Juniorgruppe 'Klinische Epidemiologie und Systemmedizin'

Dr. Jürgen Prochaska

Leiter der Juniorgruppe

Die Juniorgruppe „Thrombotische Erkrankungen und antithrombotische Therapie“ ist als BMBF-geförderte Forschergruppe in der Klinischen Epidemiologie des CTH angesiedelt und befasst sich mit klinisch-relevanten Fragestellungen auf dem Gebiet der arteriellen und venösen Thrombose. Hierfür werden Biodatenbanken von Populationsstudien und Patientenkohorten in einem holistischen Ansatz – vom genetischen Hintergrund bis zum klinischen Outcome – für innovative wissenschaftliche Projekte genutzt.

Das wissenschaftliche Arbeitsprogramm untersucht Risikofaktoren für die Entstehung thrombotischer Erkrankungen im arteriellen und venösen Gefäßsystem und deren Folgeerkrankungen, insbesondere der Herzinsuffizienz. Ein besonderer Fokus liegt auf der Untersuchung von subklinischen Phänotypen kardiovaskulärer Erkrankungen, welche als frühe asymptomatische Pathologien von besonderem Interesse und Relevanz für präventivmedizinische Ansätze sind. Begleitet werden diese Forschungsvorhaben durch wissenschaftliche Projekte zur Diagnostik, Therapie und Prävention von thrombotischen Erkrankungen.

Forschungsschwerpunkte

• Diagnostik, Therapie und Prävention von thrombotischen Erkrankungen und deren Folgeerkrankungen
• Interaktion zwischen Hämostase und dem Auftreten und Fortschreiten von Herzinsuffizienz
• Zusammenhang zwischen Erkrankungen des venösen Gefäßsystems und der arteriellen kardiovaskulären Erkrankung

Kooperationspartner

Einrichtungen der Universitätsmedizin 

• PD Dr. Christian Becker, CTH
• Prof. Dr. Espinola-Klein, Zentrum für Kardiologie – Abt. für Angiologie
• Prof. Dr. Stavros Konstantinides und PD Dr. Mareike Lankeit, Klinische Studien, CTH
• Prof. Dr. Karl Lackner, Institut für Klinische Chemie und Laboratoriumsmedizin
• Prof. Dr. Thomas Münzel, Zentrum für Kardiologie
• Dr. Marina Panova-Noeva, Juniorgruppe Klinische Plättchen-Epidemiologie, CTH
• Prof. Dr. Philipp Wild, Klinische Epidemiologie, CTH
• Prof. Dr. Stefan Tenzer, Institut für Immunologie
• Prof. Dr. Miguel Andrade, JGU, Computational Biology and Data Mining
• Prof. Dr. Dr. Perikles Simon, JGU, Sprotmedizin
• Prof. Dr. Julia Weinmann-Menke (I. Med. Klinik)
• Prof. Dr. Andreas Daiber (Molekulare Kardiologie)

Nationale Partner

• Prof. Dr. S. Bode-Böger, Universitätsklinikum Magdeburg
• Prof. Dr. Abdelhak Zoubir, TU Darmstadt
• Prof. Dr. Armin Grau, Klinikum Ludwigshafen

Internationale Partner

• Prof. Dr. Hugo ten Cate und Dr. Henri Spronk, CARIM Maastricht, Niederlande
• Prof. Dr. Carolyn S. Lam, National Heart Center Singapore
• Prof. Dr. Sanjiv S. Shah, Chicago, USA

Drittmittelförderung

• Bundesministerium für Bildung und Forschung (CTH, 01EO1503)
• Bayer AG
• Novartis Pharma
• Boehringer Ingelheim

Team - Juniorgruppe Klinische Epidemiologie

Mitarbeiter

Vincent ten Cate, M.Sc. – PostDoc
Dr. Marc Wiliam Heidorn - PostDoc
cand. med. Judith Plöger – Medizinische Doktorandin
cand. med. Jannis Franz - Medizinischer Doktorand
cand. med. Matthias Grosch - Medizinischer Doktorand
cand. med. Sophie Moll - Medizinische Doktorandin
cand. rer. nat. Silav Neid - Naturwissenschaftliche Doktorandin
cand. rer. nat. Rieke Baumkötter - Naturwissenschaftliche Doktorandin

Datenmanagement

Andreas Schmitt (Prospectus)
Stefanie Kurz (MyoVasc)
Heidrun Lamparter (thrombEVAL/VTEval)
Bianca Zäpf (FOCUS Bioseq)
Dr. Dagmar Laubert-Reh (Gutenberg-Gesundheitsstudie)

Statistik (Klinische Epidemiologie)

Markus Nagler (thrombEVAL, VTEval, FOCUS Bioseq, Prospectus)
Andreas Schulz (GHS, MyoVasc)

Wissenschaftsmanagement (Klinische Epidemiologie)

Dr. Jaqueline Kandsberger

 

 

