Jürgen Prochaska, MD
Junior group leader
The research group "Thrombotic diseases and antithrombotic therapy" is integrated in the Clinical Epidemiology of the CTH as an independent BMBF-funded junior research group investigating clinically-relevant research topics in the field of arterial and venous thrombosis. Biodata banks of population-based (Gutenberg Health Study) and diseased cohorts (thrombEVAL, VTEval, FOCUS Bioseq, MyoVasc, Prospectus) are investigated in a holistic approach incorporating genetic information, ´omics´ data, (sub)clinical phenotypes and clinical outcome.
The scientific working program investigates risk factors for the development of thrombotic diseases in the arterial and venous system and their sequelae, in particular heart failure. A specific focus is the investigation of subclinical phenotypes of cardiovascular disease, which are of particular interest for preventive medicine. These studies are complemented by research projects addressing diagnosis, therapy and prevention of thrombotic diseases.
Research interest
- Diagnosis, therapy and prevention of thrombotic diseases and its sequelae
- Interaction between hemostasis and the development and progression of the heart failure syndrome
- Cross-talk of venous diseases and arterial cardiovascular disease
Partners of collaboration
Intramural partners
- Dr. Christian Becker, PhD – CTH
- Professor Espinola-Klein, MD – Center for Cardiology, Dpt. of Angiology
- Professor Stavros Konstantinides, MD, PhD and Dr. Mareike Lankeit, MD – Clinical Studies, CTH
- Professor Karl Lackner, MD – Institute for Clinical Chemistry and Laboratory Medicine
- Professor Thomas Münzel, MD – Center for Cardiology
- Dr. Marina Panova-Noeva, MD, PhD, MSc – Junior Group Clinical Platelet Epidemiology, CTH
- Professor Philipp Wild, MD, MSc – Clinical Epidemiology, CTH
National partners
- Prof. Dr. S. Bode-Böger, University Hospital Magdeburg
International partners
- Professor Hugo ten Cate, MD, PhD and Dr. Henri Spronk, PhD – CARIM Maastricht, Netherlands
- Prof. Dr. Carolyn S. Lam, National Heart Center Singapore
Research funding
- Federal Ministry of Education and Research (CTH, 01EO1503)
Team - Junior group Clinical Epidemiology
Jürgen Prochaska, MD
Junior group leader
Deputy Head Preventive Cardiology and Medical Prevention, Senior Physician Cardiology I
DZHK PI
06131 17-2594
Further Information
Vincent ten Cate, M.Sc. – PhD
Tanja Eichkorn – MD student
Andrea Falcke – MD student
Steffen Heltsche – MD student
Paul Ludolph – MD student
Felix Müller – MD student
Judith Plöger – MD student
Johanna Rauchfuß – MD student
cand. med. Jannis Franz - MD student
cand. med. Matthias Grosch - MD student
cand. med. Sophie Moll - MD student
Data Management (Clinical Epidemiology)
Karen Buchtal (Prospectus study), Stefanie Kurz (MyoVasc)
Heidrun Lamparter (thrombEVAL/VTEval), Bianca Zäpf (FOCUS Bioseq)
Dr. Dagmar Laubert-Reh (Gutenberg-Health-Study)
Statistics (Clinical Epidemiology)
Markus Nagler (thrombEVAL, VTEval, FOCUS Bioseq, Prospectus)
Andreas Schulz (GHS, MyoVasc)
Reviews
Original articles
- Ten Cate V, Nagler M, Panova-Noeva M, Eggebrecht L, Arnold N, Lamparter H, Hermanns MI, Ten Cate H, Prins MH, Espinola-Klein C, Münzel T, Lackner KJ, Wild PS, Prochaska JH. The diagnostic performance of renal function-adjusted D-dimer testing in individuals suspected of venous thromboembolism. Haematologica 2019.
