DRUCKEN

Volker Haucke, PhD

Professor of Molecular Pharmacology

Head of Department of Molecular Pharmacology and Cell Biology

Director at the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) Berlin

Research

The research focus of the Haucke lab is the dissection of molecular mechanisms of exo-endocytosis and endolyososomal membrane dynamics as well as its role in cell signaling, especially in the nervous system. The emphasis of the lab lies on two major themes: The role of exo-endocytic and endolysosomal proteins within the brain, especially in the maintenance of neurotransmission at chemical synapses, and the regulation of membrane homeostasis in endocytosis and in the endolysosomal system by phosphoinositides and phosphoinositide metabolizing enzymes.  The aim of these studies is to provide a mechanistic understanding of the pathways of interest and their regulation by proteins and lipids as well as the the goal to use this knowledge to develop novel strategies for acute chemical and pharmacological interference.

Research Group Haucke

Selected workshop-related publications

Presynaptic Biogenesis Requires Axonal Transport of Lysosome-Related Vesicles.
Neuron 99(6):1216-1232.e7. doi: 10.1016/j.neuron.2018.08.004.
Vukoja A, Rey U, Petzoldt AG, Ott C, Vollweiter D, Quentin C, Puchkov D, Reynolds E, Lehmann M, Hohensee S, Rosa S, Lipowsky R, Sigrist SJ, Haucke V. (2018)

mTORC1 activity repression by late endosomal phosphatidylinositol 3,4-bisphosphate.
Science 356,968-972 doi: 10.1126/science.aaf8310.
Marat AL, Wallroth A, Lo WT, Müller R, Norata GD, Falasca M, Schultz C, Haucke V. (2017)

Retrograde transport of TrkB-containing autophagosomes via the endocytic adaptor AP-2 mediates neuronal complexity and prevents neurodegeneration.
Nature Communications, 8,14819 doi: 10.1038/ncomms14819.
Kononenko, N.L., Claßen, G.A., Kuijpers, M., Puchkov, D., Maritzen, T., Tempes, A., Malik, A.R., Skalecka, A., Bera, S., Jaworski, J., Haucke, V. (2017)

Synaptic Vesicle Endocytosis Occurs on Multiple Timescales and Is Mediated by Formin-Dependent Actin Assembly.
Neuron 93, 854-866 https://doi.org/10.1016/j.neuron.2017.02.011. Soykan T, Kaempf N, Sakaba T, Vollweiter D, Goerdeler F, Puchkov D, Kononenko NL, Haucke V. (2017)

A phosphoinositide conversion mechanism for exit from endosomes.
Nature, 529, 408-412 doi: 10.1038/nature16516.
Ketel, K., Krauss, M., Nicot, A.S., Puchkov, D., Wieffer, M., Müller, R., Subramanian, D., Schultz, C., Laporte, J., Haucke, V. (2016)

Selected Reviews

Presynaptic endocytic factors in autophagy and neurodegeneration.
Current Opinions in Neurobiology 48:153-159. doi: 10.1016/j.conb.2017.12.018.
Azarnia Tehran D, Kuijpers M, Haucke V. (2018)

Modes and mechanisms of synaptic vesicle recycling.
Current Opinions Neurobiology 39:17-23. doi: 10.1016/j.conb.2016.03.005.
Soykan T, Maritzen T, Haucke V.(2016)