Visual Universitätsmedizin Mainz

Publikationen Arbeitsgruppe Behl 2005-2017

Publikationen 2017

Stürner E, Behl C (2017). The Role of the Multifunctional BAG3 Protein in Cellular Protein Quality Control and in Disease.
Front Mol Neurosci. 10:177.

Feldmann A, Bekbulat F, Huesmann H, Ulbrich S, Tatzelt J, Behl C, Kern A (2017). The RAB GTPase RAB18 modulates macroautophagy and proteostasis.
Biochem Biophys Res Commun. 486(3):738-743.

Hajieva P (2017). The Effect of Polyphenols on Protein Degradation Pathways: Implications for Neuroprotection.
Molecules. 22(1):159.

Schönbühler B, Schmitt V, Huesmann H, Kern A, Gamerdinger M, Behl C (2017). BAG2 Interferes with CHIP-Mediated Ubiquitination of HSP72.
Int. J. Mol. Sci. 18(1), 69.

Publikationen 2016

Behl C (2016). Breaking BAG: The Co-Chaperone BAG3 in Health and Disease.
Trends Pharmacol Sci. 37(8):672-88.

Rodríguez AE, López-Crisosto C, Peña-Oyarzún D, Salas D, Parra V, Quiroga C, Morawe T, Chiong M, Behl C, Lavandero S (2016). BAG3 regulates total MAP1LC3B protein levels through a translational but not transcriptional mechanism.
Autophagy. 12(2):287-96.

Klionsky DJ, (...), Behl C, (...), Kern A, (...) (2016). Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Autophagy. 12(1):1-222.

Khaminets A, Behl C, Dikic I (2016). Ubiquitin-Dependent And Independent Signals In Selective Autophagy.
Trends Cell Biol. 26(1):6-16.

Kundu A, Milosch N, Antonietti P, Baumkötter F, Zymny A, Müller UC, Kins S, Hajieva P, Behl C, Kögel D (2015). Modulation of BAG3 Expression and Proteasomal Activity by sAPPα Does Not Require Membrane-Tethered Holo-APP.
Mol Neurobiol. 53(9):5985-5994.

Publikationen 2015

Kern A, Dikic I, Behl C (2015). The integration of autophagy and cellular trafficking pathways via RAB GAPs.
Autophagy. 11(12):2393-7.

Hajieva P, Moosmann B (2015). Brain protein oxidation: what does it reflect?
Neural Regen Res. 10(11):1729-30.

Felzen V, Hiebel C, Koziollek-Drechsler I, Reißig S, Wolfrum U, Kögel D, Brandts C, Behl C, Morawe T (2015). Estrogen receptor α regulates non-canonical autophagy that provides stress resistance to neuroblastoma and breast cancer cells and involves BAG3 function.
Cell Death Dis. 6:e1812.

Hiebel C, Behl C (2015). The complex modulation of lysosomal degradation pathways by cannabinoid receptors 1 and 2.
Life Sci. 138:3-7.

Meister S, Storck SE, Hameister E, Behl C, Weggen S, Clement AM, Pietrzik CU (2015). Expression of the ALS-causing variant hSOD1G93A leads to an impaired integrity and altered regulation of claudin-5 expression in an in vitro blood-spinal cord barrier model.
J Cereb Blood Flow Metab. 35(7):1112-21.

Liebl MP, Windschmitt J, Besemer AS, Schäfer AK, Reber H, Behl C, Clement AM (2015). Low-frequency magnetic fields do not aggravate disease in mouse models of Alzheimer's disease and amyotrophic lateral sclerosis.
Sci Rep. 5:8585.

Granold M, Moosmann B, Staib-Lasarzik I, Arendt T, Del Rey A, Engelhard K, Behl C, Hajieva P (2015). High membrane protein oxidation in the human cerebral cortex.
Redox Biol. 4:200-7.

Renziehausen J, Hiebel C, Nagel H, Kundu A, Kins S, Kögel D, Behl C, Hajieva P (2015). The Cleavage Product of Amyloid-β Protein Precursor sAβPPα Modulates BAG3-Dependent Aggresome Formation and Enhances Cellular Proteasomal Activity.
J Alzheimers Dis. 44(3):879-96.

