Visual Universitätsmedizin Mainz

Junior group 'Systemic inflammation and vascular disease'

Susanne Karbach, MD

Junior group leader

Our group investigates the impact of inflammation mediators on the vasculature and coagulation system. In particular we are interested in the crosstalk between autoimmune disorders and the associated cardiovasular comorbitity of these disorders.

Research interest

  • Role of IL-6 and IL-6-induced cytokines for the interaction of cells and factors of the immune system and blood coagulation
  • IL-17A, IL-6 and vasculare dysfunction / inflammation
  • Psoriasis and salt-water-homeostasis
  • Organ-crosstalk skin-vasculature

Partners of collaboration

Partners at the University Medical Center Mainz

  • Prof. Philip Wenzel (CTH)
  • Prof. Ari Waisman (Institute for Molecular Medicine)
  • Prof. Andreas Daiber (Center for Cardiology – Cardiology I)
  • Prof. Bernhard Lämmle as senior professor (CTH)
  • PD Dr. Kerstin Jurk (CTH)
  • Prof. Wolfram Ruf (CTH)
  • Jun.-Prof. Christoph Reinhardt (CTH)
  • PD Dr. Mareike Lankeit, Dr. Lukas Hobohm (CTH)
  • Prof. Huige Li (Department of Pharmacology)
  • Prof. Dr. Ellen Closs (Department of Pharmacology)
  • Prof. Dr. Markus Radsak (3rd Medical Department, Institute for Immunology)
  • Prof. Christine Espinola-Klein (Center for Cardiology, Cardiology I - Angiology)

International Partners

  • Prof. Jens Titze (Vanderbilt University, Nashville, USA)
  • Prof. Dominik Müller (Max-Delbrück-Center of Molecular Medicine, Berlin) 
  • Dr. Henry Spronk (CARIM, Maastricht, the Netherlands)
  • Prof. Thomas Korn (Experimental Neuroimmunology TU Munich)
  • Prof. Ingo Bechmann (Institute of Anatomy, University of Leipzig)

Third Party Funding

  • DFG TransRegio 156
  • BMBF (CTH, 01EO1503)
  • DFG (KA 4035/1-1)
  • Boehringer Ingelheim Stiftung
  • DZHK

Biography - Susanne Karbach

Positions:
Since 2018 – Junior Group Leader 'Systemic inflammation and vascular disease', CTH, University Medical Center of the Johannes Gutenberg-University, Mainz
Since 2016 – Senior Physician (Clinical focus on non-invasive cardiology, heart failure, echocardiography), Center of Cardiology, University Medical Center of the Johannes Gutenberg-University, Mainz
2008 - 2015 – Residency in Internal Medicine / Cardiology, Center of Cardiology, University Medical Center of the Johannes Gutenberg-University, Mainz

Research Career:
2020 – Habilitation in Internal Medicine, Center of Cardiology, University Medical Center of the Johannes Gutenberg-University, Mainz
2010 - 2012 – PostDoc (with Prof. Ari Waisman), Institut of Moleculare Medicine, University Medical Center of the Johannes Gutenberg-University, Mainz

Professional Education:
2008 – MD, Department of Pharmacology, University Medical Center of the Johannes Gutenberg-University, Mainz
2000 - 2007 – Medical Degree, University Medical Center of the Johannes Gutenberg-University, Mainz, Université de Bourgogne, Dijon, France

ORCID Researcher ID:
0000-0003-4462-374

Team - Junior group 'Systemic inflammation and vascular disease'

Karbach, MD
Susanne Karbach, MD
Position: Physician Cardiology I, Scientist

Further Information

Dipl.-Chem. Ringen
Julia Ringen, Dipl.-Chem.
Position: PhD student

06131 17-8036

MD Wild
Johannes Wild, MD
Position: PostDoc
Qualifications: Specialist Internal Medicine

