Visual Universitätsmedizin Mainz

Univ.-Prof. Dr. med. Clemens Sommer

Univ.-Prof. Dr. med. Sommer
Funktionen: Direktor des Instituts für Neuropathologie
06131 17-7308
06131 17-6606
Studium und beruflicher Werdegang Prof. Sommer


Studium der Humanmedizin an der Julius-Maximilians-Universität Würzburg als Stipendiat des Freistaats Bayern nach dem Bayerischen Begabtenförderungsgesetz


Promotion, Universität Würzburg


Arzt im Praktikum in der Abteilung für Neuropathologie der Ruprecht-Karls-Universität Heidelberg
(Dir.: Prof. Dr. M. Kiessling)


Assistenzarzt in der Abteilung für Neuropathologie (Heidelberg)


Facharzt für Neuropathologie


Oberarzt in der Abteilung für Neuropathologie (Heidelberg)


Habilitation für das Fach Neuropathologie


Univ.-Professor (C3) für Neuropathologie an der Medizinischen Fakultät Ulm in der Abteilung Pathologie des Instituts für Pathologie und Rechtsmedizin

seit 2005

Univ.-Professor und Leiter des Instituts für Neuropathologie, Universitätsmedizin der Johannes Gutenberg-Universität Mainz



Mitgliedschaften / Ämter

Mitgliedschaften / Ämter

seit 1995

Deutsche Gesellschaft für Neuropathologie und Neuroanatomie

seit 1998

Neurowissenschaftliche Gesellschaft

seit 2004

International Society for Cerebral Blood Flow and Metabolism


Schatzmeister der DGNN

seit 2013

Delegierter der DGNN ins Scientific Committee von German Medical Science

Editorial Boards

  • Acta Neuropathologica
  • Acta Neuropathologica Communications
  • Experimental & Translational Stroke Medicine (Associate Editor)
  • Stroke


  • Neuroprotektion nach zerebraler Ischämie
  • Regulation von Neurotransmitterrezeptoren unter physiologischen und pathologischen Bedingungen
  • Antiphosphalipid Syndrom

Ausgewählte Publikationen


Thal SC, Timaru-Kast R, Wilde F, Merk P, Johnson F, Frauenknecht K, Sebastiani A, Sommer C, Staib-Lasarzik I, Werner C, Engelhard K:
Propofol impairs neurogenesis and neurologic recovery and increases mortality rate in adults rats after traumatic brain injury.
Crit Care Med (2014) 42 (1): 129-41


Schmidt A, Wellmann J, Schilling M, Strecker JK, Sommer C, Schäbitz WR, Diederich K, Minnerup J:
Meta-analysis of the efficacy of different training strategies in animal models of ischemic stroke.
Stroke (2014) 45 (1): 239-47


Ridwan S, Bauer H, Frauenknecht K, Hefti K, von Pein H, Sommer C:
Distribution of the hematopoietic growth factor G-CSF and its receptor in the adult human brain with specific reference to Alzheimer's disease.
J Anat (2014) 224 (4): 377-91


Frauenknecht K, Katzav A, Grimm C, Chapman J, Sommer CJ:
Altered receptor binding densities in experimental antiphospholipid syndrome despite only moderately enhanced autoantibody levels and absence of behavioral features.
Immunobiology (2014) 219 (5): 341-9


Inui T, Alessandri B, Heimann A, Nishimura F, Frauenknecht K, Sommer C, Kempski O:
Neuroprotective effect of ceftriaxone on the penumbra in a rat venous ischemia model.
Neurosciene (2013) 242C: 1-10


Frauenknecht K, Katzav A, Grimm C, Chapman J, Sommer CJ:
Neurological impairment in experimental antiphospholipid syndrome is associated with increased ligand binding to hippocampal and cortical serotonergic 5-HT1A receptors.
Immunbiology (2013) 218 (4): 517-26


Zille M, Farr TD, Przesdzing I, Müller J, Sommer C, Dimagl U, Wunder A:
Visualizing cell death in experimental focal cerebral ischemia: promises, problems, and perspectives.
J Cereb Blood Flow Metab (2012) 32 (2): 213-31


Hänggi D, Perrin J, Eicker S, Beseoglu K, Etminan N, Kamp MA, Heiroth JH, Bege N, Macht S, Frauenknecht K, Sommer C, Kissel T, Steiger HJ:
Local delivery of nimodipine by prolonged-release microparticles-feasibility, effectiveness and dose-finding in experimental subarachnoid hemorrhage.
PLoS One (2012) 7 (9): e42597


Diederich K*. Quennet V*, Bauer H, Müller HD, Wersching H, Schäbitz WR, Minnerup J#, Sommer C#:
* both authors contributed equally
# shared senior authorship
Successful regeneration after experimental stroke by granulocyte-colony stimulating factor is not further enhanced by constraint-induced movement therapy either in concurrent or in sequential combination therapy.
Stroke (2012) 43 (1): 185-192


