Visual Universitätsmedizin Mainz


Below you can find the publications of the scientists of the Institute of Pathobiochemistry from the year 2010 to date. The most important publications of each research group – older ones as well - are given on the respective pages.


Publications 2019

Chakraborty D, Felzen V, Hiebel C, Stürner E, Perumal N, Manicam C, Sehn E, Grus F, Wolfrum U, Behl C.(2019) Enhanced autophagic-lysosomal activity and increased BAG3-mediated selective macroautophagy as adaptive response of neuronal cells to chronic oxidative stress. Redox Biol. 2019 Apr 2;24:101181. doi: 10.1016/j.redox.2019.101181. [Epub ahead of print]

Walter S, Jumpertz T, Hüttenrauch M, Ogorek I, Gerber H, Storck SE, Zampar S, Dimitrov M, Lehmann S, Lepka K, Berndt C, Wiltfang J, Becker-Pauly C, Beher D, Pietrzik CU, Fraering PC, Wirths O, Weggen S. (2019) The metalloprotease ADAMTS4 generates N-truncated Aβ4-x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer's disease. Acta Neuropathol. 2019 Feb;137(2):239-257. doi: 10.1007/s00401-018-1929-5. Epub 2018 Nov 13.

Peters F, Scharfenberg F, Colmorgen C, Armbrust F, Wichert R, Arnold P, Potempa B, Potempa J, Pietrzik CU, Häsler R, Rosenstiel P, Becker-Pauly C. (2019) Tethering soluble meprin α in an enzyme complex to the cell surface affects IBD-associated genes. FASEB J. 2019 Mar 27:fj201802391R. doi: 10.1096/fj.201802391R. [Epub ahead of print]

Kunath S, Moosmann B. (2019) What is the rate-limiting step towards aging? Chemical reaction kinetics might reconcile contradictory observations in experimental aging research. Geroscience. 2019 Feb 27. doi: 10.1007/s11357-019-00058-2. [Epub ahead of print]

van Well EM, Bader V, Patra M, Sánchez-Vicente A, Meschede J, Furthmann N, Schnack C, Blusch A, Longworth J, Petrasch-Parwez E, Mori K, Arzberger T, Trümbach D, Angersbach L, Showkat C, Sehr DA, Berlemann LA, Goldmann P, Clement AM, Behl C, Woerner AC, Saft C, Wurst W, Haass C, Ellrichmann G, Gold R, Dittmar G, Hipp MS, Hartl FU, Tatzelt J, Winklhofer KF. (2019) A protein quality control pathway regulated by linear ubiquitination. EMBO J. 2019 Mar 18. pii: e100730. doi: 10.15252/embj.2018100730. [Epub ahead of print]

Christ MG, Huesmann H, Nagel H, Kern A, Behl C. (2019) Sigma-1 Receptor Activation Induces Autophagy and Increases Proteostasis Capacity In Vitro and In Vivo. Cells. 2019 Mar 2;8(3). pii: E211. doi: 10.3390/cells8030211.

Publications 2018

Di Spiezio A., Sandin E. S., Dore R., Muller-Fielitz H., Storck S. E., Bernau M., Mier W., Oster H., Joehren O., Pietrzik C. U., Lehnert H., Schwaninger M. (2018) The LepR-mediated leptin transport across brain barriers controls food reward. MOLECULAR METABOLISM. 2018; 8: 13-22 Article

Eggert S., Gonzalez A. C., Thomas C., Schilling S., Schwarz S. M., Tischer C., Adam V., Strecker P., Schmidt V., Willnow T. E., Hermey G., Pietrzik C. U., Koo E. H., Kins S. (2018) Dimerization leads to changes in APP (amyloid precursor protein) trafficking mediated by LRP1 and SorLA. CELLULAR AND MOLECULAR LIFE SCIENCES. 2018; 75 (2): 301-322 Article

Goel P., Jumpertz T., Ticha A., Ogorek I., Mikles D. C., Hubalek M., Pietrzik C. U., Strisovsky K., Schmidt B., Weggen S. (2018) Discovery and validation of 2-styryl substituted benzoxazin-4-ones as a novel scaffold for rhomboid protease inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2018; 28 (8): 1417-1422 Article

Granold M., Hajieva P., Tosa M. I., Irimie F.-D., Moosmann B. (2018) Modern diversification of the amino acid repertoire driven by oxygen. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2018; 115 (1): 41-46 Article

Hajieva P., Baeken M. W., Moosmann B. (2018) The role of Plasma Membrane Calcium ATPases (PMCAs) in neurodegenerative disorders. NEUROSCIENCE LETTERS. 2018; 663: 29-38 Review

Kern A., Spang N., Huesmann H., Behl C. (2018) Novel Modulators of Proteostasis: RNAi Screen of Chromosome I in a Heat Stress Paradigm in C-elegans. CELLS. 2018; 7 (6):  Article