Origialarbeiten

• Pallares Robles A, Ten Cate V, Schulz A, Prochaska JH, Rapp S, Koeck T, Panova-Noeva M, Heitmeier S, Schwers S, Leineweber K, Seyfarth HJ, Opitz CF, Spronk H, Espinola-Klein C, Lackner KJ, Münzel T, Andrade-Navarro MA, Konstantinides SV, Ten Cate H, Wild PS. Association of FXI activity with thrombo-inflammation, extracellular matrix, lipid metabolism and apoptosis in venous thrombosis. Sci Rep. 2022 Jun 13;12(1):9761. https://doi.org/10.1038/s41598-022-13174-5
• van Paridon PCS, Panova-Noeva M, van Oerle R, Schulz A, Prochaska JH, Arnold N, Schmidtmann I, Beutel M, Pfeiffer N, Münzel T, Lackner KJ, Ten Cate H, Wild PS, Spronk HMH. Relationships between coagulation factors and thrombin generation in a general population with arterial and venous disease background. Thromb J. 2022 Jun 8;20(1):32. https://doi.org/10.1186/s12959-022-00392-0
• Keller K, Prochaska JH, Coldewey M, Göbel S, Schmitt VH, Hahad O, Ullmann A, Nagler M, Lamparter H, Espinola-Klein C, Münzel T, Wild PS. Atherosclerosis and Its Impact on the Outcomes of Patients with Deep Venous Thrombosis. Life (Basel). 2022 May 14;12(5):734. https://doi.org/10.3390/life12050734
• Panova-Noeva M, Wagner B, Nagler M, Koeck T, Ten Cate V, Eggebrecht L, Prochaska JH, Meyer I, Gerdes C, Spronk HM, Lackner KJ, Ten Cate H, Leineweber K, Heitmeier S, Konstantinides S, Wild PS. Variation of platelet function in clinical phenotypes of acute venous thromboembolism - Results from the GMP-VTE project. J Thromb Haemost. 2022 Mar;20(3):705-715. https://doi.org/10.1111/jth.15595
• Schmitt VH, Leuschner A, Jünger C, Pinto A, Hahad O, Schulz A, Arnold N, Tröbs SO, Panova-Noeva M, Keller K, Zeller T, Beutel M, Pfeiffer N, Strauch K, Blankenberg S, Lackner KJ, Prochaska JH, Wild PS, Münzel T. Cardiovascular profiling in the diabetic continuum: results from the population-based Gutenberg Health Study. Clin Res Cardiol. 2022 Mar;111(3):272-283. https://doi.org/10.1007/s00392-021-01879-y
• Jünger C, Prochaska JH, Gori T, Schulz A, Binder H, Daiber A, Koeck T, Rapp S, Lackner KJ, Münzel T, Wild PS. Rationale and design of the effects of EMpagliflozin on left ventricular DIAstolic function in diabetes (EmDia) study. J Cardiovasc Med (Hagerstown). 2022 Mar 1;23(3):191-197. https://doi.org/10.2459/jcm.0000000000001267
• Arnold N, Hermanns IM, Schulz A, Hahad O, Schmitt VH, Panova-Noeva M, Prochaska JH, Binder H, Pfeiffer N, Beutel M, Lackner KJ, Münzel T, Wild PS. Renin, aldosterone, the aldosterone-to-renin ratio, and incident hypertension among normotensive subjects from the general population. Cardiovasc Res. 2022 Feb 23:cvac019. https://doi.org/10.1093/cvr/cvac019
• Heidorn MW, Steck S, Müller F, Tröbs SO, Buch G, Schulz A, Schwuchow-Thonke S, Schuch A, Strauch K, Schmidtmann I, Lackner KJ, Gori T, Münzel T, Wild PS, Prochaska JH. FEV₁ Predicts Cardiac Status and Outcome in Chronic Heart Failure. Chest. 2022 Jan;161(1):179-189. https://doi.org/10.1016/j.chest.2021.07.2176
• Keller K, Sinning C, Schulz A, Jünger C, Schmitt VH, Hahad O, Zeller T, Beutel M, Pfeiffer N, Strauch K, Blankenberg S, Lackner KJ, Prochaska JH, Schulz E, Münzel T, Wild PS. Right atrium size in the general population. Sci Rep. 2021 Nov 18;11(1):22523. https://doi.org/10.1038/s41598-021-01968-y
• Prochaska JH, Arnold N, Falcke A, Kopp S, Schulz A, Buch G, Moll S, Panova-Noeva M, Jünger C, Eggebrecht L, Pfeiffer N, Beutel M, Binder H, Grabbe S, Lackner KJ, Ten Cate-Hoek A, Espinola-Klein C, Münzel T, Wild PS. Chronic venous insufficiency, cardiovascular disease, and mortality: a population study. Eur Heart J. 2021 Oct 21;42(40):4157-4165. https://doi.org/10.1093/eurheartj/ehab495
• Wasielica-Poslednik J, Hampel U, Ries L, Faysal R, Schulz A, Prochaska JH, Wild PS, Schmidtmann I, Münzel T, Beutel ME, Lackner KJ, Pfeiffer N, Schuster AK. Prevalence of corneal arcus and associated factors in a German population-Results from the Gutenberg Health Study. PLoS One. 2021 Sep 21;16(9):e0255893. https://doi.org/10.1371/journal.pone.0255893
• Schmitt VH, Prochaska JH, Föll AS, Schulz A, Keller K, Hahad O, Koeck T, Tröbs SO, Rapp S, Beutel M, Pfeiffer N, Strauch K, Lackner KJ, Münzel T, Wild PS. Galectin-3 for prediction of cardiac function compared to NT-proBNP in individuals with prediabetes and type 2 diabetes mellitus. Sci Rep. 2021 Sep 24;11(1):19012. https://doi.org/10.1038/s41598-021-98227-x
