Visual Universitätsmedizin Mainz

Professorship "Vascular Inflammation"

Prof. Philip Wenzel, MD

Vascular inflammation is an important principle in the continuum of cardiovascular diseases. It is important in the pathophysiology of arterial hypertension and hypercholesterolemia and leads to endothelial dysfunction. In myocardial infarction, venous thromboembolism and ischemia-reperfusion injury, but also in chronic inflammatory diseases such as psoriasis and exogenous environmental factors such as stress and noise exposure, it is of great importance with potentially modifiable therapeutic target structures. In this context, our work group focuses on the importance of CD11b + myeloid cells, especially monocytes / macrophages.

An independent aspect of our group is dedicated to the influence of coagulation factors in the contact phase system, thrombin amplification and the tissue factor system in vascular inflammation.

Research interests

  • Role of inflammatory myelomonocytic cells in vascular dysfunction and venous and arterial thrombosis

  • Proinflammatory Cytokines and activation of inflammatory pathways in vascular biology

  • Interplay of coagulation factors, leukocytes and platelets in vascular dysfunction

Partners of Collaboration

  • Christian Becker (Dermatology, University Medical Center Mainz)
  • Ari Waisman (Institute of Molecular Medicine, University Medical Center Mainz)
  • Christoph Reinhardt (CTH, University Medical Center Mainz)
  • Wolfram Ruf (Alexander von Humboldt-Professorship, University Medical Center Mainz)
  • Thomas Renné (Karolinska Institutet, Stockholm)
  • Zaverio Ruggeri (Scripps Research, La Jolla, USA)
  • Miguel Andrade (Institute for Molecular Biology)
  • Jens Titze (Duke Singapore, Singapore)
  • Philip Tsao (Stanford University School of Medicine, Palo Alto, USA)
  • Stefan Tenzer (Paul Klein Center for Immune Intervention, University Medical Center Mainz)

Research Funding

Team - Professorship 'Vascular Inflammation'

Wenzel, MD
Professor Philip Wenzel, MD
Position: Deputy director Cardiology I, DZHK Principal Investigator

06131 17-7695
wenzelp@uni-mainz.de

Karbach, MD
Susanne Karbach, MD
Position: Physician Cardiology I, Scientist

karbasu@uni-mainz.de
Further Information

> Homepage Junior Group Karbach

Aluia
Melania Aluia
Position: PhD Student

06131 17-8036
melania.aluia@unimedizin-mainz.de

Brandt, MD
Jan Moritz Brandt, MD
Position: Physician Cardiology I, Virchow-Fellow

brandtmo@uni-mainz.de
Further Information

Conze
Anne-Kristin Conze
Position: Technical assistant

06131 17-8034
anne-kristin.conze@unimedizin-mainz.de

Dörschmann
Hendrik Dörschmann
Position: PhD student

06131 17-8036
h.doerschmann@uni-mainz.de

PhD Finger
Stefanie Finger, PhD
Position: Lab manager

stefanie.finger@unimedizin-mainz.de

PhD Garlapati
Venkata Subbaiah Garlapati, PhD
Position: Post-Doc

06131 17-8036
garlapati.venkatasubbaiah@unimedizin-mainz.de

Luo
Qi Luo
Position: PhD student

06131 17-8036
Qi.Luo@unimedizin-mainz.de

Perius
Katharina Perius
Position: Technician

06131 17-8034
06131 17-8047

Virchow Fellow

MD Molitor
Michael Molitor, MD
Position: Physician Cardiology I
Virchow Fellow, CTH

06131 17-8036
micmolit@uni-mainz.de

Former team members

  • Anja Conrad, tec (Max-Delbrück-Center, Berlin)
  • Isabel Schmidgen, MD, Dermatology, University Medical Center Mainz
  • Jan Stratmann, MD, Clinic for Haematology and Oncology, University Medical Center Frankfurt
  • Daniel Minwegen, MD Neurology, University Mediacal Center Göttingen
  • Tanja Schönfelder, DVM, Max-Planck-Forschungsstelle für Neurogenetik, Frankfurt a. M. 
  • Eleni Giokoglu, MD, Clinic for Cardiology, University Medical Center Frankfurt
  • Panagiotis Efentakis, PhD, National and Kapodistrian University Athens, Griechenland
  • Jeremy Lagrange, PhD, INSERM U1116 - DCAC, Faculté de Médecine, Nancy, Frankreich
  • Dr. med. Wolf-Stephan Rudi, Cardiology, Ludwigs-Maximilians-University Munich
  • Dr. rer. nat. Sabine Kossmann, CSL Behring, Marburg

