Dr. Emilie Renaud
I was born and brought up in Lyon, France. I did my PhD in France at the CEA near Paris, from 2004 to 2008. The study of the cancer-prone genetic disorder Xeroderma Pigmentosum gave me first insights into the crucial role of DNA damage response in cellular transformation. My postdoctoral research at the Gustave Roussy Institute in France involved another genetic disease called Fanconi Anemia. My project focused on : 1) validating a checkpoint recovery defect in patients' cells, 2) showing impaired epigenetic modifications of chromatin leading to chromosomal aberrations and 3) identifying a new role of FANCD2 as a critical factor to maintain the proliferation and survival of melanoma cells.
Then I moved to Wiesbaden, Germany in 2015. The goal of my project at TU Darmstadt was to mimic computerized tomography scans and to assess the impact of X-rays on mouse development. To do so, different knockout and knockin mice models of homologous recombination were irradiated with X-rays, at the embryonic or new born stage. I eventually took the opportunity to work in translational research on thyroid cancer and joined Pr. Dr. Rajalingam's lab at the beginning of 2019.
- 01/2019 - till present Postdoc in Prof. Rajalingam's Group
- 12/2015 - 12/2018 Postdoc at TU Darmstadt, Darmstadt, Germany
- 11/2008 - 04/2015 Postdoc at the Gustave Roussy Institute, Villejuif, France
- 09/2004 - 09/2008 PhD student at the CEA, Fontenay-aux-roses, France
- 09/2003 - 06/2004 Master Biologie-Santé, Bordeaux, France
- Krishnan A, Berthelet J, Renaud E, et al. Proteogenomics analysis unveils a TFG-RET gene fusion and druggable targets in papillary thyroid carcinomas. Nat Commun. 2020;11(1):2056.
- Bourseguin J, Bonet C, Renaud E, Giuliano S, Ballotti R, Rosselli F, Bertolotto C. FANCD2 functions as a critical factor downstream MITF to maintain proliferation and survival of melanoma cells. 2016, Scientific Reports, 6:36539.
- Renaud E, Barascu A and Rosselli F. Impaired TIP60-mediated H4K16 acetylation restrains homologous recombination in Fanconi anemia pathway-deficient cells. 2016, Nucleic Acids Research, 44(2):648-56.
- Renaud E and Rosselli F. Fanc pathway promotes UV-induced stalled replication forks recovery by acting both upstream and downstream Polη and Rev1. 2013, Plos One, 8(1):e53693.
- Guervilly JH, Renaud E, Takata M and Rosselli F. USP1 deubiquitinase maintains phosphorylated CHK1 by limiting its DDB1-dependent degradation. 2011, Human Molecular Genetics, 20(11):2171-81
- Renaud E, Miccoli L, Zacal N, Biard DS, Craescu CT, Rainbow AJ and Angulo JF. Differential contribution of XPC, RAD23A, RAD23B and centrin 2 to the UV-response in human cells. 2011, DNA repair, 10(8):835-47.
- Renaud E, Charbonnier JB, Miron S, Le Du MH, Blouquit Y, Duchambon P, Christova P, Shosheva A, Rose T, Angulo JF and Craescu CT. Structural, thermodynamic and cellular characterization of human centrin 2 interaction with xeroderma pigmentosum group C protein. 2007, Journal of Molecular Biology, 373 (4):1032-46.