Liesz A, Sun L, Zhou W, Schwarting S, Mracsko E, Zorn M, Bauer H, Sommer C, Veltkamp:
FTY720 reduces post-ischemic brain lymphocyte influx but does not improve outcome in permanent murine cerebral ischemia.
PLoS One (2011) 6 (6): e21312


Müller HD, Berger C, Schwab S, Sommer C:
Pravastatin treatment causes a shift in the balance of hippocampal neurotransmitter binding densities towards inhibition.
Brain Res (2010) 1316: 17-26


Clemens N, Frauenknecht K, Katzav A, Sommer C, von Landenberg P:
In vitro effects of antiphospholipid syndrome-IgG fractions and human monoclonal antiphospholipid IgG antibody on human umbilical vein endothelial cells and monocytes.
Ann NY Acad Sci (2009) 1173: 805-13


Diederich K, Sevimli S, Dörr H, Kösters E, Hoppen M, Lewejohann L, Klocke R, Minnerup J, Knecht S, Nikol S, Sachser N, Schneider A, Gorji A, Sommer C*, Schäbitz WR*
*shared senior-authorship
The role of granulocyte-colony stimulation factor (G-CSF) in the healthy brain: A characterization of G-CSF-deficient mice.
J Neurosci (2009) 29 (37): 11572-81


Frauenknecht K, Plaschke K, Sommer C:
Transient oligemia is associated with long-term changes in binding densities of cortical inhibitory GABAA receptors in the rat brain.
Brain Res (2009) 1271: 95-102


Hänggi D, Eicker S, Beseoglu K, Rapp M, Perrin J, Nawatny J, Turowski B, Sommer C, Steiger HJ:
Dose-related efficacy of a continuous intracisternal nimodipine treatment on cerebral vasospasm in the rat double subarachnoid hemorrhage model.
Neurosurgery (2009) 64 (6): 1155-61


Liesz A, Suri-Payer E, Veltkamp C, Doerr H, Sommer C, Rivest S, Giese T, Veltkamp R:
Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke.
Nat Med (2009) 15 (2): 192-9


Müller HD, Neder A, Sommer C, Schäbitz WR:
Different postischemic protein expression of the GABAA receptor alpha2 subunit and the plasticity-associated protein MAP1B after treatment with BDNF versus G-CSF in the rat brain.
Restor Neurol Neurosci (2009) 27 (1): 27-39


Plaschke K, Frauenknecht K, Sommer C, Heiland S:
A single systemic transient hypotension induces long-term changes in rats' MRI parameters and behavior: relation to aging.
Neurol Res (2009) 31 (3): 304-12


Sommer C:
Brain plasticity after ischemic stroke: an update.
Acta Neuropathol (2009) 117 (5): 467-8


Sommer C:
Neuronal plasticity after ischemic preconditioning and TIA-like preconditioning ischemic periods.
Acta Neuropathol (2009) 117 (5): 511-23


Berger C, Stauder A, Xia F, Sommer C, Schwab S
Neuroprotection and glutamate attenuation by acetylsalicylic acid in temporary but not in permanent cerebral ischemia
Exp Neurol (2008) 210(2):543-8


Schabitz WR, Kruger C, Pitzer C, Weber D, Laage R, Gassler N, Aronowski J, Mier W, Kirsch F, Dittgen T, Bach A, Sommer C, Schneider A
A neuroprotective function for the hematopietic protein granulocyte-macrophage colony stimulating factor (GM-CSF)
J Cereb Blood Flow Metab (2008) 28(1):29-43


Sommer C
Ischemic preconditioning: postischemic structural changes in the brain
J Neuropathol Exp Neurol (2008) 67(2) :85-92


Schabitz WR, Steigleder T, Cooper-Kuhn CM, Schwab S, Sommer C, Schneider A, Kuhn KG
Intravenous brain-derived neurotrophic factor enhances poststroke sensorimotor recovery and stimulates neurogenesis
Stroke (2007) 38(7):2165-72


Tanay E, Mundel P, Sommer C
Short term ischemia usually used for ischemic preconditioning causes loss of dendritic intergrity after long-term survival in the gerbil hippocampus
Brain Res (2006) 1112: 222-226


Henninger N, Eberius KH, Sicard KM, Kollmar R, Sommer C, Schwab S, Schäbitz W-R
A new model of thromboembolic stroke in the posterior circulation of the rat
J Neurosci Meth (2006) 156: 1-9


Herrlinger U, Rieger J, Koch D, Loeser S, Blaschke B, Kortmann R-D, Steinbach JP,
Hundsberger T, Wick W, Meyermann R, Tan T-C, Sommer C, Bamberg M, Reifenberger G, Weller M
Phase II trial of CCNU plus temozolomide chemotherapy in addition to radiotherapy in newly diagnosed glioblastoma: UKT-03
J Clin Oncol (2006) 24: 4412-4417


Krüger C, Cira D, Sommer C, Fischer A, Schäbitz W-R, Schneider A
Long-term gene expression changes in the cortex following cortical ischemia revealed by transcriptional profiling
Exp Neurol (2006) 200: 135-152