• Arnold N, Deiseroth A, Hahad O, Diestelmeier S, Schulz A, Daubenbüchel A, Gori T, Binder H, Pfeiffer N, Prochaska J, Beutel M, Lackner KJ, Münzel T, Wild PS. Domains of Physical Activity in Relation to Stiffness Index in the General Population. J Am Heart Assoc. 2021 Aug 17;10(16):e020930. https://doi.org/10.1161/jaha.121.020930
• Reagh JJ, Zheng H, Stolz U, Parry BA, Chang AM, House SL, Giordano NJ, Cohen J, Singer AJ, Francis S, Prochaska JH, Zeserson E, Wild PS, Limkakeng AT Jr, Walters EL, LoVecchio F, Theodoro D, Hollander JE, Kabrhel C, Fermann GJ. Sex-related differences in D-dimer levels for venous thromboembolism screening. Acad Emerg Med. 2021 Aug;28(8):873-881. https://doi.org/10.1111/acem.14220
• Schmitt VH, Billaudelle AM, Schulz A, Keller K, Hahad O, Tröbs SO, Koeck T, Michal M, Schuster AK, Toenges G, Lackner KJ, Prochaska JH, Münzel T, Wild PS. Disturbed Glucose Metabolism and Left Ventricular Geometry in the General Population. J Clin Med. 2021 Aug 27;10(17):3851. https://doi.org/10.3390/jcm10173851
• Dahlen B, Schulz A, Göbel S, Tröbs SO, Schwuchow-Thonke S, Spronk HM, Prochaska JH, Arnold N, Lackner KJ, Gori T, Ten Cate H, Münzel T, Wild PS, Panova-Noeva M. The impact of platelet indices on clinical outcome in heart failure: results from the MyoVasc study. ESC Heart Fail. 2021 Aug;8(4):2991-3001. https://doi.org/10.1002/ehf2.13390
• Göbel S, Prochaska JH, Tröbs SO, Panova-Noeva M, Espinola-Klein C, Michal M, Lackner KJ, Gori T, Münzel T, Wild PS. Rationale, design and baseline characteristics of the MyoVasc study: A prospective cohort study investigating development and progression of heart failure. Eur J Prev Cardiol. 2021 Aug 9;28(9):1009-1018. https://doi.org/10.1177/2047487320926438
• Göbel S, Prochaska JH, Tröbs SO, Panova-Noeva M, Espinola-Klein C, Michal M, Lackner KJ, Gori T, Münzel T, Wild PS. Rationale, design and baseline characteristics of the MyoVasc study: A prospective cohort study investigating development and progression of heart failure. Eur J Prev Cardiol. 2021 Aug 9;28(9):1009-1018. https://doi.org/10.1177/2047487320926438
• Reagh JJ, Zheng H, Stolz U, Parry BA, Chang AM, House SL, Giordano NJ, Cohen J, Singer AJ, Francis S, Prochaska JH, Zeserson E, Wild PS, Limkakeng AT Jr, Walters EL, LoVecchio F, Theodoro D, Hollander JE, Kabrhel C, Fermann GJ. Sex- related Differences in D-dimer Levels for Venous Thromboembolism Screening. Acad Emerg Med. 2021 Aug;28(8):873-881. https://doi.org/10.1111/acem.14220
• Ten Cate V, Koeck T, Prochaska J, Schulz A, Panova-Noeva M, Rapp S, Eggebrecht L, Lenz M, Glunz J, Sauer M, Ewert R, Halank M, Münzel T, Heitmeier S, Andrade-Navarro MA, Lackner KJ, Konstantinides SV, Leineweber K, Wild PS. A targeted proteomics investigation of the obesity paradox in venous thromboembolism. Blood Adv. 2021 Jul 27;5(14):2909-2918. https://doi.org/10.1182/bloodadvances.2020003800
• Michal M, Eggebrecht L, Göbel S, Panova-Noeva M, Nagler M, Arnold N, Lauterbach M, Bickel C, Wiltink J, Beutel ME, Münzel T, Wild PS, Prochaska JH. The relevance of depressive symptoms for the outcome of patients receiving vitamin K-antagonists: Results from the thrombEVAL cohort study. Eur Heart J Cardiovasc Pharmacother. 2021 Jul 23;7(4):271-279. https://doi.org/10.1093/ehjcvp/pvz085
• Dahlen B, Müller F, Tröbs SO, Heidorn MW, Schulz A, Arnold N, Hermanns MI, Schwuchow-Thonke S, Prochaska JH, Gori T, Ten Cate H, Lackner KJ, Münzel T, Wild PS, Panova-Noeva M. Sex-Specific Relationship Between Parathyroid Hormone and Platelet Indices in Phenotypes of Heart Failure-Results From the MyoVasc Study. Front Cardiovasc Med. 2021 Jun 16;8:682521. https://doi.org/10.3389/fcvm.2021.682521
• Ten Cate V, Prochaska JH, Schulz A, Koeck T, Pallares Robles A, Lenz M, Eggebrecht L, Rapp S, Panova-Noeva M, Ghofrani HA, Meyer FJ, Espinola-Klein C, Lackner KJ, Michal M, Schuster AK, Strauch K, Zink AM, Laux V, Heitmeier S, Konstantinides SV, Münzel T, Andrade-Navarro MA, Leineweber K, Wild PS. Protein
  expression profiling suggests relevance of non-canonical pathways in isolated pulmonary embolism. Blood. 2021 May 13;137(19):2681-2693. https://doi.org/10.1182/blood.2019004571
