 2021 Jun;41(3):206-216.
  • Rukoyatkina N, Shpakova V, Sudnitsyna J, Panteleev M, Makhoul S, Gambaryan S, Jurk K. Curcumin at Low Doses Potentiates and at High Doses Inhibits ABT-737-Induced Platelet Apoptosis. Int J Mol Sci. 2021 May 20;22(10):5405.
  • Herken K, Glauner M, Robert SC, Maas M, Zippel S, Nowak-Göttl U, Zieger B, Lahav J, Fender AC, Jurk K, Kehrel BE. Age-Dependent Control of Collagen-Dependent Platelet Responses by Thrombospondin-1-Comparative Analysis of Platelets from Neonates, Children, Adolescents, and Adults. Int J Mol Sci. 2021 May 5;22(9):4883.
  • Gresele P, Falcinelli E, Bury L, Pecci A, Alessi MC, Borhany M, Heller PG, Santoro C, Cid AR, Orsini S, Fontana P, De Candia E, Podda G, Kannan M, Jurk K, Castaman G, Falaise C, Guglielmini G, Noris P; BAT-VAL Study Investigators. The ISTH bleeding assessment tool as predictor of bleeding events in inherited platelet disorders: Communication from the ISTH SSC Subcommittee on Platelet Physiology. J Thromb Haemost. 2021 May;19(5):1364-1371.
  • Neubauer K, Jurk K, Petermann V, Kumm E, Zieger B. Impaired Platelet Function in Sept8-Deficient Mice In Vitro. Thromb Haemost. 2021 Apr;121(4):484-494.
  • Ascher S, Wilms E, Pontarollo G, Kiouptsi K, Malinarich F, Kittner JM, Bosmann M, Jurk K and Reinhardt C. Response by Ascher et al to Letter Regarding Article, "Gut Microbiota Restricts NETosis in Acute Mesenteric Ischemia-Reperfusion Injury". Arterioscler Thromb Vasc Biol. 2021 Jan;41(1):e74-e75.
  • Zimmer N, Krebs FK, Zimmer S, Mitzel-Rink H, Kumm EJ, Jurk K, Grabbe S, Loquai C and Tuettenberg A. Platelet-Derived GARP Induces Peripheral Regulatory T Cells-Potential Impact on T Cell Suppression in Patients with Melanoma-Associated Thrombocytosis. Cancers (Basel). 2020;12.
  • Swieringa F, Solari FA, Pagel O, Beck F, Huang J, Feijge MAH, Jurk K, Korver-Keularts I, Mattheij NJA, Faber J, Pohlenz J, Russo A, Stumpel C, Schrander DE, Zieger B, van der Meijden PEJ, Zahedi RP, Sickmann A and Heemskerk JWM. Impaired iloprost-induced platelet inhibition and phosphoproteome changes in patients with confirmed pseudohypoparathyroidism type Ia, linked to genetic mutations in GNAS. Sci Rep. 2020;10:11389.
  • Schnorbus B, Daiber A, Jurk K, Warnke S, Koenig J, Lackner KJ, Munzel T and Gori T. Effects of clopidogrel vs. prasugrel vs. ticagrelor on endothelial function, inflammatory parameters, and platelet function in patients with acute coronary syndrome undergoing coronary artery stenting: a randomized, blinded, parallel study. Eur Heart J. 2020;41:3144-3152.
  • Pielsticker C, Brodde MF, Raum L, Jurk K* and Kehrel BE*. Plasmin-Induced Activation of Human Platelets Is Modulated by Thrombospondin-1, Bona Fide Misfolded Proteins and Thiol Isomerases. Int J Mol Sci. 2020;21. *Shared senior authorship.
  • Neubauer K*, Jurk K*, Petermann V, Kumm E and Zieger B. Impaired Platelet Function in Sept8-Deficient Mice In Vitro. Thromb Haemost. 2020. *Shared first authorship.
  • Makhoul S*, Kumm E*, Zhang P, Walter U and Jurk K. The Serine/Threonine Protein Phosphatase 2A (PP2A) Regulates Syk Activity in Human Platelets. Int J Mol Sci. 2020;21. *Shared first authorship.
  • Lehwald N, Duhme C, Pinchuk I, Kirchner J, Wieferich K, Schmelzle M, Jurk K, Windmoller BA, Hubner W, Homey B, Bode J, Kubitz R, Benhidjeb T, Kruger M, Robson SC, Knoefel WT, Kehrel BE and Schulte Am Esch J. Platelets Boost Recruitment of CD133(+) Bone Marrow Stem Cells to Endothelium and the Rodent Liver-The Role of P-Selectin/PSGL-1 Interactions. Int J Mol Sci. 2020;21.