Selected reviews

  • Wild J, Wenzel P. Myeloid cells, tissue homeostasis, and anatomical barriers as innate immune effectors in arterial hypertension. J Mol Med (Berl). epub ahead of print, Jan 14 2021
  • Jung R, Wild J, Ringen J, Karbach S, Wenzel P. Innate immune mechanisms of arterial hypertension and autoimmune disease. Am J Hypertens. epub ahead of print, Sep 15 2020
  • Wenzel P. Monocytes as immune targets in arterial hypertension. Br J Pharmacol. 2019;176:1966-1977.
  • Lagrange J, Wenzel P. The regulatory role of coagulation factors in vascular function. Frontiers in bioscience. 2019;24:494-513.
  • Karbach S, Lagrange J, Wenzel P. Thromboinflammation and Vascular Dysfunction. Hamostaseologie. 2019;39:180-187.
  • Wenzel P, Kossmann S, Munzel T, Daiber A. Redox regulation of cardiovascular inflammation - Immunomodulatory function of mitochondrial and Nox-derived reactive oxygen and nitrogen species. Free Radic Biol Med. 2017;109:48-60.

Selected original articles

  • Molitor M, Rudi WS, Garlapati V, Finger S, Schuler R, Kossmann S, Lagrange J, Nguyen TS, Wild J, Knopp T, Karbach SH, Knorr M, Ruf W, Munzel T, Wenzel P. Nox2+ myeloid cells drive vascular inflammation and endothelial dysfunction in heart failure after myocardial infarction via angiotensin II receptor type 1. Cardiovasc Res. 2021;117:162-177.
  • Lagrange J, Finger S, Kossmann S, Garlapati V, Ruf W, Wenzel P. Angiotensin II Infusion Leads to Aortic Dissection in LRP8 Deficient Mice. Int J Mol Sci. 2020;21
  • Karbach S, Hobohm L, Wild J, Munzel T, Gori T, Wegner J, Steinbrink K, Wenzel P, Keller K. Impact of Psoriasis on Mortality Rate and Outcome in Myocardial Infarction. J Am Heart Assoc. 2020;9:e016956.
  • Finger S, Knorr M, Molitor M, Schuler R, Garlapati V, Waisman A, Brandt M, Munzel T, Bopp T, Kossmann S, Karbach S, Wenzel P. A sequential interferon gamma directed chemotactic cellular immune response determines survival and cardiac function post-myocardial infarction. Cardiovasc Res. 2019;115:1907-1917.
  • Jansen T, Kroller-Schon S, Schonfelder T, Foretz M, Viollet B, Daiber A, Oelze M, Brandt M, Steven S, Kvandova M, Kalinovic S, Lagrange J, Keaney JF, Jr., Munzel T, Wenzel P, Schulz E. alpha1AMPK deletion in myelomonocytic cells induces a pro-inflammatory phenotype and enhances angiotensin II-induced vascular dysfunction. Cardiovasc Res. 2018;114:1883-1893.
  • Subramaniam S, Jurk K, Hobohm L, Jackel S, Saffarzadeh M, Schwierczek K, Wenzel P, Langer F, Reinhardt C, Ruf W. Distinct contributions of complement factors to platelet activation and fibrin formation in venous thrombus development. Blood. 2017;129:2291-2302.
  • Sag CM, Schnelle M, Zhang J, Murdoch CE, Kossmann S, Protti A, Santos CXC, Sawyer G, Zhang X, Mongue-Din H, Richards DA, Brewer AC, Prysyazhna O, Maier LS, Wenzel P, Eaton PJ, Shah AM. Distinct Regulatory Effects of Myeloid Cell and Endothelial Cell NAPDH Oxidase 2 on Blood Pressure. Circulation. 2017;135:2163-2177.
  • Kossmann S, Lagrange J, Jackel S, Jurk K, Ehlken M, Schonfelder T, Weihert Y, Knorr M, Brandt M, Xia N, Li H, Daiber A, Oelze M, Reinhardt C, Lackner K, Gruber A, Monia B, Karbach SH, Walter U, Ruggeri ZM, Renne T, Ruf W, Munzel T, Wenzel P. Platelet-localized FXI promotes a vascular coagulation-inflammatory circuit in arterial hypertension. Sci Transl Med. 2017;9