Schomacher M, Müller HD, Sommer C
Short-term ischemia usually used for ischemic preconditioning downregulates central cannabinoid (CB1) receptors in the gerbil hippocampus
Acta Neuropathol (2006) 111: 8-14


Sommer C, Schomacher M, Berger C, Kuhnert K, Müller HD, Schwab S, Schäbitz W-R
Neuroprotective cannabinoid receptor antagonist SR141716A prevents downregulation of excitotoxic NMDA receptors in the ischemic penumbra
Acta Neuropathol (2006) 112: 277-286


Schneider A, Krueger C, Steigleder T, Weber D, Pitzer C, Laage R, Aronowski J, Maurer MH, Gassler N, Mier W, Hasselblatt M, Kollmar R, Schwab S, Sommer C, Bach A, Kuhn H-G,
Schäbitz W-R
The hematopoietic factor G-CSF is a neuronal ligand that counteracts programmed cell death and drives neurogenesis
J Clin Invest (2005) 115: 2083-2098


Berger C, Schaebitz W-R, Wolf M, Mueller H, Sommer C, Schwab S
Hypothermia and brain-derived neurotrophic factor reduce glutamate synergistically in acute stroke
Exp Neurol (2004) 185: 305-312


Schäbitz W-R, Berger C, Kollmar R, Seitz M, Tanay E, Kiessling M, Schwab S, Sommer C
Effect of BDNF treatment and forced arm use on functional motor recovery after small cortical ischemia
Stroke (2004) 35: 992-997


Schäbitz W-R, Schade H, Heiland S, Kollmar R, Bardutzky J, Henninger N, Müller H, Carl UM, Toyokuni S, Sommer C, Schwab S
Neuroprotection by hyperbaric oxygenation after experimental focal cerebral ischemia monitored by MR-imaging
Stroke (2004) 35: 1175-1179


Schäbitz W-R, Kollmar R, Schwaninger M, Jüttler E, Bardutzky J, Schoelzke M, Sommer C, Schwab S
Neuroprotective effect of Granulocyte-Colony Stimulating Factor after focal cerebral ischemia
Stroke (2003) 34: 745-751


Sommer C, Kollmar R, Schwab S, Kiessling M, Schäbitz W-R
Exogenous brain-derived neurotrophic factor prevents postischemic downregulation of [3H]muscimol binding to GABAA receptors in the cortical penumbra
Mol Brain Res (2003) 111: 24-30


Sommer C, Fahrner A, Kiessling M
Postischemic neuroprotection in the ischemia-tolerant state gerbil hippocampus is associated with increased binding to inhibitory GABAA receptors
Acta Neuropathol (2003) 105: 197-202


van den Boom J, Wolter M, Kuick R, Misek DE, Youkilis A, Wechsler DS, Sommer C, Reifenberger G, Hanash SM
Characterization of gene expression profiles associated with glioma progression using oligonucleotide-based microarray analysis and real-time reverse transcription-polymerase chain reaction
Am J Pathol (2003) 163: 1033-1043


Sommer C, Kiessling M
Ischemia and ischemia tolerance induction differentially regulate protein expression of GluR1, GluR2 and AMPA receptor binding protein (ABP) in the gerbil hippocampus: GluR2 (GluR-B) reduction does not predict neuronal death
Stroke (2002) 33: 1093-1100


Sommer C, Fahrner A, Kiessling M
[3H]Muscimol binding to GABAA receptors is upregulated in CA1 neurons of the gerbil hippocampus in the ischemia tolerant state
Stroke (2002) 33: 1698-1705


Roth SU*, Sommer C*, Mundel P, Kiessling M
*Both authors contributed equally
Expression of Synaptopodin, an actin-associated protein, in the rat hippocampus after limbic epilepsy
Brain Pathol (2001) 11: 169-181


Schäbitz W-R, Hoffmann TT, Heiland S, Kollmar R, Bardutzky J, Sommer C, Schwab S
Delayed neuroprotective effect of IGF-1 after experimental transient focal cerebral ischemia monitored with MR-imaging
Stroke (2001) 32: 1226-1233


Schäbitz W-R, Sommer C, Zoder W, Kiessling M, Schwaninger M, Schwab S
Intravenous Brain-Derived Neurotrophic Factor reduces infarct size and counterregulates Bax and Bcl-2 expression after temporary focal cerebral ischemia
Stroke (2000) 31: 2212-2217


Sommer C, Roth SU, Kuhn R, Kiessling M
Metabotropic glutamate receptor subtypes are differentially expressed after transient cerebral ischemia without, during and after tolerance induction in the gerbil hippocampus
Brain Res (2000) 872: 172-180


Rump A, Sommer C, Gass P, Bele S, Meissner D, Kiessling M
Editing of GluR2 RNA in the gerbil hippocampus after global cerebral ischemia
J Cereb Blood Flow Metab (1996) 16: 1362-1365


Sommer C, Gass P, Kiessling M
Selective c-JUN expression in CA1 neurons of the gerbil hippocampus during and after acquisition of an ischemia-tolerant state
Brain Pathol (1995) 5: 135-144