- Eggebrecht L, Prochaska JH, Tröbs SO, Schwuchow-Thonke S, Göbel S, Diestelmeier S, Schulz A, Arnold N, Panova-Noeva M, Koeck T, Rapp S, Gori T, Lackner KJ, Ten Cate H, Münzel T, Wild PS. Direct oral anticoagulants and vitamin K antagonists are linked to differential profiles of cardiac function and lipid metabolism. Clin Res Cardiol 2019.
- Eggebrecht L, Nagler M, Göbel S, Lamparter H, Keller K, Wagner B, Panova-Noeva M, Ten Cate V, Bickel C, Lauterbach M, Espinola-Klein C, Hardt R, Münzel T, Prochaska JH, Wild PS. Relevance of Polypharmacy for Clinical Outcome in Patients Receiving Vitamin K Antagonists. J Am Geriatr Soc 2019;67(3):463-470.
- Burghardt J, Klein E, Brähler E, Ernst M, Schneider A, Eckerle S, Neu MA, Wingerter A, Henninger N, Panova‐Noeva M, Prochaska J, Wild P, Beutel M, Faber J. Prevalence of mental distress among adult survivors of childhood cancer in Germany—Compared to the general population. Cancer Medicine 2019;8(4):1865-1874.
- Börschel CS, Rübsamen N, Ojeda FM, Wild PS, Hoffmann BA, Prochaska JH, Gori T, Lackner KJ, Blankenberg S, Zeller T, Münzel T, Schnabel RB. Noninvasive peripheral vascular function and atrial fibrillation in the general population. J Hypertens 2019;37(5):928-934.
- Trinchero A, Scheres LJJ, Prochaska JH, Ambaglio C, Wild PS, Middeldorp S, Konstantinides SV, Barco S. Sex-specific differences in the distal versus proximal presenting location of acute deep vein thrombosis. Thromb Res 2018;172:74-79.
- Göbel S, Prochaska JH, Eggebrecht L, Schmitz R, Jünger C, Lamparter H, Nagler M, Keller K, Coldewey M, Tröbs SO, Diestelmeier S, Schwuchow-Thonke S, Bickel C, Lauterbach M, Lackner KJ, Cate HT, Münzel T, Hardt R, Wild PS. Management of Oral Anti-Coagulation in Patients with Heart Failure-Insights from the ThrombEVAL Study. Thromb Haemost 2018;118(11):1930-1939.
- Eggebrecht L, Prochaska JH, Schulz A, Arnold N, Jünger C, Gobel S, Laubert-Reh D, Binder H, Beutel ME, Pfeiffer N, Blankenberg S, Lackner KJ, Spronk HM, Ten Cate H, Münzel T, Wild PS. Intake of Vitamin K Antagonists and Worsening of Cardiac and Vascular Disease: Results From the Population-Based Gutenberg Health Study. J Am Heart Assoc 2018;7(17):e008650.
- Prochaska JH, Luther N, Brähler M, Schulz A, Hermanns MI, Lackner KJ, Espinola-Klein C, Münzel T, Wild PS, Becker C. Acute deep vein thrombosis suppresses peripheral T cell effector function. Br J Haematol 2019;184(5):847-850.
- Faber J, Wingerter A, Neu MA, Henninger N, Eckerle S, Münzel T, Lackner KJ, Beutel ME, Blettner M, Rathmann W, Peters A, Meisinger C, Linkohr B, Neuhauser H, Kaatsch P, Spix C, Schneider A, Merzenich H, Panova-Noeva M, Prochaska JH, Wild PS. Burden of cardiovascular risk factors and cardiovascular disease in childhood cancer survivors: data from the German CVSS-study. Eur Heart J 2018;39(17):1555-1562.
- Magnussen C, Ojeda FM, Wild PS, Sorensen N, Rostock T, Hoffmann BA, Prochaska J, Lackner KJ, Beutel ME, Blettner M, Pfeiffer N, Rzayeva N, Sinning CR, Blankenberg S, Münzel T, Zeller T, Schnabel RB. Atrial Fibrillation Manifestations Risk Factors and Sex Differences in a Population-Based Cohort (From the Gutenberg Health Study). Am J Cardiol 2018;122(1):76-82.
