Visual Universitätsmedizin Mainz

Professorship "Vascular Inflammation"

Prof. Philip Wenzel, MD

Vascular inflammation is an important principle in the continuum of cardiovascular diseases. It is important in the pathophysiology of arterial hypertension and hypercholesterolemia and leads to endothelial dysfunction. In myocardial infarction, venous thromboembolism and ischemia-reperfusion injury, but also in chronic inflammatory diseases such as psoriasis and exogenous environmental factors such as stress and noise exposure, it is of great importance with potentially modifiable therapeutic target structures. In this context, our work group focuses on the importance of CD11b + myeloid cells, especially monocytes / macrophages.

An independent aspect of our group is dedicated to the influence of coagulation factors in the contact phase system, thrombin amplification and the tissue factor system in vascular inflammation.

Research interests

  • Role of inflammatory myelomonocytic cells in vascular dysfunction and venous and arterial thrombosis

  • Proinflammatory Cytokines and activation of inflammatory pathways in vascular biology

  • Interplay of coagulation factors, leukocytes and platelets in vascular dysfunction

Partners of Collaboration

  • Christian Becker (Dermatology, University Medical Center Mainz)
  • Ari Waisman (Institute of Molecular Medicine, University Medical Center Mainz)
  • Christoph Reinhardt (CTH, University Medical Center Mainz)
  • Wolfram Ruf (Alexander von Humboldt-Professorship, University Medical Center Mainz)
  • Thomas Renné (Karolinska Institutet, Stockholm)
  • Zaverio Ruggeri (Scripps Research, La Jolla, USA)
  • Miguel Andrade (Institute for Molecular Biology)
  • Jens Titze (Duke Singapore, Singapore)
  • Philip Tsao (Stanford University School of Medicine, Palo Alto, USA)
  • Stefan Tenzer (Paul Klein Center for Immune Intervention, University Medical Center Mainz)

Research Funding

Team - Professorship 'Vascular Inflammation'

Wenzel, MD
Professor Philip Wenzel, MD
Position: Deputy director Cardiology I, DZHK Principal Investigator

06131 17-7695

Karbach, MD
Susanne Karbach, MD
Position: Physician Cardiology I, Scientist
Further Information

> Homepage Junior Group Karbach

Melania Aluia
Position: PhD Student

06131 17-8036

Brandt, MD
Jan Moritz Brandt, MD
Position: Physician Cardiology I, Virchow-Fellow
Further Information

Anne-Kristin Conze
Position: Technical assistant

06131 17-8034

Hendrik Dörschmann
Position: PhD student

06131 17-8036

PhD Finger
Stefanie Finger, PhD
Position: Lab manager

PhD Garlapati
Venkata Subbaiah Garlapati, PhD
Position: Post-Doc

06131 17-8036

Qi Luo
Position: PhD student

06131 17-8036

Katharina Perius
Position: Technician

06131 17-8034
06131 17-8047

Virchow Fellow

MD Molitor
Michael Molitor, MD
Position: Physician Cardiology I
Virchow Fellow, CTH

06131 17-8036

Former team members

  • Anja Conrad, tec (Max-Delbrück-Center, Berlin)
  • Isabel Schmidgen, MD, Dermatology, University Medical Center Mainz
  • Jan Stratmann, MD, Clinic for Haematology and Oncology, University Medical Center Frankfurt
  • Daniel Minwegen, MD Neurology, University Mediacal Center Göttingen
  • Tanja Schönfelder, DVM, Max-Planck-Forschungsstelle für Neurogenetik, Frankfurt a. M. 
  • Eleni Giokoglu, MD, Clinic for Cardiology, University Medical Center Frankfurt
  • Panagiotis Efentakis, PhD, National and Kapodistrian University Athens, Griechenland
  • Jeremy Lagrange, PhD, INSERM U1116 - DCAC, Faculté de Médecine, Nancy, Frankreich
  • Dr. med. Wolf-Stephan Rudi, Cardiology, Ludwigs-Maximilians-University Munich
  • Dr. rer. nat. Sabine Kossmann, CSL Behring, Marburg