Pasillas MP, Shields S, Reilly R, Strnadel J, Behl C, Park R, Yates JR 3rd, Klemke R, Gonias SL, Coppinger JA (2015). Proteomic analysis reveals a role for Bcl2-associated athanogene 3 and Major Vault Protein in resistance to apoptosis in senescent cells by regulating ERK1/2 activation.
Mol Cell Proteomics. 14(1):1-14.

Hajieva P, Bayatti N, Granold M, Behl C, Moosmann B (2015). Membrane protein oxidation determines neuronal degeneration.
J Neurochem. 133(3):352-67.

Publikationen 2014

Spang N*, Feldmann A*, Huesmann H, Bekbulat F, Schmitt V, Hiebel C, Koziollek-Drechsler I, Clement AM, Moosmann B, Jung J, Behrends C, Dikic I, Kern A, Behl C (2014). RAB3GAP1 and RAB3GAP2 modulate basal and rapamycin-induced autophagy. (* equal contribution)
Autophagy. 10(12):2297-309.

Milosch N, Tanriöver G, Kundu A, Rami A, François JC, Baumkötter F, Weyer SW, Samanta A, Jäschke A, Brod F, Buchholz CJ, Kins S, Behl C, Müller UC, Kögel D (2014). Holo-APP and G-protein-mediated signaling are required for sAPPα-induced activation of the Akt survival pathway.
Cell Death Dis. 5:e1391.

Hiebel C, Kromm T, Stark M, Behl C (2014). Cannabinoid receptor 1 modulates the autophagic flux independent of mTOR- and BECLIN1-complex.
J Neurochem. 131(4): 484-97.

Stark M, Behl C (2014). The Ginkgo biloba Extract EGb 761 Modulates Proteasome Activity and Polyglutamine Protein Aggregation.
Evidence-Based Complementary and Alternative Medicine 2014:940186.

Liebl MP, Kaya AM, Tenzer S, Mittenzwei R, Koziollek-Drechsler I, Schild HR, Moosmann B, Behl C, Clement AM (2014). Dimerization of visinin-like protein 1 is regulated by oxidative stress and calcium and is a pathological hallmark of amyotrophic lateral sclerosis.
Free Radic Biol Med. 72:41-54.

Brendel A, Renziehausen J, Behl C, Hajieva P (2014). Downregulation of PMCA2 increases the vulnerability of midbrain neurons to mitochondrial complex I inhibition.
Neurotoxicology 40:43-51.

Publikationen 2013

Weichert A, Besemer AS, Liebl M, Hellmann N, Koziollek-Drechsler I, Ip P, Decker H, Robertson J, Chakrabartty A, Behl C, Clement AM (2013). Wild-type Cu/Zn superoxide dismutase stabilizes mutant variants by heterodimerization.
Neurobiol Dis. 62:479-488.

Blödt S, Kuhlmey A, Bartholomeyczik S, Behl C, Betsch F, Brinkhaus B, Frühwald M, Füsgen I, Jansen S, Köppel C, Krüger E, Macher M, Michalsen A, Rapp MA, Riepe MW, Schimpf D, Teut M, Warme B, Warning A, Wilkens J, Witt CM (2013). [Dementia in Germany: Results of an interdisciplinary expert workshop.]
Wien Med Wochenschr. 163:536-40. German.

Stumm C, Hiebel C, Hanstein R, Purrio M, Nagel H, Conrad A, Lutz B, Behl C, Clement AB (2013). Cannabinoid receptor 1 deficiency in a mouse model of Alzheimer's disease leads to enhanced cognitive impairment despite of a reduction in amyloid deposition.
Neurobiol Aging.
34(11): 2574-84.

Brendel A, Felzen V, Morawe T, Manthey D, Behl C (2013). Differential regulation of apoptosis-associated genes by estrogen receptor alpha in human neuroblastoma cells.
Restor Neurol Neurosci. 31: 199-211.