  • Kumm EJ, Pagel O, Gambaryan S, Walter U, Zahedi RP, Smolenski A and Jurk K. The Cell Cycle Checkpoint System MAST(L)-ENSA/ARPP19-PP2A is Targeted by cAMP/PKA and cGMP/PKG in Anucleate Human Platelets. Cells. 2020;9.
  • Krueger I, Gremer L, Mangels L, Klier M, Jurk K, Willbold D, Bock HH and Elvers M. Reelin Amplifies Glycoprotein VI Activation and AlphaIIb Beta3 Integrin Outside-In Signaling via PLC Gamma 2 and Rho GTPases. Arterioscler Thromb Vasc Biol. 2020;40:2391-2403.
  • Kiouptsi K, Jackel S, Wilms E, Pontarollo G, Winterstein J, Karwot C, Gross K, Jurk K and Reinhardt C. The Commensal Microbiota Enhances ADP-Triggered Integrin alphaIIbbeta3 Activation and von Willebrand Factor-Mediated Platelet Deposition to Type I Collagen. Int J Mol Sci. 2020;21.
  • Grill A, Kiouptsi K, Karwot C, Jurk K and Reinhardt C. Evaluation of blood collection methods and anticoagulants for platelet function analyses on C57BL/6J laboratory mice. Platelets. 2020;31:981-988.
  • Döhrmann M, Makhoul S, Gross K, Krause M, Pillitteri D, von Auer C, Walter U, Lutz J, Volf I, Kehrel BE and Jurk K. CD36-fibrin interaction propagates FXI-dependent thrombin generation of human platelets. FASEB J. 2020;34:9337-9357.
  • Comer S, Nagy Z, Bolado A, von Kriegsheim A, Gambaryan S, Walter U, Pagel O, Zahedi RP, Jurk K and Smolenski A. The RhoA regulators Myo9b and GEF-H1 are targets of cyclic nucleotide-dependent kinases in platelets. J Thromb Haemost. 2020;18:3002-3012.
  • Bochenek ML, Leidinger C, Rosinus NS, Gogiraju R, Guth S, Hobohm L, Jurk K, Mayer E, Munzel T, Lankeit M, Bosmann M, Konstantinides S and Schafer K. Activated Endothelial TGFbeta1 Signaling Promotes Venous Thrombus Nonresolution in Mice Via Endothelin-1: Potential Role for Chronic Thromboembolic Pulmonary Hypertension. Circ Res. 2020;126:162-181.
  • Ascher S, Wilms E, Pontarollo G, Formes H, Bayer F, Muller M, Malinarich F, Grill A, Bosmann M, Saffarzadeh M, Brandao I, Gross K, Kiouptsi K, Kittner JM, Lackner KJ, Jurk K and Reinhardt C. Gut Microbiota Restricts NETosis in Acute Mesenteric Ischemia-Reperfusion Injury. Arterioscler Thromb Vasc Biol. 2020;40:2279-2292.
  • Makhoul S, Dorschel S, Gambaryan S, Walter U and Jurk K. Feedback Regulation of Syk by Protein Kinase C in Human Platelets. Int J Mol Sci. 2020;21.
  • van Geffen JP, Brouns SLN, Batista J, McKinney H, Kempster C, Nagy M, Sivapalaratnam S, Baaten C, Bourry N, Frontini M, Jurk K, Krause M, Pillitteri D, Swieringa F, Verdoold R, Cavill R, Kuijpers MJE, Ouwehand WH, Downes K and Heemskerk JWM. High-throughput elucidation of thrombus formation reveals sources of platelet function variability. Haematologica. 2019;104:1256-1267.
  • Trabold K*, Makhoul S*, Gambaryan S, van Ryn J, Walter U and Jurk K. The Direct Thrombin Inhibitors Dabigatran and Lepirudin Inhibit GPIbalpha-Mediated Platelet Aggregation. Thromb Haemost. 2019;119:916-929. *Shared first authorship.
  • Makhoul S, Trabold K, Gambaryan S, Tenzer S, Pillitteri D, Walter U and Jurk K. cAMP- and cGMP-elevating agents inhibit GPIbalpha-mediated aggregation but not GPIbalpha-stimulated Syk activation in human platelets. Cell Commun Signal. 2019;17:122.       
  • Kiouptsi K, Jackel S, Pontarollo G, Grill A, Kuijpers MJE, Wilms E, Weber C, Sommer F, Nagy M, Neideck C, Jansen Y, Ascher S, Formes H, Karwot C, Bayer F, Kollar B, Subramaniam S, Molitor M, Wenzel P, Rosenstiel P, Todorov H, Gerber S, Walter U, Jurk K, Heemskerk JWM, van der Vorst EPC, Doring Y and Reinhardt C. The Microbiota Promotes Arterial Thrombosis in Low-Density Lipoprotein Receptor-Deficient Mice. mBio. 2019;10.
