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Study design


The Gutenberg COVID-19 study is a prospective cohort study based on a representative population sample of the Rhine Hesse region. In order to ensure representativeness, the participants are obtained through a random sample drawn by the resident's registration office.

With the aim of including a total of 10,000 participants, the study comprises the drawing of 1,008 persons in representative waves.

Objectives of the Gutenberg COVID-19 Study

The objective of the Gutenberg COVID-19 Study is to analyze the impact of the SARS-CoV2 pandemic on public health:

  • Spread of SARS-CoV2 infection in the population
  • Quantification of the impact of the pandemic on society
  • Changes in the utilization of medical care during the pandemic
  • Psychosocial, occupational and lifestyle-related implications
  • Identification of risk factors of symptomatic SARS-CoV2 infections
  • Investigation of predictors for severity and long-term effects of SARS-CoV2
  • Relevance of infectious diseases for public health during the infection season
  • Establishment of a sustainable scientific resource for translational research on SARS-CoV2
  • Harmonized data for (inter)national network analyses
  • Establishment of a biobank for cells of the immune system