- Panova-Noeva M, Schulz A, Arnold N, Hermanns MI, Prochaska JH, Laubert-Reh D, Spronk HM, Blettner M, Beutel M, Pfeiffer N, Münzel T, Lackner KJ, Ten Cate H, Wild PS. Coagulation and inflammation in long-term cancer survivors: results from the adult population. J Thromb Haemost 2018;16(4):699-708.
- Panova-Noeva M, Schulz A, Spronk HM, Beicht A, Laubert-Reh D, van Oerle R, Arnold N, Prochaska JH, Blettner M, Beutel M, Pfeiffer N, Münzel T, Lackner KJ, Ten Cate H, Wild PS. Clinical Determinants of Thrombin Generation Measured in Presence and Absence of Platelets-Results from the Gutenberg Health Study. Thromb Haemost 2018;118(5):873-882.
- Parry BA, Chang AM, Schellong SM, House SL, Fermann GJ, Deadmon EK, Giordano NJ, Chang Y, Cohen J, Robak N, Singer AJ, Mulrow M, Reibling ET, Francis S, Griffin SM, Prochaska JH, Davis B, McNelis P, Delgado J, Kumpers P, Werner N, Gentile NT, Zeserson E, Wild PS, Limkakeng AT, Jr., Walters EL, LoVecchio F, Theodoro D, Hollander JE, Kabrhel C. International, multicenter evaluation of a new D-dimer assay for the exclusion of venous thromboembolism using standard and age-adjusted cut-offs. Thromb Res 2018;166:63-70.
- Prochaska JH, Göbel S, Nagler M, Knöpfler T, Eggebrecht L, Lamparter H, Panova-Noeva M, Keller K, Coldewey M, Bickel C, Lauterbach M, Hardt R, Espinola-Klein C, Ten Cate H, Rostock T, Münzel T, Wild PS. Sustained atrial fibrillation increases the risk of anticoagulation-related bleeding in heart failure. Clin Res Cardiol 2018;107(12):1170-1179.
- Hahad O, Beutel M, Gori T, Schulz A, Blettner M, Pfeiffer N, Rostock T, Lackner K, Sørensen M, Prochaska JH, Wild PS, Münzel T. Annoyance to different noise sources is associated with atrial fibrillation in the Gutenberg Health Study. Int J Cardiol. 2018;264:79-84.
- Eggebrecht L*, Prochaska JH*, Schleuter L, Nagler M, Hardt R, Schinzel H, Münzel T, Wild PS. [Physicians' Opinion on Health Care in Oral Anticoagulation]. Dtsch Med Wochenschr 2017.
- Arnold N, Gori T, Schnabel RB, Schulz A, Prochaska JH, Zeller T, Binder H, Pfeiffer N, Beutel M, Espinola-Klein C, Lackner KJ, Blankenberg S, Münzel T, Wild PS (2017) Relation between Arterial Stiffness and Markers of Inflammation and Hemostasis - Data from the Population-based Gutenberg Health Study. Scientific reports 7: 6346
- Prochaska JH, Frank B, Nagler M, Lamparter H, Weisser G, Schulz A, Eggebrecht L, Göbel S, Arnold N, Panova-Noeva M, Hermanns I, Pinto A, Konstantinides S, Ten Cate H, Lackner KJ, Münzel T, Espinola-Klein C, Wild PS (2017) Age-related diagnostic value of D-dimer testing and the role of inflammation in patients with suspected deep vein thrombosis. Scientific reports 7: 4591
- Luque Ramos A, Ohlmeier C, Enders D, Linder R, Horenkamp-Sonntag D, Prochaska JH, Mikolajczyk R, Garbe E (2017) Initiation and duration of dual antiplatelet therapy after inpatient percutaneous coronary intervention with stent implantation in Germany: An electronic healthcare database cohort study. Z Evid Fortbild Qual Gesundhwes 120: 31-38
- Prochaska JH, Göbel S, Keller K, Coldewey M, Ullmann A, Lamparter H, Schulz A, Schinzel H, Bickel C, Lauterbach M, Michal M, Hardt R, Binder H, Espinola-Klein C, Lackner KJ, Ten Cate H, Münzel T, Wild PS (2017) e-Health based management of patients receiving oral anticoagulation therapy: results from the observational thrombEVAL study. Journal of thrombosis and haemostasis
- Panova-Noeva M, Arnold N, Hermanns MI, Prochaska JH, Schulz A, Spronk HM, Binder H, Pfeiffer N, Beutel M, Blankenberg S, Zeller T, Lotz J, Münzel T, Lackner KJ, ten Cate H, Wild PS. Mean Platelet Volume and Arterial Stiffness – Clinical Relationship and Common Genetic Variability. Sci Rep 2017. Vol 7 pp. 40229.
