DRUCKEN

Univ.-Prof. Dr. rer. nat. Tobias Bopp

Univ.-Prof. Dr. rer. nat. Tobias Bopp

General Information

E-Mail

 boppt@uni-mainz.de

Current position

Professor for Molecular Immunology, W3

 

Academic Education

2003-2006
  • Doctoral thesis at the Department of Immunology, University Medical Center, Mainz University
1997 - 2003
  • Biology (Diploma), Johannes Gutenberg University Mainz, Germany, E. Schmitt

 

Scientific Degrees

PhD thesis
  • Dr. rer. nat. ("magna cum laude"), Institute for Immunology, Johannes Gutenberg University Mainz, 2006, E. Schmitt

 

Professional Career

2019 - present
  • Director at the Institute for Immunology, University Medical Center, Johannes Gutenberg-University Mainz
2012 - 2018
  • W2 Professor for Molecular Immunology, Institute for Immunology, Johannes Gutenberg University Mainz
2008 - 2011
  • Groupleader, Institute for Immunology, Johannes Gutenberg University Mainz, Prof. H. Schild
2006 - 2008
  • Postdoctoral Fellow, Institute for Immunology, Johannes Gutenberg University Mainz, Prof. E. Schmitt

 

Honours and Other Activities

2018
  • DKTK (German Cancer Consortium) Faculty Member
2017
  • Co-Speaker of the CRC SFB1292
  • Member of the committee for science and research promotion of the University Medical Center Mainz
  • Member of the committee for habilitation and junior development of the University Medical Center Mainz
  • Speaker and coordinator of the "Forschungszentrum für Immuntherapie" (FZI) at the University Medical Center of the Johannes Gutenberg University Mainz
  • Expert committee member Elite Network of Bavaria
  • Speaker of the UCT/CCC section "Cancer Immunotherapy"
2016
  • Member of the Steering Committee of the "Forschungszentrum für Immuntherapie" (FZI) at the University Medical Center of the Johannes Gutenberg University Mainz
  • Member of the NOVARTIS Advisory Board for Immunology
  • Faculty member of the German Immuneregulation Meeting
  • Member of the advisory board of the Comprehensive Cancer Center Mainz
2014
  • Member of the Teaching committee of the "Forschungszentrum für Immuntherapie" (FZI) at the University Medical Center of the Johannes Gutenberg University Mainz
2013
  • Elected Spokesman of the Section "T cells: Subpopulations and Functions" within the German Society for Immunology (DGfI)
  • Speaker of the Members of the "Mainz Research School of Translational Biomedicine" (TRANSMED)
2012
  • Member of the PhD Thesis Evaluation committee at the University of Oslo, Norway
  • Auswahlsymposium zum "Paul Ehrlich- und Ludwig Darmstaedter-Nachwuchspreis"
2010
  • "Fritz und Ursula Melchers Award" of the DGfI
  • Administration of animal experiments (according to FELASA C)
2008 - present
  • Referee for international scientific journals (Cell, Nature Reviews Immunology, Nature Immunology, Immunity, EMBO, JEM, JCI, JACI, TII, Blood, etc.)
2008
  • Founding member of the "Forschungszentrum für Immuntherapie" (FZI) at the University Medical Center of the Johannes Gutenberg University Mainz
  • Boehringer Ingelheim Award
2007 - 2009
  • Promotion by the Carl-Zeiss-Foundation

 

Selected Publications

  1. Bohn T, Rapp S, Luther N, Klein M, Bruehl TJ, Kojima N, Aranda Lopez P, Hahlbrock J, Muth S, Endo S, Pektor S, Brand A, Renner K, Popp V, Gerlach K, Vogel D, Lueckel C, Arnold-Schild D, Pouyssegur J, Kreutz M, Huber M, Koenig J, Weigmann B, Probst HC, von Stebut E, Becker C, Schild H, Schmitt E, and Bopp T. (2018) Tumor immunoevasion via acidosis dependent induction of regulatory tumor-associated macrophages. Nature Immunology in press.

     

  2. Ulges A*, Witsch EJ*, Pramanik G, Klein M, Birkner K, Bühler U, Wasser B, LuessiF, Stergiou N, Dietzen S, Brühl TJ, Bohn T, Bündgen G, Kunz H, Waisman A, Schild H, Schmitt E, Zipp F$, Bopp T$ (2016). Protein kinase CK2 governs the molecular decision between encephalitogenic TH17 cell and Treg cell development. Proc Natl Acad Sci U S A. 113: 10145-50.
  3.  

  4. Paterka M, Siffrin V, Voss JO, Werr J, Hoppmann N, Gollan R, Belikan P, Bruttger J, Birkenstock J, Jung S, Esplugues E, Yogev N, Flavell RA, Bopp T, Zipp F. (2016) Gatekeeper role of brain antigen-presenting CD11c+ cells in neuroinflammation. EMBO J. 35(1):89-101.

     

  5. Ulges A, Klein M, Reuter S, Gerlitzki B, Hoffmann M, Grebe N, Staudt V, Stergiou N, Bohn T, Brühl T-J, Muth S, Yurugi H, Rajalingam K, Bellinghausen I, Tuettenberg A, Hahn S, Reißig S, Haben I, Zipp F, Waisman A, Probst HC, Beilhack A, Buchou T, Filhol-Cochet O, Boldyreff B,  Breloer M, Jonuleit H, Schild H, Schmitt E, Bopp T (2015) Protein kinase CK2 enables regulatory T cells to suppress excessive TH2 responses in vivo. Nat. Immunol. 16: 267–275
  6.  

  7. Schmitt E, Klein M & Bopp T (2013) Th9 cells, new players in adaptive immunity. Trends Immunol. 48: 115–125
  8.  

  9. Schmitt E, Bopp T. (2012) Amazing IL-9: revealing a new function for an "old" cytokine. J Clin Invest. 122(11):3857-9.

     

  10. Vaeth M*, Gogishvili T*, Bopp T*, Klein M, Berberich-Siebelt F, Gattenloehner S, Avots A, Sparwasser T, Grebe N, Schmitt E, Hünig T, Serfling E & Bodor J (2011) Regulatory T cells facilitate the nuclear accumulation of inducible cAMP early repressor (ICER) and suppress nuclear factor of activated T cell c1 (NFATc1). Proceedings of the National Academy of Sciences of the United States of America 108: 2480–2485.
  11.  

  12. Staudt V, Bothur E, Klein M, Lingnau K, Reuter S, Grebe N, Gerlitzki B, Hoffmann M, Ulges A, Taube C, Dehzad N, Becker M, Stassen M, Steinborn A, Lohoff M, Schild H, Schmitt E & Bopp T (2010) Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells. Immunity 33: 192–202
  13.  

  14. Bopp T, Becker C, Klein M, Klein-Hessling S, Palmetshofer A, Serfling E, Heib V, Becker M, Kubach J, Schmitt S, Stoll S, Schild H, Staege MS, Stassen M, Jonuleit H & Schmitt E (2007) Cyclic adenosine monophosphate is a key component of regulatory T cell-mediated suppression. J. Exp. Med. 204: 1303–1310
  15.  

  16. Bopp T, Palmetshofer A, Serfling E, Heib V, Schmitt S, Richter C, Klein M, Schild H, Schmitt E & Stassen M (2005) NFATc2 and NFATc3 transcription factors play a crucial role in suppression of CD4+ T lymphocytes by CD4+ CD25+ regulatory T cells. J. Exp. Med. 201: 181–187

* joint first authors, $ joint senior authors