Visual Universitätsmedizin Mainz

Junior group 'Systemic inflammation and vascular disease'

Susanne Karbach, MD

Junior group leader

Our group investigates the impact of inflammation mediators on the vasculature and coagulation system. In particular we are interested in the crosstalk between autoimmune disorders and the associated cardiovasular comorbitity of these disorders.

 


Research interest

  • Role of IL-6 and IL-6-induced cytokines for the interaction of cells and factors of the immune system and blood coagulation
  • IL-17A, IL-6 and vasculare dysfunction / inflammation
  • Psoriasis and salt-water-homeostasis
  • Organ-crosstalk skin-vasculature

Partners of collaboration

Partners at the University Medical Center Mainz

  • Prof. Philip Wenzel (CTH)
  • Prof. Ari Waisman (Institute for Molecular Medicine)
  • Prof. Andreas Daiber (Center for Cardiology – Cardiology I)
  • Prof. Bernhard Lämmle as senior professor (CTH)
  • PD Dr. Kerstin Jurk (CTH)
  • Prof. Wolfram Ruf (CTH)
  • Jun.-Prof. Christoph Reinhardt (CTH)
  • PD Dr. Mareike Lankeit, Dr. Lukas Hobohm (CTH)
  • Prof. Huige Li (Department of Pharmacology)
  • Prof. Dr. Ellen Closs (Department of Pharmacology)
  • Prof. Dr. Markus Radsak (3rd Medical Department, Institute for Immunology)
  • Prof. Christine Espinola-Klein (Center for Cardiology, Cardiology I - Angiology)

Internationale Kooperationen 

  • Prof. Jens Titze (Vanderbilt University, Nashville, USA)
  • Prof. Dominik Müller (Max-Delbrück-Center of Molecular Medicine, Berlin) 
  • Dr. Henry Spronk (CARIM, Maastricht, the Netherlands)
  • Prof. Thomas Korn (Experimental Neuroimmunology TU Munich)
  • Prof. Ingo Bechmann (Institute of Anatomy, University of Leipzig)

Third Party Funding

  • CRC/Transregio 156
  • BMBF (CTH, 01EO1503)
  • DFG (KA 4035/1-1)
  • Boehringer Ingelheim Stiftung
  • DZHK

Team - Junior group 'Systemic inflammation and vascular disease'

Karbach, MD
Susanne Karbach, MD
Position: Physician Cardiology I, Scientist

Further Information

Knopp
Tanja Knopp
Position: PhD student

06131 17-8036

Dipl.-Chem. Ringen
Julia Ringen, Dipl.-Chem.
Position: PhD student

06131 17-8036

MD Wild
Johannes Wild, MD
Position: PostDoc
Qualifications: Specialist Internal Medicine