  • Karbach SH, Schonfelder T, Brandao I, Wilms E, Hormann N, Jackel S, Schuler R, Finger S, Knorr M, Lagrange J, Brandt M, Waisman A, Kossmann S, Schafer K, Munzel T, Reinhardt C, Wenzel P. Gut Microbiota Promote Angiotensin II-Induced Arterial Hypertension and Vascular Dysfunction. J Am Heart Assoc. 2016;5
  • Wenzel P, Rossmann H, Muller C, Kossmann S, Oelze M, Schulz A, Arnold N, Simsek C, Lagrange J, Klemz R, Schonfelder T, Brandt M, Karbach SH, Knorr M, Finger S, Neukirch C, Hauser F, Beutel ME, Kroller-Schon S, Schulz E, Schnabel RB, Lackner K, Wild PS, Zeller T, Daiber A, Blankenberg S, Munzel T. Heme oxygenase-1 suppresses a pro-inflammatory phenotype in monocytes and determines endothelial function and arterial hypertension in mice and humans. European heart journal. 2015;36:3437-3446.
  • Hinkel R, Lange P, Petersen B, Gottlieb E, Ng JK, Finger S, Horstkotte J, Lee S, Thormann M, Knorr M, El-Aouni C, Boekstegers P, Reichart B, Wenzel P, Niemann H, Kupatt C. Heme Oxygenase-1 Gene Therapy Provides Cardioprotection Via Control of Post-Ischemic Inflammation: An Experimental Study in a Pre-Clinical Pig Model. Journal of the American College of Cardiology. 2015;66:154-165.
  • Kossmann S, Hu H, Steven S, Schonfelder T, Fraccarollo D, Mikhed Y, Brahler M, Knorr M, Brandt M, Karbach SH, Becker C, Oelze M, Bauersachs J, Widder J, Munzel T, Daiber A, Wenzel P. Inflammatory Monocytes Determine Endothelial Nitric-oxide Synthase Uncoupling and Nitro-oxidative Stress Induced by Angiotensin II. The Journal of biological chemistry. 2014;289:27540-27550.
  • Kossmann S, Schwenk M, Hausding M, Karbach SH, Schmidgen MI, Brandt M, Knorr M, Hu H, Kroller-Schon S, Schonfelder T, Grabbe S, Oelze M, Daiber A, Munzel T, Becker C, Wenzel P. Angiotensin II-Induced Vascular Dysfunction Depends on Interferon-gamma-Driven Immune Cell Recruitment and Mutual Activation of Monocytes and NK-Cells. Arterioscler Thromb Vasc Biol. 2013;33:1313-1319.
  • Wenzel P, Knorr M, Kossmann S, Stratmann J, Hausding M, Schuhmacher S, Karbach SH, Schwenk M, Yogev N, Schulz E, Oelze M, Grabbe S, Jonuleit H, Becker C, Daiber A, Waisman A, Munzel T. Lysozyme M-Positive Monocytes Mediate Angiotensin II-Induced Arterial Hypertension and Vascular Dysfunction. Circulation. 2011;124:1370-1381.
  • Wenzel P, Schuhmacher S, Kienhofer J, Muller J, Hortmann M, Oelze M, Schulz E, Treiber N, Kawamoto T, Scharffetter-Kochanek K, Munzel T, Burkle A, Bachschmid MM, Daiber A. Manganese superoxide dismutase and aldehyde dehydrogenase deficiency increase mitochondrial oxidative stress and aggravate age-dependent vascular dysfunction. Cardiovasc Res. 2008;80:280-289.
  • Wenzel P, Hink U, Oelze M, Schuppan S, Schaeuble K, Schildknecht S, Ho KK, Weiner H, Bachschmid M, Munzel T, Daiber A. Role of reduced lipoic acid in the redox regulation of mitochondrial aldehyde dehydrogenase (ALDH-2) activity. Implications for mitochondrial oxidative stress and nitrate tolerance. J Biol Chem. 2007;282:792-799.
Editorial Commentary

Under Pressure: A New Role for CD11c+ Myeloid Cells in Hypertension.
Kossmann S, Wenzel P.

Hypertension. 2018 Jan 29. pii: HYPERTENSIONAHA.117.10216. [Epub ahead of print]