  • Karbach S, Lagrange J, Wenzel P. Thromboinflammation and Vascular Dysfunction. Hamostaseologie 2018.
  • Lagrange J, Wenzel P. The regulatory role of coagulation factors in vascular function. Front Biosci (Landmark Ed) 2019;24:494-513.
  • Wenzel P. Monocytes as immune targets in arterial hypertension. Br J Pharmacol 2019;176(12):1966-1977.
  • Carnevale D, Wenzel P. Mechanical stretch on endothelial cells interconnects innate and adaptive immune response in hypertension. Cardiovasc Res 2018.
  • Schönfelder T, Jäckel S, Wenzel P (2017) Mouse models of deep vein thrombosis. Gefasschirurgie 22: 28-33
  • Lagrange J, Kossmann S, Wenzel P (2017) Assessment of Vascular Dysfunction and Inflammation Induced by Angiotensin II in Mice. Methods Mol Biol 1559: 439-453
  • Wenzel P, Kossmann S, Münzel T, Daiber A (2017) Redox regulation of cardiovascular inflammation - Immunomodulatory function of mitochondrial and Nox-derived reactive oxygen and nitrogen species. Free Radic Biol Med 109: 48-60
  • Knorr M, Münzel T, Wenzel P. Interplay of NK cells and monocytes in vascular inflammation and myocardial infarction. Frontiers in physiology. 5:295, 2014.

Original articles

  • Finger S, Knorr M, Molitor M, Schüler R, Garlapati V, Waisman A, Brandt M, Münzel T, Bopp T, Kossmann S, Karbach S, Wenzel P. A sequential interferon gamma directed chemotactic cellular immune response determines survival and cardiac function post-myocardial infarction. Cardiovasc Res. 2019 1;115(13):1907-1917.
  • Efentakis P, Varela A, Chavdoula E, Sigala F, Sanoudou D, Tenta R, Gioti K, Kostomitsopoulos N, Papapetropoulos A, Tasouli A, Farmakis D, Davos CH, Klinakis A, Suter T, Cokkinos DV, Iliodromitis EK, Wenzel P, Andreadou I. Levosimendan prevents doxorubicin-induced cardiotoxicity in time- and dose dependent manner: Implications for inotropy. Cardiovasc Res. 2019 Jun 22. pii: cvz163. doi: 10.1093/cvr/cvz163. [Epub ahead of print]
  • Brandt M, Giokoglu E, Garlapati V, Bochenek ML, Molitor M, Hobohm L, Schönfelder T, Münzel T, Kossmann S, Karbach SH, Schäfer K, Wenzel P. Pulmonary Arterial Hypertension and Endothelial Dysfunction Is Linked to NADPH Oxidase-Derived Superoxide Formation in Venous Thrombosis and Pulmonary Embolism in Mice. Oxid Med Cell Longev 2018;2018:1860513.
  • Jansen T, Kröller-Schön S, Schönfelder T, Foretz M, Viollet B, Daiber A, Oelze M, Brandt M, Steven S, Kvandova M, Kalinovic S, Lagrange J, Keaney JF, Jr., Münzel T, Wenzel P, Schulz E. alpha1AMPK deletion in myelomonocytic cells induces a pro-inflammatory phenotype and enhances angiotensin II-induced vascular dysfunction. Cardiovasc Res 2018;114(14):1883-1893.
  • Gogiraju R, Hubert A, Fahrer J, Straub BK, Brandt M, Wenzel P, Münzel T, Konstantinides S, Hasenfuss G, Schäfer K. Endothelial Leptin Receptor Deletion Promotes Cardiac Autophagy and Angiogenesis Following Pressure Overload by Suppressing Akt/mTOR Signaling. Circ Heart Fail 2019;12(1):e005622.
  • Kiouptsi K, Finger S, Garlapati VS, Knorr M, Brandt M, Walter U, Wenzel P, Reinhardt C. Hypoxia evokes increased PDI and PDIA6 expression in the infarcted myocardium of ex-germ-free and conventionally raised mice. Biol Open 2019;8(1).
  • Kröller-Schön S, Jansen T, Tran TLP, Kvandova M, Kalinovic S, Oelze M, Keaney JF, Jr., Foretz M, Viollet B, Daiber A, Kossmann S, Lagrange J, Frenis K, Wenzel P, Münzel T, Schulz E. Endothelial alpha1AMPK modulates angiotensin II-mediated vascular inflammation and dysfunction. Basic Res Cardiol 2019;114(2):8.
  • Schüler R, Brand A, Klebow S, Wild J, Veras FP, Ullmann E, Roohani S, Kolbinger F, Kossmann S, Wohn C, Daiber A, Münzel T, Wenzel P, Waisman A, Clausen BE, Karbach S. Antagonization of IL-17A Attenuates Skin Inflammation and Vascular Dysfunction in Mouse Models of Psoriasis. J Invest Dermatol 2019;139(3):638-647.
  • Bochenek ML, Bauer T, Gogiraju R, Nadir Y, Mann A, Schönfelder T, Hunig L, Brenner B, Münzel T, Wenzel P, Konstantinides S, Schäfer K. The endothelial tumor suppressor p53 is essential for venous thrombus formation in aged mice. Blood Adv 2018;2(11):1300-1314.
  • Lagrange J, Kossmann S, Kiouptsi K, Wenzel P. Visualizing Leukocyte Rolling and Adhesion in Angiotensin II-Infused Mice: Techniques and Pitfalls. J Vis Exp 2018(131).
  • Schönfelder T, Brandt M, Kossmann S, Knopp T, Münzel T, Walter U, Karbach SH, Wenzel P. Lack of T-bet reduces monocytic interleukin-12 formation and accelerates thrombus resolution in deep vein thrombosis. Sci Rep 2018;8(1):3013.
  • Siegismund CS, Escher F, Lassner D, Kühl U, Gross U, Fruhwald F, Wenzel P, Münzel T, Frey N, Linke RP, Schultheiss HP. Intramyocardial inflammation predicts adverse outcome in patients with cardiac AL amyloidosis. Eur J Heart Fail 2018;20(4):751-757.
  • Sotiriou E, Heiner S, Jansen T, Brandt M, Schmidt KH, Kreitner KF, Emrich T, Schultheiss HP, Schulz E, Münzel T, Wenzel P. Therapeutic implications of a combined diagnostic workup including endomyocardial biopsy in an all-comer population of patients with heart failure: a retrospective analysis. ESC Heart Fail 2018.
  • Kossmann S, Lagrange J, Jäckel S, Jurk K, Ehlken M, Schönfelder T, Weihert Y, Knorr M, Brandt M, Xia N, Li H, Daiber A, Oelze M, Reinhardt C, Lackner K, Gruber A, Monia B, Karbach SH, Walter U, Ruggeri ZM, Renné T, Ruf W, Münzel T, Wenzel P  (2017) Platelet-localized FXI promotes a vascular coagulation-inflammatory circuit in arterial hypertension. Sci Transl Med 9

