Visual Universitätsmedizin Mainz

Juniorprofessorship 'Systems Interactions of Hemostasis'

Assistant Professor for Systems Interactions of Hemostasis

Jun. Prof. Dr. Carsten Deppermann

Platelets are small, anucleate cells that patrol the vasculature to immediately respond to vessel breaches and restore hemostasis. There has been accumulating evidence that platelets also interact with and regulate cells of the (innate) immune system. It is now accepted that they play roles beyond hemostasis and contribute to thromboinflammatory processes in disease.

We are currently employing intravital microscopy, tissue clearing, primary cell culture, flow cytometry and other state-of-the-art techniques to understand the complex interplay between platelets and the innate immune system in the liver, kidney and intestine under (patho)physiologic conditions. We are also studying the mechanisms through which platelet clearance in health and disease feeds back to platelet production by megakaryocytes in the bone marrow.

Research Funding

Biography - Carsten Deppermann

Positions:
Since 2021 – Assistant Professor for Systems Interactions of Hemostasis, CTH, University Medical Center of the Johannes Gutenberg-University, Mainz
2019 - 2021 – Group Leader, Institute of Clinical Chemistry and Laboratory Medicine, University Medical Centre Hamburg-Eppendorf

Research Career:
2016 - 2019 – Postdoctoral Fellow (with Prof. Dr. Paul Kubes), Snyder Institute for Chronic Diseases, Calgary, Canada, DFG Research Fellowship

Professional Education:
2011 - 2015 – PhD, Experimental Biomedicine, Rudolf Virchow Centre, Würzburg, Supervisor Prof. Dr. Bernhard Nieswandt
2005 - 2010 – Studies in biochemistry, University of Frankfurt/Main, Master (Diplom), thesis supervisor Prof. Dr. Mirko Schmidt

Researcher IDs:
ORCID: 0000-0003-3740-8635
Google Scholar: Link

Twitter:
Link

Team

Casari
Martina Casari
Position: PhD Student

06131 17-8013

Jun. Prof. Dr. Deppermann
Carsten Deppermann, Jun. Prof. Dr.
Position: Juniorgroup leader

06131 17-8215

Mandel
Jonathan Mandel
Position: PhD Student

06131 17-8013

Mros
Bettina Mros
Position: TechnicianBettina.Mros@unimedizin-mainz.de

06131 17-8013

Stepanyan
Maria Stepanyan
Position: Visiting Student

06131 17-8013

We are currently looking for motivated Master, MD or PhD students. Students with interests in platelet/cell biology, innate immunity and microscopy are encouraged to apply via e-mail to  deppermann@uni-mainz.de including a letter of motivation and CV.

