Professor Wolfram Ruf, MD
Professorship for Cell Signaling Pathways of the Hemostatic System
The hemostatic system is comprised of the coagulation and fibrinolytic protease cascades, platelets, and cellular receptors on immune and vascular cells. The hemostatic response to infection and tissue injury supports inflammatory and immune reactions, but the coagulation pathways are increasingly recognized as major players and molecular targets for interventional therapy in cancer progression, atherosclerosis, chronic inflammatory disorders, and the metabolic syndrome associated with obesity. We are interested in the crosstalk of coagulation and inflammation and study contributions of inflammatory processes to the initiation of coagulation by tissue factor (TF). Our research also broadly addresses open question related to the roles of TF and coagulation protease signaling networks in the integration and modulation of inflammatory stimuli in immune cells. We are interested in the control of macrophage phenotypes by coagulation proteases and their receptors in chronic inflammation and use novel genetic mouse models that selectively delete or alter signaling specificity of components of the hemostatic system in innate immune cell populations. This genetic platform is employed in combination with transcriptional and proteomics approaches for generating fundamentally novel insights into cellular and molecular connections between coagulation and inflammation. We are interested in translational research that deciphers molecular mechanisms of diseases of the cardiovascular system and evaluates clinically relevant interventional proof-of-principle molecular probes in disease models.
Scientific Director CTH, Alexander von Humboldt-Professorship "Experimental Hemostasiology", Deputy Speaker of CTH, Deputy Speaker of CTVB, Principal Investigator DZHK
06131 17-8222
06131 17-3456Technical Assistant
06131 17-8028
Post Doc, Virchow Fellow
06131 17-8028
Junior group leader
Physician UCT Mainz
Specialist in Internal Medicine, Hematology and Oncology, Additional qualification: Palliative Care, Hemostaseology
06131 17-8014 (Office) bzw. -8027 (Lab)
PhD student
06131 17-8021
06131 17-8047PhD student
06131 17-8018
PhD student
PhD student
06131 17-8021
06131 17-8047Scientific Coordination CTH
06131 17-8056
PhD student
06131 17-8021
06131 17-8047PhD student
06131/17-8021
06131/17-8047Research Coordinator
06131 17-8048
PhD student
06131 17-8021
06131 17-8047Post Doc
06131 17-8014
Technician
06131 17-8028
PhD student
06131 17-8018
PhD student
06131 17-8018
We are looking forward to applications from highly motivated scientists.
Find out more (Pdf-file, 64,2 KB).
V, Molitor M, Michna T, Harms GS, Finger S, Jung R, Lagrange J,
Efentakis P, Wild J, Knorr M, Karbach S, Wild S, Vujacic-Mirski K,
Münzel T, Daiber A, Brandt M, Gori T, Milting H, Tenzer S, Ruf W*,
Wenzel P*. Targeting myeloid cell coagulation signaling blocks MAP
kinase/TGF-β1-driven fibrotic remodeling in ischemic heart failure. J Clin Invest. 2023 Feb 15;133(4):e156436. *Corresponding Author
MI, Röhrig N, Raker VK, Springer J, Becker D, Ritz S, Bros M, Stege H,
Haist M, Grabbe S, Haub J, Becker C, Reyda S, Disse J, Schmidt T, Mahnke
K, Weiler H, Ruf W*, Steinbrink K*. Protease- and cell type-specific activation of protease-activated receptor 2 in cutaneous inflammation. J Thromb Haemost. 2022 Dec;20(12):2823-2836. *Corresponding Author
ML, Gogiraju R, Großmann S, Krug J, Orth J, Reyda S, Georgiadis GS,
Spronk HM, Konstantinides S, Münzel T, Griffin JH, Wild P,
Espinola-Klein C, Ruf W*, Schäfer K*. EPCR-PAR1 biased signaling regulates perfusion recovery and neovascularization in peripheral ischemia. JCI Insight. 2022 Jul 22;7(14):e157701. *Shared Authorship
N, Hollerbach A, Royce J, Ritter S, Pedrosa D, Madhusudhan T, Teifel S,
Meineck M, Häuser F, Canisius A, Nguyen TS, Braun J, Bruns K, Etzold A,
Zechner U, Strand S, Radsak M, Strand D, Gu JM, Weinmann-Menke J, Esmon
CT, Teyton L, Lackner KJ*, Ruf W*. Lipid presentation by the protein C receptor links coagulation with autoimmunity. Science. 2021 Mar 12;371(6534):eabc0956. *Shared Authorship
Y, Mendolicchio GL, Zampolli A, Marchese P, Rothmeier AS, Orje JN, Gale
AJ, Krishnaswamy S, Gruber A, Østergaard H, Petersen LC, Ruf W*, Ruggeri ZM*. Selective factor VIII activation by the tissue factor-factor VIIa-factor Xa complex. Blood. 2017 Oct 5;130(14):1661-1670. *Corresponding Author
S, Itkin T, Chakrabarty S, Graf C, Kollet O, Ludin A, Golan K,
Kalinkovich A, Ledergor G, Wong E, Niemeyer E, Porat Z, Erez A, Sagi I,
Esmon CT, Ruf W*, Lapidot T*. PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells. Nat Med. 2015 Nov;21(11):1307-17. *Corresponding Author