• Hahad O, Arnold N, Prochaska JH, Panova-Noeva M, Schulz A, Lackner KJ, Pfeiffer N, Schmidtmann I, Michal M, Beutel M, Wild PS, Keaney JF Jr, Daiber A, Münzel T. Cigarette Smoking Is Related to Endothelial Dysfunction of Resistance, but Not Conduit Arteries in the General Population-Results From the Gutenberg Health Study. Front Cardiovasc Med. 2021 May 19;8:674622. https://doi.org/10.3389/fcvm.2021.674622
• Rodionov RN, Beyer-Westendorf J, Bode-Böger SM, Eggebrecht L, Konstantinides S, Martens-Lobenhoffer J, Nagler M, Prochaska J, Wild P. Homoarginine and methylarginines independently predict long-term outcome in patients presenting with suspicion of venous thromboembolism. Sci Rep. 2021 May 5;11(1):9569. https://doi.org/10.1038/s41598-021-88986-y
• Tröbs SO, Prochaska JH, Schwuchow-Thonke S, Schulz A, Müller F, Heidorn MW, Göbel S, Diestelmeier S, Lerma Monteverde J, Lackner KJ, Gori T, Münzel T, Wild PS. Association of Global Longitudinal Strain With Clinical Status and Mortality in Patients With Chronic Heart Failure. JAMA Cardiol. 2021 Apr 1;6(4):448-456. https://doi.org/10.1001/jamacardio.2020.7184
• Arnold N, Merzenich H, Wingerter A, Schulz A, Schneider A, Prochaska JH, Göbel S, Neu MA, Henninger N, Panova-Noeva M, Eckerle S, Spix C, Schmidtmann I, Lackner KJ, Beutel ME, Pfeiffer N, Münzel T, Faber J, Wild PS. Promotion of Arterial Stiffness by Childhood Cancer and Its Characteristics in Adult Long-
  Term Survivors. J Am Heart Assoc. 2021 Feb;10(5):e015609. https://doi.org/10.1161/jaha.119.015609
• van Paridon PCS, Panova-Noeva M, van Oerle R, Schulz A, Prochaska JH, Arnold N, Schmidtmann I, Beutel M, Pfeiffer N, Münzel T, Lackner KJ, Hackeng TM, Ten Cate H, Wild PS, Spronk HMH. Relation between Tissue Factor Pathway Inhibitor Activity and Cardiovascular Risk Factors and Diseases in a Large Population Sample. Thromb Haemost. 2021 Feb;121(2):174-181. https://doi.org/10.1055/s-0040-1715897
• Eggebrecht L, Ludolph P, Göbel S, Panova-Noeva M, Arnold N, Nagler M, Bickel C, Lauterbach M, Hardt R, Cate HT, Lackner KJ, Espinola-Klein C, Münzel T, Prochaska JH, Wild PS. Cost saving analysis of specialized, eHealth-based management of patients receiving oral anticoagulation therapy: Results from the thrombEVAL study. Sci Rep. 2021 Jan 28;11(1):2577. https://doi.org/10.1038/s41598-021-82076-9
• Hahad O, Wild PS, Prochaska JH, Schulz A, Lackner KJ, Pfeiffer N, Schmidtmann I, Michal M, Beutel M, Daiber A, Münzel T. Midregional pro atrial natriuretic peptide: a novel important biomarker for noise annoyance-induced cardiovascular morbidity and mortality? Clin Res Cardiol. 2021 Jan;110(1):29-39. https://doi.org/10.1007/s00392-020-01645-6
• Lenz M, Schulz A, Koeck T, Rapp S, Nagler M, Sauer M, Eggebrecht L, Ten Cate V, Panova-Noeva M, Prochaska JH, Lackner KJ, Münzel T, Leineweber K, Wild PS, Andrade-Navarro MA. Missing value imputation in proximity extension assay-based targeted proteomics data. PLoS One. 2020 Dec 14;15(12):e0243487. https://doi.org/10.1371/journal.pone.0243487
• Panova-Noeva M, Wagner B, Nagler M, Koeck T, Ten Cate V, Prochaska JH, Heitmeier S, Meyer I, Gerdes C, Laux V, Konstantinides S, Spronk HM, Münzel T, Lackner KJ, Leineweber K, Ten Cate H, Wild PS. Comprehensive platelet phenotyping supports the role of platelets in the pathogenesis of acute venous
  thromboembolism - results from clinical observation studies. EBioMedicine. 2020 Oct;60:102978. https://doi.org/10.1016/j.ebiom.2020.102978
• Lagrange J, Wagner B, Nagler M, Ten Cate V, Pallares Robles A, Koeck T, Rapp S, Prochaska JH, Spronk HM, Wenzel P, Ruf W, Ten Cate H, Wild PS, Panova-Noeva M. Characterization of Thrombin Generation Curve Shape in Presence of Platelets from Acute Venous Thromboembolism Patients. J Clin Med. 2020 Sep 7;9(9):2892. https://doi.org/10.3390/jcm9092892
• van Paridon PCS, Panova-Noeva M, van Oerle R, Schultz A, Hermanns IM, Prochaska JH, Arnold N, Binder H, Schmidtmann I, Beutel ME, Pfeiffer N, Münzel T, Lackner KJ, Ten Cate H, Wild PS, Spronk HMH. Thrombin generation in cardiovascular disease and mortality - results from the Gutenberg Health Study.
  Haematologica. 2020 Sep 1;105(9):2327-2334. https://doi.org/10.3324/haematol.2019.221655