Original articles

  • Heestermans M, Naudin C, Mailer RK, Konrath S, Klaetschke K, Jämsä A, Frye M, Deppermann C, Pula G, Kuta P, Friese MA, Gelderblom M, Sickmann A, Preston RJS, Nofer JR, Rose-John S, Butler LM, Salomon O, Stavrou EX, Renné T. Identification of the factor XII contact activation site enables sensitive coagulation diagnostics. Nat Commun. 2021 Sep 22;12(1):5596. https://doi.org/10.1038/s41467-021-25888-7
  • Englert H, Rangaswamy C, Deppermann C, Sperhake JP, Krisp C, Schreier D, Gordon E, Konrath S, Haddad M, Pula G, Mailer RK, Schlüter H, Kluge S, Langer F, Püschel K, Panousis K, Stavrou EX, Maas C, Renné T and Frye M. Defective NET clearance contributes to sustained FXII activation in COVID-19-associated pulmonary thrombo-inflammation. EBioMedicine 67:1033822021 (2021) https://doi.org/10.1016/j.ebiom.2021.103382
  • Zindel J, Peiseler M, Hossain M, Deppermann C, Lee WY, Haenni B, Zuber B, Deniset JF, Surewaard BGJ, Candinas D and Kubes P. Primordial GATA6 macrophages function as extravascular platelets in sterile injury. Science 371(6533):eabe0595 (2021) https://doi.org/10.1126/science.abe0595
  • Mailer RK, Allende M, Heestermans M, Schweizer M, Deppermann C, Frye M, Pula G, Odeberg J, Gelderblom M, Rose-John S, Sickmann A, Blankenberg S, Huber T, Kubisch C, Maas C, Gambaryan S, Firsov S, Stavrou EX, Butler L and Renné T. Xenotropic and polytropic retrovirus receptor 1 regulates procoagulant platelet polyphosphate. Blood 137(10):1392-1405 (2020) https://doi.org/10.1182/blood.2019004617
  • Deppermann C*, Peiseler M*, Zindel J, Zbytnuik L, Lee WY, Pasini E, Baciu C, Matelski J, Lee Y, Kumar D, Humar A, Surewaard B, Kubes P and Bhat M. Tacrolimus impairs Kupffer cell capacity to control bacteremia: why transplant recipients are susceptible to infection. Hepatology (2020) https://doi.org/10.1002/hep.31499 *equal contribution
  • Deppermann C, Kratofil RM, Peiseler M, David BA, Zindel J, Castanheira FVES, van der Wal F, Carestia A, Jenne CN, Marth JD and Kubes P. Macrophage galactose lectin is critical for Kupffer cells to clear aged platelets. J. Exp. Med. 217(4): e20190723 (2020) https://doi.org/10.1084/jem.20190723
  • Jorch SK, Surewaard BGJ, Hossain M, Peiseler M, Deppermann C, Deng J, Bogoslowski A, van der Wal F, Omri A, Hickey MJ and Kubes P. GATA6+ macrophages in the peritoneum function as a portal for Staphylococcus aureus dissemination. J. Clin. Invest. 129(11): 4643-56 (2019) https://doi.org/10.1172/JCI127286
  • Deniset JF, Belke D, Lee W-Y, Jorch SK, Deppermann C, Hassanabad AF, Turnbull JD, Teng G, Rozich I, Hudspeth K, Kanno Y, Brooks SR, Hadjantonakis A-K, O’Shea JJ, Weber GF, Fedak PWM and Kubes P. Gata6+ Pericardial Cavity Macrophages Relocate to the Injured Heart and Prevent Cardiac Fibrosis. Immunity 51: 131-40 (2019) https://doi.org/10.1016/j.immuni.2019.06.010
  • Malehmir M, Pfister D, Gallage S, Szydlowska M, Inverso D, Kotsiliti E, Leone V, Peiseler M, Surewaard B, Rath D, Ali S, Wolf M, Drescher H, Healy M, Dauch D, Kroy D, Krenkel O, Kohlhepp M, Engleitner T, Olkus A, Sijmonsma T, Volz J, Deppermann C, Stegner D, Helbling P, Nombela-Arrieta C, Rafiei A, Hinterleitner M, Rall M, Baku F, Borst O, Wilson CL, Leslie J, O’Connor T, Weston CJ, Adams DH, Sheriff L, Teijeiro A, Prinz M, Bogeska R, Anstee N, Bongers MN, Notohamiprodjo M, Geisler T, Withers DJ, Ware J, Mann DA, Augustin HG, Vegiopoulos A, Milsom MD, Rose AJ, Lalor PF, Llovet JM, Pinyol R, Tacke F, Rad R, Matter M, Djouder N, Kubes P, Knolle PA, Unger K, Zender L, Nieswandt B, Gawaz M, Weber A and Heikenwälder M. Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer. Nat. Medicine 25(4): 641-55 (2019) https://doi.org/10.1038/s41591-019-0379-5