06131 17-8036

Former Team Members

Rebecca Jung

Publications

  • Brandt M, Dörschmann H, Khraisat S, Knopp T, Ringen J, Kalinovic S, Garlapati V, Siemer S, Molitor M, Göbel S, Stauber R, Helena Karbach S, Münzel T, Daiber A, Wenzel P. Telomere Shortening in Hypertensive Heart Disease Depends on Oxidative DNA Damage and Predicts Impaired Recovery of Cardiac Function in Heart Failure. Hypertension. 2022 Jul 18:101161HYPERTENSIONAHA12118935.
  • Wild J, Keller K, Karbach S, Weinmann-Menke J, Münzel T, Hobohm L. Case-Fatality and Temporal Trends in Patients with Psoriasis and End-Stage Renal Disease. J Clin Med. 2022 Jul 26;11(15):4328.
  • Wild J, Ringen J, Bieler T, Knopp T, Lagrange J, Molitor M, Sies K, Kropp A, Keller K, Daiber A, Münzel T, Rauh M, Waisman A, Wenzel P, Titze J, Karbach S. Epicutaneous Application of Imiquimod to Model Psoriasis-Like Skin Disease Induces Water-Saving Aestivation Motifs and Vascular Inflammation. J Invest Dermatol. 2022 May 14:S0022-202X(22)00392-X
  • Wegner J, Karbach S, Drosos I, Schnorbus B, Muxel S, Schmidt F, Wenzel P, Waisman A, Münzel T, Gori T, von Stebut E. TNF-α blockade may lead to improvement of vascular function in psoriasis patients. Exp Dermatol. 2022 Feb;31(2):237-241.
  • Efentakis P, Molitor M, Kossmann S, Bochenek ML, Wild J, Lagrange J, Finger S, Jung R, Karbach S, Schäfer K, Schulz A, Wild P, Münzel T, Wenzel P. Tubulin-folding cofactor E deficiency promotes vascular dysfunction by increased endoplasmic reticulum stress. Eur Heart J. 2022 Feb 10;43(6):488-500.
  • Maifeld A, Wild J, Karlsen TV, Rakova N, Wistorf E, Linz P, Jung R, Birukov A, Gimenez-Rivera VA, Wilck N, Bartolomaeus T, Dechend R, Kleinewietfeld M, Forslund SK, Krause A, Kokolakis G, Philipp S, Clausen BE, Brand A, Waisman A, Kurschus FC, Wegner J, Schultheis M, Luft FC, Boschmann M, Kelm M, Wiig H, Kuehne T, Müller DN, Karbach S, Markó L. Skin Sodium Accumulates in Psoriasis and Reflects Disease Severity. J Invest Dermatol. 2022 Jan;142(1):166-178.e8.
  • Xia N, Hasselwander S, Reifenberg G, Habermeier A, Closs EI, Mimmler M, Jung R, Karbach S, Lagrange J, Wenzel P, Daiber A, Münzel T, Hövelmeyer N, Waisman A, Li H. B Lymphocyte-Deficiency in Mice Causes Vascular Dysfunction by Inducing Neutrophilia. Biomedicines. 2021 Nov 14;9(11):1686.
  • Keller K, Hobohm L, Ostad MA, Karbach S, Espinola-Klein C, Münzel T, Gelfand JM, Konstantinides SV, Steinbrink K, Gori T. Psoriasis and its impact on the clinical outcome of patients with pulmonary embolism. Int J Cardiol. 2021 Nov 15;343:114-121.
  • Neulen A, Molitor M, Kosterhon M, Pantel T, Karbach SH, Wenzel P, Gaul T, Ringel F, Thal SC. Analysis of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage with High Frequency Transcranial Duplex Ultrasound. J Vis Exp. 2021 Jun 3;(172).
  • Knopp T, Bieler T, Jung R, Ringen J, Molitor M, Jurda A, Münzel T, Waisman A, Wenzel P, Karbach SH, Wild J. Effects of Dietary Protein Intake on Cutaneous and Systemic Inflammation in Mice with Acute Experimental Psoriasis. Nutrients. 2021 May 31;13(6):1897.