Storck S. E., Hartz A. M. S., Bernard J., Wolf A., Kachlmeier A., Mahringer A., Weggen S.a, Pahnke J., Pietrzik C. U. (2018) The concerted amyloid-beta clearance of LRP1 and ABCB1/P-gp across the blood-brain barrier is linked by PICALM. BRAIN BEHAVIOR AND IMMUNITY. 2018; 73: 21-33 Article

Weckmann K., Diefenthaeler P., Baeken M. W., Yusifli K., Turck C. W., Asara J. M., Behl C., Hajieva P. (2018) Metabolomics profiling reveals differential adaptation of major energy metabolism pathways associated with autophagy upon oxygen and glucose reduction. SCIENTIFIC REPORTS. 2018; 8:  Article

Windschmitt J., Jacobi B., Buelbuel Y., Sester L., Tappe J., Hiebel C., Behl C., Theobald M., Munder M. (2018) Arginine Depletion in Combination with Canavanine Supplementation Induces Massive Cell Death in Myeloma Cells By Interfering with Their Protein Metabolism and Bypassing Potential Rescue Mechanisms. BLOOD. 2018; 132:  Meeting Abstract

Zandl-Lang M., Fanaee-Danesh E., Sun Y., Albrecher N. M., Gali C. C., Cancar I., Kober A., Tam-Amersdorfer C., Stracke A., Storck S. M., Saeed A., Stefulj J., Pietrzik C. U., Wilson M. R., Bjorkhem I., Panzenboeck U. (2018) Regulatory effects of simvastatin and apoJ on APP processing and,amyloid-beta clearance in blood-brain barrier endothelial cells. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS. 2018; 1863 (1): 40-60 Article

Publications 2017

Granold M, Hajieva P, Tosa M, Irimie FD, Moosmann B (2018). Modern diversification of the amino acid repertoire driven by oxygen. Proc. Natl. Acad. Sci. USA 115, 41-46.

Sebastiani A, Gölz C, Sebastiani PG, Bobkiewicz W, Behl C, Mittmann T, Thal SC, Engelhard K (2017). Sequestosome 1 Deficiency Delays, but Does Not Prevent Brain Damage Formation Following Acute Brain Injury in Adult Mice.
Front Neurosci. 2017 Dec 19;11:678.

Goel P, Jumpertz T, Mikles DC, Ticha A, Nguyen MTN, Verhelst SHL, Hubalek M, Johnson DC, Bachovchin D, Ogorek I, Pietrzik CU, Strisovsky K, Schmidt B, Weggen S (2017). Discovery and biological evaluation of potent and selective N-methylene saccharin derived inhibitors for rhomboid intramembrane proteases.
Biochemistry. 2017 Nov 29 [Epub ahead of print]

Behl C, Ziegler C (2017). Beyond Amyloid - Widening the View on Alzheimer's Disease.
J Neurochem. 2017 Oct 20 [Epub ahead of print]

Storck SE, Pietrzik CU (2017). Endothelial LRP1 - A Potential Target for the Treatment of Alzheimer's Disease.
Pharm Res. 2017 Sep 25 [Epub ahead of print]

Zandl-Lang M, Fanaee-Danesh E, Sun Y, Albrecher NM, Gali CC, Čančar I, Kober A, Tam-Amersdorfer C, Stracke A, Storck SM, Saeed A, Stefulj J, Pietrzik CU, Wilson MR, Björkhem I, Panzenboeck U (2017).Regulatory effects of simvastatin and apoJ on APP processing and amyloid-β clearance in blood-brain barrier endothelial cells.
Biochim Biophys Acta. 1863(1):40-60.

Behl C (2017). Amyloid in Alzheimer's Disease: Guilty Beyond Reasonable Doubt?
Trends Pharmacol Sci. 38(10):849-851.

Eggert S, Gonzalez AC, Thomas C, Schilling S, Schwarz SM, Tischer C, Adam V, Strecker P, Schmidt V, Willnow TE, Hermey G, Pietrzik CU, Koo EH, Kins S (2017). Dimerization leads to changes in APP (amyloid precursor protein) trafficking mediated by LRP1 and SorLA.
Cell Mol Life Sci. 2017 Aug 10 [Epub ahead of print]

Steffen J, Krohn M, Schwitlick C, Brüning T, Paarmann K, Pietrzik CU, Biverstål H, Jansone B, Langer O, Pahnke J (2017). Expression of endogenous mouse APP modulates β-amyloid deposition in hAPP-transgenic mice.
Acta Neuropathol Commun. 5(1):49.

Herr UM, Strecker P, Storck SE, Thomas C, Rabiej V, Junker A, Schilling S, Schmidt N, Dowds CM, Eggert S, Pietrzik CU, Kins S (2017). LRP1 Modulates APP Intraneuronal Transport and Processing in Its Monomeric and Dimeric State.
Front Mol Neurosci. 10:118.

