Professorship for Clinical Trials

Stavros V. Konstantinides, MD, PhD, FESC
Medical Director of the CTH

The 'Clinical Trial' module of the CTH initiates, designs, coordinates and conducts multicenter clinical trials on thrombotic disorders and antithrombotic treatment. Our research mainly focuses on advancing and optimizing the management of venous thromboembolism (VTE). In ongoing prospective cohort studies and interventional trials, we are developing and evaluating novel strategies for risk stratification of patients with acute pulmonary embolism (PE). Further studies of our Module concentrate on the feasibility and safety of home treatment of selected low-risk patients with PE, and on the risk of developing Chronic Thromboembolic Pulmonary Hypertension (CTEPH) after acute VTE.

Beyond individual research projects, the vision of our Module and of the CTH is to play a leading role in networking national and European research groups and centers of excellence in the field of PE. With the support of experts from 15 European countries and from North America, we are currently in the process of constructing the European Pulmonary Embolism Network (EPENet).

Research Interests

• Development and evaluation of multimarker strategies and combined scores for risk stratification of intermediate-risk PE
• Selection of low-risk patients with acute PE for early discharge and home treatment
• Investigation of cardiovascular risk factors common to arterial and venous thrombosis
• Long-term follow-up after acute VTE to assess the incidence and pathogenesis of CTEPH

Partners of Collaboration

• Partners of the University Medical Center Mainz:  Prof. H. Binder, IMBEI; Prof. C. Espinola-Klein, Department of Medicine II, Sec. Angiology; Prof. T. Münzel, Department of Medicine II; Prof. A. Kuhn, IZKS Mainz
• European partners: Prof. C. Becattini, Perugia, IT; Prof. C. Binder, Vienna, AT; Prof. B. Brenner, Haifa, IL; Prof. P. Corris, Newcastle, UK;  Prof. D. Jimenez, Madrid, ES; Dr. M. Kozak, Ljubljana, SLO; Prof. N. Kucher, Bern, CH; Prof. I. Lang, Vienna, AT; Prof. N. Meneveau, Besançon, FR; Prof. G. Meyer, Paris, FR; Prof. M. Monreal, Barcelona, ES; Prof. P. Pruszczyk, Warsaw, PL; Prof. M. Samarzija, Zagreb, HR; Prof. B. Stefanovic, Belgrade, SRB; Prof. A. Torbicki, Otwock, PL; Prof. T. Thum, Hannover, DE; Prof. D. Tziakas, Alexandroupolis, GR; Prof. F. Verschuren, Leuven, BE
  
• Prof. S.Z. Goldhaber, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, US, and the North American Thrombosis Forum (NATF)

Research Funding

• Bundesministerium für Bildung und Forschung – German Federal Ministry for Education and Research (Clinical Trial Funding Program, 2015-2020)
• Deutsche Gesellschaft für Kardiologie, Herz- und Kreislaufforschung – German Cardiac Society
• Pharmaceutical industry (co-funding of investigator initiated clinical trials of the Module)