Korac J, Schaeffer V, Kovacevic I, Clement AM, Jungblut B, Behl C, Terzic J, Dikic I (2013). Ubiquitin-independent function of optineurin in autophagic clearance of protein aggregates.
J Cell Sci. 126: 580-92.

Publikationen 2012

Büchner B, Gallenmüller C, Lautenschläger R, Kuhn K, Wittig I, Schöls L, Rapaport D, Seelow D, Freisinger P, Prokisch H, Sperl W, Wenz T, Behl C, Deschauer M, Kornblum C, Schneiderat P, Abicht A, Schuelke M, Meitinger T, Klopstock T und und das mitoNET-Consortium (2012)
Das Deutsche Netzwerk für mitochondriale Erkrankungen (mitoNET).
Medizinische Genetik 24: 193-199.

Klionsky DJ, (...), Behl C, (...) (2012). Guidelines for the use and interpretation of assays for monitoring autophagy.
Autophagy 8: 445-544.

Clement AM (2012).Two in one against motor neuron degeneration: Tackling oxidative stress and inflammation with a sulfasalazine derivative.
J Neurochem. 122(5):869-71.

Behl C (2012). Brain aging and late-onset Alzheimer's disease: many open questions.
Int Psychogeriatr. 24 Suppl 1: S3-9.

Morawe T, Hiebel C, Kern A, Behl C (2012). Protein Homeostasis, Aging and Alzheimer's Disease.
Mol Neurobiol. 46(1):41-54.

Kögel D, Deller T, Behl C (2012). Roles of amyloid precursor protein family members in neuroprotection, stress signaling and aging.
Exp Brain Res. 217:471-9.

Publikationen 2011

Gamerdinger M, Carra S, Behl C (2011). Emerging roles of molecular chaperones and co-chaperones in selective autophagy: focus on BAG proteins.
J Mol Med (Berl). 89:1175-82.

Behl C (2011). BAG3 and friends: Co-chaperones in selective autophagy during aging and disease.
Autophagy 7(7):795-8.

Schindeldecker M, Stark M, Behl C, Moosmann B (2011). Differential cysteine depletion in respiratory chain complexes enables the distinction of longevity from aerobicity.
Mech. Ageing Dev. 132:171-179.

Gamerdinger M, Kaya AM, Wolfrum U, Clement AM, Behl C (2011). BAG3 mediates chaperone-based aggresome-targeting and selected autophagy of misfolded proteins.
EMBO Rep. 12(2):149-56.

Witte I, Altenhöfer S, Wilgenbus P, Amort J, Clement AM, Pautz A, Li H, Förstermann U, Horke S (2011) Beyond reduction of atherosclerosis: PON2 provides apoptosis resistance and stabilizes tumor cells.
Cell Death Dis. 2:e112.

Publikationen 2010

Altenhöfer S, Witte I, Teiber JF, Wilgenbus P, Pautz A, Li H, Daiber A, Witan H, Clement AM, Förstermann U, Horke S (2010) One enzyme, two functions: PON2 prevents mitochondrial superoxide formation and apoptosis independent from its lactonase activity.
J Biol Chem. 285(32): 24398-403.

Mocko JB, Kern A, Moosmann B, Behl C, Hajieva P (2010) Phenothiazines interfere with dopaminergic neurodegeneration in Caenorhabditis elegans models of Parkinson's disease.
Neurobiol Dis. 40(1): 120-9.

Haege S, Galetzka D, Zechner U, Haaf T, Gamerdinger M, Behl C, Hiemke C, Schmitt U (2010) Spatial learning and expression patterns of PP1 mRNA in mouse hippocampus.
Neuropsychobiology 61(4):188-96.

Clement AB, Gimpl G, Behl C (2010) Oxidative stress resistance in hippocampal cells is associated with altered membrane fluidity and enhanced nonamyloidogenic cleavage of endogenous amyloid precursor protein.
Free Radic Biol Med. 48(9):1236-41.

Manthey D, Gamerdinger M, Behl C (2010) The selective beta1-adrenoceptor antagonist nebivolol is a potential oestrogen receptor agonist with neuroprotective abilities.
Br J Pharmacol 159(6):1264-73.