• Ten Cate V, Eggebrecht L, Schulz A, Panova-Noeva M, Lenz M, Koeck T, Rapp S, Arnold N, Lackner KJ, Konstantinides S, Espinola-Klein C, Münzel T, Prochaska JH, Wild PS. Isolated Pulmonary Embolism Is Associated With a High Risk of Arterial Thrombotic Disease: Results From the VTEval Study. Chest. 2020 Jul;158(1):341-349. https://doi.org/10.1016/j.chest.2020.01.055
• Lauterbach M, Uhrich E, Eggebrecht L, Göbel S, Panova-Noeva M, Nagler M, Ten Cate V, Bickel C, Espinola-Klein C, Münzel T, Wild PS, Prochaska JH. Specialized Management of Oral Anticoagulation Therapy Improves Outcome in Patients with Chronic Renal Insufficiency. J Clin Med. J Clin Med. 2020 Feb 28;9(3):645. https://doi.org/10.3390/jcm9030645
• Panova-Noeva M, Wagner B, Nagler M, Arnold N, Prochaska JH, Eckerle S, Spronk HM, Merzenich H, Wingerter A, Schneider A, Danckwardt S, Ten Cate H, Faber J, Wild PS. Relation between platelet coagulant and vascular function, sex-specific analysis in adult survivors of childhood cancer compared to a
  population-based sample. Sci Rep. 2019 Dec 27;9(1):20090. https://doi.org/10.1038/s41598-019-56626-1
• Herzog J, Schmidt FP, Hahad O, Mahmoudpour SH, Mangold AK, Garcia Andreo P, Prochaska J, Koeck T, Wild PS, Sørensen M, Daiber A, Münzel T. Acute exposure to nocturnal train noise induces endothelial dysfunction and pro-thromboinflammatory changes of the plasma proteome in healthy subjects. Basic
  Res Cardiol. 2019 Oct 29;114(6):46. https://doi.org/10.1007/s00395-019-0753-y
• Hahad O, Wild PS, Prochaska JH, Schulz A, Hermanns I, Lackner KJ, Pfeiffer N, Schmidtmann I, Beutel M, Gori T, Deanfield JE, Münzel T. Endothelial Function Assessed by Digital Volume Plethysmography Predicts the Development and Progression of Type 2 Diabetes Mellitus. J Am Heart Assoc. 2019 Oct 15;8(20):e012509. https://doi.org/10.1161/jaha.119.012509
• Labenz C, Prochaska JH, Huber Y, Nagel M, Straub BK, Wild P, Galle PR, Schattenberg JM. Cardiovascular Risk Categories in Patients With Nonalcoholic Fatty Liver Disease and the Role of Low-Density Lipoprotein Cholesterol. Hepatol Commun. 2019 Sep 30;3(11):1472-1481.019. https://doi.org/10.1002/hep4.1428
• Prochaska JH, Hausner C, Nagler M, Göbel S, Eggebrecht L, Panova-Noeva M, Arnold N, Lauterbach M, Bickel C, Michal M, Hardt R, Espinola-Klein C, Lackner KJ, Münzel T, Wild PS. Subtherapeutic Anticoagulation Control under Treatment with Vitamin K-Antagonists-Data from a Specialized Coagulation Service. Thromb Haemost. 2019 Aug;119(8):1347-1357. https://doi.org/10.1055/s-0039-1692175
• Börschel CS, Rübsamen N, Ojeda FM, Wild PS, Hoffmann BA, Prochaska JH, Gori T, Lackner KJ, Blankenberg S, Zeller T, Münzel T, Schnabel RB. Noninvasive peripheral vascular function and atrial fibrillation in the general population. J Hypertens. 2019.
• Münzel T, Hahad O, Gori T, Hollmann S, Arnold N, Prochaska JH, Schulz A, Beutel M, Pfeiffer N, Schmidtmann I, Lackner KJ, Keaney JF Jr, Wild PS. Heart rate, mortality, and the relation with clinical and subclinical cardiovascular diseases: results from the Gutenberg Health Study. Clin Res Cardiol. 2019.
• Ten Cate V, Nagler M, Panova-Noeva M, Eggebrecht L, Arnold N, Lamparter H, Hermanns MI, Ten Cate H, Prins MH, Espinola-Klein C, Münzel T, Lackner KJ, Wild PS, Prochaska JH. The diagnostic performance of renal function-adjusted D-dimer testing in individuals suspected of venous thromboembolism. Haematologica 2019.
• Eggebrecht L, Prochaska JH, Tröbs SO, Schwuchow-Thonke S, Göbel S, Diestelmeier S, Schulz A, Arnold N, Panova-Noeva M, Koeck T, Rapp S, Gori T, Lackner KJ, Ten Cate H, Münzel T, Wild PS. Direct oral anticoagulants and vitamin K antagonists are linked to differential profiles of cardiac function and lipid metabolism. Clin Res Cardiol 2019.
• Eggebrecht L, Nagler M, Göbel S, Lamparter H, Keller K, Wagner B, Panova-Noeva M, Ten Cate V, Bickel C, Lauterbach M, Espinola-Klein C, Hardt R, Münzel T, Prochaska JH, Wild PS. Relevance of Polypharmacy for Clinical Outcome in Patients Receiving Vitamin K Antagonists. J Am Geriatr Soc 2019;67(3):463-470.
• Burghardt J, Klein E, Brähler E, Ernst M, Schneider A, Eckerle S, Neu MA, Wingerter A, Henninger N, Panova‐Noeva M, Prochaska J, Wild P, Beutel M, Faber J. Prevalence of mental distress among adult survivors of childhood cancer in Germany—Compared to the general population. Cancer Medicine 2019;8(4):1865-1874.