Team - Module Clinical Trials

Project management

Research

Study assistance

Reviews / Editorials

• Barco S, Konstantinides SV. Optimizing the Personalized, Risk-Adjusted Management of Pulmonary Embolism: An Integrated Clinical Trial Programme. Hamostaseologie 2018.
• Petris AO, Konstantinides S, Tint D, Cimpoesu D, Pop C. Therapeutic Advances in Emergency Cardiology: Acute Pulmonary Embolism. Am J Ther 2019;26(2):e248-e256.
• Aissaoui N, Konstantinides S, Meyer G. What's new in severe pulmonary embolism? Intensive Care Med 2019;45(1):75-77.
• Konstantinides SV, Barco S. Prevention of early complications and late consequences after acute pulmonary embolism: Focus on reperfusion techniques. Thromb Res 2018;164:163-169.
• Barco S, Konstantinides SV. Pulmonary Embolism: Contemporary Medical Management and Future Perspectives. Ann Vasc Dis 2018;11(3):265-276.
• Barco S, Konstantinides S, Huisman MV, Klok FA. Diagnosis of recurrent venous thromboembolism. Thromb Res 2018;163:229-235.
• Mazzolai L, Aboyans V, Ageno W, Agnelli G, Alatri A, Bauersachs R, Brekelmans MPA, Buller HR, Elias A, Farge D, Konstantinides S, Palareti G, Prandoni P, Righini M, Torbicki A, Vlachopoulos C, Brodmann M. Diagnosis and management of acute deep vein thrombosis: a joint consensus document from the European Society of Cardiology working groups of aorta and peripheral vascular diseases and pulmonary circulation and right ventricular function. Eur Heart J 2018;39(47):4208-4218.
• Konstantinides SV. Introduction to the Special Issue: 'Update on Pulmonary Embolism'. Hamostaseologie 2018;38(2):71-72.
• Konstantinides SV. Diagnosis of Cerebral Venous Thrombosis: The Complementary Value of Imaging Methods. Thromb Haemost 2018;118(6):956.
• Huisman MV, Barco S, Cannegieter SC, Le Gal G, Konstantinides SV, Reitsma PH, Rodger M, Vonk Noordegraaf A, Klok FA. Pulmonary embolism. Nat Rev Dis Primers 2018;4:18028.
• Konstantinides SV. Detection and treatment of chronic thromboembolic pulmonary hypertension: Still a lot of homework to do. Hellenic J Cardiol 2018;59(1):24-25.
• Barco S, Konstantinides SV. Risk-adapted management of pulmonary embolism. Thromb Res 2017;151 Suppl 1:S92-S96.
• Barco S, Konstantinides S, Huisman MV, Klok FA Diagnosis of recurrent venous thromboembolism. Thrombosis research 2018;163:229-235.
• Konstantinides SV (2017) Diagnosis of pulmonary embolism: progress after many YEARS. Lancet 390: 210-211
• Konstantinides SV, Barco S Prevention of early complications and late consequences after acute pulmonary embolism: Focus on reperfusion techniques. Thrombosis research 2018;164:163-169.
• Schäfer K, Drosos I, Konstantinides S (2017) Perivascular adipose tissue: epiphenomenon or local risk factor? Int J Obes (Lond) 41(9):1311-1323
• Schulman S, Ageno W, Konstantinides SV (2017) Venous thromboembolism: Past, present and future. Thrombosis and haemostasis 117: 1219-122
• Barco S, Konstantinides SV (2017) Catheter-directed thrombolysis for acute pulmonary embolism: Where do we stand? Lung India 34: 221-222
• Konstantinides SV. The Elusive Evidence for Inferior Vena Cava Filters to Prevent Pulmonary Embolism. J Am Coll Cardiol 2017;70(13):1598-1600.
• Barco S, Konstantinides SV (2017) Risk-adapted management of pulmonary embolism. Thrombosis research 151 Suppl 1: S92-S96
• Konstantinides SV, Barco S (2017) Systemic Thrombolytic Therapy for Acute Pulmonary Embolism: Who Is a Candidate? Semin Respir Crit Care Med 38: 56-65
• Ponikowski P, et al. (2016) 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. European heart journal
• Harjola VP, Mebazaa A, Celutkiene J, Bettex D, Bueno H, Chioncel O, Crespo-Leiro MG, Falk V, Filippatos G, Gibbs S, Leite-Moreira A, Lassus J, Masip J, Mueller C, Mullens W, Naeije R, Nordegraaf AV, Parissis J, Riley JP, Ristic A et al. (2016) Contemporary management of acute right ventricular failure: a statement from the Heart Failure Association and the Working Group on Pulmonary Circulation and Right Ventricular Function of the European Society of Cardiology. European journal of heart failure 18: 226-41
• Konstantinides SV (2016) Trends in pregnancy outcomes in patients with pulmonary hypertension: still a long way to go. European journal of heart failure 18: 1129-31
• Konstantinides SV (2016) Trends in incidence versus case fatality rates of pulmonary embolism: Good news or bad news? Thrombosis and haemostasis 115: 233-5
• Konstantinides SV (2016) Trends in Pulmonary Embolism Outcomes: Are We Really Making Progress? Journal of the American College of Cardiology 67: 171-3