Reilly R, Mroz MS, Dempsey E, Wynne K, Keely SJ, McKone EF, Hiebel C, Behl C, Coppinger JA (2017). Targeting the PI3K/Akt/mTOR signalling pathway in Cystic Fibrosis.
Sci Rep. 7(1):7642.

Stürner E, Behl C (2017). The Role of the Multifunctional BAG3 Protein in Cellular Protein Quality Control and in Disease.
Front Mol Neurosci. 10:177.

Feldmann A, Bekbulat F, Huesmann H, Ulbrich S, Tatzelt J, Behl C, Kern A (2017). The RAB GTPase RAB18 modulates macroautophagy and proteostasis.
Biochem Biophys Res Commun. 486(3):738-743.

Hajieva P (2017). The Effect of Polyphenols on Protein Degradation Pathways: Implications for Neuroprotection.
Molecules. 22(1):159.

Schönbühler B, Schmitt V, Huesmann H, Kern A, Gamerdinger M, Behl C (2017). BAG2 Interferes with CHIP-Mediated Ubiquitination of HSP72.
Int. J. Mol. Sci. 18(1), 69.

Wild K, August A, Pietrzik CU, Kins S (2017). Structure and Synaptic Function of Metal Binding to the Amyloid Precursor Protein and its Proteolytic Fragments.
Front Mol Neurosci. 10:21.

Becker-Pauly C, Pietrzik CU (2017). The Metalloprotease Meprin β Is an Alternative β-Secretase of APP.
Front Mol Neurosci. 9:159.

Brandscheid C, Schuck F, Reinhardt S, Schäfer KH, Pietrzik CU, Grimm M, Hartmann T, Schwiertz A, Endres K (2017). Altered Gut Microbiome Composition and Tryptic Activity of the 5xFAD Alzheimer's Mouse Model.
J Alzheimers Dis. 56(2):775-788.

Bedau T, Peters F, Prox J, Arnold P, Schmidt F, Finkernagel M, Köllmann S, Wichert R, Otte A, Ohler A, Stirnberg M, Lucius R, Koudelka T, Tholey A, Biasin V, Pietrzik CU, Kwapiszewska G, Becker-Pauly C (2017). Ectodomain shedding of CD99 within highly conserved regions is mediated by the metalloprotease meprin β and promotes transendothelial cell migration.
FASEB J. 31(3):1226-1237.

Ohlow MJ, Sohre S, Granold M, Schreckenberger M, Moosmann B (2017). Why Have Clinical Trials of Antioxidants to Prevent Neurodegeneration Failed? - A Cellular Investigation of Novel Phenothiazine-Type Antioxidants Reveals Competing Objectives for Pharmaceutical Neuroprotection.
Pharm Res. 34(2):378-393.

Publications 2016

Becker-Pauly C, Pietrzik CU (2016). Mice are not Men: ADAM30 Findings Emphasize a Broader Look Towards Murine Alzheimer's Disease Models.
EBioMedicine. 9:19-20.

Safina D, Schlitt F, Romeo R, Pflanzner T, Pietrzik CU, Narayanaswami V, Edenhofer F, Faissner A (2016). Low-density lipoprotein receptor-related protein 1 is a novel modulator of radial glia stem cell proliferation, survival, and differentiation.
Glia. 64(8):1363-80.

Schmidt F, Müller M, Prox J, Arnold P, Schönherr C, Tredup C, Minder P, Ebsen H, Janssen O, Annaert W, Pietrzik C, Schmidt-Arras D, Sterchi EE, Becker-Pauly C (2016).Tetraspanin 8 is an interactor of the metalloprotease meprin β within tetraspanin-enriched microdomains.
Biol Chem. 397(9):857-69.

Behl C (2016). Breaking BAG: The Co-Chaperone BAG3 in Health and Disease.
Trends Pharmacol Sci. 37(8):672-88.

Sebastiani A, Granold M, Ditter A, Sebastiani P, Gölz C, Pöttker B, Luh C, Schaible EV, Radyushkin K, Timaru-Kast R, Werner C, Schäfer MK, Engelhard K, Moosmann B, Thal SC (2016). Posttraumatic Propofol Neurotoxicity Is Mediated via the Pro-Brain-Derived Neurotrophic Factor-p75 Neurotrophin Receptor Pathway in Adult Mice.
Crit Care Med. 2016 44(2):e70-82.

Rodríguez AE, López-Crisosto C, Peña-Oyarzún D, Salas D, Parra V, Quiroga C, Morawe T, Chiong M, Behl C, Lavandero S (2016). BAG3 regulates total MAP1LC3B protein levels through a translational but not transcriptional mechanism.
Autophagy. 12(2):287-96.

