Direktor der Hautklinik und Poliklinik der Universitätsmedizin der Johannes Gutenberg-Universität Mainz KöR
06131-17-7112
06131-17-6629PD Dr. Matthias Bros
Wiss. Angestellter
mbros@uni-mainz.de
Tel.: 06131-17-9846
Fax: 06131-17-9656
Evelyn Montermann
Technische Angestellte
monterma@uni-mainz.de
Tel.: 06131-17-9852
Ingrid Tubbe
Technische Angestellte
tubbe@uni-mainz.de
Tel.: 06131-17-9852
Frederic Fittler
Biomediziner/Doktorand
ffittler@students.uni-mainz.de
Tel.: 06131-17-9758
Dr. Michael Kuske
PostDoc
mikuske@uni-mainz.de
Tel.: 06131-17-8793
Carolina Medina Montano
Biologin / Doktorandin
gmedinam@uni-mainz.de
Tel. 06131-17-9758
Nadine Röhrig
Technische Angestellte
n.roehrig@uni-mainz.de
Tel. 06131-17-9758
Dr. Henner Stege
Mediziner / PostDoc
Henner.Stege@unimedizin-mainz.de
Tel. 06131-17-8793
Maximilian Haist
Mediziner / PostDoc
Maximilian.Haist@unimedizin-mainz.de
Tel. 06131-17-8793
Tanja Klaus
Biologin / Doktorandin
tklaus@students.uni-mainz.de
Tel. 06131-17-9758
Gebäude-Nr. 308a (PKZI)
EG, links
Tel: +49(0)6131-179758
Fax: +49(0)6131-179656
Haist M, Stege H, Grabbe S, Bros M. The Functional Crosstalk between Myeloid-Derived Suppressor Cells and Regulatory T Cells within the Immunosuppressive Tumor Microenvironment. Cancers (Basel). 2021 Jan 8;13(2):210.
Sahin U, Oehm P, Derhovanessian E, Jabulowsky RA, Vormehr M, Gold M, Maurus D, Schwarck-Kokarakis D, Kuhn AN, Omokoko T, Kranz LM, Diken M, Kreiter S, Haas H, Attig S, Rae R, Cuk K, Kemmer-Brück A, Breitkreuz A, Tolliver C, Caspar J, Quinkhardt J, Hebich L, Stein M, Hohberger A, Vogler I, Liebig I, Renken S, Sikorski J, Leierer M, Müller V, Mitzel-Rink H, Miederer M, Huber C, Grabbe S, Utikal J, Pinter A, Kaufmann R, Hassel JC, Loquai C, Türeci Ö. An RNA vaccine drives immunity in checkpoint-inhibitor-treated melanoma. Nature. 2020 Sep;585(7823):107-112.
Wagener K, Bros M, Krumb M, Langhanki J, Pektor S, Worm M, Schinnerer M, Montermann E, Miederer M, Frey H, Opatz T, Rösch F. Targeting of Immune Cells with Trimannosylated Liposomes. Advanced Therapeutics 2020 3(6):1900185.
Bednarczyk M, Stege H, Grabbe S, Bros M. β2 Integrins-Multi-Functional Leukocyte Receptors in Health and Disease. Int J Mol Sci. 2020 Feb 19;21(4):1402.
Cacicedo ML, Medina-Montano C, Kaps L, Kappel C, Gehring S, Bros M. Role of Liver-Mediated Tolerance in Nanoparticle-Based Tumor Therapy. Cells. 2020 Aug 28;9(9):1985.
Hager S, Fittler FJ, Wagner E, Bros M. Nucleic Acid-Based Approaches for Tumor Therapy. Cells. 2020 Sep 9;9(9):2061.
Sudowe S, Höhn Y, Renzing A, Maxeiner J, Montermann E, Habermeier A, Closs E, Bros M, Reske-Kunz AB. Inhibition of antigen-specific immune responses by co-application of an indoleamine 2,3-dioxygenase (IDO)-encoding vector requires antigen transgene expression focused on dendritic cells. Amino Acids. 2020 Mar;52(3):411-424.
Liu D, Schilling B, Liu D, Sucker A, Livingstone E, Jerby-Arnon L, Zimmer L, Gutzmer R, Satzger I, Loquai C, Grabbe S, Vokes N, Margolis CA, Conway J, He MX, Elmarakeby H, Dietlein F, Miao D, Tracy A, Gogas H, Goldinger SM, Utikal J, Blank CU, Rauschenberg R, von Bubnoff D, Krackhardt A, Weide B, Haferkamp S, Kiecker F, Izar B, Garraway L, Regev A, Flaherty K, Paschen A, Van Allen EM, Schadendorf D. Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma. Nat Med. 2019 Dec;25(12):1916-1927.
Bros M, Haas K, Moll L, Grabbe S. RhoA as a Key Regulator of Innate and Adaptive Immunity. Cells. 2019 Jul 17;8(7):733.
Käfer R, Schmidtke L, Schrick K, Montermann E, Bros M, Kleinert H, Pautz A.