• Sista AK, Goldhaber SZ, Vedantham S, Kline JA, Kuo WT, Kahn SR, Kabrhel C, McLaughlin VV, White SB, Kim NH, Gray M, Simon MA, Benenati JF, Misra S, Sterling KM, Kee ST, Konstantinides SV, Jaff MR, Kearon C (2016) Research Priorities in Submassive Pulmonary Embolism: Proceedings from a Multidisciplinary Research Consensus Panel. Journal of vascular and interventional radiology : JVIR 27: 787-94
• Konstantinides SV, Barco S, Lankeit M, Meyer G. Management of Pulmonary Embolism: An Update. Journal of the American College of Cardiology 67:976-990. 2016.
• Konstantinides SV, Wärntges S. Acute phase treatment of venous thromboembolism: advanced therapy. Systemic fibrinolysis and pharmacomechanical therapy. Thrombosis and haemostasis 113. 2015.
• Comerota AJ, Sandset PM, Konstantinides S, de Graaf R, Wakefield TW, Arnoldussen CW, Lam YL, van Gent WB, de Wolf MA, Catarinella FS, Kurstjens RL, Alshabatat A, Wittens CH. Theme 4: Invasive management of (recurrent) VTE and PTS. Thrombosis research 136 Suppl 1:S19-25. 2015.
• Klok FA, Meyer G, Konstantinides S. Management of intermediate-risk pulmonary embolism: uncertainties and challenges. European journal of haematology. 2015.
• Konstantinides S. [Coronary heart disease: Genetic score identifies risk patients]. Deutsche medizinische Wochenschrift. 140:1418. 2015.
• Konstantinides SV, Wärntges S. Acute phase treatment of venous thromboembolism: advanced therapy. Systemic fibrinolysis and pharmacomechanical therapy. Thrombosis and haemostasis. 113. 2015.
• Wärntges S, Konstantinides SV. Progress in the management of acute pulmonary embolism. Current opinion in pulmonary medicine. 2015.
• Hellenkamp K, Käberich A, Schwung J, Konstantinides S, Lankeit M. Risk stratification of normotensive pulmonary embolism based on the sPESI - Does it work for all patients? International journal of cardiology. 197:162-163. 2015.
• Konstantinides SV, Torbicki A, [...], Lankeit M, [...], Task Force for the D, Management of Acute Pulmonary Embolism of the European Society of C. 2014 ESC guidelines on the diagnosis and management of acute pulmonary embolism. European heart journal. 35:3033-3069, 3069a-3069k. 2014.
• Wilkens H, Lang I, Blankenburg T, Grohe C, Guth S, Held M, Klepetko W, Konstantinides S, Kramm T, Kruger U, Lankeit M, Schafers HJ, Seyfarth HJ, Mayer E.  [Chronic thromboembolic pulmonary hypertension - A position paper.]. Deutsche medizinische Wochenschrift. 2014.
• Lankeit M, Konstantinides S. Aktuelle Therapie und Sekundärprävention der Lungenembolie, p. 77-90, Gefässchirurgie - Zeitschrift für vaskuläre und endovaskuläre Medizin, vol. 19. 2014.
• Lankeit M, Konstantinides, S. Thrombolyse bei akuter Lungenembolie – Risikostratifizierung, risikoadaptierte Diagnostik und Therapie, p. 6-11, Klinikarzt, vol. 433. 2014.
• Clemens A, Strack A, Noack H, Konstantinides S, Brueckmann M, Lip GY.  Anticoagulant-related gastrointestinal bleeding--could this facilitate early detection of benign or malignant gastrointestinal lesions? Annals of medicine 46:672-678, 2014.
• Käberich A, Wärntges S, Konstantinides S. Risk-adapted management of acute pulmonary embolism: recent evidence, new guidelines. Rambam Maimonides medical journal. 5:e0040, 2014.
• Klok FA, Kooiman J, Huisman MV, Konstantinides S, Lankeit M. Predicting anticoagulant-related bleeding in patients with venous thromboembolism: a clinically oriented review. The European respiratory journal. 2014.
• Klok FA, van der Hulle T, den Exter PL, Lankeit M, Huisman MV, Konstantinides S. The post-PE syndrome: a new concept for chronic complications of pulmonary embolism. Blood reviews. 2014.
• Konstantinides S, Torbicki A. Management of venous thrombo-embolism: an update. European heart journal. 2014.
• Konstantinides SV, Torbicki A. Management of pulmonary embolism: recent evidence and the new European guidelines. The European respiratory journal. 44:1385-1390, 2014.
• Marti C, John G, Konstantinides S, Combescure C, Sanchez O, Lankeit M, Meyer G, Perrier A. Systemic thrombolytic therapy for acute pulmonary embolism: a systematic review and meta-analysis. European heart journal. 2014.
• Konstantinides S, Lankeit M. Pulmonary embolism hotline 2012. Recent and expected trials. Hamostaseologie. 33(1):43-50. doi: 10.5482/HAMO-12-12-0024, 2013.
• Konstantinides S, Goldhaber SZ. Pulmonary embolism: risk assessment and management. Eur Heart J. 33(24):3014-22, 2012.

