Project group leader
Phone +49 6131 39 24552
Fax 39 24743
Our research interest lies on the impact of oxidative stress on neurodegeneration. Within our current projects we are investigating the role of mitochondria in oxidative neurodegeneration. Besides being the energy supplier via oxidative phosphorylation mitochondria play a crucial role in various metabolic and biosynthetic processes and have a key function in the control of cell cycle and in apoptosis.
Our research projects are particularly exploring how mitochondria behave under various stress conditions such as inhibition of respiratory chain complexes, hypoxia or glucose deprivation and how far damaged mitochondria contribute to the enhancement of intracellular oxidation processes (protein oxidation, lipid peroxidation). Moreover, we are investigating how the accumulation of damaged mitochondria accelerates the cellular degradation machinery, especially macroautophagy and mitoautophagy.
For further information please refer to .
Granold M, Moosmann B, Staib-Lasarzik I, Arendt T, Del Rey A, Engelhard K, Behl C, Hajieva P (2015). High membrane protein oxidation in the human cerebral cortex. Redox Biol. 2014 Dec 24;4C:200-207. [Epub ahead of print]
Hajieva P*, Bayatti N, Granold M, Behl C*, Moosmann B (2014) Membrane protein oxidation determines neuronal degeneration. J Neurochem. 2014 Nov 13 [Epub ahead of print]
Renziehausen J, Nagel H, Kundu A, Kins S, Kögel D, Behl C*, Hajieva P* (2014) The cleavage product of amyloid precursor protein sAPPα modulates Bag3-dependent aggresome formation and enhances the cellular proteasomal activity. J Alzheimers Dis. 2014 Oct 31. [Epub ahead of print]
Brendel A, Renziehausen J, Behl C*, Hajieva P* (2013) Downregulation of PMCA2 increases the vulnerability of midbrain neurons to mitochondrial complex I inhibitor. Neurotoxicology 40, 43-51.
Mocko J, Kern A, Moosmann B, Behl C*, Hajieva P* (2010) Phenothiazines interfere with dopaminergic neurodegeneration in Caenorhabditis elegans models of Parkinson's disease. Neurobiol Dis. 40 (1), 120-129.
Hajieva P*, Mocko J*, Moosmann B, Behl C (2009) Novel imine antioxidants at low nanomolar concentrations protect dopaminergic cells from oxidative neurotoxicity. J Neurochem. 110(1), 118-132.
Gamerdinger M, Hajieva P, Kaya M, Wolfrum U, Hartl U, Behl C (2009) Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3. EMBO J. , 28(7), 889-901.
Journal of Alzheimer’s Disease
Journal of Neurochemistry
European Journal of Biochemistry
Journal of Neuroscience
Free Radicals in Biology and Medicine
Neurobiology of Aging
Journal of Psychiatry
Journal of Visualized Experiments
German Network for Mitochondrial Disorders (mitoNET)
Gesellschaft für Biochemie und Molekularbiologie (GBM)