  • Wild J, Jung R, Knopp T, Efentakis P, Benaki D, Grill A, Wegner J, Molitor M, Garlapati V, Rakova N, Markó L, Marton A, Mikros E, Münzel T, Kossmann S, Rauh M, Nakano D, Kitada K, Luft F, Waisman A, Wenzel P, Titze J, Karbach S. Aestivation motifs explain hypertension and muscle mass loss in mice with psoriatic skin barrier defect. Acta Physiol (Oxf). 2021 May;232(1):e13628.
  • Rudi WS, Molitor M, Garlapati V, Finger S, Wild J, Münzel T, Karbach SH, Wenzel P. ACE Inhibition Modulates Myeloid Hematopoiesis after Acute Myocardial Infarction and Reduces Cardiac and Vascular Inflammation in Ischemic Heart Failure. Antioxidants (Basel). 2021 Mar 5;10(3):396.
  • Neulen A, Molitor M, Kosterhon M, Pantel T, Holzbach E, Rudi WS, Karbach SH, Wenzel P, Ringel F, Thal SC. Correlation of cardiac function and cerebral perfusion in a murine model of subarachnoid hemorrhage. Sci Rep. 2021 Feb 8;11(1):3317.
  • Molitor M, Rudi WS, Garlapati V, Finger S, Schüler R, Kossmann S, Lagrange J, Nguyen TS, Wild J, Knopp T, Karbach SH, Knorr M, Ruf W, Münzel T, Wenzel P. Nox2+ myeloid cells drive vascular inflammation and endothelial dysfunction in heart failure after myocardial infarction via angiotensin II receptor type 1. Cardiovasc Res. 2021 Jan 1;117(1):162-177.
  • Karbach S, Hobohm L, Wild J, Münzel T, Gori T, Wegner J, Steinbrink K, Wenzel P, Keller K. Impact of Psoriasis on Mortality Rate and Outcome in Myocardial Infarction. J Am Heart Assoc. 2020 Sep 15;9(18):e016956.
  • Göbel S, Schwuchow-Thonke S, Jansen T, Karbach S, Emrich T, Gori T, Knies F, Schulz E, Münzel T, Keller K, Wenzel P. Safety of transradial and transfemoral left ventricular compared with transfemoral right ventricular endomyocardial biopsy. ESC Heart Fail. 2020 Sep 19;7(6):4015–23.
  • Wild J, Hobohm L, Münzel T, Wenzel P, Steinbrink K, Karbach S, Keller K. Psoriasis and Its Impact on In-Hospital Outcome in Patients Hospitalized with Acute Kidney Injury. J Clin Med. 2020 Sep 17;9(9):3004.
  • Gamrekelashvili J, Kapanadze T, Sablotny S, Ratiu C, Dastagir K, Lochner M, Karbach S, Wenzel P, Sitnow A, Fleig S, Sparwasser T, Kalinke U, Holzmann B, Haller H, Limbourg FP. Notch and TLR signaling coordinate monocyte cell fate and inflammation. Elife. 2020 Jul 29;9:e57007.
  • Chen W, Werner F, Illerhaus A, Knopp T, Völker K, Potapenko T, Hofmann U, Frantz S, Baba HA, Rösch M, Zernecke A, Karbach S, Wenzel P, Kuhn M. Stabilization of Perivascular Mast Cells by Endothelial CNP (C-Type Natriuretic Peptide). Arterioscler Thromb Vasc Biol. 2020 Mar;40(3):682-696
  • Mufazalov IA, Andruszewski D, Schelmbauer C, Heink S, Blanfeld M, Masri J, Tang Y, Schüler R, Eich C, Wunderlich FT, Karbach SH, Bluestone JA, Korn T, Waisman A. Cutting Edge: IL-6-Driven Immune Dysregulation Is Strictly Dependent on IL-6R α-Chain Expression. J Immunol. 2020 Feb 15;204(4):747-751.