The RNA-Binding Protein KSRP Modulates Cytokine Expression of CD4+ T Cells. J Immunol Res. 2019 Aug 14;2019:4726532.
Johann T, Keth J, Bros M, Frey H. A general concept for the introduction of hydroxamic acids into polymers. Chem Sci. 2019 Jun 17;10(29):7009-7022.
Kramer S, Langhanki J, Krumb M, Opatz T, Bros M, Zentel R. HPMA-Based Nanocarriers for Effective Immune System Stimulation. Macromol Biosci. 2019 Jun;19(6):e1800481.
Teschner D, Cholaszczyńska A, Ries F, Beckert H, Theobald M, Grabbe S, Radsak M, Bros M. CD11b Regulates Fungal Outgrowth but Not Neutrophil Recruitment in a Mouse Model of Invasive Pulmonary Aspergillosis. Front Immunol. 2019 Feb 4;10:123.
Paßlick D, Piradashvili K, Bamberger D, Li M, Jiang S, Strand D, R Wich P, Landfester K, Bros M, Grabbe S, Mailänder V. Delivering all in one: Antigen- nanocapsule loaded with dual adjuvant yields superadditive effects by DC-directed T cell stimulation. J Control Release. 2018 Nov 10;289:23-34.
Bros M, Nuhn L, Simon J, Moll L, Mailänder V, Landfester K, Grabbe S. The Protein Corona as a Confounding Variable of Nanoparticle-Mediated Targeted Vaccine Delivery. Front Immunol. 2018 Aug 2;9:1760.
Hobernik D, Bros M. DNA Vaccines-How Far From Clinical Use? Int J Mol Sci. 2018 Nov 15;19(11):3605. doi: 10.3390/ijms19113605.
Bros M, Youns M, Kollek V, Buchmüller D, Bollmann F, Seo EJ, Schupp J, Montermann E, Usanova S, Kleinert H, Efferth T, Reske-Kunz AB. Differentially Tolerized Mouse Antigen Presenting Cells Share a Common miRNA Signature Including Enhanced mmu-miR-223-3p Expression Which Is Sufficient to Imprint a Protolerogenic State. Front Pharmacol. 2018 Aug 17;9:915.
Castor T, Yogev N, Blank T, Barwig C, Prinz M, Waisman A, Bros M, Reske-Kunz AB. Inhibition of experimental autoimmune encephalomyelitis by tolerance-promoting DNA vaccination focused to dendritic cells. PLoS One. 2018 Feb 6;13(2):e0191927.
Bent R, Moll L, Grabbe S, Bros M. Interleukin-1 Beta-A Friend or Foe in Malignancies? Int J Mol Sci. 2018 Jul 24;19(8):2155.
Hajek E, Krebs F, Bent R, Haas K, Bast A, Steinmetz I, Tuettenberg A, Grabbe S, Bros M. BRAF inhibitors stimulate inflammasome activation and interleukin 1 beta production in dendritic cells. Oncotarget. 2018 Jun 19;9(47):28294-28308.
Shen L, Tenzer S, Hess M, Distler U, Tubbe I, Montermann E, Schimmer S, Dittmer U, Grabbe S, Bros M. Friend virus limits adaptive cellular immune responses by imprinting a maturation-resistant and T helper type 2-biased immunophenotype in dendritic cells. PLoS One. 2018 Feb 9;13(2):e0192541.
Shen L, Tenzer S, Storck W, Hobernik D, Raker VK, Fischer K, Decker S, Dzionek A, Krauthäuser S, Diken M, Nikolaev A, Maxeiner J, Schuster P, Kappel C, Verschoor A, Schild H, Grabbe S, Bros M. Protein corona-mediated targeting of nanocarriers to B cells allows redirection of allergic immune responses. J Allergy Clin Immunol. 2018 Nov;142(5):1558-1570.
Weber B, Kappel C, Scherer M, Helm M, Bros M, Grabbe S, Barz M. PeptoSomes for Vaccination: Combining Antigen and Adjuvant in Polypept(o)ide-Based Polymersomes. Macromol Biosci. 2017 Oct;17(10).
Sahin U, Derhovanessian E, Miller M, Kloke BP, Simon P, Löwer M, Bukur V, Tadmor AD, Luxemburger U, Schrörs B, Omokoko T, Vormehr M, Albrecht C, Paruzynski A, Kuhn AN, Buck J, Heesch S, Schreeb KH, Müller F, Ortseifer I, Vogler I, Godehardt E, Attig S, Rae R, Breitkreuz A, Tolliver C, Suchan M, Martic G, Hohberger A, Sorn P, Diekmann J, Ciesla J, Waksmann O, Brück AK, Witt M, Zillgen M, Rothermel A, Kasemann B, Langer D, Bolte S, Diken M, Kreiter S, Nemecek R, Gebhardt C, Grabbe S, Höller C, Utikal J, Huber C, Loquai C, Türeci Ö. Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer. Nature. 2017 Jul 13;547(7662):222-226.