Klionsky DJ, (...), Behl C, (...), Kern A, (...) (2016). Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Autophagy. 12(1):1-222.

Schönherr C, Bien J, Isbert S, Wichert R, Prox J, Altmeppen H, Kumar S, Walter J, Lichtenthaler SF, Weggen S, Glatzel M, Becker-Pauly C, Pietrzik CU (2016). Generation of aggregation prone N-terminally truncated amyloid β peptides by meprin β depends on the sequence specificity at the cleavage site.
Mol Neurodegener. 11(1):19.

Storck SE, Meister S, Nahrath J, Meißner JN, Schubert N, Di Spiezio A, Baches S, Vandenbroucke RE, Bouter Y, Prikulis I, Korth C, Weggen S, Heimann A, Schwaninger M, Bayer TA, Pietrzik CU (2016). Endothelial LRP1 transports amyloid-β1-42 across the blood-brain barrier.
J Clin Invest. 126(1):123-36.

Rabiej VK, Pflanzner T, Wagner T, Goetze K, Storck SE, Eble JA, Weggen S, Mueller-Klieser W, Pietrzik CU (2016). Low density lipoprotein receptor-related protein 1 mediated endocytosis of β1-integrin influences cell adhesion and cell migration.
Exp Cell Res. 340(1):102-15.

Khaminets A, Behl C, Dikic I (2016). Ubiquitin-Dependent And Independent Signals In Selective Autophagy.
Trends Cell Biol. 26(1):6-16.

Kundu A, Milosch N, Antonietti P, Baumkötter F, Zymny A, Müller UC, Kins S, Hajieva P, Behl C, Kögel D (2015). Modulation of BAG3 Expression and Proteasomal Activity by sAPPα Does Not Require Membrane-Tethered Holo-APP.
Mol Neurobiol. 53(9):5985-5994.

Publications 2015

Kern A, Dikic I, Behl C (2015). The integration of autophagy and cellular trafficking pathways via RAB GAPs.
Autophagy. 11(12):2393-7.

Hajieva P, Moosmann B (2015). Brain protein oxidation: what does it reflect?
Neural Regen Res. 10(11):1729-30.

Jäckle F, Schmidt F, Wichert R, Arnold P, Prox J, Mangold M, Ohler A, Pietrzik CU, Koudelka T, Tholey A, Gütschow M, Stirnberg M, Becker-Pauly C (2015). Metalloprotease meprin β is activated by transmembrane serine protease matriptase-2 at the cell surface thereby enhancing APP shedding.
Biochem J. 470(1):91-103.

Felzen V, Hiebel C, Koziollek-Drechsler I, Reißig S, Wolfrum U, Kögel D, Brandts C, Behl C, Morawe T (2015). Estrogen receptor α regulates non-canonical autophagy that provides stress resistance to neuroblastoma and breast cancer cells and involves BAG3 function.
Cell Death Dis. 6:e1812.

Hiebel C, Behl C (2015). The complex modulation of lysosomal degradation pathways by cannabinoid receptors 1 and 2.
Life Sci. 138:3-7.

Schindeldecker M, Moosmann B (2015). Protein-borne methionine residues as structural antioxidants in mitochondria.
Amino Acids. 47(7):1421-32.

Meister S, Storck SE, Hameister E, Behl C, Weggen S, Clement AM, Pietrzik CU (2015). Expression of the ALS-causing variant hSOD1G93A leads to an impaired integrity and altered regulation of claudin-5 expression in an in vitro blood-spinal cord barrier model.
J Cereb Blood Flow Metab. 35(7):1112-21.

Hartmann EK, Ziebart A, Thomas R, Liu T, Schad A, Tews M, Moosmann B, Kamuf J, Duenges B, Thal SC, David M (2015). Inhalation therapy with the synthetic TIP-like peptide AP318 attenuates pulmonary inflammation in a porcine sepsis model.
BMC Pulm Med. 15(1):2.

Songarj P, Luh C, Staib-Lasarzik I, Engelhard K, Moosmann B, Thal SC (2015). The antioxidative, non-psychoactive tricyclic phenothiazine reduces brain damage after experimental traumatic brain injury in mice.
Neurosci Lett. 584:253-8.

Liebl MP, Windschmitt J, Besemer AS, Schäfer AK, Reber H, Behl C, Clement AM (2015). Low-frequency magnetic fields do not aggravate disease in mouse models of Alzheimer's disease and amyotrophic lateral sclerosis.
Sci Rep. 5:8585.

Granold M, Moosmann B, Staib-Lasarzik I, Arendt T, Del Rey A, Engelhard K, Behl C, Hajieva P (2015). High membrane protein oxidation in the human cerebral cortex.
Redox Biol. 4:200-7.