  • Sag CM, Schnelle M, Zhang J, Murdoch CE, Kossmann S, Protti A, Santos CXC, Sawyer G, Zhang X, Mongue-Din H, Richards DA, Brewer AC, Prysyazhna O, Maier LS, Wenzel P, Eaton PJ, Shah AM (2017) Distinct Regulatory Effects of Myeloid Cell and Endothelial Cell NAPDH Oxidase 2 on Blood Pressure. Circulation 135: 2163-2177
  • Steven S, Oelze M, Hanf A, Kröller-Schön S, Kashani F, Roohani S, Welschof P, Kopp M, Godtel-Armbrust U, Xia N, Li H, Schulz E, Lackner KJ, Wojnowski L, Bottari SP, Wenzel P, Mayoux E, Münzel T, Daiber A (2017) The SGLT2 inhibitor empagliflozin improves the primary diabetic complications in ZDF rats. Redox Biol 13: 370-385
  • Subramaniam S, Jurk K, Hobohm L, Jäckel S, Saffarzadeh M, Schwierczek K, Wenzel P, Langer F, Reinhardt C, Ruf W (2017) Distinct contributions of complement factors to platelet activation and fibrin formation in venous thrombus development. Blood 129: 2291-2302
  • Steven S, Oelze M, Brandt M, Ullmann E, Kröller-Schön S, Heeren T, Tran LP, Daub S, Dib M, Stalleicken D, Wenzel P, Münzel T, Daiber A (2017) Pentaerythritol Tetranitrate In Vivo Treatment Improves Oxidative Stress and Vascular Dysfunction by Suppression of Endothelin-1 Signaling in Monocrotaline-Induced Pulmonary Hypertension. Oxid Med Cell Longev 2017: 4353462
  • Steven S, Jurk K, Kopp M, Kröller-Schön S, Mikhed Y, Schwierczek K, Roohani S, Kashani F, Oelze M, Klein T, Tokalov S, Danckwardt S, Strand S, Wenzel P, Münzel T, Daiber A (2017) Glucagon-like peptide-1 receptor signalling reduces microvascular thrombosis, nitro-oxidative stress and platelet activation in endotoxaemic mice. British journal of pharmacology 174: 1620-1632
  • Brandt M, Garlapati V, Oelze M, Sotiriou E, Knorr M, Kröller-Schön S, Kossmann S, Schönfelder T, Morawietz H, Schulz E, Schultheiss HP, Daiber A, Münzel T, Wenzel P (2016) NOX2 amplifies acetaldehyde-mediated cardiomyocyte mitochondrial dysfunction in alcoholic cardiomyopathy. Scientific reports 6: 32554
  • Karbach SH, Schönfelder T, Brandao I, Wilms E, Hörmann N, Jäckel S, Schüler R, Finger SKnorr MLagrange J, Brandt M, Waisman A, Kossmann S, Schäfer K, Münzel T, Reinhardt C, Wenzel P (2016) Gut Microbiota Promote Angiotensin II-Induced Arterial Hypertension and Vascular Dysfunction. Journal of the American Heart Association 5
  • Steven S, Jurk K, Kopp M, Kröller-Schön S, Mikhed Y, Schwierczek K, Roohani S, Kashani F, Oelze M, Klein T, Tokalov S, Danckwardt S, Strand S, Wenzel P, Münzel T, Daiber A (2016) Glucagon-like peptide-1 receptor signalling reduces microvascular thrombosis, nitro-oxidative stress and platelet activation in endotoxaemic mice. British journal of pharmacology