Original articles

• von Bardeleben RS, Hobohm L, Kreidel F, Ostad MA, Schulz E, Konstantinides S, Lankeit M, Feldman T, Münzel T, Keller K. Incidence and in-hospital safety outcomes of patients undergoing percutaneous mitral valve edge-to-edge repair using MitraClip: five-year German national patient sample including 13,575 implants. EuroIntervention 2019;14(17):1725-1732.
• Tziakas DN, Chalikias G, Pavlaki M, Kareli D, Gogiraju R, Hubert A, Bohm E, Stamoulis P, Drosos I, Kikas P, Mikroulis D, Giatromanolaki A, Georgiadis GS, Konstantinou F, Argyriou C, Münzel T, Konstantinides SV, Schäfer K. Lysed Erythrocyte Membranes Promote Vascular Calcification. Circulation 2019;139(17):2032-2048.
• Sacco C, Zane F, Granziera S, Holm K, Creemers-Schild D, Hotz MA, Turpini E, Valentini A, Righini C, Karkos PD, Verhamme P, Di Nisio M, Konstantinides S, Pecci A, Barco S, Lemierre Study G. Lemierre Syndrome: Clinical Update and Protocol for a Systematic Review and Individual Patient Data Meta-analysis. Hamostaseologie 2019;39(1):76-86.
• Kresoja KP, Ebner M, Rogge NIJ, Sentler C, Keller K, Hobohm L, Hasenfuss G, Konstantinides SV, Pieske B, Lankeit M. Prediction and prognostic importance of in-hospital major bleeding in a real-world cohort of patients with pulmonary embolism. Int J Cardiol 2019;290:144-149.
• Kotrubiec M, Plywaczewska M, Jimenez D, Lankeit M, Ciurzynski M, Konstantinides S, Pruszczyk P. The Prognostic Value of Renal Function in Acute Pulmonary Embolism-A Multi-Centre Cohort Study. Thromb Haemost 2019;119(1):140-148.
• Klok FA, Pruefer D, Rolf A, Konstantinides SV. Magnetic resonance direct thrombus imaging for pre-operative assessment of acute thrombosis in chronic thromboembolic pulmonary hypertension. Eur Heart J 2019;40(11):944.
• Gogiraju R, Hubert A, Fahrer J, Straub BK, Brandt M, Wenzel P, Münzel T, Konstantinides S, Hasenfuss G, Schafer K. Endothelial Leptin Receptor Deletion Promotes Cardiac Autophagy and Angiogenesis Following Pressure Overload by Suppressing Akt/mTOR Signaling. Circ Heart Fail 2019;12(1):e005622.
• Chalikias G, Serif L, Kikas P, Thomaidis A, Stakos D, Makrygiannis D, Chatzikyriakou S, Papoulidis N, Voudris V, Lantzouraki A, Müller M, Arampatzis S, Konstantinides S, Tziakas D. Long-term impact of acute kidney injury on prognosis in patients with acute myocardial infarction. Int J Cardiol 2019;283:48-54.
• Barco S, Mahmoudpour SH, Planquette B, Sanchez O, Konstantinides SV, Meyer G. Prognostic value of right ventricular dysfunction or elevated cardiac biomarkers in patients with low-risk pulmonary embolism: a systematic review and meta-analysis. Eur Heart J 2019;40(11):902-910.
• Barco S, Klok FA, Mahe I, Marchena PJ, Ballaz A, Rubio CM, Adarraga MD, Mastroiacovo D, Konstantinides SV, Monreal M, Investigators R. Impact of sex, age, and risk factors for venous thromboembolism on the initial presentation of first isolated symptomatic acute deep vein thrombosis. Thromb Res 2019;173:166-171.
• Wilkens H, Konstantinides S, Lang IM, Bunck AC, Gerges M, Gerhardt F, Grgic A, Grohe C, Guth S, Held M, Hinrichs JB, Hoeper MM, Klepetko W, Kramm T, Kruger U, Lankeit M, Meyer BC, Olsson KM, Schafers HJ, Schmidt M, Seyfarth HJ, Ulrich S, Wiedenroth CB, Mayer E. Chronic thromboembolic pulmonary hypertension (CTEPH): Updated Recommendations from the Cologne Consensus Conference 2018. Int J Cardiol 2018;272S:69-78.
• Trinchero A, Scheres LJJ, Prochaska JH, Ambaglio C, Wild PS, Middeldorp S, Konstantinides SV, Barco S. Sex-specific differences in the distal versus proximal presenting location of acute deep vein thrombosis. Thromb Res 2018;172:74-79.
• Schmidtmann I, Konstantinides S, Binder H. Power of the Wilcoxon-Mann-Whitney test for non-inferiority in the presence of death-censored observations. Biom J 2018.
• Lankeit M, Krieg V, Hobohm L, Kölmel S, Liebetrau C, Konstantinides S, Hamm CW, Mayer E, Wiedenroth CB, Guth S. Pulmonary endarterectomy in chronic thromboembolic pulmonary hypertension. J Heart Lung Transplant 2017.
• Klok FA, Barco S, Konstantinides SV, Dartevelle P, Fadel E, Jenkins D, Kim NH, Madani M, Matsubara H, Mayer E, Pepke-Zaba J, Delcroix M, Lang IM. Determinants of diagnostic delay in chronic thromboembolic pulmonary hypertension: results from the European CTEPH Registry. Eur Respir J 2018;52(6).