Renziehausen J, Hiebel C, Nagel H, Kundu A, Kins S, Kögel D, Behl C, Hajieva P (2015). The Cleavage Product of Amyloid-β Protein Precursor sAβPPα Modulates BAG3-Dependent Aggresome Formation and Enhances Cellular Proteasomal Activity.
J Alzheimers Dis. 44(3):879-96.

Pasillas MP, Shields S, Reilly R, Strnadel J, Behl C, Park R, Yates JR 3rd, Klemke R, Gonias SL, Coppinger JA (2015). Proteomic analysis reveals a role for Bcl2-associated athanogene 3 and Major Vault Protein in resistance to apoptosis in senescent cells by regulating ERK1/2 activation.
Mol Cell Proteomics. 14(1):1-14.

Hajieva P, Bayatti N, Granold M, Behl C, Moosmann B (2015). Membrane protein oxidation determines neuronal degeneration.
J Neurochem. 133(3):352-67.

Publications 2014

Spang N*, Feldmann A*, Huesmann H, Bekbulat F, Schmitt V, Hiebel C, Koziollek-Drechsler I, Clement AM, Moosmann B, Jung J, Behrends C, Dikic I, Kern A, Behl C (2014). RAB3GAP1 and RAB3GAP2 modulate basal and rapamycin-induced autophagy. (* equal contribution)
Autophagy. 10(12):2297-309.

Milosch N, Tanriöver G, Kundu A, Rami A, François JC, Baumkötter F, Weyer SW, Samanta A, Jäschke A, Brod F, Buchholz CJ, Kins S, Behl C, Müller UC, Kögel D (2014). Holo-APP and G-protein-mediated signaling are required for sAPPα-induced activation of the Akt survival pathway.
Cell Death Dis. 5:e1391.

Hiebel C, Kromm T, Stark M, Behl C (2014). Cannabinoid receptor 1 modulates the autophagic flux independent of mTOR- and BECLIN1-complex.
J Neurochem. 131(4): 484-97.

Stark M, Behl C (2014). The Ginkgo biloba Extract EGb 761 Modulates Proteasome Activity and Polyglutamine Protein Aggregation.
Evidence-Based Complementary and Alternative Medicine 2014:940186.

Liebl MP, Kaya AM, Tenzer S, Mittenzwei R, Koziollek-Drechsler I, Schild HR, Moosmann B, Behl C, Clement AM (2014). Dimerization of visinin-like protein 1 is regulated by oxidative stress and calcium and is a pathological hallmark of amyotrophic lateral sclerosis.
Free Radic Biol Med. 72:41-54.

Tucher J, Linke D, Koudelka T, Cassidy L, Tredup C, Wichert R, Pietrzik C, Becker-Pauly C, Tholey A (2014). LC-MS based cleavage site profiling of the proteases ADAM10 and ADAM17 using proteome-derived peptide libraries.
J Proteome Res. 13(4):2205-14.

Martínez Vera NP, Schmidt R, Langer K, Zlatev I, Wronski R, Auer E, Havas D, Windisch M, von Briesen H, Wagner S, Stab J, Deutsch M, Pietrzik C, Fazekas F, Ropele S (2014). Tracking of magnetite labeled nanoparticles in the rat brain using MRI.
PLoS One. 9(3):e92068.

Brendel A, Renziehausen J, Behl C, Hajieva P (2014). Downregulation of PMCA2 increases the vulnerability of midbrain neurons to mitochondrial complex I inhibition.
Neurotoxicology 40:43-51.

Publications 2013

Weichert A, Besemer AS, Liebl M, Hellmann N, Koziollek-Drechsler I, Ip P, Decker H, Robertson J, Chakrabartty A, Behl C, Clement AM (2013). Wild-type Cu/Zn superoxide dismutase stabilizes mutant variants by heterodimerization.
Neurobiol Dis. 62:479-488.

Meister S, Zlatev I, Stab J, Docter D, Baches S, Stauber RH, Deutsch M, Schmidt R, Ropele S, Windisch M, Langer K, Wagner S, von Briesen H, Weggen S, Pietrzik CU (2013). Nanoparticulate flurbiprofen reduces amyloid-β42 generation in an in vitro blood-brain barrier model.
Alzheimers Res Ther. 5(6):51.

Blödt S, Kuhlmey A, Bartholomeyczik S, Behl C, Betsch F, Brinkhaus B, Frühwald M, Füsgen I, Jansen S, Köppel C, Krüger E, Macher M, Michalsen A, Rapp MA, Riepe MW, Schimpf D, Teut M, Warme B, Warning A, Wilkens J, Witt CM (2013). [Dementia in Germany: Results of an interdisciplinary expert workshop.]
Wien Med Wochenschr. 163:536-40. German.

Maier W, Bednorz M, Meister S, Roebroek A, Weggen S, Schmitt U, Pietrzik CU (2013). LRP1 is critical for the surface distribution and internalization of the NR2B NMDA receptor subtype.
Mol Neurodegener. 8:25.