  • Hollerbach A, Muller-Calleja N, Ritter S, Hauser F, Canisius A, Orning C, Jurk K and Lackner KJ. Platelet Activation by Antiphospholipid Antibodies Depends on Epitope Specificity and is Prevented by mTOR Inhibitors. Thromb Haemost. 2019;119:1147-1153.
  • Duhme C, Lehwald N, Kehrel BE, Bauchrowitz E, Ngepi A, Schmelzle M, Kolokotronis T, Benhidjeb T, Kruger M, Jurk K, Knoefel WT, Robson SC and Schulte Am Esch J. CD133(+) bone marrow stem cells (BMSC) control platelet activation - Role of ectoNTPDase-1 (CD39). Blood Cells Mol Dis. 2019;77:142-148.
  • Althaus K, Zieger B, Bakchoul T, Jurk K; THROMKID-Plus Studiengruppe der Gesellschaft für Thrombose- und Hämostaseforschung (GTH) und der Gesellschaft für Pädiatrische Onkologie und Hämatologie (GPOH). Standardization of Light Transmission Aggregometry for Diagnosis of Platelet Disorders: An Inter-Laboratory External Quality Assessment. Thromb Haemost. 2019;119:1154-1161.
  • Urbahn MA, Kaup SC, Reusswig F, Kruger I, Spelleken M, Jurk K, Klier M, Lang PA and Elvers M. Phospholipase D1 regulation of TNF-alpha protects against responses to LPS. Sci Rep. 2018;8:10006.
  • Makhoul S, Walter E, Pagel O, Walter U, Sickmann A, Gambaryan S, Smolenski A, Zahedi RP and Jurk K. Effects of the NO/soluble guanylate cyclase/cGMP system on the functions of human platelets. Nitric Oxide. 2018;76:71-80.
  • Klatt C, Kruger I, Zey S, Krott KJ, Spelleken M, Gowert NS, Oberhuber A, Pfaff L, Luckstadt W, Jurk K, Schaller M, Al-Hasani H, Schrader J, Massberg S, Stark K, Schelzig H, Kelm M and Elvers M. Platelet-RBC interaction mediated by FasL/FasR induces procoagulant activity important for thrombosis. J Clin Invest. 2018;128:3906-3925.
  • Ebert J, Wilgenbus P, Teiber JF, Jurk K, Schwierczek K, Döhrmann M, Xia N, Li H, Spiecker L, Ruf W and Horke S. Paraoxonase-2 regulates coagulation activation through endothelial tissue factor. Blood. 2018;131:2161-2172.
  • Subramaniam S, Jurk K, Hobohm L, Jackel S, Saffarzadeh M, Schwierczek K, Wenzel P, Langer F, Reinhardt C and Ruf W. Distinct contributions of complement factors to platelet activation and fibrin formation in venous thrombus development. Blood. 2017;129:2291-2302.
  • Steven S, Jurk K, Kopp M, Kroller-Schon S, Mikhed Y, Schwierczek K, Roohani S, Kashani F, Oelze M, Klein T, Tokalov S, Danckwardt S, Strand S, Wenzel P, Munzel T and Daiber A. Glucagon-like peptide-1 receptor signalling reduces microvascular thrombosis, nitro-oxidative stress and platelet activation in endotoxaemic mice. Br J Pharmacol. 2017;174:1620-1632.
  • Loroch S, Trabold K, Gambaryan S, Reiss C, Schwierczek K, Fleming I, Sickmann A, Behnisch W, Zieger B, Zahedi RP, Walter U and Jurk K. Alterations of the platelet proteome in type I Glanzmann thrombasthenia caused by different homozygous delG frameshift mutations in ITGA2B. Thromb Haemost. 2017;117:556-569.
  • Kossmann S, Lagrange J, Jackel S, Jurk K, Ehlken M, Schonfelder T, Weihert Y, Knorr M, Brandt M, Xia N, Li H, Daiber A, Oelze M, Reinhardt C, Lackner K, Gruber A, Monia B, Karbach SH, Walter U, Ruggeri ZM, Renne T, Ruf W, Munzel T and Wenzel P. Platelet-localized FXI promotes a vascular coagulation-inflammatory circuit in arterial hypertension. Sci Transl Med. 2017;9.
  • Kiouptsi K, Grill A, Mann A, Dohrmann M, Lillich M, Jackel S, Malinarich F, Formes H, Manukyan D, Subramaniam S, Khandagale A, Karwot C, Thal SC, Bosmann M, Scharrer I, Jurk K and Reinhardt C. Mice deficient in the anti-haemophilic coagulation factor VIII show increased von Willebrand factor plasma levels. PLoS One. 2017;12:e0183590.