• Klok FA, Barco S, Konstantinides SV. Evaluation of VTE-BLEED for predicting intracranial or fatal bleeding in stable anticoagulated patients with venous thromboembolism. Eur Respir J 2018;51(4).
• Kaymaz C, Akbal OY, Hakgor A, Tokgoz HC, Karagoz A, Tanboga IH, Tanyeri S, Keskin B, Turkday S, Demir D, Dogan C, Bayram Z, Acar RD, Guvendi B, Ozdemir N, Tapson VF, Konstantinides S. A five-year, single-centre experience on ultrasound-assisted, catheter-directed thrombolysis in patients with pulmonary embolism at high risk and intermediate to high risk. EuroIntervention 2018;14(10):1136-1143.
• Barco S, Vicaut E, Klok FA, Lankeit M, Meyer G, Konstantinides SV, Investigators P. Improved identification of thrombolysis candidates amongst intermediate-risk pulmonary embolism patients: implications for future trials. Eur Respir J 2018;51(1).
• Barco S, Russo M, Vicaut E, Becattini C, Bertoletti L, Beyer-Westendorf J, Bouvaist H, Couturaud F, Danays T, Dellas C, Duerschmied D, Empen K, Ferrari E, Galie N, Jimenez D, Klok FA, Kostrubiec M, Kozak M, Kupatt C, Lang IM, Lankeit M, Meneveau N, Palazzini M, Pruszczyk P, Rugolotto M, Salvi A, Sanchez O, Schellong S, Sobkowicz B, Meyer G, Konstantinides SV. Incomplete echocardiographic recovery at 6 months predicts long-term sequelae after intermediate-risk pulmonary embolism. A post-hoc analysis of the Pulmonary Embolism Thrombolysis (PEITHO) trial. Clin Res Cardiol 2019;108(7):772-778.
• Barco S, Ende-Verhaar YM, Becattini C, Jimenez D, Lankeit M, Huisman MV, Konstantinides SV, Klok FA. Differential impact of syncope on the prognosis of patients with acute pulmonary embolism: a systematic review and meta-analysis. Eur Heart J 2018;39(47):4186-4195.
• Bochenek ML, Bauer T, Gogiraju R, Nadir Y, Mann A, Schönfelder T, Hunig L, Brenner B, Münzel T, Wenzel P, Konstantinides S, Schäfer K. The endothelial tumor suppressor p53 is essential for venous thrombus formation in aged mice. Blood Adv 2018;2(11):1300-1314.
• Hellenkamp K, Pruszczyk P, Jimenez D, Wyzgal A, Barrios D, Ciurzynski M, Morillo R, Hobohm L, Keller K, Kurnicka K, Kostrubiec M, Wachter R, Hasenfuss G, Konstantinides S, Lankeit M. Prognostic impact of copeptin in pulmonary embolism: a multicentre validation study. Eur Respir J 2018;51(4).
• Rodger M, Langlois N, Middeldorp S, Kahn S, Sandset PM, Brighton T, Huisman MV, Meyer G, Konstantinides S, Ageno W, Morange P, Garcia D, Kreuziger LB, Young L, Key N, Monreal M, Jimenez D. Initial strides for invent-VTE: Towards global collaboration to accelerate clinical research in venous thromboembolism. Thromb Res 2018;163:128-131.
• Klok FA, Ageno W, Barco S, Binder H, Brenner B, Duerschmied D, Empen K, Faggiano P, Ficker JH, Galiè N, Ghuysen A, Held M, Heydenreich N, Huisman MV, Jiménez D, Kozak M, Lang IM, Lankeit M, Münzel T, Petris A, Pruszczyk P, Quitzau K, Schellong S, Schmidt KH, Stefanovic BS, Verschuren F, Wolf-Puetz A, Meyer G, Konstantinides SV, Investigators P-. Dabigatran after Short Heparin Anticoagulation for Acute Intermediate-Risk Pulmonary Embolism: Rationale and Design of the Single-Arm PEITHO-2 Study. Thromb Haemost 2017;117(12):2425-2434.
• Prochaska JH, Frank B, Nagler M, Lamparter H, Weisser G, Schulz A, Eggebrecht L, Göbel S, Arnold N, Panova-Noeva M, Hermanns I, Pinto A, Konstantinides S, Ten Cate H, Lackner KJ, Münzel T, Espinola-Klein C, Wild PS. Age-related diagnostic value of D-dimer testing and the role of inflammation in patients with suspected deep vein thrombosis. Sci Rep 2017;7(1):4591.
• Schütz E, Bochenek ML, Riehl DR, Bosmann M, Münzel T, Konstantinides S, Schäfer K (2017) Absence of transforming growth factor beta 1 in murine platelets reduces neointima formation without affecting arterial thrombosis. Thrombosis and haemostasis 117: 1782-1797
• Klok FA, Barco S, Konstantinides SV. Evaluation of VTE-BLEED for predicting intracranial or fatal bleeding in stable anticoagulated patients with venous thromboembolism. Eur Respir J 2018;51(4).
• Lankeit M, Krieg V, Hobohm L, Kölmel S, Liebetrau C, Konstantinides S, Hamm CW, Mayer E, Wiedenroth CB, Guth S (2017) Pulmonary endarterectomy in chronic thromboembolic pulmonary hypertension. J Heart Lung Transplant