  • Wild J, Schüler R, Knopp T, Molitor M, Kossmann S, Münzel T, Daiber A, Waisman A, Wenzel P, Karbach SH. Telmisartan Lowers Elevated Blood Pressure in Psoriatic Mice without Attenuating Vascular Dysfunction and Inflammation. Int J Mol Sci. 2019 Aug 30;20(17):4261.
  • Schüler R, Efentakis P, Wild J, Lagrange J, Garlapati V, Molitor M, Kossmann S, Oelze M, Stamm P, Li H, Schäfer K, Münzel T, Daiber A, Waisman A, Wenzel P, Karbach SH. T Cell-Derived IL-17A Induces Vascular Dysfunction via Perivascular Fibrosis Formation and Dysregulation of ·NO/cGMP Signaling. Oxid Med Cell Longev. 2019 Jul 18;2019:6721531
  • Schüler R, Brand A, Klebow S, Wild J, Veras FP, Ullmann E, Roohani S, Kolbinger F, Kossmann S, Wohn C, Daiber A, Münzel T, Wenzel P, Waisman A, Clausen BE, Karbach S. Antagonization of IL-17A Attenuates Skin Inflammation and Vascular Dysfunction in Mouse Models of Psoriasis. J Invest Dermatol 2019;139(3):638-647.
  • Karbach S, Lagrange J, Wenzel P. Thromboinflammation and Vascular Dysfunction. Hamostaseologie 2018.
  • Brandt M, Giokoglu E, Garlapati V, Bochenek ML, Molitor M, Hobohm L, Schönfelder T, Münzel T, Kossmann S, Karbach SH, Schäfer K, Wenzel P. Pulmonary Arterial Hypertension and Endothelial Dysfunction Is Linked to NADPH Oxidase-Derived Superoxide Formation in Venous Thrombosis and Pulmonary Embolism in Mice. Oxid Med Cell Longev 2018;2018:1860513.
  • Schönfelder T, Brandt M, Kossmann S, Knopp T, Münzel T, Walter U, Karbach SH, Wenzel P. Lack of T-bet reduces monocytic interleukin-12 formation and accelerates thrombus resolution in deep vein thrombosis. Sci Rep 2018;8(1):3013.
  • Kossmann S, Lagrange J, Jäckel S, Jurk K, Ehlken M, Schönfelder T, Weihert Y, Knorr M, Brandt M, Xia N, Li H, Daiber A, Oelze M, Reinhardt C, Lackner K, Gruber A, Monia B, Karbach SH, Walter U, Ruggeri ZM, Renne T, Ruf W, Münzel T, Wenzel P (2017) Platelet-localized fxi promotes a vascular coagulation-inflammatory circuit in arterial hypertension. Science translational medicine 9
  • Karbach SH, Schönfelder T, Brandao I, Wilms E, Hormann N, Jäckel S, Schuler R, Finger S, Knorr M, Lagrange J, Brandt M, Waisman A, Kossmann S, Schäfer K, Münzel T, Reinhardt C, Wenzel P (2016) Gut microbiota promote angiotensin ii-induced arterial hypertension and vascular dysfunction. Journal of the American Heart Association 5 
  • Klebow S, Hahn M, Nikoalev A, Wunderlich FT, Hövelmeyer N, Karbach* SH, Waisman* A (2016) Il-6 signaling in myelomonocytic cells is not crucial for the development of imq-induced psoriasis. PloS one 11:e0151913 
  • Uluckan O, Jimenez M, Karbach S, Jeschke A, Grana O, Keller J, Busse B, Croxford AL, Finzel S, Koenders M, van den Berg W, Schinke T, Amling M, Waisman A, Schett G, Wagner EF (2016) Chronic skin inflammation leads to bone loss by il-17-mediated inhibition of wnt signaling in osteoblasts. Science translational medicine 8:330ra337 