  • Wenzel P, Rossmann H, Müller C, Kossmann S, Oelze M, Schulz A, Arnold N, Simsek C, Lagrange J, Klemz R, Schönfelder TBrandt MKarbach SH, Knorr MFinger S, Neukirch C, Häuser F, Beutel ME, Kröller-Schön S, Schulz E, Schnabel RB, Lackner K, Wild PS, Zeller T, Daiber A, Blankenberg S, Münzel T. Heme oxygenase-1 suppresses a pro-inflammatory phenotype in monocytes and determines endothelial function and arterial hypertension in mice and humans. European heart journal. 2015.
  • Karbach S, Croxford AL, Oelze M, Schuler R, Minwegen D, Wegner J, Koukes L, Yogev N, Nikolaev A, Reissig S, Ullmann A, Knorr M, Waldner M, Neurath MF, Li H, Wu Z, Brochhausen C, Scheller J, Rose-John S, Piotrowski C, Bechmann I, Radsak M, Wild P, Daiber A, von Stebut E*, Wenzel P*, Waisman A*, Munzel T*. Interleukin 17 drives vascular inflammation, endothelial dysfunction, and arterial hypertension in psoriasis-like skin disease. Arteriosclerosis, thrombosis, and vascular biology. 34:2658-2668, 2014. 
  • * these authors contributed equally
  • Kossmann S, Hu H, Steven SSchönfelder T, Fraccarollo D, Mikhed Y, Brähler M, Knorr MBrandt MKarbach SHBecker C, Oelze M, Bauersachs J, Widder J, Münzel TDaiber A,Wenzel P. Inflammatory Monocytes Determine Endothelial Nitric Oxide Synthase Uncoupling and Nitro-oxidative Stress Induced by Angiotensin II. Journal of Biological Chemistry. pii: jbc.M114.604231, 2014.
  • Brandt M, Schönfelder T, Schwenk M, Becker CJäckel SReinhardt C, Stark K, Massberg S, Münzel T, von Brühl ML, Wenzel P. Deep vein thrombus formation induced by flow reduction in mice is determined by venous side branches. Clinical Hemorheology and Microcirculation. 56(2):145-5, 2014.
  • Kossmann S, Schwenk M, Hausding M, Karbach S, Schmidgen M, Brandt MKnorr M, Hu H, Kröller-Schön S, Schönfelder TGrabbe S, Oelze M, Daiber AMünzel T, Becker CWenzel P. Angiotensin II–Induced Vascular Dysfunction Depends on Interferon-γ–Driven Immune Cell Recruitment and Mutual Activation of Monocytes and NK-Cells. Arteriosclerosis, Thrombosis, and Vascular Biology. 33:1313-1319, 2013.
  • Wenzel PKnorr M, Kossmann S, Stratmann J, Hausding M, Schuhmacher S, Karbach SH, Schwenk M, Yogev N, Schulz E, Oelze M, Grabbe S, Jonuleit H, Becker C, Daiber A, Waisman A, Munzel T. Lysozyme M-positive monocytes mediate angiotensin II-induced arterial hypertension and vascular dysfunction. Circulation. 2011; 124(12):1370-81, 2011.
  • Team 2011: PD Dr. Philip Wenzel, Dr. Maike Knorr und Kollegen, II. Med. Klinik und Poliklinik, Interview mit Philip Wenzel und Maike Knorr im Magazin "Circulation" vom 6. Dez. 2011 (Pdf-file, 997,0 KB)
Editorial Commentary

Under Pressure: A New Role for CD11c+ Myeloid Cells in Hypertension.
Kossmann S, Wenzel P.

Hypertension. 2018 Jan 29. pii: HYPERTENSIONAHA.117.10216. [Epub ahead of print]