Stumm C, Hiebel C, Hanstein R, Purrio M, Nagel H, Conrad A, Lutz B, Behl C, Clement AB (2013). Cannabinoid receptor 1 deficiency in a mouse model of Alzheimer's disease leads to enhanced cognitive impairment despite of a reduction in amyloid deposition.
Neurobiol Aging.
34(11): 2574-84.

Wagner T, Dieckmann M, Jaeger S, Weggen S, Pietrzik CU (2013). Stx5 is a novel interactor of VLDL-R to affect its intracellular trafficking and processing.
Exp Cell Res. 319(13):1956-72.

Gil SY, Youn BS, Byun K, Huang H, Namkoong C, Jang PG, Lee JY, Jo YH, Kang GM, Kim HK, Shin MS, Pietrzik CU, Lee B, Kim YB, Kim MS (2013). Clusterin and LRP2 are critical components of the hypothalamic feeding regulatory pathway.
Nat Commun. 4:1862.

Brendel A, Felzen V, Morawe T, Manthey D, Behl C (2013). Differential regulation of apoptosis-associated genes by estrogen receptor alpha in human neuroblastoma cells.
Restor Neurol Neurosci. 31: 199-211.

Korac J, Schaeffer V, Kovacevic I, Clement AM, Jungblut B, Behl C, Terzic J, Dikic I (2013). Ubiquitin-independent function of optineurin in autophagic clearance of protein aggregates.
J Cell Sci. 126: 580-92.

Jefferson T, Auf dem Keller U, Bellac C, Metz VV, Broder C, Hedrich J, Ohler A, Maier W, Magdolen V, Sterchi E, Bond JS, Jayakumar A, Traupe H, Chalaris A, Rose-John S, Pietrzik CU, Postina R, Overall CM, Becker-Pauly C (2013). The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10.
Cell Mol Life Sci. 70: 309-33.

Publications 2012

Fuhrmeister J, Tews M, Kromer A, Moosmann B (2012). Prooxidative toxicity and selenoprotein suppression by cerivastatin in muscle cells.
Toxicol Lett. 215: 219-27.

Büchner B, Gallenmüller C, Lautenschläger R, Kuhn K, Wittig I, Schöls L, Rapaport D, Seelow D, Freisinger P, Prokisch H, Sperl W, Wenz T, Behl C, Deschauer M, Kornblum C, Schneiderat P, Abicht A, Schuelke M, Meitinger T, Klopstock T und und das mitoNET-Consortium (2012)
Das Deutsche Netzwerk für mitochondriale Erkrankungen (mitoNET).
Medizinische Genetik 24: 193-199.

Rennhack A, Jumpertz T, Ness J, Baches S, Pietrzik CU, Weggen S, Bulic B (2012). Synthesis of a potent photoreactive acidic γ-secretase modulator for target identification in cells.
Bioorg Med Chem. 20(21):6523-32.

Klionsky DJ, (...), Behl C, (...) (2012). Guidelines for the use and interpretation of assays for monitoring autophagy.
Autophagy 8: 445-544.

Bien J, Jefferson T, Causevic M, Jumpertz T, Muenter L, Multhaup G, Weggen S, Becker-Pauly C, Pietrzik CU. (2012). The metalloprotease meprin β generates amino terminal truncated Aβ-peptide species.
J Biol Chem. 287(40):33304-13.

Zettl H, Ness J, Hähnke V, Beher D, Jumpertz T, Saric A, Baumann K, Pietrzik CU, Bulic B, Schneider G, Weggen S. (2012). Discovery of γ-Secretase Modulators with a Novel Activity Profile by Text-Based Virtual Screening.
ACS Chem Biol. 7(9):1488-95.

Clement AM (2012).Two in one against motor neuron degeneration: Tackling oxidative stress and inflammation with a sulfasalazine derivative.
J Neurochem. 122(5):869-71.

Behl C (2012). Brain aging and late-onset Alzheimer's disease: many open questions.
Int Psychogeriatr. 24 Suppl 1: S3-9.

Ohlow MJ, Granold M, Schreckenberger M, Moosmann B (2012). Is the chromanol head group of vitamin E nature's final truth on chain-breaking antioxidants?
FEBS Lett. 586, 711-716.

Wagner S, Zensi A, Wien SL, Tschickardt SE, Maier W, Vogel T, Worek F, Pietrzik CU, Kreuter J, von Briesen H (2012). Uptake Mechanism of ApoE-Modified Nanoparticles on Brain Capillary Endothelial Cells as a Blood-Brain Barrier Model.
PLoS One. 7(3):e32568.

Morawe T, Hiebel C, Kern A, Behl C (2012). Protein Homeostasis, Aging and Alzheimer's Disease.
Mol Neurobiol. 46(1):41-54.