• Börschel CS, Rübsamen N, Ojeda FM, Wild PS, Hoffmann BA, Prochaska JH, Gori T, Lackner KJ, Blankenberg S, Zeller T, Münzel T, Schnabel RB. Noninvasive peripheral vascular function and atrial fibrillation in the general population. J Hypertens 2019;37(5):928-934.
• Trinchero A, Scheres LJJ, Prochaska JH, Ambaglio C, Wild PS, Middeldorp S, Konstantinides SV, Barco S. Sex-specific differences in the distal versus proximal presenting location of acute deep vein thrombosis. Thromb Res 2018;172:74-79.
• Göbel S, Prochaska JH, Eggebrecht L, Schmitz R, Jünger C, Lamparter H, Nagler M, Keller K, Coldewey M, Tröbs SO, Diestelmeier S, Schwuchow-Thonke S, Bickel C, Lauterbach M, Lackner KJ, Cate HT, Münzel T, Hardt R, Wild PS. Management of Oral Anti-Coagulation in Patients with Heart Failure-Insights from the ThrombEVAL Study. Thromb Haemost 2018;118(11):1930-1939.
• Eggebrecht L, Prochaska JH, Schulz A, Arnold N, Jünger C, Gobel S, Laubert-Reh D, Binder H, Beutel ME, Pfeiffer N, Blankenberg S, Lackner KJ, Spronk HM, Ten Cate H, Münzel T, Wild PS. Intake of Vitamin K Antagonists and Worsening of Cardiac and Vascular Disease: Results From the Population-Based Gutenberg Health Study. J Am Heart Assoc 2018;7(17):e008650.
• Prochaska JH, Luther N, Brähler M, Schulz A, Hermanns MI, Lackner KJ, Espinola-Klein C, Münzel T, Wild PS, Becker C. Acute deep vein thrombosis suppresses peripheral T cell effector function. Br J Haematol 2019;184(5):847-850.
• Faber J, Wingerter A, Neu MA, Henninger N, Eckerle S, Münzel T, Lackner KJ, Beutel ME, Blettner M, Rathmann W, Peters A, Meisinger C, Linkohr B, Neuhauser H, Kaatsch P, Spix C, Schneider A, Merzenich H, Panova-Noeva M, Prochaska JH, Wild PS. Burden of cardiovascular risk factors and cardiovascular disease in childhood cancer survivors: data from the German CVSS-study. Eur Heart J 2018;39(17):1555-1562.
• Magnussen C, Ojeda FM, Wild PS, Sorensen N, Rostock T, Hoffmann BA, Prochaska J, Lackner KJ, Beutel ME, Blettner M, Pfeiffer N, Rzayeva N, Sinning CR, Blankenberg S, Münzel T, Zeller T, Schnabel RB. Atrial Fibrillation Manifestations Risk Factors and Sex Differences in a Population-Based Cohort (From the Gutenberg Health Study). Am J Cardiol 2018;122(1):76-82.
• Panova-Noeva M, Schulz A, Arnold N, Hermanns MI, Prochaska JH, Laubert-Reh D, Spronk HM, Blettner M, Beutel M, Pfeiffer N, Münzel T, Lackner KJ, Ten Cate H, Wild PS. Coagulation and inflammation in long-term cancer survivors: results from the adult population. J Thromb Haemost 2018;16(4):699-708.
• Panova-Noeva M, Schulz A, Spronk HM, Beicht A, Laubert-Reh D, van Oerle R, Arnold N, Prochaska JH, Blettner M, Beutel M, Pfeiffer N, Münzel T, Lackner KJ, Ten Cate H, Wild PS. Clinical Determinants of Thrombin Generation Measured in Presence and Absence of Platelets-Results from the Gutenberg Health Study. Thromb Haemost 2018;118(5):873-882.
• Parry BA, Chang AM, Schellong SM, House SL, Fermann GJ, Deadmon EK, Giordano NJ, Chang Y, Cohen J, Robak N, Singer AJ, Mulrow M, Reibling ET, Francis S, Griffin SM, Prochaska JH, Davis B, McNelis P, Delgado J, Kumpers P, Werner N, Gentile NT, Zeserson E, Wild PS, Limkakeng AT, Jr., Walters EL, LoVecchio F, Theodoro D, Hollander JE, Kabrhel C. International, multicenter evaluation of a new D-dimer assay for the exclusion of venous thromboembolism using standard and age-adjusted cut-offs. Thromb Res 2018;166:63-70.
• Prochaska JH, Göbel S, Nagler M, Knöpfler T, Eggebrecht L, Lamparter H, Panova-Noeva M, Keller K, Coldewey M, Bickel C, Lauterbach M, Hardt R, Espinola-Klein C, Ten Cate H, Rostock T, Münzel T, Wild PS. Sustained atrial fibrillation increases the risk of anticoagulation-related bleeding in heart failure. Clin Res Cardiol 2018;107(12):1170-1179.
• Hahad O, Beutel M, Gori T, Schulz A, Blettner M, Pfeiffer N, Rostock T, Lackner K, Sørensen M, Prochaska JH, Wild PS, Münzel T. Annoyance to different noise sources is associated with atrial fibrillation in the Gutenberg Health Study. Int J Cardiol. 2018;264:79-84.
• Eggebrecht L*, Prochaska JH*, Schleuter L, Nagler M, Hardt R, Schinzel H, Münzel T, Wild PS. [Physicians' Opinion on Health Care in Oral Anticoagulation]. Dtsch Med Wochenschr 2017.