Kern A, Ackermann B, Clement AM, Duerk H, Behl C (2010) HSF1-controlled and age-associated chaperone capacity in neurons and muscle cells of C. elegans.
PLoS One. 2010 Jan 5;5(1):e8568.

Luh C, Kuhlmann CR, Ackermann B, Timaru-Kast R, Luhmann HJ, Behl C, Werner C, Engelhard K, Thal SC (2010) Inhibition of myosin light chain kinase reduces brain edema formation after traumatic brain injury.
J Neurochem. 112(4):1015-25.

Publikationen 2009

Clement AB, Gamerdinger M, Tamboli IY, Lütjohann D, Walter J, Greeve I, Gimpl G, Behl C (2009) Adaptation of neuronal cells to chronic oxidative stress is associated with altered lipid homeostasis and lysosomal function.
J. Neurochem. 111, 669-82

Witan H, Gorlovoy P, Kaya AM, Koziollek-Drechsler I, Neumann H, Behl C*, Clement AM (2009) Wild-type Cu/Zn superoxide dismutase (SOD1) does not facilitate, but impedes the formation of protein aggregates of amyotrophic lateral sclerosis causing mutant SOD1. (*co-corresponding author)
Neurobiol. Disease 36, 331-42.

Kern A, Behl C (2009) The Unsolved Relationship of Brain Aging and Late-Onset Alzheimer Disease.
Biochimica et Biophysica Acta 1790, 1124-32

Bondesson M, Jönsson J, Pongratz I, Olea N, Cravedi JP, Zalko D, Håkansson H, Halldin K, Di Lorenzo D, Behl C, Manthey D, Balaguer P, Demeneix B, Fini JB, Laudet V, Gustafsson JA (2009) A CASCADE of effects of bisphenol A
Reprod Toxicol. 28, 563-567

Hajieva P, Mocko J, Moosmann B, Behl C (2009) Novel Imine Antioxidants at Low Nanomolar Concentrations Protect Dopaminergic Cells from Oxidative Neurotoxicity.
J. Neurochem. 110, 118-32

Hanstein R, Trotter J, Behl C*, Clement AB (2009) Corticotropin-Releasing Hormone protects neurons towards oxidative stress by increasing Connexin43 expression and promoting gap junctional coupling. (*co-corresponding author)
Mol. Endocrinology 23, 1479-1493

Gamerdinger M, Hajieva P, Kaya AM, Wolfrum U, Hartl FU, Behl C (2009) Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3.
EMBO J. 28, 889-901.

Hajieva P, Kuhlmann C, Luhmann HJ, Behl C (2009) Impaired calcium homeostasis in aged hippocampal neurons.
Neurosci. Lett., 451, 119-123.

Publikationen 2008

Bender A, Hajieva P, Moosmann B (2008) Adaptive antioxidant methionine accumulation in respiratory chain complexes explains the use of a deviant genetic code in mitochondria.
Proc Natl Acad Sci U S A. 105(43):16496-501.

Hanstein R, Lu A, Wurst W, Holsboer F, Deussing JM, Clement, AB, Behl C (2008) Transgenic overexpression of corticotropin releasing hormone provides partial protection against neurodegeneration in an in vivo model of acute excitotoxic stress.
Neuroscience 156, 712-721.

Waldron E, Isbert S, Kern A, Jaeger S, Martin AM, Hébert SS, Behl C, Weggen S, De Strooper B, Pietrzik CU (2008) Increased AICD generation does not result in increased nuclear translocation or activation of target gene transcription.
Exp Cell Res. 314(13):2419-33.