  • Gotru SK, van Geffen JP, Nagy M, Mammadova-Bach E, Eilenberger J, Volz J, Manukjan G, Schulze H, Wagner L, Eber S, Schambeck C, Deppermann C, Brouns S, Nurden P, Greinacher A, Sachs U, Nieswandt B, Hermanns HM, Heemskerk JWM and Braun A. Defective Zn2+ homeostasis in mouse and human platelets with α- and δ-storage pool diseases. Sci. Rep. 9(1): 8333 (2019) https://doi.org/10.1038/s41598-019-44751-w
  • Surewaard BGJ, Thanabalasuriar A, Zeng Z, Tkaczyk C, Cohen TS, Bardoel BW, Jorch SK, Deppermann C, Bubeck Wardenburg J, Davis RP, Jenne CN, Stover KC, Sellman BR and Kubes P. α-Toxin Induces Platelet Aggregation and Liver Injury during Staphylococcus aureus Sepsis. Cell Host Microbe 24(2): 271-84 (2018) https://doi.org/10.1016/j.chom.2018.06.017
  • Drube S, Grimlowski R, Deppermann C, Fröbel J, Kraft F, Andreas N, Stegner D, Dudeck J, Weber F, Rödiger M, Göpfert C, Drube J, Reich D, Nieswandt B, Dudeck A and Kamradt T. The Neurobeachin-like 2 protein (Nbeal2) regulates mast cell homeostasis. J. Immunol. 199(8): 2948-57 (2017) https://doi.org/10.4049/jimmunol.1700556
  • Deppermann C, Kraft P, Volz J, Schuhmann MK, Beck S, Wolf K, Stegner D, Stoll G and Nieswandt B. Platelet secretion is crucial to prevent bleeding in the ischemic brain but not in the inflamed skin or lung in mice. Blood 129(12): 1702-07 (2017) https://doi.org/10.1182/blood-2016-12-750711
  • Pachel C, Mathes D, Arias-Loza A-P, Heitzmann W, Nordbeck P, Deppermann C, Lorenz V, Hofmann U, Nieswandt B and Frantz S. Inhibition of platelet GPVI protects against myocardial ischemia-reperfusion injury. Arterioscler. Thromb. Vasc. Biol. 36(4): 629-35 (2016) https://doi.org/10.1161/atvbaha.115.305873
  • Lowe KL, Finney BA, Deppermann C, Hagerling R, Gazit SL, Frampton J, Buckley CD, Camerer E, Nieswandt B, Kiefer F and Watson SP. Podoplanin and CLEC-2 drive cerebrovascular patterning and integrity during development. Blood 125(24): 3769-77 (2015) https://doi.org/10.1182/blood-2014-09-603803
  • Kraft P, Göb E, Schuhmann MK, Göbel K, Deppermann C, Thielmann I, Herrmann AM, Lorenz K, Brede M, Stoll G, Meuth SG, Nieswandt B, Pfeilschifter W and Kleinschnitz C. FTY720 ameliorates acute ischemic stroke in mice by reducing thrombo-inflammation but not by direct neuroprotection. Stroke 44(11): 3202-10 (2013) https://doi.org/10.1161/strokeaha.113.002880
  • Stegner D*, Deppermann C*, Kraft P, Morowski M, Kleinschnitz C, Stoll G and Nieswandt B. Munc13-4 mediated secretion is essential for infarct progression but not intracranial haemostasis in acute stroke. J. Thromb. Haemost. 11(7): 1430-33 (2013) *equal contribution https://doi.org/10.1111/jth.12293
  • Deppermann C, Cherpokova D, Nurden P, Schulz JN, Thielmann I, Kraft P, Vögtle T, Kleinschnitz C, Dütting S, Krohne G, Eming S, Nurden A, Eckes B, Stoll G, Stegner D and Nieswandt B. Gray platelet syndrome and defective thrombo-inflammation in Nbeal2-deficient mice. J. Clin. Invest. 123(8): 3331-42 (2013) https://doi.org/10.1172/JCI69210

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