Bamberger D, Hobernik D, Konhäuser M, Bros M, Wich PR. Surface Modification of Polysaccharide-Based Nanoparticles with PEG and Dextran and the Effects on Immune Cell Binding and Stimulatory Characteristics. Mol Pharm. 2017 Dec 4;14(12):4403-4416. doi: 10.1021/acs.molpharmaceut.7b00507.
Käfer R, Schrick K, Schmidtke L, Montermann E, Hobernik D, Bros M, Chen CY, Kleinert H, Pautz A. Inactivation of the KSRP gene modifies collagen antibody induced arthritis. Mol Immunol. 2017 Jul;87:207-216. Doi: 10.1016/j.molimm.2017.05.003.
Heller P, Hobernik D, Lächelt U, Schinnerer M, Weber B, Schmidt M, Wagner E, Bros M, Barz M. Combining reactive triblock copolymers with functional cross-linkers: A versatile pathway to disulfide stabilized-polyplex libraries and their application as pDNA vaccines. J Control Release. 2017 Jul 28;258:146-160. doi: 10.1016/j.jconrel.2017.05.012. Epub 2017 May 10. PMID: 28501672.
Grabbe S, Haas H, Diken M, Kranz LM, Langguth P, Sahin U. Translating nanoparticulate-personalized cancer vaccines into clinical applications: case study with RNA-lipoplexes for the treatment of melanoma. Nanomedicine (Lond). 2016 Oct;11(20):2723-2734.
Grabbe S, Landfester K, Schuppan D, Barz M, Zentel R. Nanoparticles and the immune system: challenges and opportunities. Nanomedicine (Lond). 2016 Oct;11(20):2621-2624.
Shen L, Krauthäuser S, Fischer K, Hobernik D, Abassi Y, Dzionek A, Nikolaev
A, Voltz N, Diken M, Krummen M, Montermann E, Tubbe I, Lorenz S, Strand D,
Schild H, Grabbe S, Bros M. Vaccination with trifunctional nanoparticles that
address CD8<sup>+</sup> dendritic cells inhibits growth of established melanoma.
Nanomedicine (Lond). 2016 Oct;11(20):2647-2662. doi: 10.2217/nnm-2016-0174. Epub
2016 Sep 15. PMID: 27628310.
Mohr N, Kappel C, Kramer S, Bros M, Grabbe S, Zentel R. Targeting cells of the immune system: mannosylated HPMA-LMA block-copolymer micelles for targeting of dendritic cells. Nanomedicine (Lond). 2016 Oct;11(20):2679-2697.
Hahn SA, Neuhoff A, Landsberg J, Schupp J, Eberts D, Leukel P, Bros M, Weilbaecher M, Schuppan D, Grabbe S, Tueting T, Lennerz V, Sommer C, Jonuleit H, Tuettenberg A. A key role of GARP in the immune suppressive tumor microenvironment. Oncotarget. 2016 Jul 12;7(28):42996-43009.
Kranz LM, Diken M, Haas H, Kreiter S, Loquai C, Reuter KC, Meng M, Fritz D, Vascotto F, Hefesha H, Grunwitz C, Vormehr M, Hüsemann Y, Selmi A, Kuhn AN, Buck J, Derhovanessian E, Rae R, Attig S, Diekmann J, Jabulowsky RA, Heesch S, Hassel J, Langguth P, Grabbe S, Huber C, Türeci Ö, Sahin U. Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy. Nature. 2016 Jun 16;534(7607):396-401.
Zahnreich S, Mayer A, Loquai C, Grabbe S, Schmidberger H. Radiotherapy with BRAF inhibitor therapy for melanoma: progress and possibilities. Future Oncol. 2016 Jan;12(1):95-106.
Scherer M, Kappel C, Mohr N, Fischer K, Heller P, Forst R, Depoix F, Bros M, Zentel R. Functionalization of Active Ester-Based Polymersomes for Enhanced Cell Uptake and Stimuli-Responsive Cargo Release. Biomacromolecules. 2016 Oct 10;17(10):3305-3317.
Trojandt S, Bellinghausen I, Reske-Kunz AB, Bros M. Tumor-derived immuno-modulators induce overlapping pro-tolerogenic gene expression signatures in human dendritic cells. Hum Immunol. 2016 Dec;77(12):1223-1231.
Bros M, Montermann E, Cholaszczyńska A, Reske-Kunz AB. The phosphodiesterase 4 inhibitor roflumilast augments the Th17-promoting capability of dendritic cells by enhancing IL-23 production, and impairs their T cell stimulatory activity due to elevated IL-10. Int Immunopharmacol. 2016 Jun;35:174-184.
Käfer R, Usanova S, Montermann E, Loquai C, Reske-Kunz AB, Bros M. Inhibitors of β-catenin affect the immuno-phenotype and functions of dendritic cells in an inhibitor-specific manner. Int Immunopharmacol. 2016 Mar;32:118-124.
Tappertzhofen K, Beck S, Montermann E, Huesmann D, Barz M, Koynov K, Bros M, Zentel R. Bioreducible Poly-L-Lysine-Poly[HPMA] Block Copolymers Obtained by RAFT-Polymerization as Efficient Polyplex-Transfection Reagents. Macromol Biosci. 2016 Jan;16(1):106-20.