  • Kiouptsi K, Gambaryan S, Walter E, Walter U, Jurk K and Reinhardt C. Hypoxia impairs agonist-induced integrin alphaIIbbeta3 activation and platelet aggregation. Sci Rep. 2017;7:7621.
  • Jackel S, Kiouptsi K, Lillich M, Hendrikx T, Khandagale A, Kollar B, Hormann N, Reiss C, Subramaniam S, Wilms E, Ebner K, Bruhl MV, Rausch P, Baines JF, Haberichter S, Lammle B, Binder CJ, Jurk K, Ruggeri ZM, Massberg S, Walter U, Ruf W and Reinhardt C. Gut microbiota regulate hepatic von Willebrand factor synthesis and arterial thrombus formation via Toll-like receptor-2. Blood. 2017;130:542-553.
  • Gowert NS, Kruger I, Klier M, Donner L, Kipkeew F, Gliem M, Bradshaw NJ, Lutz D, Kober S, Langer H, Jander S, Jurk K, Frotscher M, Korth C, Bock HH and Elvers M. Loss of Reelin protects mice against arterial thrombosis by impairing integrin activation and thrombus formation under high shear conditions. Cell Signal. 2017;40:210-221.
  • Beck F, Geiger J, Gambaryan S, Solari FA, Dell'Aica M, Loroch S, Mattheij NJ, Mindukshev I, Potz O, Jurk K, Burkhart JM, Fufezan C, Heemskerk JW, Walter U, Zahedi RP and Sickmann A. Temporal quantitative phosphoproteomics of ADP stimulation reveals novel central nodes in platelet activation and inhibition. Blood. 2017;129:e1-e12.
  • Alflen A, Prufer S, Ebner K, Reuter S, Aranda Lopez P, Scharrer I, Banno F, Stassen M, Schild H, Jurk K, Bosmann M, Beckert H and Radsak MP. ADAMTS-13 regulates neutrophil recruitment in a mouse model of invasive pulmonary aspergillosis. Sci Rep. 2017;7:7184.
  • Manukyan D, Muller-Calleja N, Jackel S, Luchmann K, Monnikes R, Kiouptsi K, Reinhardt C, Jurk K, Walter U and Lackner KJ. Cofactor-independent human antiphospholipid antibodies induce venous thrombosis in mice. J Thromb Haemost. 2016;14:1011-20.

Reviews

  • Jurk K. Thrombozytopenie [Thrombocytopenia]. MMW Fortschr Med. 2021 Oct;163(17):60-62.
  • Huang J, Zhang P, Solari FA, Sickmann A, Garcia A, Jurk K, Heemskerk JWM. Molecular Proteomics and Signalling of Human Platelets in Health and Disease. Int J Mol Sci. 2021 Sep 13;22(18):9860.
  • Baidildinova G, Nagy M, Jurk K, Wild PS, Ten Cate H, van der Meijden PEJ. Soluble Platelet Release Factors as Biomarkers for Cardiovascular Disease. Front Cardiovasc Med. 2021 Jun 21;8:684920.
  • Jurk K, Shiravand Y. Platelet Phenotyping and Function Testing in Thrombocytopenia. J Clin Med. 2021 Mar 7;10(5):1114.
  • Lutz J, Jurk K. Platelets in Advanced Chronic Kidney Disease: Two Sides of the Coin. Semin Thromb Hemost 2020;46(3):342-356.
  • Jurk K and Walter U. New Insights into Platelet Signalling Pathways by Functional and Proteomic Approaches. Hamostaseologie. 2019;39:140-151.
  • Jurk K. Platelet granules - secretory and secretive. Hamostaseologie. 2017;37:208-210.
  • Pagel O, Walter E, Jurk K and Zahedi RP. Taking the stock of granule cargo: Platelet releasate proteomics. Platelets. 2017;28:119-128.
  • Lutz J, Jurk K and Schinzel H. Direct oral anticoagulants in patients with chronic kidney disease: patient selection and special considerations. Int J Nephrol Renovasc Dis. 2017;10:135-143.
  • Lutz J and Jurk K. Antiplatelet Agents and Anticoagulants in Patients with Chronic Kidney Disease - from Pathophysiology to Clinical Practice. Curr Pharm Des. 2017;23:1366-1376.

Editorials

  • Kuijpers MJE, Heemskerk JWM, Jurk K. Molecular Mechanisms of Hemostasis, Thrombosis and Thrombo-Inflammation. Int J Mol Sci. 2022 May 23;23(10):5825.
  • Jurk K. Functional Diversity of Primed Platelets-Powered by Machine Learning. Thromb Haemost. 2022 May;122(5):661.