• Chrysanthopoulou A, Kambas K, Stakos D, Mitroulis I, Mitsios A, Vidali V, Angelidou I, Bochenek M, Arelaki S, Arampatzioglou A, Galani IE, Skendros P, Couladouros EA, Konstantinides S, Andreakos E, Schäfer K, Ritis K (2017) Interferon lambda1/IL-29 and inorganic polyphosphate are novel regulators of neutrophil-driven thromboinflammation. J Pathol 243(1):111-122
• Kaymaz C, Öztürk S, Akbal Ö, Tanboga IH, Yilmaz F, Poci N, Turkday S, Hakgör A, Yildiz C, Aktemur T, Özdemir N, Konstantinides S (2017) Ultrasound-Assisted Catheter-Directed Thrombolysis in High-Risk and Intermediate-High-Risk Pulmonary Embolism: Results From a Single-Center Cohort. Angiology 68: 433-440
• Barco S, Corti M, Trinchero A, Picchi C, Ambaglio C, Konstantinides SV, Dentali F, Barone M (2017) Survival and recurrent venous thromboembolism in patients with first proximal or isolated distal deep vein thrombosis and no pulmonary embolism. Journal of thrombosis and haemostasis  
• Bochenek ML, Rosinus NS, Lankeit M, Hobohm L, Bremmer F, Schutz E, Klok FA, Horke S, Wiedenroth CB, Münzel T, Lang IM, Mayer E, Konstantinides S, Schäfer K (2017) From thrombosis to fibrosis in chronic thromboembolic pulmonary hypertension. Thrombosis and haemostasis 117: 769-783
• Hoeper MM, Lam CS, Vachiery JL, Bauersachs J, Gerges C, Lang IM, Bonderman D, Olsson KM, Gibbs JS, Dorfmuller P, Guazzi M, Galie N, Manes A, Handoko ML, Vonk-Noordegraaf A, Lankeit M, Konstantinides S, Wachter R, Opitz C, Rosenkranz S (2017) Pulmonary hypertension in heart failure with preserved ejection fraction: a plea for proper phenotyping and further research. European heart journal 7;38(38):2869-2873
• Keller K, von Bardeleben RS, Ostad MA, Hobohm L, Münzel T, Konstantinides S, Lankeit M (2017) Temporal Trends in the Prevalence of Infective Endocarditis in Germany Between 2005 and 2014. Am J Cardiol 119: 317-322
• Klok FA, Barco S, Konstantinides SV (2017) External validation of the VTE-BLEED score for predicting major bleeding in stable anticoagulated patients with venous thromboembolism. Thrombosis and haemostasis 
• Konstantinides SV, Vicaut E, Danays T, Becattini C, Bertoletti L, Beyer-Westendorf J, Bouvaist H, Couturaud F, Dellas C, Duerschmied D, Empen K, Ferrari E, Galie N, Jimenez D, Kostrubiec M, Kozak M, Kupatt C, Lang IM, Lankeit M, Meneveau N et al. (2017) Impact of Thrombolytic Therapy on the Long-Term Outcome of Intermediate-Risk Pulmonary Embolism. Journal of the American College of Cardiology 69: 1536-1544
• Ragia G, Kolovou V, Kolovou G, Konstantinides S, Maltezos E, Tavridou A, Tziakas D, Maitland-van der Zee AH, Manolopoulos VG (2017) A novel acenocoumarol pharmacogenomic dosing algorithm for the Greek population of EU-PACT trial. Pharmacogenomics 18: 23-34
• Becattini C, Agnelli G, Lankeit M, Masotti L, Pruszczyk P, Casazza F, Vanni S, Nitti C, Kamphuisen P, Vedovati MC, De Natale MG, Konstantinides S (2016) Acute pulmonary embolism: mortality prediction by the 2014 European Society of Cardiology risk stratification model. The European respiratory journal 
• Bleker SM, Buchmuller A, Chauleur C, Ainle FN, Donnelly J, Verhamme P, Jacobsen AF, Ganzevoort W, Prins M, Beyer-Westendorf J, DeSancho M, Konstantinides S, Pabinger I, Rodger M, Decousus H, Middeldorp S (2016) Low-molecular-weight heparin to prevent recurrent venous thromboembolism in pregnancy: Rationale and design of the Highlow study, a randomised trial of two doses. Thrombosis research 144: 62-68
• Drosos I, Chalikias G, Pavlaki M, Kareli D, Epitropou G, Bougioukas G, Mikroulis D, Konstantinou F, Giatromanolaki A, Ritis K, Münzel T, Tziakas D, Konstantinides S, Schäfer K (2016) Differences between perivascular adipose tissue surrounding the heart and the internal mammary artery: possible role for the leptin-inflammation-fibrosis-hypoxia axis. Clinical research in cardiology : official journal of the German Cardiac Society 
• Kaymaz C, Öztürk S, Akbal Ö, Tanboga IH, Yilmaz F, Poci N, Türkday S, Hakgör A, Yildiz C, Aktemur T, Özdemir N, Konstantinides S (2016) Ultrasound-Assisted Catheter-Directed Thrombolysis in High-Risk and Intermediate-High-Risk Pulmonary Embolism: Results From a Single-Center Cohort. Angiology 
• Klok FA, Hösel V, Clemens A, Yollo WD, Tilke C, Schulman S, Lankeit M, Konstantinides SV (2016) Prediction of bleeding events in patients with venous thromboembolism on stable anticoagulation treatment. The European respiratory journal 