06131 17-8036

Former Team Members

Rebecca Jung

Publications

  • Wild J, Jung R, Knopp T, Efentakis P, Benaki D, Grill A, Wegner J, Molitor M, Garlapati V, Rakova N, Markó L, Marton A, Mikros E, Münzel T, Kossmann S, Rauh M, Nakano D, Kitada K, Luft F, Waisman A, Wenzel P, Titze J, Karbach S. Aestivation motifs explain hypertension and muscle mass loss in mice with psoriatic skin barrier defect. Acta Physiol (Oxf). 2021 May;232(1):e13628.
  • Maifeld A, Wild J, Karlsen TV, Rakova N, Wistorf E, Linz P, Jung R, Birukov A, Gimenez-Rivera VA, Wilck N, Bartolomaeus T, Dechend R, Kleinewietfeld M, Forslund SK, Krause A, Kokolakis G, Philipp S, Clausen BE, Brand A, Waisman A, Kurschus FC, Wegner J, Schultheis M, Luft FC, Boschmann M, Kelm M, Wiig H, Kuehne T, Müller DN, Karbach S, Markó L. Skin Sodium Accumulates in Psoriasis and Reflects Disease Severity. J Invest Dermatol. 2022 Jan;142(1):166-178.e8.
  • Karbach S, Hobohm L, Wild J, Münzel T, Gori T, Wegner J, Steinbrink K, Wenzel P, Keller K. Impact of Psoriasis on Mortality Rate and Outcome in Myocardial Infarction. J Am Heart Assoc. 2020 Sep 15;9(18):e016956.
  • Wild J, Schüler R, Knopp T, Molitor M, Kossmann S, Münzel T, Daiber A, Waisman A, Wenzel P, Karbach SH. Telmisartan Lowers Elevated Blood Pressure in Psoriatic Mice without Attenuating Vascular Dysfunction and Inflammation. Int J Mol Sci. 2019 Aug 30;20(17):4261.
  • Schüler R, Efentakis P, Wild J, Lagrange J, Garlapati V, Molitor M, Kossmann S, Oelze M, Stamm P, Li H, Schäfer K, Münzel T, Daiber A, Waisman A, Wenzel P, Karbach SH. T Cell-Derived IL-17A Induces Vascular Dysfunction via Perivascular Fibrosis Formation and Dysregulation of ·NO/cGMP Signaling. Oxid Med Cell Longev. 2019 Jul 18;2019:6721531
  • Schüler R, Brand A, Klebow S, Wild J, Veras FP, Ullmann E, Roohani S, Kolbinger F, Kossmann S, Wohn C, Daiber A, Münzel T, Wenzel P, Waisman A, Clausen BE, Karbach S. Antagonization of IL-17A Attenuates Skin Inflammation and Vascular Dysfunction in Mouse Models of Psoriasis. J Invest Dermatol 2019;139(3):638-647.
  • Karbach S, Lagrange J, Wenzel P. Thromboinflammation and Vascular Dysfunction. Hamostaseologie 2018.
  • Brandt M, Giokoglu E, Garlapati V, Bochenek ML, Molitor M, Hobohm L, Schönfelder T, Münzel T, Kossmann S, Karbach SH, Schäfer K, Wenzel P. Pulmonary Arterial Hypertension and Endothelial Dysfunction Is Linked to NADPH Oxidase-Derived Superoxide Formation in Venous Thrombosis and Pulmonary Embolism in Mice. Oxid Med Cell Longev 2018;2018:1860513.
  • Schönfelder T, Brandt M, Kossmann S, Knopp T, Münzel T, Walter U, Karbach SH, Wenzel P. Lack of T-bet reduces monocytic interleukin-12 formation and accelerates thrombus resolution in deep vein thrombosis. Sci Rep 2018;8(1):3013.
  • Kossmann S, Lagrange J, Jäckel S, Jurk K, Ehlken M, Schönfelder T, Weihert Y, Knorr M, Brandt M, Xia N, Li H, Daiber A, Oelze M, Reinhardt C, Lackner K, Gruber A, Monia B, Karbach SH, Walter U, Ruggeri ZM, Renne T, Ruf W, Münzel T, Wenzel P (2017) Platelet-localized fxi promotes a vascular coagulation-inflammatory circuit in arterial hypertension. Science translational medicine 9
  • Karbach SH, Schönfelder T, Brandao I, Wilms E, Hormann N, Jäckel S, Schuler R, Finger S, Knorr M, Lagrange J, Brandt M, Waisman A, Kossmann S, Schäfer K, Münzel T, Reinhardt C, Wenzel P (2016) Gut microbiota promote angiotensin ii-induced arterial hypertension and vascular dysfunction. Journal of the American Heart Association 5 
  • Klebow S, Hahn M, Nikoalev A, Wunderlich FT, Hövelmeyer N, Karbach* SH, Waisman* A (2016) Il-6 signaling in myelomonocytic cells is not crucial for the development of imq-induced psoriasis. PloS one 11:e0151913 
  • Uluckan O, Jimenez M, Karbach S, Jeschke A, Grana O, Keller J, Busse B, Croxford AL, Finzel S, Koenders M, van den Berg W, Schinke T, Amling M, Waisman A, Schett G, Wagner EF (2016) Chronic skin inflammation leads to bone loss by il-17-mediated inhibition of wnt signaling in osteoblasts. Science translational medicine 8:330ra337 
  • Wenzel P, Rossmann H, Müller C, Kossmann S, Oelze M, Schulz A, Arnold N, Simsek C, Lagrange J, Klemz R, Schönfelder T, Brandt M, Karbach SH, Knorr M, Finger S, Neukirch C, Hauser F, Beutel ME, Kröller-Schön S, Schulz E, Schnabel RB, Lackner K, Wild PS, Zeller T, Daiber A, Blankenberg S, Münzel T (2015) Heme oxygenase- 1 suppresses a pro-inflammatory phenotype in monocytes and determines endothelial function and arterial hypertension in mice and humans. Eur Heart J 36:3437-3446.
  • Croxford* AL, Karbach* S, Kurschus FC, Wörtge S, Nikolaev A, Yogev N, Klebow S, Schüler R, Reissig S, Piotrowski C, Brylla E, Bechmann I, Scheller J, Rose-John S, Wunderlich FT, Münzel T, von Stebut E, Waisman A (2014) Il-6 regulates neutrophil microabscess formation in IL-17a-driven psoriasiform lesions. J Invest Dermatol 134:728-735
  • Karbach S, Croxford AL, Oelze M, Schüler R, Minwegen D, Wegner J, Koukes L, Yogev N, Nikolaev A, Reissig S, Ullmann A, Knorr M, Waldner M, Neurath MF, Li H, Wu Z, Brochhausen C, Scheller J, Rose-John S, Piotrowski C, Bechmann I, Radsak M, Wild P, Daiber A, von Stebut E, Wenzel P, Waisman A, Münzel T (2014) Interleukin 17 drives vascular inflammation, endothelial dysfunction, and arterial hypertension in psoriasis-like skin disease. Arterioscler Thromb Vasc Biol 34:2658-2668
  • Karbach S, Wenzel P, Waisman A, Münzel T, Daiber A (2014) Enos uncoupling in cardiovascular diseases--the role of oxidative stress and inflammation. Current pharmaceutical design 20:3579-3594
  • El Malki* K, Karbach* SH, Huppert* J, Zayoud M, Reissig S, Schüler R, Nikolaev A, Karram K, Münzel T, Kuhlmann CR, Luhmann HJ, von Stebut E, Wörtge S, Kurschus FC, Waisman A (2013) An alternative pathway of imiquimod-induced psoriasis-like skin inflammation in the absence of interleukin-17 receptor a signaling. J Invest Dermatol 133:441-451
  • Simon* A, Karbach* S, Habermeier A, Closs EI (2013) Decoding the substrate supply to human neuronal nitric oxide synthase. PloS one 8:e67707
  • Karbach S, Jansen T, Horke S, Heeren T, Scholz A, Coldewey M, Karpi A, Hausding M, Kröller-Schön S, Oelze M, Münzel T, Daiber A (2012) Hyperglycemia and oxidative stress in cultured endothelial cells--a comparison of primary endothelial cells with an immortalized endothelial cell line. J Diabetes Complications 26:155-162
  • Wenzel P, Knorr M, Kossmann S, Stratmann J, Hausding M, Schuhmacher S, Karbach SH, Schwenk M, Yogev N, Schulz E, Oelze M, Grabbe S, Jonuleit H, Becker C, Daiber A, Waisman A, Münzel T (2011) Lysozyme m-positive monocytes mediate angiotensin II-induced arterial hypertension and vascular dysfunction. Circulation 124:1370-1381 
  • *contributed equally