Müller UC, Pietrzik CU, Deller T (2012). The physiological functions of the β-amyloid precursor protein APP.
Exp Brain Res. 217(3-4):325-9.

Pflanzner T, Petsch B, André-Dohmen B, Müller-Schiffmann A, Tschickardt S, Weggen S, Stitz L, Korth C, Pietrzik CU (2012). Cellular prion protein participates in amyloid-β transcytosis across the blood-brain barrier.
J Cereb Blood Flow Metab. 32(4): 628-32.

Jumpertz T, Rennhack A, Ness J, Baches S, Pietrzik CU, Bulic B, Weggen S (2012). Presenilin Is the Molecular Target of Acidic γ-Secretase Modulators in Living Cells.
PLoS One. 7(1):e30484.

Kögel D, Deller T, Behl C (2012). Roles of amyloid precursor protein family members in neuroprotection, stress signaling and aging.
Exp Brain Res. 217:471-9.

Isbert S, Wagner K, Eggert S, Schweitzer A, Multhaup G, Weggen S, Kins S, Pietrzik CU (2012). APP dimer formation is initiated in the endoplasmic reticulum and differs between APP isoforms.
Cell Mol Life Sci. 69(8): 1353-75.

Wagner T, Pietrzik CU (2012). The role of lipoprotein receptors on the physiological function of APP.
Exp Brain Res. 217(3-4): 377-87.


Jefferson T, Auf dem Keller U, Bellac C, Metz VV, Broder C, Hedrich J, Ohler A, Maier W, Magdolen V, Sterchi E, Bond JS, Jayakumar A, Traupe H, Chalaris A, Rose-John S, Pietrzik CU, Postina R, Overall CM, Becker-Pauly C. (2012). The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10.
Cell Mol Life Sci. 2012 Sep 1. [Epub ahead of print]

Bien J, Jefferson T, Causevic M, Jumpertz T, Muenter L, Multhaup G, Weggen S, Becker-Pauly C, Pietrzik CU. (2012). The metalloprotease meprin β generates amino terminal truncated Aβ-peptide species.
J Biol Chem. 2012 Aug 9. [Epub ahead of print]

Zettl H, Ness J, Hähnke V, Beher D, Jumpertz T, Saric A, Baumann K, Pietrzik CU, Bulic B, Schneider G, Weggen S. (2012). Discovery of γ-Secretase Modulators with a Novel Activity Profile by Text-Based Virtual Screening.
ACS Chem Biol. 2012 Jul 2. [Epub ahead of print]


Bien J, Jefferson T, Causevic M, Jumpertz T, Muenter L, Multhaup G, Weggen S, Becker-Pauly C, Pietrzik CU. (2012). The metalloprotease meprin β generates amino terminal truncated Aβ-peptide species.
J Biol Chem. 2012 Aug 9. [Epub ahead of print]

Zettl H, Ness J, Hähnke V, Beher D, Jumpertz T, Saric A, Baumann K, Pietrzik CU, Bulic B, Schneider G, Weggen S. (2012). Discovery of γ-Secretase Modulators with a Novel Activity Profile by Text-Based Virtual Screening.
ACS Chem Biol. 2012 Jul 2. [Epub ahead of print]

Publications 2011

Jefferson T, Causevic M, Auf dem Keller U, Schilling O, Isbert S, Geyer R, Maier W, Tschickardt S, Jumpertz T, Weggen S, Bond JS, Overall CM, Pietrzik CU, Becker-Pauly C (2011). Metalloprotease Meprin {beta} Generates Nontoxic N-terminal Amyloid Precursor Protein Fragments in Vivo.
J Biol Chem. 286(31):27741-50.

Gamerdinger M, Carra S, Behl C (2011). Emerging roles of molecular chaperones and co-chaperones in selective autophagy: focus on BAG proteins.
J Mol Med (Berl). 89:1175-82.

Behl C (2011). BAG3 and friends: Co-chaperones in selective autophagy during aging and disease. Autophagy 7(7):795-8.

Meng F, Yao D, Shi Y, Kabakoff J, Wu W, Reicher J, Ma Y, Moosmann B, Masliah E, Lipton SA, Gu Z (2011). Oxidation of the cysteine-rich regions of parkin perturbs its E3 ligase activity and contributes to protein aggregation.
Mol. Neurodegener. 6:e34.

Heneka MT, Kummer MP, Weggen S, Bulic B, Multhaup G, Münter L, Hüll M, Pflanzner T, Pietrzik CU (2011). Molecular Mechanisms and Therapeutic Application of NSAIDs and Derived Compounds in Alzheimer's Disease.
Curr Alzheimer Res. 8(2):115-31.