• Konstantinides SV, Barco S, Rosenkranz S, Lankeit M, Held M, Gerhardt F, Bruch L, Ewert R, Faehling M, Freise J, Ghofrani HA, Grünig E, Halank M, Heydenreich N, Hoeper MM, Leuchte HH, Mayer E, Meyer FJ, Neurohr C, Opitz C et al. (2016) Late outcomes after acute pulmonary embolism: rationale and design of FOCUS, a prospective observational multicenter cohort study. Journal of thrombosis and thrombolysis 
• Koc M, Kostrubiec M, Elikowski W, Meneveau N, Lankeit M, Grifoni S, Kuch-Wocial A, Petris A, Zaborska B, Stefanovic BS, Hugues T, Torbicki A, Konstantinides S, Pruszczyk P, Ri HI. Outcome of patients with right heart thrombi: the Right Heart Thrombi European Registry. The European respiratory journal 47:869-875. 2016.
• Klok FA, Niemann C, Dellas C, Hasenfuss G, Konstantinides S, Lankeit M. Performance of five different bleeding-prediction scores in patients with acute pulmonary embolism. Journal of thrombosis and thrombolysis 41:312-320. 2016.
• Klok FA, Dzikowska-Diduch O, Kostrubiec M, Vliegen HW, Pruszczyk P, Hasenfuss G, Huisman MV, Konstantinides S, Lankeit M. Derivation of a clinical prediction score for chronic thromboembolic pulmonary hypertension after acute pulmonary embolism. Journal of thrombosis and haemostasis 14:121-128. 2016.
• Jimenez D, Lobo JL, Fernandez-Golfin C, Portillo AK, Nieto R, Lankeit M, Konstantinides S, Prandoni P, Muriel A, Yusen RD, investigators P. Effectiveness of prognosticating pulmonary embolism using the ESC algorithm and the Bova score. Thrombosis and haemostasis 115:827-834. 2016.
• Hobohm L, Hellenkamp K, Hasenfuss G, Münzel T, Konstantinides S, Lankeit M. Comparison of risk assessment strategies for not-high-risk pulmonary embolism. The European respiratory journal 47:1170-1178. 2016.
• Barco S, Lankeit M, Binder H, Schellong S, Christ M, Beyer-Westendorf J, Duerschmied D, Bauersachs R, Empen K, Held M, Schwaiblmair M, Fonseca C, Jimenez D, Becattini C, Quitzau K, Konstantinides S. Home treatment of patients with low-risk pulmonary embolism with the oral factor Xa inhibitor rivaroxaban. Rationale and design of the HoT-PE Trial. Thrombosis and haemostasis 116. 2016.
• Stakos DA, Kambas K, Konstantinidis T, Mitroulis I, Apostolidou E, Arelaki S, Tsironidou V, Giatromanolaki A, Skendros P, Konstantinides S, Ritis K. Expression of functional tissue factor by neutrophil extracellular traps in culprit artery of acute myocardial infarction. European heart journal. 36:1405-1414. 2015.
• Klok FA, Tesche C, Rappold L, Dellas C, Hasenfuss G, Huisman MV, Konstantinides S, Lankeit M.  External validation of a simple non-invasive algorithm to rule out chronic thromboembolic pulmonary hypertension after acute pulmonary embolism. Thrombosis research 135:796-801. 2015.
• Klok FA, Niemann C, Dellas C, Hasenfuss G, Konstantinides S, Lankeit M. 2015. Performance of five different bleeding-prediction scores in patients with acute pulmonary embolism. Journal of thrombosis and thrombolysis. 2015.
• Klok FA, Dzikowska-Diduch O, Kostrubiec M, Vliegen HW, Pruszczyk P, Hasenfuss G, Huisman MV, Konstantinides S, Lankeit M. 2015. Derivation of a clinical prediction score for chronic thromboembolic pulmonary hypertension after acute pulmonary embolism. Journal of thrombosis and haemostasis : JTH.
• Hellenkamp K, Schwung J, Rossmann H, Kaeberich A, Wachter R, Hasenfuss G, Konstantinides S, Lankeit M. Risk stratification of normotensive pulmonary embolism: prognostic impact of copeptin. The European respiratory journal. 2015.
• Fernandez C, Bova C, Sanchez O, Prandoni P, Lankeit M, Konstantinides S, Vanni S, Fernandez-Golfin C, Yusen RD, Jimenez D. Validation of a Model for Identification of Patients at Intermediate to High Risk for Complications Associated with Acute Symptomatic Pulmonary Embolism. Chest. 2015.
• Käeberich A, Seeber V, Jimenez D, Kostrubiec M, Dellas C, Hasenfuss G, Giannitsis E, Pruszczyk P, Konstantinides S, Lankeit M. Age-adjusted hsTnT cut-off value for risk stratification of pulmonary embolism. The European respiratory journal. 2015.
• Prochaska JH, Coldewey M, Gobel S, Keller K, Hendelmeier M, Konstantinides S, Münzel T, Wild PS, for the thromb ESG. Evaluation of oral anticoagulation therapy: rationale and design of the thrombEVAL study programme. Eur J Prev Cardiol. 2014. 