• Arnold N, Gori T, Schnabel RB, Schulz A, Prochaska JH, Zeller T, Binder H, Pfeiffer N, Beutel M, Espinola-Klein C, Lackner KJ, Blankenberg S, Münzel T, Wild PS (2017) Relation between Arterial Stiffness and Markers of Inflammation and Hemostasis - Data from the Population-based Gutenberg Health Study. Scientific reports 7: 6346
• Prochaska JH, Frank B, Nagler M, Lamparter H, Weisser G, Schulz A, Eggebrecht L, Göbel S, Arnold N, Panova-Noeva M, Hermanns I, Pinto A, Konstantinides S, Ten Cate H, Lackner KJ, Münzel T, Espinola-Klein C, Wild PS (2017) Age-related diagnostic value of D-dimer testing and the role of inflammation in patients with suspected deep vein thrombosis. Scientific reports 7: 4591
• Luque Ramos A, Ohlmeier C, Enders D, Linder R, Horenkamp-Sonntag D, Prochaska JH, Mikolajczyk R, Garbe E (2017) Initiation and duration of dual antiplatelet therapy after inpatient percutaneous coronary intervention with stent implantation in Germany: An electronic healthcare database cohort study. Z Evid Fortbild Qual Gesundhwes 120: 31-38
• Prochaska JH, Göbel S, Keller K, Coldewey M, Ullmann A, Lamparter H, Schulz A, Schinzel H, Bickel C, Lauterbach M, Michal M, Hardt R, Binder H, Espinola-Klein C, Lackner KJ, Ten Cate H, Münzel T, Wild PS (2017) e-Health based management of patients receiving oral anticoagulation therapy: results from the observational thrombEVAL study. Journal of thrombosis and haemostasis 
• Panova-Noeva M, Arnold N, Hermanns MI, Prochaska JH, Schulz A, Spronk HM, Binder H, Pfeiffer N, Beutel M, Blankenberg S, Zeller T, Lotz J, Münzel T, Lackner KJ, ten Cate H, Wild PS. Mean Platelet Volume and Arterial Stiffness – Clinical Relationship and Common Genetic Variability. Sci Rep 2017. Vol 7 pp. 40229.
• Prochaska JH, Göbel S, Keller K, Coldewey M, Ullmann A, Lamparter H, Jünger C, Al-Bayati Z, Baer C, Walter U, Bickel C, Ten Cate H, Münzel T, Wild PS. Quality of oral anticoagulation with phenprocoumon in regular medical care and its potential for improvement in a telemedicine-based coagulation service - results from the prospective, multi-center, observational cohort study thrombEVAL. BMC Med. 2015 Jan 23;13(1):14. 
• Michal M, Prochaska JH, Keller K, Göbel S, Coldewey M, Ullmann A, Schulz A, Lamparter H, Münzel T, Reiner I, Beutel ME, Wild PS. Symptoms of depression and anxiety predict mortality in patients undergoing oral anticoagulation: Results from the thrombEVAL study program. Int J Cardiol. 2015; 187:614-9.
• Zolfaghari S, Harenberg J, Frölich J, Weiss C, Wehling M, Wild P, Prochaska J, Beyer-Westendorf J, Koscielny J, Lip GY. Development of recommendations to continue anticoagulation with one of the two types of oral anticoagulants based on the identification of patients´ preference. Semin Thromb Hemost. 2015 Mar;41(2):166-77.
• Keller K, Prochaska JH, Coldewey M, Gobel S, Ullmann A, Jünger C, Lamparter H, Ariza L, Bickel C, Lauterbach M, Konstantinides S, Rostock T, Münzel T, Wild PS. History of deep vein thrombosis is a discriminator for concomitant atrial fibrillation in pulmonary embolism. Thromb Res. 2015 Nov; 136(5):899-906.
• Prochaska JH, Gobel S, Hendelmeier M, Coldewey M, Keller K, Konstantinides S, Münzel T, Wild PS. Evaluation of oral anticoagulation therapy with vitamin K antagonists: Rationale and design of the thrombEVAL study programme. Eur J Prev Cardiol. 2015 May;22(5):622-8.
• Frank B, Ariza L, Lamparter H, Grossmann V, Prochaska JH, Ullmann A, Kindler F, Weisser G, Walter U, Lackner KJ, Espinola-Klein C, Münzel T, Konstantinides SV, Wild PS. Rationale and design of three observational, prospective cohort studies including biobanking to evaluate and improve diagnostics, management strategies and risk stratification in venous thrombobembolism: the VTEval Project. BMJ Open. 2015 Jul 1; 5(7):e008157.
• Schnabel RB, Wild PS, Prochaska JH, Ojeda FM, Zeller T, Rzayeva N, Ebrahim A, Lackner KJ, Beutel ME, Pfeiffer N, Sinning CR, Oertelt-Prigione S, Regitz-Zagrosek V, Binder H, Münzel T, Blankenberg S. Sex differences in correlates of intermediate phenotypes and prevalent cardiovascular disease in the general population. Front Cardiovasc Med. 2015 Apr 15;2:15.
• Haarmann A, Deiss A, Prochaska J, Foerch C, Weksler B, Romero I, Couraud PO, Stoll G, Rieckmann P, Buttmann M. Evaluation of soluble junctional adhesion molecule-A as a biomarker of human brain endothelial barrier breakdown. PLoS One. 2010 Oct 21;5(10):e13568.