  • Wenzel P, Rossmann H, Müller C, Kossmann S, Oelze M, Schulz A, Arnold N, Simsek C, Lagrange J, Klemz R, Schönfelder T, Brandt M, Karbach SH, Knorr M, Finger S, Neukirch C, Hauser F, Beutel ME, Kröller-Schön S, Schulz E, Schnabel RB, Lackner K, Wild PS, Zeller T, Daiber A, Blankenberg S, Münzel T (2015) Heme oxygenase- 1 suppresses a pro-inflammatory phenotype in monocytes and determines endothelial function and arterial hypertension in mice and humans. Eur Heart J 36:3437-3446.
  • Croxford* AL, Karbach* S, Kurschus FC, Wörtge S, Nikolaev A, Yogev N, Klebow S, Schüler R, Reissig S, Piotrowski C, Brylla E, Bechmann I, Scheller J, Rose-John S, Wunderlich FT, Münzel T, von Stebut E, Waisman A (2014) Il-6 regulates neutrophil microabscess formation in IL-17a-driven psoriasiform lesions. J Invest Dermatol 134:728-735
  • Karbach S, Croxford AL, Oelze M, Schüler R, Minwegen D, Wegner J, Koukes L, Yogev N, Nikolaev A, Reissig S, Ullmann A, Knorr M, Waldner M, Neurath MF, Li H, Wu Z, Brochhausen C, Scheller J, Rose-John S, Piotrowski C, Bechmann I, Radsak M, Wild P, Daiber A, von Stebut E, Wenzel P, Waisman A, Münzel T (2014) Interleukin 17 drives vascular inflammation, endothelial dysfunction, and arterial hypertension in psoriasis-like skin disease. Arterioscler Thromb Vasc Biol 34:2658-2668
  • Karbach S, Wenzel P, Waisman A, Münzel T, Daiber A (2014) Enos uncoupling in cardiovascular diseases--the role of oxidative stress and inflammation. Current pharmaceutical design 20:3579-3594
  • El Malki* K, Karbach* SH, Huppert* J, Zayoud M, Reissig S, Schüler R, Nikolaev A, Karram K, Münzel T, Kuhlmann CR, Luhmann HJ, von Stebut E, Wörtge S, Kurschus FC, Waisman A (2013) An alternative pathway of imiquimod-induced psoriasis-like skin inflammation in the absence of interleukin-17 receptor a signaling. J Invest Dermatol 133:441-451
  • Simon* A, Karbach* S, Habermeier A, Closs EI (2013) Decoding the substrate supply to human neuronal nitric oxide synthase. PloS one 8:e67707
  • Karbach S, Jansen T, Horke S, Heeren T, Scholz A, Coldewey M, Karpi A, Hausding M, Kröller-Schön S, Oelze M, Münzel T, Daiber A (2012) Hyperglycemia and oxidative stress in cultured endothelial cells--a comparison of primary endothelial cells with an immortalized endothelial cell line. J Diabetes Complications 26:155-162
  • Wenzel P, Knorr M, Kossmann S, Stratmann J, Hausding M, Schuhmacher S, Karbach SH, Schwenk M, Yogev N, Schulz E, Oelze M, Grabbe S, Jonuleit H, Becker C, Daiber A, Waisman A, Münzel T (2011) Lysozyme m-positive monocytes mediate angiotensin II-induced arterial hypertension and vascular dysfunction. Circulation 124:1370-1381 
  • *contributed equally

Reviews

  • Herster F, Karbach S, Chatterjee M, Weber ANR. Platelets: Underestimated Regulators of Autoinflammation in Psoriasis. J Invest Dermatol. 2021 Jun;141(6):1395-1403.
  • Jung R, Wild J, Ringen J, Karbach S, Wenzel P. Innate Immune Mechanisms of Arterial Hypertension and Autoimmune Disease. Am J Hypertens. 2021 Mar 11;34(2):143-153.

Comments

  • Knopp T, Karbach S, Wenzel P. Myeloid Cells to the Rescue: Improving Thrombus Resolution. Thromb Haemost. 2020 Feb;120(2):197-198.