Rolyan H, Feike AC, Upadhaya AR, Waha A, Van Dooren T, Haass C, Birkenmeier G, Pietrzik CU, Van Leuven F, Thal DR (2011). Amyloid-β protein modulates the perivascular clearance of neuronal apolipoprotein E in mouse models of Alzheimer's disease. 
J Neural Transm.

Schindeldecker M, Stark M, Behl C, Moosmann B (2011). Differential cysteine depletion in respiratory chain complexes enables the distinction of longevity from aerobicity.
Mech. Ageing Dev. 132:171-179.

Ohlow MJ, Moosmann B (2011). Phenothiazine: The seven lives of pharmacology’s first lead structure.
Drug Discov. Today 16:119-131.

Gamerdinger M, Kaya AM, Wolfrum U, Clement AM, Behl C (2011). BAG3 mediates chaperone-based aggresome-targeting and selected autophagy of misfolded proteins.
EMBO Rep. 12(2):149-56.

Moosmann B (2011). Respiratory chain cysteine and methionine usage indicate a causal role for thiyl radicals in aging.
Exp. Gerontol. 46:164-169.

Witte I, Altenhöfer S, Wilgenbus P, Amort J, Clement AM, Pautz A, Li H, Förstermann U, Horke S (2011). Beyond reduction of atherosclerosis: PON2 provides apoptosis resistance and stabilizes tumor cells.
Cell Death Dis. 2:e112.

Hahn S, Brüning T, Ness J, Czirr E, Baches S, Gijsen H, Korth C, Pietrzik CU, Bulic B, Weggen S (2011) Presenilin-1 (PSEN1) but not amyloid precursor protein (APP) mutations present in mouse models of Alzheimer's disease attenuate the response of cultured cells to γ-secretase modulators (GSMs) regardless of their potency and structure.
J Neurochem. 116(3):385-95.

Pflanzner T, Janko MC, André-Dohmen B, Reuss S, Weggen S, Roebroek AJ, Kuhlmann CR, Pietrzik CU (2010) LRP1 mediates bidirectional transcytosis of amyloid-beta across the blood-brain barrier.
Neurobiol Aging 32(12):2323.e1-11.

Publications 2010

Altenhöfer S, Witte I, Teiber JF, Wilgenbus P, Pautz A, Li H, Daiber A, Witan H, Clement AM, Förstermann U, Horke S (2010) One enzyme, two functions: PON2 prevents mitochondrial superoxide formation and apoptosis independent from its lactonase activity.
J Biol Chem. 285(32): 24398-403.

Mocko JB, Kern A, Moosmann B, Behl C, Hajieva P (2010) Phenothiazines interfere with dopaminergic neurodegeneration in Caenorhabditis elegans models of Parkinson's disease.
Neurobiol Dis.

Haege S, Galetzka D, Zechner U, Haaf T, Gamerdinger M, Behl C, Hiemke C, Schmitt U (2010) Spatial learning and expression patterns of PP1 mRNA in mouse hippocampus.
Neuropsychobiology 61(4):188-96.

Clement AB, Gimpl G, Behl C (2010) Oxidative stress resistance in hippocampal cells is associated with altered membrane fluidity and enhanced nonamyloidogenic cleavage of endogenous amyloid precursor protein.
Free Radic Biol Med. 48(9):1236-41.

Manthey D, Gamerdinger M, Behl C (2010) The selective beta1-adrenoceptor antagonist nebivolol is a potential oestrogen receptor agonist with neuroprotective abilities.
Br J Pharmacol 159(6):1264-73.

Kern A, Ackermann B, Clement AM, Duerk H, Behl C (2010) HSF1-controlled and age-associated chaperone capacity in neurons and muscle cells of C. elegans.
PLoS One. 2010 Jan 5;5(1):e8568.

Luh C, Kuhlmann CR, Ackermann B, Timaru-Kast R, Luhmann HJ, Behl C, Werner C, Engelhard K, Thal SC (2010) Inhibition of myosin light chain kinase reduces brain edema formation after traumatic brain injury.
J Neurochem. 112(4):1015-25.

Pflanzner T, Kuhlmann CR, Pietrzik CU (2010) Blood-Brain-Barrier Models for the Investigation of Transporter- and Receptor-Mediated Amyloid-beta Clearance in Alzheimer's Disease.
Curr Alzheimer Res. 7(7):578-90.

Kirschbaum KM, Uhr M, Holthoewer D, Namendorf C, Pietrzik C, Hiemke C, Schmitt U (2010) Pharmacokinetics of acute and sub-chronic aripiprazole in P-glycoprotein deficient mice.
Neuropharmacology 59(6):474-9.

Reekmans SM, Pflanzner T, Gordts PL, Isbert S, Zimmermann P, Annaert W, Weggen S, Roebroek AJ, Pietrzik CU (2010) Inactivation of the proximal NPXY motif impairs early steps in LRP1 biosynthesis.
Cell Mol Life Sci. 67(1):135-45.