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05.03.2024 The Institute for Medical Microbiology and Hygiene congratulates Sara Vieira-Silva and Gwen Falony on their recent publication in the Journal Gastroenterology: “Dysbiosis and Associated Stool Features Improve Prediction of Response to Biological Therapy in Inflammatory Bowel Disease”. Inflammatory bowel diseases (IBDs) comprise a group of complex gastrointestinal tract disorders. An imbalance of gut microbiota, called dysbiosis, contributes to the pathogenesis of these diseases and might influence therapeutic outcome. Caenepeel and Falony et al. investigated this putative association by studying the gut microbiome in a large cohort of IBD patients suffering from Crohn’s disease or ulcerative colitis, before and after therapeutic intervention. In this cohort, the authors could identify disease location as crucial covariate of the microbiome that was even more informative than the specific disease diagnosis. Of the three used biological therapies – anti-tumor necrosis factor-α, vedolizumab (anti-α4β7-integrin), and ustekinumab (anti-IL23/23) – the former achieved the biggest shift in microbiome composition and could significantly mitigate dysbiosis. In patients exhibiting dysbiosis, the authors observed anti-tumor necrosis factor-α to be more effective to achieve remission than vedolizumab, although it should be noted that the latter was mostly applied as second- or third-line biological treatment in the prospective cohort analyzed. Finally, Caenepeel and Falony et al. developed a model based on clinical data, stool characteristics, and fecal enterotype that predicted therapeutic outcome with 73.9 % accuracy and could potentially improve personalized medicine approaches for IBD patients in the future.

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Welcome to the website of the Institute of Medical Microbiology and Hygiene. The Institute represents the subject medical microbiology and hygiene in the field of patient care, research and teaching. Patient care includes Infection Medicine (microbiological diagnostics of infection diseases, screening examinations/tests and technical consultation of infectiological questions) as well as hospital hygiene. For more information about the different departments of our Institute, please use the corresponding tab at the top of the front page.

 

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Führerschein Infektionsmedizin (Basics of practical infectiology) 07.07.2021 HS Chirurgie (Geb. 505) 15:30-19:30