- Prochaska JH, Göbel S, Keller K, Coldewey M, Ullmann A, Lamparter H, Jünger C, Al-Bayati Z, Baer C, Walter U, Bickel C, Ten Cate H, Münzel T, Wild PS. Quality of oral anticoagulation with phenprocoumon in regular medical care and its potential for improvement in a telemedicine-based coagulation service - results from the prospective, multi-center, observational cohort study thrombEVAL. BMC Med. 2015 Jan 23;13(1):14.
- Michal M, Prochaska JH, Keller K, Göbel S, Coldewey M, Ullmann A, Schulz A, Lamparter H, Münzel T, Reiner I, Beutel ME, Wild PS. Symptoms of depression and anxiety predict mortality in patients undergoing oral anticoagulation: Results from the thrombEVAL study program. Int J Cardiol. 2015; 187:614-9.
- Zolfaghari S, Harenberg J, Frölich J, Weiss C, Wehling M, Wild P, Prochaska J, Beyer-Westendorf J, Koscielny J, Lip GY. Development of recommendations to continue anticoagulation with one of the two types of oral anticoagulants based on the identification of patients´ preference. Semin Thromb Hemost. 2015 Mar;41(2):166-77.
- Keller K, Prochaska JH, Coldewey M, Gobel S, Ullmann A, Jünger C, Lamparter H, Ariza L, Bickel C, Lauterbach M, Konstantinides S, Rostock T, Münzel T, Wild PS. History of deep vein thrombosis is a discriminator for concomitant atrial fibrillation in pulmonary embolism. Thromb Res. 2015 Nov; 136(5):899-906.
- Prochaska JH, Gobel S, Hendelmeier M, Coldewey M, Keller K, Konstantinides S, Münzel T, Wild PS. Evaluation of oral anticoagulation therapy with vitamin K antagonists: Rationale and design of the thrombEVAL study programme. Eur J Prev Cardiol. 2015 May;22(5):622-8.
- Frank B, Ariza L, Lamparter H, Grossmann V, Prochaska JH, Ullmann A, Kindler F, Weisser G, Walter U, Lackner KJ, Espinola-Klein C, Münzel T, Konstantinides SV, Wild PS. Rationale and design of three observational, prospective cohort studies including biobanking to evaluate and improve diagnostics, management strategies and risk stratification in venous thrombobembolism: the VTEval Project. BMJ Open. 2015 Jul 1; 5(7):e008157.
- Schnabel RB, Wild PS, Prochaska JH, Ojeda FM, Zeller T, Rzayeva N, Ebrahim A, Lackner KJ, Beutel ME, Pfeiffer N, Sinning CR, Oertelt-Prigione S, Regitz-Zagrosek V, Binder H, Münzel T, Blankenberg S. Sex differences in correlates of intermediate phenotypes and prevalent cardiovascular disease in the general population. Front Cardiovasc Med. 2015 Apr 15;2:15.
- Haarmann A, Deiss A, Prochaska J, Foerch C, Weksler B, Romero I, Couraud PO, Stoll G, Rieckmann P, Buttmann M. Evaluation of soluble junctional adhesion molecule-A as a biomarker of human brain endothelial barrier breakdown. PLoS One. 2010 Oct 21;5(10):e13568.
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