• Meyer G, Vicaut E, [...] Lankeit M, [...] Konstantinides SV. Fibrinolysis for patients with intermediate-risk pulmonary embolism. N Engl J Med. 370:1402-1411, 2014.
• Lankeit M, Jimenez D, Kostrubiec M, Dellas C, Kuhnert K, Hasenfuss G, Pruszczyk P, Konstantinides S. Validation of N-terminal pro-brain natriuretic peptide cut-off values for risk stratification of pulmonary embolism. The European respiratory journal. 43:1669-1677, 2014.
• Jimenez D, Kopecna D, Tapson V, Briese B, Schreiber D, Lobo JL, Monreal M, Aujesky D, Sanchez O, Meyer G, Konstantinides S, Yusen RD, On Behalf Of The Protect I. Derivation and validation of multimarker prognostication for normotensive patients with acute symptomatic pulmonary embolism. Am J Respir Crit Care Med. 189:718-726, 2014.
• Dellas C, Tschepe M, Seeber V, Zwiener I, Kuhnert K, Schäfer K, Hasenfuss G, Konstantinides S, Lankeit M. A novel H-FABP assay and a fast prognostic score for risk assessment of normotensive pulmonary embolism. Thrombosis and haemostasis. 111:996-1003, 2014.
• Bova C, Sanchez O, Prandoni P, Lankeit M, Konstantinides S, Vanni S, Jimenez D. Identification of intermediate-risk patients with acute symptomatic pulmonary embolism. The European respiratory journal. 2014.
• Raskob GE, Angchaisuksiri P, Blanco AN, Buller, Gallus A; Hunt BJ,  Hylek EM, Kakkar A, Konstantinides SV, McCumber M, Ozaki Y, Wendelboe A, Weitz JI. Thrombosis: a major contributor to global disease burden. Thrombosis and haemostasis 112:843-852, 2014.
• Schroeter MR, Leifheit-Nestler M, Hubert A, Schumann B, Gluckermann R, Eschholz N, Kruger N, Lutz S, Hasenfuss G, Konstantinides S, Schäfer K. Leptin promotes neointima formation and smooth muscle cell proliferation via NADPH oxidase activation and signalling in caveolin-rich microdomains. Cardiovasc Res. 99:555-565, 2013.
• Schroeter MR, Eschholz N, Herzberg S, Jerchel I, Leifheit-Nestler M, Czepluch FS, Chalikias G, Konstantinides S, Schafer K. Leptin-dependent and leptin-independent paracrine effects of perivascular adipose tissue on neointima formation. Arteriosclerosis, thrombosis, and vascular biology. 33:980-987, 2013.
• Leifheit-Nestler M, Wagner NM, Gogiraju R, Didie M, Konstantinides S, Hasenfuss G, Schäfer K. Importance of leptin signaling and signal transducer and activator of transcription-3 activation in mediating the cardiac hypertrophy associated with obesity. J Transl Med. 11:170, 2013.
• Lankeit M, Dellas C, Benz V, Hasenfuss G, Konstantinides S. The predictive value of heart-type fatty acid-binding protein is independent from symptom duration in normotensive patients with pulmonary embolism. Thromb Res. 132:543-547, 2013.
• Dellas C, Lankeit M, Reiner C, Schäfer K, Hasenfuss G, Konstantinides S. BMI-independent inverse relationship of plasma leptin levels with outcome in patients with acute pulmonary embolism. Int J Obes (Lond). 37(2):204-10, 2013.
• Lankeit M, Gómez V, Wagner C, Aujesky D, Recio M, Briongos S, Moores L, Yusen R, Konstantinides S, Jiménez D on behalf of the IRYCIS Pulmonary Embolism Study Group. A strategy combining imaging and laboratory biomarkers in comparison to a simplified clinical score for risk stratification of patients with acute pulmonary embolism. Chest. 141:916-922, 2012.
• Konstantinides S, for the PEITHO Steering Committee. Single-bolus tenecteplase plus heparin compared with heparin alone for normotensive patients with acute pulmonary embolism who have evidence of right ventricular dysfunction and myocardial injury: rationale and design of the Pulmonary Embolism Thrombolysis (PEITHO) trial. Am Heart J. 163:33-38.e1, 2012.
• Vedovati MC, Becattini C, Agnelli G, Kamphuisen PW, Masotti L, Pruszczyk P, Casazza F, Salvi A, Grifoni S, Carugati A, Konstantinides S, Schreuder M, Golebiowski M, Duranti M. Multidetector computed tomography for acute pulmonary embolism: embolic burden and clinical outcome. Chest. 142(6):1417-24, 2012.
• Lankeit M, Jiménez D, Kostrubiec M, Dellas C, Hasenfuß G, Pruszczyk P, Konstantinides S. Predictive value of the highly sensitive troponin T assay and the simplified Pulmonary Embolism Severity Index in hemodynamically stable patients with acute pulmonary embolism: a prospective validation study. Circulation. 124:2716-2724, 2011.