Reviews

• Hahad O, Prochaska JH, Daiber A, Muenzel T. Environmental Noise-Induced Effects on Stress Hormones, Oxidative Stress, and Vascular Dysfunction: Key Factors in the Relationship between Cerebrocardiovascular and Psychological Disorders. Oxid Med Cell Longev. 2019 Nov 11;2019:4623109. https://doi.org/10.1155/2019/4623109
• Panova-Noeva M, Eggebrecht L, Prochaska JH, Wild PS. Potential of Multidimensional, Large-scale Biodatabases to Elucidate Coagulation and Platelet Pathways as an Approach towards Precision Medicine in Thrombotic Disease. Hamostaseologie. 2019 Jun;39(2):152-163. https://doi.org/10.1055/s-0038-1677520
• Prochaska JH, Wild PS. Traffic-associated air pollution as a risk factor for cancer in individuals with coronary artery disease. Eur J Prev Cardiol. 2018 Jul;25(10):1117-1119. https://doi.org/10.1177/2047487318768942
• Prochaska JH, Arnold N, Jünger C, Münzel T, Wild PS. Prävention von Herz-Kreislauf-Erkrankungen [Prevention of cardiovascular diseases]. Herz. 2018 Feb;43(1):87-100. German. https://doi.org/10.1007/s00059-017-4669-8

Editorial

• Prochaska JH, Müller F, Wild PS. Impact of diesel exposure on human health: the saga continues …. Eur J Prev Cardiol. 2020 Apr 9:2047487320915335. https://doi.org/10.1177/2047487320915335
• Prochaska JH, Wild PS. Traffic-associated air pollution as a risk factor for cancer in individuals with coronary artery disease. Eur J Prev Cardiol 2018:2047487318768942. https://doi.org/10.1177/2047487318768942