Gamerdinger M, Clement AB, Behl C (2008) Effects of sulindac sulfide on the membrane architecture and the activity of gamma-secretase.
Neuropharmacology 54(6): 998-1005

Clement AB, Hanstein R, Schröder A, Nagel H, Endres, K, Fahrenholz F, Behl C (2008) Effects of neuron-specific ADAM10 modulation in an in vivo model of acute excitotoxic stress.
Neuroscience 152(2): 459-468

Witan H, Kern A, Koziollek-Drechsler I, Wade R, Behl C*, Clement AM (2008) Heterodimer formation of wild-type and amyotrophic lateral sclerosis-causing mutant Cu/Zn-Superoxide dismutase induces toxicity independent of protein aggregation.
Hum. Mol. Genet. 17 (10): 1373-1385 (*Co-korrespondierender Autor)

Moosmann B, Behl C (2008) Mitochondrially encoded cysteine predicts animal lifespan.
Aging Cell 7(1): 32-46

Publikationen 2007

Ebinger M, Behl C, Rosenhagen M, Uhr M (2007) P-Glycoprotein has negligible effects on estradiol and testosterone in mice.
Neurosci. Lett. 427(1): 6-9

Kuhlmann CRW, Tamaki R, Gamerdinger M, Lessmann V, Behl C, Kempski OS, Luhmann HJ (2007) Inhibition of the myosin light chain kinase prevents hypoxia-induced blood brain barrier disruption.
J Neurochem 102(2): 501-507

Gamerdinger M, Clement AB, Behl C (2007) Cholesterol-like effects of selective cyclooxygenase inhibitors and fibrates on cellular membranes and amyloid-beta production.
Mol Pharmacol 72(1): 141-151

Publikationen 2006

Behl C (2006) The search for novel avenues for the therapy and prevention of Alzheimer’s disease.
Drug News Perspect 19(1), 5-12

Gamerdinger M, Manthey D, Behl C (2006) Estrogen receptor subtype-specific repression of calpain expression and calpain enzymatic activity-implications for neuroprotection against Ca2+-mediated excitotoxicity.
J Neurochem 97(1), 57-68

Hajieva P, Behl C (2006) Antioxidants as a potential therapy against age-related neurodegenerative diseases: amyloid beta toxicity and Alzheimer’s disease.
Curr Pharm Design 12(6), 699-704

Manthey D, Behl C (2006) From structural biochemistry to expression profiling: Neuroprotective activities of estrogen.
Neuroscience 138(3), 845-850

Kern A, Roempp B, Prager K, Walter J, Behl C (2006) Down-regulation of endogenous amyloid precursor protein processing due to cellular aging.
J Biol Chem 281(5), 2405-2413

Publikationen 2005

Zschocke J, Bayatti N, Clement AM, Witan H, Figiel M, Engele J, Behl C (2005) Differential promotion of glutamate transporter expression and function by glucocorticoids in astrocytes from various brain regions.
J Biol Chem 280, 34924-34932

Bayatti N, Behl C (2005) The neuroprotective actions of corticotropin releasing hormone.
Aging Res Rev 4, 258-270

Ludemann N, Clement A, Hans VH, Leschik J, Behl C, Brandt R (2005) O-glycosylation of the tail domain of neurofilament protein M in human neurons and in spinal cord tissue of a rat model of amyotrophic lateral sclerosis (ALS).
J Biol Chem 280, 31648-31658

Pietrzik C, Behl C (2005) Concepts for the treatment of Alzheimer’s disease: molecular mechanisms and clinical application.
Int J Exp Pathol 86, 173-185

Goodenough S, Schleusner D, Pietrzik C, Skutella T, Behl C (2005) Glycogen synthase kinase 3ß links neuroprotection by 17ß-estradiol to key Alzheimer processes.
Neuroscience 132, 581-589

Behl C (2005) Oxidative stress in Alzheimer’s disease: implications for prevention and therapy.
Subcellular Biochemistry 38, 65-78

Zschocke J, Bayatti N, Behl C (2005) Caveolin and GLT-1 gene expression is reciprocally regulated in primary astrocytes: association of GLT-1 with non-caveolar lipid rafts.
Glia 49, 275-287

Bayatti N, Hermann H, Lutz B, Behl C (2005) Corticotropin-releasing hormone-mediated induction of intracellular signaling pathways and brain-derived neurotrophic factor expression is inhibited by the activation of the endocannabinoid system.
Endocrinology 146, 1205-1213